St8sia4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	St8sia4
Entrez Gene ID	116696
Full Name	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
Synonyms	Siat8d
General protein information	Preferred Names ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 Names CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 4 polysialyltransferase sialyltransferase 8 (alpha-2, 8-polysialyltransferase) D sialyltransferase 8 (alpha-2, 8-polysialytransferase) D sialyltransferase 8 (alpha-2, 8-sialytransferase) D
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q36
Summary	enzyme involved in polysialylation of N-CAM [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053914.1	NP_446366.1	CMP-N-acetylneuraminate-poly-alpha-2, 8-sialyltransferase

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ST8SIA4	NP_001032379.1
Canis lupus familiaris (dog)	ST8SIA4	XP_546003.3
	ST8SIA4	XP_001097339.1
Bos taurus (cattle)	ST8SIA4	NP_001001163.1
Danio rerio (zebrafish)	st8sia4	NP_001092886.1
Xenopus tropicalis (tropical clawed frog)	st8sia4	NP_001090747.1
Homo sapiens (human)	ST8SIA4	NP_005659.1
Mus musculus (house mouse)	St8sia4	NP_033209.1
Rattus norvegicus (Norway rat)	St8sia4	NP_446366.1
Gallus gallus (chicken)	ST8SIA4	NP_989614.1

Gene Ontology
Bibliography

Related articles in PubMed

Expression of polysialyltransferases (STX and PST) in adult rat olfactory bulb after an olfactory associative discrimination task.
Mione J, Manrique C, Duhoo Y, Roman FS, Guiraudie-Capraz G
Neurobiology of learning and memory13052-60(2016 Apr)

Dynamic expression of the polysialyltransferase in adult rat hippocampus performing an olfactory associative task.
Manrique C, Migliorati M, Gilbert V, Brezun JM, Chaillan FA, Truchet B, Khrestchatisky M, Guiraudie-Capraz G, Roman FS
Hippocampus24(8)979-89(2014 Aug)

Evolutionary history of the alpha2,8-sialyltransferase (ST8Sia) gene family: tandem duplications in early deuterostomes explain most of the diversity found in the vertebrate ST8Sia genes.
Harduin-Lepers A, Petit D, Mollicone R, Delannoy P, Petit JM, Oriol R
BMC evolutionary biology8258(2008 Sep)

Molecular characterization of pig ST8Sia IV--a critical gene for the formation of neural cell adhesion molecule and its response to sialic acid supplement in piglets.
Wang B, Hu H, Yu B
Nutritional neuroscience9(3-4)147-54(2006 Jun-Aug)

Differential biosynthesis of polysialic acid on neural cell adhesion molecule (NCAM) and oligosaccharide acceptors by three distinct alpha 2,8-sialyltransferases, ST8Sia IV (PST), ST8Sia II (STX), and ST8Sia III.
Angata K, Suzuki M, McAuliffe J, Ding Y, Hindsgaul O, Fukuda M
The Journal of biological chemistry275(24)18594-601(2000 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

After learning an olfactory discrimination task, no changes in the expression level of St8sia4 were observed in the olfactory bulb.
Title: Expression of polysialyltransferases (STX and PST) in adult rat olfactory bulb after an olfactory associative discrimination task.

Results suggest that sialyltransferase-X is probably involved in the proliferation of neural progenitor cells; polysialyltransferase may play a key role in synaptic plasticity of mature neural networks
Title: Dynamic expression of the polysialyltransferase in adult rat hippocampus performing an olfactory associative task.

The following St8sia4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the St8sia4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa11041	NM_053914.1 Latest version!	Rattus norvegicus ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 (St8sia4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

St8sia4 ( NM_053914.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446366.1 Rattus norvegicus ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 (St8sia4), mRNA.

Price & Availability↑

CloneID	ORa11041
Clone ID Related Accession (Same CDS sequence)	NM_053914.1
Accession Version	NM_053914.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1365bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Rattus norvegicus(Norway rat)
Product	CMP-N-acetylneuraminate-poly-alpha-2, 8-sialyltransferase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AM419015.1. On or before Jan 15, 2007 this sequence version replaced XM_346078.3, XM_001071501.1. ##Evidence-Data-START## Transcript exon combination :: AM419015.1, U90215.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052297, SAMEA2689594 [ECO:0000348] ##Evidence-Data-END##

ATGCACAAGG TGTCACATTT GAAAAGAAAC CCGAGCCCCA GGGAGGCGGC ACAGAGCGAC 
CCCAGCCCGG CTAGCGCAAA CTGCGCGGCA GGGCGCTGGG CAGCGCTGGA GAACCGGGAG 
AGCTCCACCG CTGAACGTCC TAGCGACCTG ATTCTGGGAT CTCGGCTCCA CGCTCCCTTC 
GCAAATTTCA GATTTCTCCC CCTTGATTAT TTCCCCAAAA CGGAGCCTTT ATACCAGGAG 
AAGGTGCCTG AGCTGGGACA ACCTGGACTT TCCCGGGCAC CCAAGATGCG CTCCATTAGA 
AAACGGTGGA CCATCTGCAC TATAAGTCTA CTCCTGATCT TTTATAAGAC AAAAGAAATA 
GCCAGGACTG AGGAGCACCA AGAGACGCAA CTCATCGGAG ATGGTGAATT ATGCTTGAGC 
AGATCACTTG TCAACAACTC TGATAAAATC ACTCGGAAGG CTGGTTCCAC CATCTTCCAA 
CATTCCGTAC AAGGCTGGAA AATCAATTCT TCTTTAGTCC TGGAGATAAG GAAGAATATT 
CTCCGTTTCC TAGACGCAGA ACGTGACGTG TCGGTGGTCA AGAGCAGTTT CAAGCCTGGT 
GATGTCATAC ACTATGTGCT GGACAGACGC CGGACACTAA ATATTTCCCA CGATCTGCAT 
AGCCTCCTGC CTGAAGTTTC ACCAATGAAA AACCGCAGGT TTAAGACCTG TGCTGTTGTT 
GGAAATTCCG GCATTCTACT AGACAGTGGA TGTGGAAAGG AGATCGACAG CCACAACTTT 
GTCATAAGGT GTAATCTAGC TCCCGTGGTG GAGTTCGCTG CGGATGTGGG GACTAAGTCA 
GATTTCATTA CCATGAATCC ATCAGTTGTG CAAAGAGCAT TCGGAGGCTT TCGGAATGAG 
AGTGACAGAG AAAAATTTGT GCACAGACTC TCCATGCTGA ATGACAGCGT CCTTTGGATT 
CCTGCCTTCA TGGTCAAAGG AGGAGAGAAG CACGTGGAAT GGGTTAATGC ATTAATCCTT 
AAGAATAAAC TGAAAGTGAG GACTGCCTAT CCATCACTGA GACTCATTCA TGCGGTCAGA 
GGTTACTGGC TGACCAACAA AGTTCCTATC AAAAGACCCA GCACTGGTCT CCTCATGTAC 
ACCCTTGCCA CCAGATTCTG TGACGAAATT CACCTGTATG GATTCTGGCC ATTTCCTAAG 
GATCTGAACG GAAAAGCTGT CAAATATCAT TACTATGATG ACTTGAAATA TAGATACTTT 
TCCAACGCAA GTCCTCACAG AATGCCACTG GAATTCAAAA CATTGAATGT GCTGCACAAT 
AGAGGAGCTC TAAAACTGAC CACAGGGAAG TGCATGAAGC AATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446366.1
CDS	1..1365
Translation	MHKVSHLKRNPSPREAAQSDPSPASANCAAGRWAALENRESSTAERPSDLILGSRLHAPFANFRFLPLDYFPKTEPLYQEKVPELGQPGLSRAPKMRSIRKRWTICTISLLLIFYKTKEIARTEEHQETQLIGDGELCLSRSLVNNSDKITRKAGSTIFQHSVQGWKINSSLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSGCGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWVNALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVLHNRGALKLTTGKCMKQ

Target ORF information:

RefSeq Version	NM_053914.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 (St8sia4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053914.1

ORF Insert Sequence:

ATGCACAAGG TGTCACATTT GAAAAGAAAC CCGAGCCCCA GGGAGGCGGC ACAGAGCGAC 
CCCAGCCCGG CTAGCGCAAA CTGCGCGGCA GGGCGCTGGG CAGCGCTGGA GAACCGGGAG 
AGCTCCACCG CTGAACGTCC TAGCGACCTG ATTCTGGGAT CTCGGCTCCA CGCTCCCTTC 
GCAAATTTCA GATTTCTCCC CCTTGATTAT TTCCCCAAAA CGGAGCCTTT ATACCAGGAG 
AAGGTGCCTG AGCTGGGACA ACCTGGACTT TCCCGGGCAC CCAAGATGCG CTCCATTAGA 
AAACGGTGGA CCATCTGCAC TATAAGTCTA CTCCTGATCT TTTATAAGAC AAAAGAAATA 
GCCAGGACTG AGGAGCACCA AGAGACGCAA CTCATCGGAG ATGGTGAATT ATGCTTGAGC 
AGATCACTTG TCAACAACTC TGATAAAATC ACTCGGAAGG CTGGTTCCAC CATCTTCCAA 
CATTCCGTAC AAGGCTGGAA AATCAATTCT TCTTTAGTCC TGGAGATAAG GAAGAATATT 
CTCCGTTTCC TAGACGCAGA ACGTGACGTG TCGGTGGTCA AGAGCAGTTT CAAGCCTGGT 
GATGTCATAC ACTATGTGCT GGACAGACGC CGGACACTAA ATATTTCCCA CGATCTGCAT 
AGCCTCCTGC CTGAAGTTTC ACCAATGAAA AACCGCAGGT TTAAGACCTG TGCTGTTGTT 
GGAAATTCCG GCATTCTACT AGACAGTGGA TGTGGAAAGG AGATCGACAG CCACAACTTT 
GTCATAAGGT GTAATCTAGC TCCCGTGGTG GAGTTCGCTG CGGATGTGGG GACTAAGTCA 
GATTTCATTA CCATGAATCC ATCAGTTGTG CAAAGAGCAT TCGGAGGCTT TCGGAATGAG 
AGTGACAGAG AAAAATTTGT GCACAGACTC TCCATGCTGA ATGACAGCGT CCTTTGGATT 
CCTGCCTTCA TGGTCAAAGG AGGAGAGAAG CACGTGGAAT GGGTTAATGC ATTAATCCTT 
AAGAATAAAC TGAAAGTGAG GACTGCCTAT CCATCACTGA GACTCATTCA TGCGGTCAGA 
GGTTACTGGC TGACCAACAA AGTTCCTATC AAAAGACCCA GCACTGGTCT CCTCATGTAC 
ACCCTTGCCA CCAGATTCTG TGACGAAATT CACCTGTATG GATTCTGGCC ATTTCCTAAG 
GATCTGAACG GAAAAGCTGT CAAATATCAT TACTATGATG ACTTGAAATA TAGATACTTT 
TCCAACGCAA GTCCTCACAG AATGCCACTG GAATTCAAAA CATTGAATGT GCTGCACAAT 
AGAGGAGCTC TAAAACTGAC CACAGGGAAG TGCATGAAGC AATAA