Runx3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Runx3
Entrez Gene ID	156726
Full Name	runt-related transcription factor 3
General protein information	Preferred Names runt-related transcription factor 3 Names runt-related transcription factor 3 Runt related transcription factor 3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q36
Summary	mouse homolog is a transcription factor required for establishing epigenetic silencing in cytotoxic lineage thymocytes [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_130425.1	NP_569109.1	runt-related transcription factor 3

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	RUNX3	XP_003307937.1
Homo sapiens (human)	RUNX3	NP_001026850.1
Bos taurus (cattle)	RUNX3	NP_001180087.1
Mus musculus (house mouse)	Runx3	NP_062706.2
Xenopus tropicalis (tropical clawed frog)	runx3	XP_002936643.1
Canis lupus familiaris (dog)	LOC487366	XP_852730.2
Rattus norvegicus (Norway rat)	Runx3	NP_569109.1
Danio rerio (zebrafish)	runx3	NP_571679.2
Gallus gallus (chicken)	RUNX3	XP_001232978.3

Gene Ontology
Bibliography

Related articles in PubMed

Runx3 is a key modulator during the epithelial-mesenchymal transition of alveolar type II cells in animal models of BPD.
Yang H, Fu J, Yao L, Hou A, Xue X
International journal of molecular medicine40(5)1466-1476(2017 Nov)

Hyperoxia-induced methylation decreases RUNX3 in a newborn rat model of bronchopulmonary dysplasia.
Zhu Y, Fu J, Yang H, Pan Y, Yao L, Xue X
Respiratory research1675(2015 Jun)

RUNX3 site-specific hypermethylation predicts papillary thyroid cancer recurrence.
Wang D, Cui W, Wu X, Qu Y, Wang N, Shi B, Hou P
American journal of cancer research4(6)725-37(2014)

Hoxa11 and Hoxd11 regulate chondrocyte differentiation upstream of Runx2 and Shox2 in mice.
Gross S, Krause Y, Wuelling M, Vortkamp A
PloS one7(8)e43553(2012)

Tumor suppressor, AT motif binding factor 1 (ATBF1), translocates to the nucleus with runt domain transcription factor 3 (RUNX3) in response to TGF-beta signal transduction.
Mabuchi M, Kataoka H, Miura Y, Kim TS, Kawaguchi M, Ebi M, Tanaka M, Mori Y, Kubota E, Mizushima T, Shimura T, Mizoshita T, Tanida S, Kamiya T, Asai K, Joh T
Biochemical and biophysical research communications398(2)321-5(2010 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

RUNX3 protein was down-regulated in the respiratory epithelium of a model of bronchopulmonary dysplasia.
Title: Hyperoxia-induced methylation decreases RUNX3 in a newborn rat model of bronchopulmonary dysplasia.

The following Runx3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Runx3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00398	NM_130425.1 Latest version!	Rattus norvegicus RUNX family transcription factor 3 (Runx3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Runx3 ( NM_130425.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_569109.1 Rattus norvegicus RUNX family transcription factor 3 (Runx3), mRNA.

Price & Availability↑

CloneID	ORa00398
Clone ID Related Accession (Same CDS sequence)	NM_130425.1
Accession Version	NM_130425.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1230bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-12
Organism	Rattus norvegicus(Norway rat)
Product	runt-related transcription factor 3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF421886.1. On or before Jun 25, 2006 this sequence version replaced XM_001069092.1, XM_001069039.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF421886.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689594, SAMEA2689603 [ECO:0000348] ##Evidence-Data-END##

ATGCGTATTC CCGTAGACCC AAGCACCAGC CGCCGCTTCA CTCCCCCCTC CACGGCCTTC 
CCCTGCGGCG GCGGCGGCGG CGGCAAGATG GGCGAGAACA GCGGCGCGCT GAGCGCGCAG 
GCGGCCGCGG GCCCCGGCGG CCGCACCCGG CCCGAAGTGC GCTCGATGGT GGACGTGCTG 
GCCGACCACG CGGGAGAGCT CGTGCGCACC GACAGCCCCA ACTTCCTCTG CTCCGTGCTG 
CCCTCGCACT GGCGCTGCAA CAAGACGCTG CCGGTCGCCT TCAAGGTGGT GGCACTGGGG 
GATGTTCCTG ATGGAACGGT GGTGACCGTG ATGGCGGGCA ATGACGAGAA TTACTCCGCC 
GAGCTGCGCA ACGCTTCCGC TGTCATGAAG AACCAAGTGG CCCGGTTCAA CGACCTCCGC 
TTCGTGGGCC GCAGCGGGCG AGGGAAGAGC TTCACGCTCA CAATCACCGT GTTCACCAAC 
CCTACCCAAG TGGCCACCTA CCACCGAGCC ATCAAGGTTA CTGTGGATGG ACCCCGGGAA 
CCCCGACGGC ACCGGCAGAA GATAGAGGAC CAGACCAAAG CCTTCCCCGA CCGCTTCGGA 
GACCTGCGCA TGCGTGTAAC ACCAAGCACA CCCAGCCCCC GTGGCTCTCT CAGCACCACG 
AGCCACTTCA GCAGCCAGGC CCAGACCCCA ATCCAAGGCT CCTCAGACCT GAACCCCTTC 
TCGGACCCCC GCCAGTTTGA TCGCTCCTTC CCTACGCTGC AAAGCCTCAC AGAGAGCCGC 
TTCCCGGAGG GAAGGATGCA CTACCCGGGA GCCATGTCTG CCGCCTTCCC CTACAGTGCC 
ACACCATCGG GAACCAGCCT GGGCGGCCTG AGCGTGGCCG GCATGCCGGC CAGCAGCCGC 
TTCCACCACA CCTACCTCCC TCCGCCCTAC CCGGGGGCCC CGCAGAGTCA GAGCGGGCCC 
TTTCAGGCCA ACCCTGCGCC CTACCACCTC TTCTATGGCA CCTCCTCCGG CTCCTACCAG 
TTCTCCATGG CAGCTGCCGG AGGTGGCGAG CGCTCGCCCA CCCGCATGCT GACCTCCTGC 
CCCACCGGCG CTTCGGTGTC AGCAGGCAAT CTCATGAACC CCAGCCTGGG CCAGGCTGAT 
GGCGTGGAAG CCGACGGCAG TCACAGCAAC TCGCCCACGG CCCTGAGCAC ACCGGGCCGC 
ATGGACGAGG CCGTGTGGCG GCCCTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_569109.1
CDS	1..1230
Translation	MRIPVDPSTSRRFTPPSTAFPCGGGGGGKMGENSGALSAQAAAGPGGRTRPEVRSMVDVLADHAGELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPTQVATYHRAIKVTVDGPREPRRHRQKIEDQTKAFPDRFGDLRMRVTPSTPSPRGSLSTTSHFSSQAQTPIQGSSDLNPFSDPRQFDRSFPTLQSLTESRFPEGRMHYPGAMSAAFPYSATPSGTSLGGLSVAGMPASSRFHHTYLPPPYPGAPQSQSGPFQANPAPYHLFYGTSSGSYQFSMAAAGGGERSPTRMLTSCPTGASVSAGNLMNPSLGQADGVEADGSHSNSPTALSTPGRMDEAVWRPY

Target ORF information:

RefSeq Version	NM_130425.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus RUNX family transcription factor 3 (Runx3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_130425.1

ORF Insert Sequence:

ATGCGTATTC CCGTAGACCC AAGCACCAGC CGCCGCTTCA CTCCCCCCTC CACGGCCTTC 
CCCTGCGGCG GCGGCGGCGG CGGCAAGATG GGCGAGAACA GCGGCGCGCT GAGCGCGCAG 
GCGGCCGCGG GCCCCGGCGG CCGCACCCGG CCCGAAGTGC GCTCGATGGT GGACGTGCTG 
GCCGACCACG CGGGAGAGCT CGTGCGCACC GACAGCCCCA ACTTCCTCTG CTCCGTGCTG 
CCCTCGCACT GGCGCTGCAA CAAGACGCTG CCGGTCGCCT TCAAGGTGGT GGCACTGGGG 
GATGTTCCTG ATGGAACGGT GGTGACCGTG ATGGCGGGCA ATGACGAGAA TTACTCCGCC 
GAGCTGCGCA ACGCTTCCGC TGTCATGAAG AACCAAGTGG CCCGGTTCAA CGACCTCCGC 
TTCGTGGGCC GCAGCGGGCG AGGGAAGAGC TTCACGCTCA CAATCACCGT GTTCACCAAC 
CCTACCCAAG TGGCCACCTA CCACCGAGCC ATCAAGGTTA CTGTGGATGG ACCCCGGGAA 
CCCCGACGGC ACCGGCAGAA GATAGAGGAC CAGACCAAAG CCTTCCCCGA CCGCTTCGGA 
GACCTGCGCA TGCGTGTAAC ACCAAGCACA CCCAGCCCCC GTGGCTCTCT CAGCACCACG 
AGCCACTTCA GCAGCCAGGC CCAGACCCCA ATCCAAGGCT CCTCAGACCT GAACCCCTTC 
TCGGACCCCC GCCAGTTTGA TCGCTCCTTC CCTACGCTGC AAAGCCTCAC AGAGAGCCGC 
TTCCCGGAGG GAAGGATGCA CTACCCGGGA GCCATGTCTG CCGCCTTCCC CTACAGTGCC 
ACACCATCGG GAACCAGCCT GGGCGGCCTG AGCGTGGCCG GCATGCCGGC CAGCAGCCGC 
TTCCACCACA CCTACCTCCC TCCGCCCTAC CCGGGGGCCC CGCAGAGTCA GAGCGGGCCC 
TTTCAGGCCA ACCCTGCGCC CTACCACCTC TTCTATGGCA CCTCCTCCGG CTCCTACCAG 
TTCTCCATGG CAGCTGCCGG AGGTGGCGAG CGCTCGCCCA CCCGCATGCT GACCTCCTGC 
CCCACCGGCG CTTCGGTGTC AGCAGGCAAT CTCATGAACC CCAGCCTGGG CCAGGCTGAT 
GGCGTGGAAG CCGACGGCAG TCACAGCAAC TCGCCCACGG CCCTGAGCAC ACCGGGCCGC 
ATGGACGAGG CCGTGTGGCG GCCCTACTGA