Creld2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Gene Symbol	Creld2
Entrez Gene ID	76737
Full Name	cysteine-rich with EGF-like domains 2
Synonyms	5730592L21Rik,C85758
General protein information	Preferred Names cysteine-rich with EGF-like domains 2 Names cysteine-rich with EGF-like domain protein 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15\|15 E3

mRNA and Protein(s)

mRNA Protein Name

NM_029720.2 NP_083996.1 protein disulfide isomerase Creld2 precursor
Pathways from BioSystems

mRNA	Protein	Name
NM_029720.2	NP_083996.1	protein disulfide isomerase Creld2 precursor

Homologies

	LOC720586	XP_001116152.2
Canis lupus familiaris (dog)	CRELD2	XP_005625788.1
Bos taurus (cattle)	CRELD2	NP_001039656.1
Xenopus tropicalis (tropical clawed frog)	LOC100497878	XP_002932231.1
Homo sapiens (human)	CRELD2	NP_001128573.1
Pan troglodytes (chimpanzee)	CRELD2	XP_001139663.1
Danio rerio (zebrafish)	creld2	NP_956817.1
Caenorhabditis elegans (roundworm)	F09E8.2	NP_502530.1
Rattus norvegicus (Norway rat)	Creld2	NP_001032285.1
Gallus gallus (chicken)	CRELD2	NP_001186426.1
Drosophila melanogaster (fruit fly)	CG11377	NP_608490.1
Mus musculus (house mouse)	Creld2	NP_083996.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007968	XP_317502.3

Gene Ontology
Bibliography

Related articles in PubMed

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.
Naba A, Clauser KR, Mani DR, Carr SA, Hynes RO
Scientific reports740495(2017 Jan)

Efficient CRISPR-mediated mutagenesis in primary immune cells using CrispRGold and a C57BL/6 Cas9 transgenic mouse line.
Chu VT, Graf R, Wirtz T, Weber T, Favret J, Li X, Petsch K, Tran NT, Sieweke MH, Berek C, K?hn R, Rajewsky K
Proceedings of the National Academy of Sciences of the United States of America113(44)12514-12519(2016 Nov)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Motor phenotypes and molecular networks associated with germline deficiency of Ciz1.
Xiao J, Vemula SR, Xue Y, Khan MM, Kuruvilla KP, Marquez-Lona EM, Cobb MR, LeDoux MS
Experimental neurology283(Pt A)110-20(2016 Sep)

Cartilage-specific ablation of XBP1 signaling in mouse results in a chondrodysplasia characterized by reduced chondrocyte proliferation and delayed cartilage maturation and mineralization.
Cameron TL, Gresshoff IL, Bell KM, Pir?g KA, Sampurno L, Hartley CL, Sanford EM, Wilson R, Ermann J, Boot-Handford RP, Glimcher LH, Briggs MD, Bateman JF
Osteoarthritis and cartilage23(4)661-70(2015 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results strongly suggest that Creld2 may be directly regulated by BMP9 and ER stress response may play an important role in regulating osteogenic differentiation
Title: Endoplasmic reticulum (ER) stress inducible factor cysteine-rich with EGF-like domains 2 (Creld2) is an important mediator of BMP9-regulated osteogenic differentiation of mesenchymal stem cells.

These results show that the mouse CRELD2 and ALG12 genes are arranged as a unique bidirectional gene pair.
Title: Role of an ER stress response element in regulating the bidirectional promoter of the mouse CRELD2 - ALG12 gene pair.

CRELD2 could be a novel mediator in regulating the onset and progression of various ER stress-associated diseases.
Title: CRELD2 is a novel endoplasmic reticulum stress-inducible gene.

The following Creld2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Creld2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu22023	NM_029720.2 Latest version!	Mus musculus cysteine-rich with EGF-like domains 2 (Creld2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Creld2 ( NM_029720.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_083996.1 Mus musculus cysteine-rich with EGF-like domains 2 (Creld2), mRNA.

Price & Availability↑

CloneID	OMu22023
Clone ID Related Accession (Same CDS sequence)	NM_029720.2
Accession Version	NM_029720.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1053bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	protein disulfide isomerase Creld2 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK017880.1. On Apr 6, 2007 this sequence version replaced NM_029720.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK017880.1, BC047370.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGCACCTGC TGCTTGCAGC CGCGTTCGGG CTGCTGCTGC TGCTGCCGCC GCCCGGGGCC 
GTAGCCTCCC GGAAGCCGAC GATGTGCCAG AGATGCCGGA CGCTGGTGGA CAAGTTCAAC 
CAGGGGATGG CCAACACGGC CAGGAAGAAT TTCGGTGGCG GCAACACGGC GTGGGAAGAG 
AAGACGCTGT CTAAGTACGA ATTCAGTGAG ATCCGGCTTC TGGAGATCAT GGAGGGTCTG 
TGTGACAGCA GTGACTTTGA GTGCAACCAA CTCTTGGAGC AGCAGGAGGA GCAGCTAGAG 
GCTTGGTGGC AGACACTGAA GAAGGAGCAC CCCAACCTAT TTGAGTGGTT CTGTGTACAC 
ACACTGAAAG CGTGCTGTCT TCCAGGCACC TACGGGCCAG ACTGTCAAGA GTGCCAGGGT 
GGGTCCGAGA GGCCTTGCAG CGGAAACGGC TATTGCAGCG GAGACGGCAG CAGACAGGGC 
GACGGGTCCT GCCAGTGTCA CACAGGCTAC AAGGGACCAC TGTGTATTGA CTGCACAGAC 
GGCTTCTTCA GCTTGCAGAG GAACGAGACC CACAGCATCT GCTCAGCCTG TGATGAGTCT 
TGCAAGACCT GCTCTGGTCC AAGCAACAAA GACTGTATCC AGTGTGAAGT GGGCTGGGCA 
CGTGTGGAGG ATGCCTGTGT GGATGTGGAT GAGTGTGCAG CAGAGACATC TCCGTGCAGC 
GATGGCCAGT ACTGTGAGAA TGTCAACGGC TCGTACACAT GTGAAGACTG TGATTCTACC 
TGCGTGGGCT GTACAGGAAA AGGCCCAGCC AACTGTAAGG AGTGTATTGC CGGCTACACC 
AAGGAGAGTG GACAGTGCAC AGATATAGAT GAATGCTCAC TAGAAGAAAA AGCCTGTAAG 
AGGAAAAACG AAAACTGCTA CAATGTTCCG GGGAGCTTCG TGTGCGTGTG TCCGGAAGGC 
TTTGAGGAGA CAGAAGACGC TTGTGTGCAG ACAGCAGAAG GCAAAGTCAC AGAGGAAAAC 
CCCACACAGC CACCCTCCCG TGAGGATTTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_083996.1
CDS	67..1119
Translation	MHLLLAAAFGLLLLLPPPGAVASRKPTMCQRCRTLVDKFNQGMANTARKNFGGGNTAWEEKTLSKYEFSEIRLLEIMEGLCDSSDFECNQLLEQQEEQLEAWWQTLKKEHPNLFEWFCVHTLKACCLPGTYGPDCQECQGGSERPCSGNGYCSGDGSRQGDGSCQCHTGYKGPLCIDCTDGFFSLQRNETHSICSACDESCKTCSGPSNKDCIQCEVGWARVEDACVDVDECAAETSPCSDGQYCENVNGSYTCEDCDSTCVGCTGKGPANCKECIAGYTKESGQCTDIDECSLEEKACKRKNENCYNVPGSFVCVCPEGFEETEDACVQTAEGKVTEENPTQPPSREDL

Target ORF information:

RefSeq Version	NM_029720.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus cysteine-rich with EGF-like domains 2 (Creld2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_029720.2

ORF Insert Sequence:

ATGCACCTGC TGCTTGCAGC CGCGTTCGGG CTGCTGCTGC TGCTGCCGCC GCCCGGGGCC 
GTAGCCTCCC GGAAGCCGAC GATGTGCCAG AGATGCCGGA CGCTGGTGGA CAAGTTCAAC 
CAGGGGATGG CCAACACGGC CAGGAAGAAT TTCGGTGGCG GCAACACGGC GTGGGAAGAG 
AAGACGCTGT CTAAGTACGA ATTCAGTGAG ATCCGGCTTC TGGAGATCAT GGAGGGTCTG 
TGTGACAGCA GTGACTTTGA GTGCAACCAA CTCTTGGAGC AGCAGGAGGA GCAGCTAGAG 
GCTTGGTGGC AGACACTGAA GAAGGAGCAC CCCAACCTAT TTGAGTGGTT CTGTGTACAC 
ACACTGAAAG CGTGCTGTCT TCCAGGCACC TACGGGCCAG ACTGTCAAGA GTGCCAGGGT 
GGGTCCGAGA GGCCTTGCAG CGGAAACGGC TATTGCAGCG GAGACGGCAG CAGACAGGGC 
GACGGGTCCT GCCAGTGTCA CACAGGCTAC AAGGGACCAC TGTGTATTGA CTGCACAGAC 
GGCTTCTTCA GCTTGCAGAG GAACGAGACC CACAGCATCT GCTCAGCCTG TGATGAGTCT 
TGCAAGACCT GCTCTGGTCC AAGCAACAAA GACTGTATCC AGTGTGAAGT GGGCTGGGCA 
CGTGTGGAGG ATGCCTGTGT GGATGTGGAT GAGTGTGCAG CAGAGACATC TCCGTGCAGC 
GATGGCCAGT ACTGTGAGAA TGTCAACGGC TCGTACACAT GTGAAGACTG TGATTCTACC 
TGCGTGGGCT GTACAGGAAA AGGCCCAGCC AACTGTAAGG AGTGTATTGC CGGCTACACC 
AAGGAGAGTG GACAGTGCAC AGATATAGAT GAATGCTCAC TAGAAGAAAA AGCCTGTAAG 
AGGAAAAACG AAAACTGCTA CAATGTTCCG GGGAGCTTCG TGTGCGTGTG TCCGGAAGGC 
TTTGAGGAGA CAGAAGACGC TTGTGTGCAG ACAGCAGAAG GCAAAGTCAC AGAGGAAAAC 
CCCACACAGC CACCCTCCCG TGAGGATTTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.
Scientific reports740495(2017 Jan)
Naba A,Clauser KR,Mani DR,Carr SA,Hynes RO

Efficient CRISPR-mediated mutagenesis in primary immune cells using CrispRGold and a C57BL/6 Cas9 transgenic mouse line.
Proceedings of the National Academy of Sciences of the United States of America113(44)12514-12519(2016 Nov)
Chu VT,Graf R,Wirtz T,Weber T,Favret J,Li X,Petsch K,Tran NT,Sieweke MH,Berek C,K?hn R,Rajewsky K

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Motor phenotypes and molecular networks associated with germline deficiency of Ciz1.
Experimental neurology283(Pt A)110-20(2016 Sep)
Xiao J,Vemula SR,Xue Y,Khan MM,Kuruvilla KP,Marquez-Lona EM,Cobb MR,LeDoux MS

Cartilage-specific ablation of XBP1 signaling in mouse results in a chondrodysplasia characterized by reduced chondrocyte proliferation and delayed cartilage maturation and mineralization.
Osteoarthritis and cartilage23(4)661-70(2015 Apr)
Cameron TL,Gresshoff IL,Bell KM,Pir?g KA,Sampurno L,Hartley CL,Sanford EM,Wilson R,Ermann J,Boot-Handford RP,Glimcher LH,Briggs MD,Bateman JF

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Creld2 cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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