Ret cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ret
Entrez Gene ID	24716
Full Name	ret proto-oncogene
General protein information	Preferred Names ret proto-oncogene Names proto-oncogene tyrosine-protein kinase receptor Ret Ret gene for receptor tyrosin Ret proto-oncogene (multiple endocrine neoplasia MEN2A MEN2B and medullary thyroid carcinoma 1 Hirschsprung disease) receptor tyrosine kinase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q42
Summary	may play a role in excretory system and enteric nervous system development; human homolog is associated with Hirschsprung disease and Multiple Endocrine Neoplasia type 2 [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017592470.1	XP_017447959.1	proto-oncogene tyrosine-protein kinase receptor Ret isoform X1
NM_001110099.1	NP_001103569.1	proto-oncogene tyrosine-protein kinase receptor Ret isoform b precursor
XM_017592471.1	XP_017447960.1	proto-oncogene tyrosine-protein kinase receptor Ret isoform X2
NM_012643.2	NP_036775.2	proto-oncogene tyrosine-protein kinase receptor Ret isoform a precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	RET	NP_001184028.1
Bos taurus (cattle)	RET	NP_001178412.1
Homo sapiens (human)	RET	NP_066124.1
	RET	XP_002805672.1
Rattus norvegicus (Norway rat)	Ret	NP_036775.2
Danio rerio (zebrafish)	ret	NP_858048.2
Pan troglodytes (chimpanzee)	RET	XP_003312612.1
Mus musculus (house mouse)	Ret	NP_033076.2
Xenopus tropicalis (tropical clawed frog)	ret	XP_002933941.2
Gallus gallus (chicken)	RET	NP_990521.1

Gene Ontology
Bibliography

Related articles in PubMed

GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand.
Yang L, Chang CC, Sun Z, Madsen D, Zhu H, Padkj?r SB, Wu X, Huang T, Hultman K, Paulsen SJ, Wang J, Bugge A, Frantzen JB, N?rgaard P, Jeppesen JF, Yang Z, Secher A, Chen H, Li X, John LM, Shan B, He Z, Gao X, Su J, Hansen KT, Yang W, J?rgensen SB
Nature medicine23(10)1158-1166(2017 Oct)

GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates.
Mullican SE, Lin-Schmidt X, Chin CN, Chavez JA, Furman JL, Armstrong AA, Beck SC, South VJ, Dinh TQ, Cash-Mason TD, Cavanaugh CR, Nelson S, Huang C, Hunter MJ, Rangwala SM
Nature medicine23(10)1150-1157(2017 Oct)

Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.
Hsu JY, Crawley S, Chen M, Ayupova DA, Lindhout DA, Higbee J, Kutach A, Joo W, Gao Z, Fu D, To C, Mondal K, Li B, Kekatpure A, Wang M, Laird T, Horner G, Chan J, McEntee M, Lopez M, Lakshminarasimhan D, White A, Wang SP, Yao J, Yie J, Matern H, Solloway M, Haldankar R, Parsons T, Tang J, Shen WD, Alice Chen Y, Tian H, Allan BB
Nature550(7675)255-259(2017 Oct)

Vitamin D regulation of GDNF/Ret signaling in dopaminergic neurons.
Pertile RAN, Cui X, Hammond L, Eyles DW
FASEB journal : official publication of the Federation of American Societies for Experimental Biology(2017 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

activation of the MAPK and PI3K-AKT pathways primarily regulated Ser-727 phosphorylation, whereas a physical interaction between RET/PTC3 and STAT1, followed by a direct tyrosine phosphorylation event, was necessary for STAT1 Tyr-701 phosphorylation. These data provide the first evidence of a direct link between IDO1 expression and the oncogenic activation of RET in thyroid carcinoma
Title: Signal Transducer and Activator of Transcription 1 Plays a Pivotal Role in RET/PTC3 Oncogene-induced Expression of Indoleamine 2,3-Dioxygenase 1.

These data provide the first evidence for a physiologic role of these isoforms in RET pathway function.
Title: Exon Skipping in the RET Gene Encodes Novel Isoforms That Differentially Regulate RET Protein Signal Transduction.

STAT3 phosphorylation by neurturin was found to be mediated specifically by GFRalpha2c and RET9 isoforms.
Title: GDNF family ligand dependent STAT3 activation is mediated by specific alternatively spliced isoforms of GFR?2 and RET.

Ret receptor is one of the IB4-reactive glycoconjugate accounting for the IB4 stain in microglia under physiological and ischemic conditions.
Title: The isolectin IB4 binds RET receptor tyrosine kinase in microglia.

Identification of a key motif that determines the differential surface levels of RET and TrkB tyrosine kinase receptors and controls depolarization enhanced RET surface insertion.
Title: Identification of a key motif that determines the differential surface levels of RET and TrkB tyrosine kinase receptors and controls depolarization enhanced RET surface insertion.

The following Ret gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ret cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa60751	XM_017592471.1 Latest version!	Rattus norvegicus ret proto-oncogene (Ret), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00
ORa12188	NM_001110099.1 Latest version!	Rattus norvegicus ret proto-oncogene (Ret), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$559.30 $799.00
ORa12231	NM_012643.2 Latest version!	Rattus norvegicus ret proto-oncogene (Ret), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$818.30 $1169.00
ORa12231	XM_017592470.1 Latest version!	Rattus norvegicus ret proto-oncogene (Ret), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$818.30 $1169.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ret ( XM_017592471.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017447960.1 Rattus norvegicus ret proto-oncogene (Ret), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa60751
Clone ID Related Accession (Same CDS sequence)	XM_017592471.1
Accession Version	XM_017592471.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3321bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	proto-oncogene tyrosine-protein kinase receptor Ret isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCCTCCA CCAAGACACA GAGCGAGCAG ATGCCCGGTA GAGCAGCCCC GCTGGGTCTC 
TACTTCTCAA GGGATGCTTA CTGGGAGAGG CTGTATGTGG ACCAGCCAGC TGGCACACCT 
CTGCTCTATG TCCATGCCCT ACGGGATGCC CCTGGAGAAG TGCCCAGCTT CCGCCTGGGC 
CAGTATCTCT ATGGCGTCTA CCGCACGCGT CTGCATGAGA ATGACTGGAT CCACATCGAT 
TCGGGCACTG GCCTCCTCTA CCTCAATCAG AGCCTGGACC ATAGTTCCTG GGAGCAGCTC 
AGCATCCGCA ATGGCGGCTT CCCCTTGCTC ACCGTCTTCC TCCAGGTCTT CCTGGGGTCC 
ACAGCCCAGA GAGAGGGAGA GTGTCATTGG CCAGGCTGTG CCCGTGTGTA CTTCTCCTTC 
ATCAACGACA CCTTCCCAAA TTGTAGCTCC TTCAAAGCCC GGGATCTCTG CACCCCGGAG 
ACGGGTGTGT CCTTCCGCAT CAGGGAGAAC AGGCCCCCTG GCACCTTCTA CCAGTTCCGC 
ATGCTACCTG TGCAGTTCCT TTGTCCTAAC ATCAGTGTGA AGTACAAACT CTTAGAAGGG 
GACGGTCTGC CCTTCCGTTG TGACCCCGAC TGTCTGGAGG TGAGCACGCG GTGGGCGCTG 
GATCGGGAGC TTCAGGAGAA GTATGTGCTG GAGGCTGAGT GCGCAGTGGC AGGCCCTGGA 
GCCAACAAGG AGAAGGTGGC CGTGTCCTTC CCGGTGACGG TGTATGATGA AGACGACTCC 
CCGCCCACCT TCTCCGGAGG TGTGGGCACC GCCAGTGCTG TGGTGGAGTT TAAGCGGAAG 
GAGGGCACTG TGGTAGCCAC TCTGCAGGTG TTTGATGCAG ATGTGGTGCC AGCATCTGGG 
GAGCTGGTGA GGCGGTACAC AAGCACACTA CTCTCAGGGG ATTCCTGGGC CCAGCAGACC 
TTCCGGGTGG AGCACACACC CAACGAGACC TTGGTCCAGT CCAACAACAA CTCCGTGCGG 
GCAACCATGC ACAATTACAA GCTGGTTCTC AACAGGAGCC TGTCCATCTC AGAGAGCCGA 
GTCCTGCAGC TAGTAGTCCT GGTCAATGAC TCAGACTTCC AGGGGCCTGG GTCAGGTGTT 
CTCTTCCTCC ATTTCAACGT GTCTGTGCTG CCTGTCACCC TGAACCTACC CATGGCCTAC 
TCCTTCCCAG TGAATAGGAG AGCCCGCCGT TATGCCCAGA TTGGGAAAGT TTGCGTGGAG 
AACTGCCAGG AGTTCAGCGG TGTCTCCATC CAGTACAAGC TGCAGCCCTC CAGCACCAAC 
TGCAGTGCCC TAGGTGTGGT CACCTCAACA GAAGACACCT CAGGGACCCT ATATGTAAAT 
GACACGGAGG CCCTGCGGCG ACCTGAGTGT ACCGAGCTTC AGTACACAGT GGTAGCCACT 
GACCGGCAGA CCCGCAGGCA GACCCAGGCT TCGTTAGTCG TCACAGTGGA GGGGACATAC 
ATTGCAGAAG AAGTGGGCTG CCCCAAGTCC TGTGCAGTAA ACAAGAGGCG ACCTGAGTGT 
GAGGAGTGTG GTGGCCTGGG TTCTCCAACT GGCAGATGTG AGTGGCGTCA GGGAGATGGT 
AAAGGGATCA CCAGGAACTT CTCCACCTGT TCTCCTAGCA CCAGGACCTG TCCTGATGGC 
CACTGTGATG CTCTGGAGAG CCGGGATATC AACATTTGCC CCCAGGACTG TCTCCGTGGC 
CCCATTGTTG GCGGGCATGA GCGAGGGGAG CGCCAGGGGA TTAAAGCCGG CTATGGCATC 
TGCAACTGTT TCCCTGATGA GAAGAAGTGC TTCTGCGAGC CAGAGGACAG CCAGGGCCCA 
TTGTGCGATG AGCTGTGCCG TACGGTCATC ACAGCCGCTG TCCTCTTCTC CTTCATAATC 
TCTGTCCTGC TGTCCACCTT CTGCATCCAC CGCTACCACA AGCATGCGCA CAAGCCACCC 
ATCGCGTCAG CCGAAATGAC CTTCTGCCGG CCGGCCCAGG GCTTCCCAAT CAGCTATTCT 
TCCTCGGGCA CCCGCCGGCC CTCACTGGAC TCCATGGAGA ACCAGGTCTC TGTGGACTCT 
TTCAAGATCC CGGAGGATCC GAAGTGGGAA TTTCCTCGGA AGAACTTAGT TCTTGGGAAA 
ACCCTGGGAG AAGGCGAGTT TGGAAAAGTA GTCAAGGCCA CAGCCTTCCG TCTGAAAGGC 
CGGGCAGGAT ACACCACAGT GGCTGTGAAA ATGCTGAAAG AAAACGCCTC CCAGAGTGAA 
CTACGAGACC TGCTCTCTGA GTTCAACCTT CTGAAACAAG TCAACCATCC ACATGTCATC 
AAGTTGTACG GGGCTTGCAG CCAGGATGGG CCACTTCTTC TCATTGTGGA GTATGCAAAG 
TATGGATCCC TGCGGGGGTT CCTGCGGGAC AGCCGCAAGA TCGGGCCTGC CTATGTGAGC 
AGTGGAGGCA GCCGCAATTC CAGCTCCCTG GACCACCCAG ACGAAAGGGT GCTGACCATG 
GGCGACCTCA TCTCCTTCGC CTGGCAGATC TCGAGGGGTA TGCAGTACTT GGCTGAAATG 
AAGCTCGTAC ATCGAGACTT AGCTGCCAGA AACATCTTGG TGGCAGAGGG ACGGAAGATG 
AAGATCTCTG ACTTTGGGCT GTCCCGAGAT GTTTATGAAG AAGATTCCTA TGTGAAGAAA 
AGCAAGGGCC GGATTCCCGT CAAATGGATG GCAATCGAGT CTCTCTTCGA TCACATCTAT 
ACCACTCAAA GTGATGTGTG GTCCTTTGGA GTGCTGCTAT GGGAGATTGT GACCCTGGGA 
GGCAACCCCT ACCCTGGAAT TCCTCCTGAA CGACTCTTCA ACCTTCTGAA GACAGGCCAC 
AGGATGGAGA GGCCAGACAA CTGCAGCGAG GAAATGTACC GCCTGATGCT GCAGTGCTGG 
AAGCAGGAGC CGGACAAGAG GCCAGTATTT GCTGACATCA GCAAGGATCT GGAGAAGATG 
ATGGTCAAAA GCAGAGACTA CTTGGACCTG GCTGCATCCA CCCCTTCGGA CTCACTGCTC 
TATGACGATG GGCTCTCGGA AGAGGAGACG CCCCTGGTGG ACTGTAACAG TGCTCCCCTC 
CCGCGCTCCC TCCCTTCCAC ATGGATTGAA AACAAACTCT ATGGCATGTC AGACCCGAAC 
TGGCCTGGAG AGAGTCCTGT ACCACTCACG AGAGCCGATG GCACTAGCAC TGGGTTCCCA 
AGATATGCAA ATGATAGTGT ATATGCTAAC TGGATGGTTT CACCCTCAGC GGCAAAATTA 
ATGGACACAT TTGATAGTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017447960.1
CDS	144..3464
Translation	MPSTKTQSEQMPGRAAPLGLYFSRDAYWERLYVDQPAGTPLLYVHALRDAPGEVPSFRLGQYLYGVYRTRLHENDWIHIDSGTGLLYLNQSLDHSSWEQLSIRNGGFPLLTVFLQVFLGSTAQREGECHWPGCARVYFSFINDTFPNCSSFKARDLCTPETGVSFRIRENRPPGTFYQFRMLPVQFLCPNISVKYKLLEGDGLPFRCDPDCLEVSTRWALDRELQEKYVLEAECAVAGPGANKEKVAVSFPVTVYDEDDSPPTFSGGVGTASAVVEFKRKEGTVVATLQVFDADVVPASGELVRRYTSTLLSGDSWAQQTFRVEHTPNETLVQSNNNSVRATMHNYKLVLNRSLSISESRVLQLVVLVNDSDFQGPGSGVLFLHFNVSVLPVTLNLPMAYSFPVNRRARRYAQIGKVCVENCQEFSGVSIQYKLQPSSTNCSALGVVTSTEDTSGTLYVNDTEALRRPECTELQYTVVATDRQTRRQTQASLVVTVEGTYIAEEVGCPKSCAVNKRRPECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTRTCPDGHCDALESRDINICPQDCLRGPIVGGHERGERQGIKAGYGICNCFPDEKKCFCEPEDSQGPLCDELCRTVITAAVLFSFIISVLLSTFCIHRYHKHAHKPPIASAEMTFCRPAQGFPISYSSSGTRRPSLDSMENQVSVDSFKIPEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKGRAGYTTVAVKMLKENASQSELRDLLSEFNLLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRDSRKIGPAYVSSGGSRNSSSLDHPDERVLTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKKSKGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKSRDYLDLAASTPSDSLLYDDGLSEEETPLVDCNSAPLPRSLPSTWIENKLYGMSDPNWPGESPVPLTRADGTSTGFPRYANDSVYANWMVSPSAAKLMDTFDS

Target ORF information:

RefSeq Version	XM_017592471.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ret proto-oncogene (Ret), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017592471.1

ORF Insert Sequence:

ATGCCCTCCA CCAAGACACA GAGCGAGCAG ATGCCCGGTA GAGCAGCCCC GCTGGGTCTC 
TACTTCTCAA GGGATGCTTA CTGGGAGAGG CTGTATGTGG ACCAGCCAGC TGGCACACCT 
CTGCTCTATG TCCATGCCCT ACGGGATGCC CCTGGAGAAG TGCCCAGCTT CCGCCTGGGC 
CAGTATCTCT ATGGCGTCTA CCGCACGCGT CTGCATGAGA ATGACTGGAT CCACATCGAT 
TCGGGCACTG GCCTCCTCTA CCTCAATCAG AGCCTGGACC ATAGTTCCTG GGAGCAGCTC 
AGCATCCGCA ATGGCGGCTT CCCCTTGCTC ACCGTCTTCC TCCAGGTCTT CCTGGGGTCC 
ACAGCCCAGA GAGAGGGAGA GTGTCATTGG CCAGGCTGTG CCCGTGTGTA CTTCTCCTTC 
ATCAACGACA CCTTCCCAAA TTGTAGCTCC TTCAAAGCCC GGGATCTCTG CACCCCGGAG 
ACGGGTGTGT CCTTCCGCAT CAGGGAGAAC AGGCCCCCTG GCACCTTCTA CCAGTTCCGC 
ATGCTACCTG TGCAGTTCCT TTGTCCTAAC ATCAGTGTGA AGTACAAACT CTTAGAAGGG 
GACGGTCTGC CCTTCCGTTG TGACCCCGAC TGTCTGGAGG TGAGCACGCG GTGGGCGCTG 
GATCGGGAGC TTCAGGAGAA GTATGTGCTG GAGGCTGAGT GCGCAGTGGC AGGCCCTGGA 
GCCAACAAGG AGAAGGTGGC CGTGTCCTTC CCGGTGACGG TGTATGATGA AGACGACTCC 
CCGCCCACCT TCTCCGGAGG TGTGGGCACC GCCAGTGCTG TGGTGGAGTT TAAGCGGAAG 
GAGGGCACTG TGGTAGCCAC TCTGCAGGTG TTTGATGCAG ATGTGGTGCC AGCATCTGGG 
GAGCTGGTGA GGCGGTACAC AAGCACACTA CTCTCAGGGG ATTCCTGGGC CCAGCAGACC 
TTCCGGGTGG AGCACACACC CAACGAGACC TTGGTCCAGT CCAACAACAA CTCCGTGCGG 
GCAACCATGC ACAATTACAA GCTGGTTCTC AACAGGAGCC TGTCCATCTC AGAGAGCCGA 
GTCCTGCAGC TAGTAGTCCT GGTCAATGAC TCAGACTTCC AGGGGCCTGG GTCAGGTGTT 
CTCTTCCTCC ATTTCAACGT GTCTGTGCTG CCTGTCACCC TGAACCTACC CATGGCCTAC 
TCCTTCCCAG TGAATAGGAG AGCCCGCCGT TATGCCCAGA TTGGGAAAGT TTGCGTGGAG 
AACTGCCAGG AGTTCAGCGG TGTCTCCATC CAGTACAAGC TGCAGCCCTC CAGCACCAAC 
TGCAGTGCCC TAGGTGTGGT CACCTCAACA GAAGACACCT CAGGGACCCT ATATGTAAAT 
GACACGGAGG CCCTGCGGCG ACCTGAGTGT ACCGAGCTTC AGTACACAGT GGTAGCCACT 
GACCGGCAGA CCCGCAGGCA GACCCAGGCT TCGTTAGTCG TCACAGTGGA GGGGACATAC 
ATTGCAGAAG AAGTGGGCTG CCCCAAGTCC TGTGCAGTAA ACAAGAGGCG ACCTGAGTGT 
GAGGAGTGTG GTGGCCTGGG TTCTCCAACT GGCAGATGTG AGTGGCGTCA GGGAGATGGT 
AAAGGGATCA CCAGGAACTT CTCCACCTGT TCTCCTAGCA CCAGGACCTG TCCTGATGGC 
CACTGTGATG CTCTGGAGAG CCGGGATATC AACATTTGCC CCCAGGACTG TCTCCGTGGC 
CCCATTGTTG GCGGGCATGA GCGAGGGGAG CGCCAGGGGA TTAAAGCCGG CTATGGCATC 
TGCAACTGTT TCCCTGATGA GAAGAAGTGC TTCTGCGAGC CAGAGGACAG CCAGGGCCCA 
TTGTGCGATG AGCTGTGCCG TACGGTCATC ACAGCCGCTG TCCTCTTCTC CTTCATAATC 
TCTGTCCTGC TGTCCACCTT CTGCATCCAC CGCTACCACA AGCATGCGCA CAAGCCACCC 
ATCGCGTCAG CCGAAATGAC CTTCTGCCGG CCGGCCCAGG GCTTCCCAAT CAGCTATTCT 
TCCTCGGGCA CCCGCCGGCC CTCACTGGAC TCCATGGAGA ACCAGGTCTC TGTGGACTCT 
TTCAAGATCC CGGAGGATCC GAAGTGGGAA TTTCCTCGGA AGAACTTAGT TCTTGGGAAA 
ACCCTGGGAG AAGGCGAGTT TGGAAAAGTA GTCAAGGCCA CAGCCTTCCG TCTGAAAGGC 
CGGGCAGGAT ACACCACAGT GGCTGTGAAA ATGCTGAAAG AAAACGCCTC CCAGAGTGAA 
CTACGAGACC TGCTCTCTGA GTTCAACCTT CTGAAACAAG TCAACCATCC ACATGTCATC 
AAGTTGTACG GGGCTTGCAG CCAGGATGGG CCACTTCTTC TCATTGTGGA GTATGCAAAG 
TATGGATCCC TGCGGGGGTT CCTGCGGGAC AGCCGCAAGA TCGGGCCTGC CTATGTGAGC 
AGTGGAGGCA GCCGCAATTC CAGCTCCCTG GACCACCCAG ACGAAAGGGT GCTGACCATG 
GGCGACCTCA TCTCCTTCGC CTGGCAGATC TCGAGGGGTA TGCAGTACTT GGCTGAAATG 
AAGCTCGTAC ATCGAGACTT AGCTGCCAGA AACATCTTGG TGGCAGAGGG ACGGAAGATG 
AAGATCTCTG ACTTTGGGCT GTCCCGAGAT GTTTATGAAG AAGATTCCTA TGTGAAGAAA 
AGCAAGGGCC GGATTCCCGT CAAATGGATG GCAATCGAGT CTCTCTTCGA TCACATCTAT 
ACCACTCAAA GTGATGTGTG GTCCTTTGGA GTGCTGCTAT GGGAGATTGT GACCCTGGGA 
GGCAACCCCT ACCCTGGAAT TCCTCCTGAA CGACTCTTCA ACCTTCTGAA GACAGGCCAC 
AGGATGGAGA GGCCAGACAA CTGCAGCGAG GAAATGTACC GCCTGATGCT GCAGTGCTGG 
AAGCAGGAGC CGGACAAGAG GCCAGTATTT GCTGACATCA GCAAGGATCT GGAGAAGATG 
ATGGTCAAAA GCAGAGACTA CTTGGACCTG GCTGCATCCA CCCCTTCGGA CTCACTGCTC 
TATGACGATG GGCTCTCGGA AGAGGAGACG CCCCTGGTGG ACTGTAACAG TGCTCCCCTC 
CCGCGCTCCC TCCCTTCCAC ATGGATTGAA AACAAACTCT ATGGCATGTC AGACCCGAAC 
TGGCCTGGAG AGAGTCCTGT ACCACTCACG AGAGCCGATG GCACTAGCAC TGGGTTCCCA 
AGATATGCAA ATGATAGTGT ATATGCTAAC TGGATGGTTT CACCCTCAGC GGCAAAATTA 
ATGGACACAT TTGATAGTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ret ( NM_001110099.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001103569.1 Rattus norvegicus ret proto-oncogene (Ret), transcript variant 2, mRNA.

Price & Availability↑

CloneID	ORa12188
Clone ID Related Accession (Same CDS sequence)	NM_001110099.1
Accession Version	NM_001110099.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3222bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Rattus norvegicus(Norway rat)
Product	proto-oncogene tyrosine-protein kinase receptor Ret isoform b precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AABR07061871.1. Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and unique C-terminus compared to isoform a. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ299017.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCGAAAG CGAGGTCCGG CGCCGCAGGG CTGGGGCTGA AGCTGTTTTT GCTGCTGCCG 
CTACTGGGAG AAGCCCCGCT GGGTCTCTAC TTCTCAAGGG ATGCTTACTG GGAGAGGCTG 
TATGTGGACC AGCCAGCTGG CACACCTCTG CTCTATGTCC ATGCCCTACG GGATGCCCCT 
GGAGAAGTGC CCAGCTTCCG CCTGGGCCAG TATCTCTATG GCGTCTACCG CACGCGTCTG 
CATGAGAATG ACTGGATCCA CATCGATTCG GGCACTGGCC TCCTCTACCT CAATCAGAGC 
CTGGACCATA GTTCCTGGGA GCAGCTCAGC ATCCGCAATG GCGGCTTCCC CTTGCTCACC 
GTCTTCCTCC AGGTCTTCCT GGGGTCCACA GCCCAGAGAG AGGGAGAGTG TCATTGGCCA 
GGCTGTGCCC GTGTGTACTT CTCCTTCATC AACGACACCT TCCCAAATTG TAGCTCCTTC 
AAAGCCCGGG ATCTCTGCAC CCCGGAGACG GGTGTGTCCT TCCGCATCAG GGAGAACAGG 
CCCCCTGGCA CCTTCTACCA GTTCCGCATG CTACCTGTGC AGTTCCTTTG TCCTAACATC 
AGTGTGAAGT ACAAACTCTT AGAAGGGGAC GGTCTGCCCT TCCGTTGTGA CCCCGACTGT 
CTGGAGGTGA GCACGCGGTG GGCGCTGGAT CGGGAGCTTC AGGAGAAGTA TGTGCTGGAG 
GCTGAGTGCG CAGTGGCAGG CCCTGGAGCC AACAAGGAGA AGGTGGCCGT GTCCTTCCCG 
GTGACGGTGT ATGATGAAGA CGACTCCCCG CCCACCTTCT CCGGAGGTGT GGGCACCGCC 
AGTGCTGTGG TGGAGTTTAA GCGGAAGGAG GGCACTGTGG TAGCCACTCT GCAGGTGTTT 
GATGCAGATG TGGTGCCAGC ATCTGGGGAG CTGGTGAGGC GGTACACAAG CACACTACTC 
TCAGGGGATT CCTGGGCCCA GCAGACCTTC CGGGTGGAGC ACACACCCAA CGAGACCTTG 
GTCCAGTCCA ACAACAACTC CGTGCGGGCA ACCATGCACA ATTACAAGCT GGTTCTCAAC 
AGGAGCCTGT CCATCTCAGA GAGCCGAGTC CTGCAGCTAG TAGTCCTGGT CAATGACTCA 
GACTTCCAGG GGCCTGGGTC AGGTGTTCTC TTCCTCCATT TCAACGTGTC TGTGCTGCCT 
GTCACCCTGA ACCTACCCAT GGCCTACTCC TTCCCAGTGA ATAGGAGAGC CCGCCGTTAT 
GCCCAGATTG GGAAAGTTTG CGTGGAGAAC TGCCAGGAGT TCAGCGGTGT CTCCATCCAG 
TACAAGCTGC AGCCCTCCAG CACCAACTGC AGTGCCCTAG GTGTGGTCAC CTCAACAGAA 
GACACCTCAG GGACCCTATA TGTAAATGAC ACGGAGGCCC TGCGGCGACC TGAGTGTACC 
GAGCTTCAGT ACACAGTGGT AGCCACTGAC CGGCAGACCC GCAGGCAGAC CCAGGCTTCG 
TTAGTCGTCA CAGTGGAGGG GACATACATT GCAGAAGAAG TGGGCTGCCC CAAGTCCTGT 
GCAGTAAACA AGAGGCGACC TGAGTGTGAG GAGTGTGGTG GCCTGGGTTC TCCAACTGGC 
AGATGTGAGT GGCGTCAGGG AGATGGTAAA GGGATCACCA GGAACTTCTC CACCTGTTCT 
CCTAGCACCA GGACCTGTCC TGATGGCCAC TGTGATGCTC TGGAGAGCCG GGATATCAAC 
ATTTGCCCCC AGGACTGTCT CCGTGGCCCC ATTGTTGGCG GGCATGAGCG AGGGGAGCGC 
CAGGGGATTA AAGCCGGCTA TGGCATCTGC AACTGTTTCC CTGATGAGAA GAAGTGCTTC 
TGCGAGCCAG AGGACAGCCA GGGCCCATTG TGCGATGAGC TGTGCCGTAC GGTCATCACA 
GCCGCTGTCC TCTTCTCCTT CATAATCTCT GTCCTGCTGT CCACCTTCTG CATCCACCGC 
TACCACAAGC ATGCGCACAA GCCACCCATC GCGTCAGCCG AAATGACCTT CTGCCGGCCG 
GCCCAGGGCT TCCCAATCAG CTATTCTTCC TCGGGCACCC GCCGGCCCTC ACTGGACTCC 
ATGGAGAACC AGGTCTCTGT GGACTCTTTC AAGATCCCGG AGGATCCGAA GTGGGAATTT 
CCTCGGAAGA ACTTAGTTCT TGGGAAAACC CTGGGAGAAG GCGAGTTTGG AAAAGTAGTC 
AAGGCCACAG CCTTCCGTCT GAAAGGCCGG GCAGGATACA CCACAGTGGC TGTGAAAATG 
CTGAAAGAAA ACGCCTCCCA GAGTGAACTA CGAGACCTGC TCTCTGAGTT CAACCTTCTG 
AAACAAGTCA ACCATCCACA TGTCATCAAG TTGTACGGGG CTTGCAGCCA GGATGGGCCA 
CTTCTTCTCA TTGTGGAGTA TGCAAAGTAT GGATCCCTGC GGGGGTTCCT GCGGGACAGC 
CGCAAGATCG GGCCTGCCTA TGTGAGCAGT GGAGGCAGCC GCAATTCCAG CTCCCTGGAC 
CACCCAGACG AAAGGGTGCT GACCATGGGC GACCTCATCT CCTTCGCCTG GCAGATCTCG 
AGGGGTATGC AGTACTTGGC TGAAATGAAG CTCGTACATC GAGACTTAGC TGCCAGAAAC 
ATCTTGGTGG CAGAGGGACG GAAGATGAAG ATCTCTGACT TTGGGCTGTC CCGAGATGTT 
TATGAAGAAG ATTCCTATGT GAAGAAAAGC AAGGGCCGGA TTCCCGTCAA ATGGATGGCA 
ATCGAGTCTC TCTTCGATCA CATCTATACC ACTCAAAGTG ATGTGTGGTC CTTTGGAGTG 
CTGCTATGGG AGATTGTGAC CCTGGGAGGC AACCCCTACC CTGGAATTCC TCCTGAACGA 
CTCTTCAACC TTCTGAAGAC AGGCCACAGG ATGGAGAGGC CAGACAACTG CAGCGAGGAA 
ATGTACCGCC TGATGCTGCA GTGCTGGAAG CAGGAGCCGG ACAAGAGGCC AGTATTTGCT 
GACATCAGCA AGGATCTGGA GAAGATGATG GTCAAAAGCA GAGACTACTT GGACCTGGCT 
GCATCCACCC CTTCGGACTC ACTGCTCTAT GACGATGGGC TCTCGGAAGA GGAGACGCCC 
CTGGTGGACT GTAACAGTGC TCCCCTCCCG CGCTCCCTCC CTTCCACATG GATTGAAAAC 
AAACTCTATG GTAGAATTTC ACATGCATTT ACTAGATTCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001103569.1
CDS	14..3235
Translation	MAKARSGAAGLGLKLFLLLPLLGEAPLGLYFSRDAYWERLYVDQPAGTPLLYVHALRDAPGEVPSFRLGQYLYGVYRTRLHENDWIHIDSGTGLLYLNQSLDHSSWEQLSIRNGGFPLLTVFLQVFLGSTAQREGECHWPGCARVYFSFINDTFPNCSSFKARDLCTPETGVSFRIRENRPPGTFYQFRMLPVQFLCPNISVKYKLLEGDGLPFRCDPDCLEVSTRWALDRELQEKYVLEAECAVAGPGANKEKVAVSFPVTVYDEDDSPPTFSGGVGTASAVVEFKRKEGTVVATLQVFDADVVPASGELVRRYTSTLLSGDSWAQQTFRVEHTPNETLVQSNNNSVRATMHNYKLVLNRSLSISESRVLQLVVLVNDSDFQGPGSGVLFLHFNVSVLPVTLNLPMAYSFPVNRRARRYAQIGKVCVENCQEFSGVSIQYKLQPSSTNCSALGVVTSTEDTSGTLYVNDTEALRRPECTELQYTVVATDRQTRRQTQASLVVTVEGTYIAEEVGCPKSCAVNKRRPECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTRTCPDGHCDALESRDINICPQDCLRGPIVGGHERGERQGIKAGYGICNCFPDEKKCFCEPEDSQGPLCDELCRTVITAAVLFSFIISVLLSTFCIHRYHKHAHKPPIASAEMTFCRPAQGFPISYSSSGTRRPSLDSMENQVSVDSFKIPEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKGRAGYTTVAVKMLKENASQSELRDLLSEFNLLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRDSRKIGPAYVSSGGSRNSSSLDHPDERVLTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKKSKGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKSRDYLDLAASTPSDSLLYDDGLSEEETPLVDCNSAPLPRSLPSTWIENKLYGRISHAFTRF

Target ORF information:

RefSeq Version	NM_001110099.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ret proto-oncogene (Ret), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001110099.1

ORF Insert Sequence:

ATGGCGAAAG CGAGGTCCGG CGCCGCAGGG CTGGGGCTGA AGCTGTTTTT GCTGCTGCCG 
CTACTGGGAG AAGCCCCGCT GGGTCTCTAC TTCTCAAGGG ATGCTTACTG GGAGAGGCTG 
TATGTGGACC AGCCAGCTGG CACACCTCTG CTCTATGTCC ATGCCCTACG GGATGCCCCT 
GGAGAAGTGC CCAGCTTCCG CCTGGGCCAG TATCTCTATG GCGTCTACCG CACGCGTCTG 
CATGAGAATG ACTGGATCCA CATCGATTCG GGCACTGGCC TCCTCTACCT CAATCAGAGC 
CTGGACCATA GTTCCTGGGA GCAGCTCAGC ATCCGCAATG GCGGCTTCCC CTTGCTCACC 
GTCTTCCTCC AGGTCTTCCT GGGGTCCACA GCCCAGAGAG AGGGAGAGTG TCATTGGCCA 
GGCTGTGCCC GTGTGTACTT CTCCTTCATC AACGACACCT TCCCAAATTG TAGCTCCTTC 
AAAGCCCGGG ATCTCTGCAC CCCGGAGACG GGTGTGTCCT TCCGCATCAG GGAGAACAGG 
CCCCCTGGCA CCTTCTACCA GTTCCGCATG CTACCTGTGC AGTTCCTTTG TCCTAACATC 
AGTGTGAAGT ACAAACTCTT AGAAGGGGAC GGTCTGCCCT TCCGTTGTGA CCCCGACTGT 
CTGGAGGTGA GCACGCGGTG GGCGCTGGAT CGGGAGCTTC AGGAGAAGTA TGTGCTGGAG 
GCTGAGTGCG CAGTGGCAGG CCCTGGAGCC AACAAGGAGA AGGTGGCCGT GTCCTTCCCG 
GTGACGGTGT ATGATGAAGA CGACTCCCCG CCCACCTTCT CCGGAGGTGT GGGCACCGCC 
AGTGCTGTGG TGGAGTTTAA GCGGAAGGAG GGCACTGTGG TAGCCACTCT GCAGGTGTTT 
GATGCAGATG TGGTGCCAGC ATCTGGGGAG CTGGTGAGGC GGTACACAAG CACACTACTC 
TCAGGGGATT CCTGGGCCCA GCAGACCTTC CGGGTGGAGC ACACACCCAA CGAGACCTTG 
GTCCAGTCCA ACAACAACTC CGTGCGGGCA ACCATGCACA ATTACAAGCT GGTTCTCAAC 
AGGAGCCTGT CCATCTCAGA GAGCCGAGTC CTGCAGCTAG TAGTCCTGGT CAATGACTCA 
GACTTCCAGG GGCCTGGGTC AGGTGTTCTC TTCCTCCATT TCAACGTGTC TGTGCTGCCT 
GTCACCCTGA ACCTACCCAT GGCCTACTCC TTCCCAGTGA ATAGGAGAGC CCGCCGTTAT 
GCCCAGATTG GGAAAGTTTG CGTGGAGAAC TGCCAGGAGT TCAGCGGTGT CTCCATCCAG 
TACAAGCTGC AGCCCTCCAG CACCAACTGC AGTGCCCTAG GTGTGGTCAC CTCAACAGAA 
GACACCTCAG GGACCCTATA TGTAAATGAC ACGGAGGCCC TGCGGCGACC TGAGTGTACC 
GAGCTTCAGT ACACAGTGGT AGCCACTGAC CGGCAGACCC GCAGGCAGAC CCAGGCTTCG 
TTAGTCGTCA CAGTGGAGGG GACATACATT GCAGAAGAAG TGGGCTGCCC CAAGTCCTGT 
GCAGTAAACA AGAGGCGACC TGAGTGTGAG GAGTGTGGTG GCCTGGGTTC TCCAACTGGC 
AGATGTGAGT GGCGTCAGGG AGATGGTAAA GGGATCACCA GGAACTTCTC CACCTGTTCT 
CCTAGCACCA GGACCTGTCC TGATGGCCAC TGTGATGCTC TGGAGAGCCG GGATATCAAC 
ATTTGCCCCC AGGACTGTCT CCGTGGCCCC ATTGTTGGCG GGCATGAGCG AGGGGAGCGC 
CAGGGGATTA AAGCCGGCTA TGGCATCTGC AACTGTTTCC CTGATGAGAA GAAGTGCTTC 
TGCGAGCCAG AGGACAGCCA GGGCCCATTG TGCGATGAGC TGTGCCGTAC GGTCATCACA 
GCCGCTGTCC TCTTCTCCTT CATAATCTCT GTCCTGCTGT CCACCTTCTG CATCCACCGC 
TACCACAAGC ATGCGCACAA GCCACCCATC GCGTCAGCCG AAATGACCTT CTGCCGGCCG 
GCCCAGGGCT TCCCAATCAG CTATTCTTCC TCGGGCACCC GCCGGCCCTC ACTGGACTCC 
ATGGAGAACC AGGTCTCTGT GGACTCTTTC AAGATCCCGG AGGATCCGAA GTGGGAATTT 
CCTCGGAAGA ACTTAGTTCT TGGGAAAACC CTGGGAGAAG GCGAGTTTGG AAAAGTAGTC 
AAGGCCACAG CCTTCCGTCT GAAAGGCCGG GCAGGATACA CCACAGTGGC TGTGAAAATG 
CTGAAAGAAA ACGCCTCCCA GAGTGAACTA CGAGACCTGC TCTCTGAGTT CAACCTTCTG 
AAACAAGTCA ACCATCCACA TGTCATCAAG TTGTACGGGG CTTGCAGCCA GGATGGGCCA 
CTTCTTCTCA TTGTGGAGTA TGCAAAGTAT GGATCCCTGC GGGGGTTCCT GCGGGACAGC 
CGCAAGATCG GGCCTGCCTA TGTGAGCAGT GGAGGCAGCC GCAATTCCAG CTCCCTGGAC 
CACCCAGACG AAAGGGTGCT GACCATGGGC GACCTCATCT CCTTCGCCTG GCAGATCTCG 
AGGGGTATGC AGTACTTGGC TGAAATGAAG CTCGTACATC GAGACTTAGC TGCCAGAAAC 
ATCTTGGTGG CAGAGGGACG GAAGATGAAG ATCTCTGACT TTGGGCTGTC CCGAGATGTT 
TATGAAGAAG ATTCCTATGT GAAGAAAAGC AAGGGCCGGA TTCCCGTCAA ATGGATGGCA 
ATCGAGTCTC TCTTCGATCA CATCTATACC ACTCAAAGTG ATGTGTGGTC CTTTGGAGTG 
CTGCTATGGG AGATTGTGAC CCTGGGAGGC AACCCCTACC CTGGAATTCC TCCTGAACGA 
CTCTTCAACC TTCTGAAGAC AGGCCACAGG ATGGAGAGGC CAGACAACTG CAGCGAGGAA 
ATGTACCGCC TGATGCTGCA GTGCTGGAAG CAGGAGCCGG ACAAGAGGCC AGTATTTGCT 
GACATCAGCA AGGATCTGGA GAAGATGATG GTCAAAAGCA GAGACTACTT GGACCTGGCT 
GCATCCACCC CTTCGGACTC ACTGCTCTAT GACGATGGGC TCTCGGAAGA GGAGACGCCC 
CTGGTGGACT GTAACAGTGC TCCCCTCCCG CGCTCCCTCC CTTCCACATG GATTGAAAAC 
AAACTCTATG GTAGAATTTC ACATGCATTT ACTAGATTCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ret ( NM_012643.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036775.2 Rattus norvegicus ret proto-oncogene (Ret), transcript variant 1, mRNA.

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CloneID	ORa12231
Clone ID Related Accession (Same CDS sequence)	XM_017592470.1 , NM_012643.2
Accession Version	NM_012643.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3348bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Rattus norvegicus(Norway rat)
Product	proto-oncogene tyrosine-protein kinase receptor Ret isoform a precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AABR07061871.1. On Oct 23, 2007 this sequence version replaced NM_012643.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: AJ299016.1 [ECO:0000331] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCGAAAG CGAGGTCCGG CGCCGCAGGG CTGGGGCTGA AGCTGTTTTT GCTGCTGCCG 
CTACTGGGAG AAGCCCCGCT GGGTCTCTAC TTCTCAAGGG ATGCTTACTG GGAGAGGCTG 
TATGTGGACC AGCCAGCTGG CACACCTCTG CTCTATGTCC ATGCCCTACG GGATGCCCCT 
GGAGAAGTGC CCAGCTTCCG CCTGGGCCAG TATCTCTATG GCGTCTACCG CACGCGTCTG 
CATGAGAATG ACTGGATCCA CATCGATTCG GGCACTGGCC TCCTCTACCT CAATCAGAGC 
CTGGACCATA GTTCCTGGGA GCAGCTCAGC ATCCGCAATG GCGGCTTCCC CTTGCTCACC 
GTCTTCCTCC AGGTCTTCCT GGGGTCCACA GCCCAGAGAG AGGGAGAGTG TCATTGGCCA 
GGCTGTGCCC GTGTGTACTT CTCCTTCATC AACGACACCT TCCCAAATTG TAGCTCCTTC 
AAAGCCCGGG ATCTCTGCAC CCCGGAGACG GGTGTGTCCT TCCGCATCAG GGAGAACAGG 
CCCCCTGGCA CCTTCTACCA GTTCCGCATG CTACCTGTGC AGTTCCTTTG TCCTAACATC 
AGTGTGAAGT ACAAACTCTT AGAAGGGGAC GGTCTGCCCT TCCGTTGTGA CCCCGACTGT 
CTGGAGGTGA GCACGCGGTG GGCGCTGGAT CGGGAGCTTC AGGAGAAGTA TGTGCTGGAG 
GCTGAGTGCG CAGTGGCAGG CCCTGGAGCC AACAAGGAGA AGGTGGCCGT GTCCTTCCCG 
GTGACGGTGT ATGATGAAGA CGACTCCCCG CCCACCTTCT CCGGAGGTGT GGGCACCGCC 
AGTGCTGTGG TGGAGTTTAA GCGGAAGGAG GGCACTGTGG TAGCCACTCT GCAGGTGTTT 
GATGCAGATG TGGTGCCAGC ATCTGGGGAG CTGGTGAGGC GGTACACAAG CACACTACTC 
TCAGGGGATT CCTGGGCCCA GCAGACCTTC CGGGTGGAGC ACACACCCAA CGAGACCTTG 
GTCCAGTCCA ACAACAACTC CGTGCGGGCA ACCATGCACA ATTACAAGCT GGTTCTCAAC 
AGGAGCCTGT CCATCTCAGA GAGCCGAGTC CTGCAGCTAG TAGTCCTGGT CAATGACTCA 
GACTTCCAGG GGCCTGGGTC AGGTGTTCTC TTCCTCCATT TCAACGTGTC TGTGCTGCCT 
GTCACCCTGA ACCTACCCAT GGCCTACTCC TTCCCAGTGA ATAGGAGAGC CCGCCGTTAT 
GCCCAGATTG GGAAAGTTTG CGTGGAGAAC TGCCAGGAGT TCAGCGGTGT CTCCATCCAG 
TACAAGCTGC AGCCCTCCAG CACCAACTGC AGTGCCCTAG GTGTGGTCAC CTCAACAGAA 
GACACCTCAG GGACCCTATA TGTAAATGAC ACGGAGGCCC TGCGGCGACC TGAGTGTACC 
GAGCTTCAGT ACACAGTGGT AGCCACTGAC CGGCAGACCC GCAGGCAGAC CCAGGCTTCG 
TTAGTCGTCA CAGTGGAGGG GACATACATT GCAGAAGAAG TGGGCTGCCC CAAGTCCTGT 
GCAGTAAACA AGAGGCGACC TGAGTGTGAG GAGTGTGGTG GCCTGGGTTC TCCAACTGGC 
AGATGTGAGT GGCGTCAGGG AGATGGTAAA GGGATCACCA GGAACTTCTC CACCTGTTCT 
CCTAGCACCA GGACCTGTCC TGATGGCCAC TGTGATGCTC TGGAGAGCCG GGATATCAAC 
ATTTGCCCCC AGGACTGTCT CCGTGGCCCC ATTGTTGGCG GGCATGAGCG AGGGGAGCGC 
CAGGGGATTA AAGCCGGCTA TGGCATCTGC AACTGTTTCC CTGATGAGAA GAAGTGCTTC 
TGCGAGCCAG AGGACAGCCA GGGCCCATTG TGCGATGAGC TGTGCCGTAC GGTCATCACA 
GCCGCTGTCC TCTTCTCCTT CATAATCTCT GTCCTGCTGT CCACCTTCTG CATCCACCGC 
TACCACAAGC ATGCGCACAA GCCACCCATC GCGTCAGCCG AAATGACCTT CTGCCGGCCG 
GCCCAGGGCT TCCCAATCAG CTATTCTTCC TCGGGCACCC GCCGGCCCTC ACTGGACTCC 
ATGGAGAACC AGGTCTCTGT GGACTCTTTC AAGATCCCGG AGGATCCGAA GTGGGAATTT 
CCTCGGAAGA ACTTAGTTCT TGGGAAAACC CTGGGAGAAG GCGAGTTTGG AAAAGTAGTC 
AAGGCCACAG CCTTCCGTCT GAAAGGCCGG GCAGGATACA CCACAGTGGC TGTGAAAATG 
CTGAAAGAAA ACGCCTCCCA GAGTGAACTA CGAGACCTGC TCTCTGAGTT CAACCTTCTG 
AAACAAGTCA ACCATCCACA TGTCATCAAG TTGTACGGGG CTTGCAGCCA GGATGGGCCA 
CTTCTTCTCA TTGTGGAGTA TGCAAAGTAT GGATCCCTGC GGGGGTTCCT GCGGGACAGC 
CGCAAGATCG GGCCTGCCTA TGTGAGCAGT GGAGGCAGCC GCAATTCCAG CTCCCTGGAC 
CACCCAGACG AAAGGGTGCT GACCATGGGC GACCTCATCT CCTTCGCCTG GCAGATCTCG 
AGGGGTATGC AGTACTTGGC TGAAATGAAG CTCGTACATC GAGACTTAGC TGCCAGAAAC 
ATCTTGGTGG CAGAGGGACG GAAGATGAAG ATCTCTGACT TTGGGCTGTC CCGAGATGTT 
TATGAAGAAG ATTCCTATGT GAAGAAAAGC AAGGGCCGGA TTCCCGTCAA ATGGATGGCA 
ATCGAGTCTC TCTTCGATCA CATCTATACC ACTCAAAGTG ATGTGTGGTC CTTTGGAGTG 
CTGCTATGGG AGATTGTGAC CCTGGGAGGC AACCCCTACC CTGGAATTCC TCCTGAACGA 
CTCTTCAACC TTCTGAAGAC AGGCCACAGG ATGGAGAGGC CAGACAACTG CAGCGAGGAA 
ATGTACCGCC TGATGCTGCA GTGCTGGAAG CAGGAGCCGG ACAAGAGGCC AGTATTTGCT 
GACATCAGCA AGGATCTGGA GAAGATGATG GTCAAAAGCA GAGACTACTT GGACCTGGCT 
GCATCCACCC CTTCGGACTC ACTGCTCTAT GACGATGGGC TCTCGGAAGA GGAGACGCCC 
CTGGTGGACT GTAACAGTGC TCCCCTCCCG CGCTCCCTCC CTTCCACATG GATTGAAAAC 
AAACTCTATG GCATGTCAGA CCCGAACTGG CCTGGAGAGA GTCCTGTACC ACTCACGAGA 
GCCGATGGCA CTAGCACTGG GTTCCCAAGA TATGCAAATG ATAGTGTATA TGCTAACTGG 
ATGGTTTCAC CCTCAGCGGC AAAATTAATG GACACATTTG ATAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036775.2
CDS	14..3361
Translation	MAKARSGAAGLGLKLFLLLPLLGEAPLGLYFSRDAYWERLYVDQPAGTPLLYVHALRDAPGEVPSFRLGQYLYGVYRTRLHENDWIHIDSGTGLLYLNQSLDHSSWEQLSIRNGGFPLLTVFLQVFLGSTAQREGECHWPGCARVYFSFINDTFPNCSSFKARDLCTPETGVSFRIRENRPPGTFYQFRMLPVQFLCPNISVKYKLLEGDGLPFRCDPDCLEVSTRWALDRELQEKYVLEAECAVAGPGANKEKVAVSFPVTVYDEDDSPPTFSGGVGTASAVVEFKRKEGTVVATLQVFDADVVPASGELVRRYTSTLLSGDSWAQQTFRVEHTPNETLVQSNNNSVRATMHNYKLVLNRSLSISESRVLQLVVLVNDSDFQGPGSGVLFLHFNVSVLPVTLNLPMAYSFPVNRRARRYAQIGKVCVENCQEFSGVSIQYKLQPSSTNCSALGVVTSTEDTSGTLYVNDTEALRRPECTELQYTVVATDRQTRRQTQASLVVTVEGTYIAEEVGCPKSCAVNKRRPECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTRTCPDGHCDALESRDINICPQDCLRGPIVGGHERGERQGIKAGYGICNCFPDEKKCFCEPEDSQGPLCDELCRTVITAAVLFSFIISVLLSTFCIHRYHKHAHKPPIASAEMTFCRPAQGFPISYSSSGTRRPSLDSMENQVSVDSFKIPEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKGRAGYTTVAVKMLKENASQSELRDLLSEFNLLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRDSRKIGPAYVSSGGSRNSSSLDHPDERVLTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKKSKGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKSRDYLDLAASTPSDSLLYDDGLSEEETPLVDCNSAPLPRSLPSTWIENKLYGMSDPNWPGESPVPLTRADGTSTGFPRYANDSVYANWMVSPSAAKLMDTFDS

Target ORF information:

RefSeq Version	NM_012643.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ret proto-oncogene (Ret), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012643.2

ORF Insert Sequence:

ATGGCGAAAG CGAGGTCCGG CGCCGCAGGG CTGGGGCTGA AGCTGTTTTT GCTGCTGCCG 
CTACTGGGAG AAGCCCCGCT GGGTCTCTAC TTCTCAAGGG ATGCTTACTG GGAGAGGCTG 
TATGTGGACC AGCCAGCTGG CACACCTCTG CTCTATGTCC ATGCCCTACG GGATGCCCCT 
GGAGAAGTGC CCAGCTTCCG CCTGGGCCAG TATCTCTATG GCGTCTACCG CACGCGTCTG 
CATGAGAATG ACTGGATCCA CATCGATTCG GGCACTGGCC TCCTCTACCT CAATCAGAGC 
CTGGACCATA GTTCCTGGGA GCAGCTCAGC ATCCGCAATG GCGGCTTCCC CTTGCTCACC 
GTCTTCCTCC AGGTCTTCCT GGGGTCCACA GCCCAGAGAG AGGGAGAGTG TCATTGGCCA 
GGCTGTGCCC GTGTGTACTT CTCCTTCATC AACGACACCT TCCCAAATTG TAGCTCCTTC 
AAAGCCCGGG ATCTCTGCAC CCCGGAGACG GGTGTGTCCT TCCGCATCAG GGAGAACAGG 
CCCCCTGGCA CCTTCTACCA GTTCCGCATG CTACCTGTGC AGTTCCTTTG TCCTAACATC 
AGTGTGAAGT ACAAACTCTT AGAAGGGGAC GGTCTGCCCT TCCGTTGTGA CCCCGACTGT 
CTGGAGGTGA GCACGCGGTG GGCGCTGGAT CGGGAGCTTC AGGAGAAGTA TGTGCTGGAG 
GCTGAGTGCG CAGTGGCAGG CCCTGGAGCC AACAAGGAGA AGGTGGCCGT GTCCTTCCCG 
GTGACGGTGT ATGATGAAGA CGACTCCCCG CCCACCTTCT CCGGAGGTGT GGGCACCGCC 
AGTGCTGTGG TGGAGTTTAA GCGGAAGGAG GGCACTGTGG TAGCCACTCT GCAGGTGTTT 
GATGCAGATG TGGTGCCAGC ATCTGGGGAG CTGGTGAGGC GGTACACAAG CACACTACTC 
TCAGGGGATT CCTGGGCCCA GCAGACCTTC CGGGTGGAGC ACACACCCAA CGAGACCTTG 
GTCCAGTCCA ACAACAACTC CGTGCGGGCA ACCATGCACA ATTACAAGCT GGTTCTCAAC 
AGGAGCCTGT CCATCTCAGA GAGCCGAGTC CTGCAGCTAG TAGTCCTGGT CAATGACTCA 
GACTTCCAGG GGCCTGGGTC AGGTGTTCTC TTCCTCCATT TCAACGTGTC TGTGCTGCCT 
GTCACCCTGA ACCTACCCAT GGCCTACTCC TTCCCAGTGA ATAGGAGAGC CCGCCGTTAT 
GCCCAGATTG GGAAAGTTTG CGTGGAGAAC TGCCAGGAGT TCAGCGGTGT CTCCATCCAG 
TACAAGCTGC AGCCCTCCAG CACCAACTGC AGTGCCCTAG GTGTGGTCAC CTCAACAGAA 
GACACCTCAG GGACCCTATA TGTAAATGAC ACGGAGGCCC TGCGGCGACC TGAGTGTACC 
GAGCTTCAGT ACACAGTGGT AGCCACTGAC CGGCAGACCC GCAGGCAGAC CCAGGCTTCG 
TTAGTCGTCA CAGTGGAGGG GACATACATT GCAGAAGAAG TGGGCTGCCC CAAGTCCTGT 
GCAGTAAACA AGAGGCGACC TGAGTGTGAG GAGTGTGGTG GCCTGGGTTC TCCAACTGGC 
AGATGTGAGT GGCGTCAGGG AGATGGTAAA GGGATCACCA GGAACTTCTC CACCTGTTCT 
CCTAGCACCA GGACCTGTCC TGATGGCCAC TGTGATGCTC TGGAGAGCCG GGATATCAAC 
ATTTGCCCCC AGGACTGTCT CCGTGGCCCC ATTGTTGGCG GGCATGAGCG AGGGGAGCGC 
CAGGGGATTA AAGCCGGCTA TGGCATCTGC AACTGTTTCC CTGATGAGAA GAAGTGCTTC 
TGCGAGCCAG AGGACAGCCA GGGCCCATTG TGCGATGAGC TGTGCCGTAC GGTCATCACA 
GCCGCTGTCC TCTTCTCCTT CATAATCTCT GTCCTGCTGT CCACCTTCTG CATCCACCGC 
TACCACAAGC ATGCGCACAA GCCACCCATC GCGTCAGCCG AAATGACCTT CTGCCGGCCG 
GCCCAGGGCT TCCCAATCAG CTATTCTTCC TCGGGCACCC GCCGGCCCTC ACTGGACTCC 
ATGGAGAACC AGGTCTCTGT GGACTCTTTC AAGATCCCGG AGGATCCGAA GTGGGAATTT 
CCTCGGAAGA ACTTAGTTCT TGGGAAAACC CTGGGAGAAG GCGAGTTTGG AAAAGTAGTC 
AAGGCCACAG CCTTCCGTCT GAAAGGCCGG GCAGGATACA CCACAGTGGC TGTGAAAATG 
CTGAAAGAAA ACGCCTCCCA GAGTGAACTA CGAGACCTGC TCTCTGAGTT CAACCTTCTG 
AAACAAGTCA ACCATCCACA TGTCATCAAG TTGTACGGGG CTTGCAGCCA GGATGGGCCA 
CTTCTTCTCA TTGTGGAGTA TGCAAAGTAT GGATCCCTGC GGGGGTTCCT GCGGGACAGC 
CGCAAGATCG GGCCTGCCTA TGTGAGCAGT GGAGGCAGCC GCAATTCCAG CTCCCTGGAC 
CACCCAGACG AAAGGGTGCT GACCATGGGC GACCTCATCT CCTTCGCCTG GCAGATCTCG 
AGGGGTATGC AGTACTTGGC TGAAATGAAG CTCGTACATC GAGACTTAGC TGCCAGAAAC 
ATCTTGGTGG CAGAGGGACG GAAGATGAAG ATCTCTGACT TTGGGCTGTC CCGAGATGTT 
TATGAAGAAG ATTCCTATGT GAAGAAAAGC AAGGGCCGGA TTCCCGTCAA ATGGATGGCA 
ATCGAGTCTC TCTTCGATCA CATCTATACC ACTCAAAGTG ATGTGTGGTC CTTTGGAGTG 
CTGCTATGGG AGATTGTGAC CCTGGGAGGC AACCCCTACC CTGGAATTCC TCCTGAACGA 
CTCTTCAACC TTCTGAAGAC AGGCCACAGG ATGGAGAGGC CAGACAACTG CAGCGAGGAA 
ATGTACCGCC TGATGCTGCA GTGCTGGAAG CAGGAGCCGG ACAAGAGGCC AGTATTTGCT 
GACATCAGCA AGGATCTGGA GAAGATGATG GTCAAAAGCA GAGACTACTT GGACCTGGCT 
GCATCCACCC CTTCGGACTC ACTGCTCTAT GACGATGGGC TCTCGGAAGA GGAGACGCCC 
CTGGTGGACT GTAACAGTGC TCCCCTCCCG CGCTCCCTCC CTTCCACATG GATTGAAAAC 
AAACTCTATG GCATGTCAGA CCCGAACTGG CCTGGAGAGA GTCCTGTACC ACTCACGAGA 
GCCGATGGCA CTAGCACTGG GTTCCCAAGA TATGCAAATG ATAGTGTATA TGCTAACTGG 
ATGGTTTCAC CCTCAGCGGC AAAATTAATG GACACATTTG ATAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ret ( XM_017592470.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017447959.1 Rattus norvegicus ret proto-oncogene (Ret), transcript variant X1, mRNA.

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CloneID	ORa12231
Clone ID Related Accession (Same CDS sequence)	XM_017592470.1 , NM_012643.2
Accession Version	XM_017592470.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3348bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	proto-oncogene tyrosine-protein kinase receptor Ret isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGAAAG CGAGGTCCGG CGCCGCAGGG CTGGGGCTGA AGCTGTTTTT GCTGCTGCCG 
CTACTGGGAG AAGCCCCGCT GGGTCTCTAC TTCTCAAGGG ATGCTTACTG GGAGAGGCTG 
TATGTGGACC AGCCAGCTGG CACACCTCTG CTCTATGTCC ATGCCCTACG GGATGCCCCT 
GGAGAAGTGC CCAGCTTCCG CCTGGGCCAG TATCTCTATG GCGTCTACCG CACGCGTCTG 
CATGAGAATG ACTGGATCCA CATCGATTCG GGCACTGGCC TCCTCTACCT CAATCAGAGC 
CTGGACCATA GTTCCTGGGA GCAGCTCAGC ATCCGCAATG GCGGCTTCCC CTTGCTCACC 
GTCTTCCTCC AGGTCTTCCT GGGGTCCACA GCCCAGAGAG AGGGAGAGTG TCATTGGCCA 
GGCTGTGCCC GTGTGTACTT CTCCTTCATC AACGACACCT TCCCAAATTG TAGCTCCTTC 
AAAGCCCGGG ATCTCTGCAC CCCGGAGACG GGTGTGTCCT TCCGCATCAG GGAGAACAGG 
CCCCCTGGCA CCTTCTACCA GTTCCGCATG CTACCTGTGC AGTTCCTTTG TCCTAACATC 
AGTGTGAAGT ACAAACTCTT AGAAGGGGAC GGTCTGCCCT TCCGTTGTGA CCCCGACTGT 
CTGGAGGTGA GCACGCGGTG GGCGCTGGAT CGGGAGCTTC AGGAGAAGTA TGTGCTGGAG 
GCTGAGTGCG CAGTGGCAGG CCCTGGAGCC AACAAGGAGA AGGTGGCCGT GTCCTTCCCG 
GTGACGGTGT ATGATGAAGA CGACTCCCCG CCCACCTTCT CCGGAGGTGT GGGCACCGCC 
AGTGCTGTGG TGGAGTTTAA GCGGAAGGAG GGCACTGTGG TAGCCACTCT GCAGGTGTTT 
GATGCAGATG TGGTGCCAGC ATCTGGGGAG CTGGTGAGGC GGTACACAAG CACACTACTC 
TCAGGGGATT CCTGGGCCCA GCAGACCTTC CGGGTGGAGC ACACACCCAA CGAGACCTTG 
GTCCAGTCCA ACAACAACTC CGTGCGGGCA ACCATGCACA ATTACAAGCT GGTTCTCAAC 
AGGAGCCTGT CCATCTCAGA GAGCCGAGTC CTGCAGCTAG TAGTCCTGGT CAATGACTCA 
GACTTCCAGG GGCCTGGGTC AGGTGTTCTC TTCCTCCATT TCAACGTGTC TGTGCTGCCT 
GTCACCCTGA ACCTACCCAT GGCCTACTCC TTCCCAGTGA ATAGGAGAGC CCGCCGTTAT 
GCCCAGATTG GGAAAGTTTG CGTGGAGAAC TGCCAGGAGT TCAGCGGTGT CTCCATCCAG 
TACAAGCTGC AGCCCTCCAG CACCAACTGC AGTGCCCTAG GTGTGGTCAC CTCAACAGAA 
GACACCTCAG GGACCCTATA TGTAAATGAC ACGGAGGCCC TGCGGCGACC TGAGTGTACC 
GAGCTTCAGT ACACAGTGGT AGCCACTGAC CGGCAGACCC GCAGGCAGAC CCAGGCTTCG 
TTAGTCGTCA CAGTGGAGGG GACATACATT GCAGAAGAAG TGGGCTGCCC CAAGTCCTGT 
GCAGTAAACA AGAGGCGACC TGAGTGTGAG GAGTGTGGTG GCCTGGGTTC TCCAACTGGC 
AGATGTGAGT GGCGTCAGGG AGATGGTAAA GGGATCACCA GGAACTTCTC CACCTGTTCT 
CCTAGCACCA GGACCTGTCC TGATGGCCAC TGTGATGCTC TGGAGAGCCG GGATATCAAC 
ATTTGCCCCC AGGACTGTCT CCGTGGCCCC ATTGTTGGCG GGCATGAGCG AGGGGAGCGC 
CAGGGGATTA AAGCCGGCTA TGGCATCTGC AACTGTTTCC CTGATGAGAA GAAGTGCTTC 
TGCGAGCCAG AGGACAGCCA GGGCCCATTG TGCGATGAGC TGTGCCGTAC GGTCATCACA 
GCCGCTGTCC TCTTCTCCTT CATAATCTCT GTCCTGCTGT CCACCTTCTG CATCCACCGC 
TACCACAAGC ATGCGCACAA GCCACCCATC GCGTCAGCCG AAATGACCTT CTGCCGGCCG 
GCCCAGGGCT TCCCAATCAG CTATTCTTCC TCGGGCACCC GCCGGCCCTC ACTGGACTCC 
ATGGAGAACC AGGTCTCTGT GGACTCTTTC AAGATCCCGG AGGATCCGAA GTGGGAATTT 
CCTCGGAAGA ACTTAGTTCT TGGGAAAACC CTGGGAGAAG GCGAGTTTGG AAAAGTAGTC 
AAGGCCACAG CCTTCCGTCT GAAAGGCCGG GCAGGATACA CCACAGTGGC TGTGAAAATG 
CTGAAAGAAA ACGCCTCCCA GAGTGAACTA CGAGACCTGC TCTCTGAGTT CAACCTTCTG 
AAACAAGTCA ACCATCCACA TGTCATCAAG TTGTACGGGG CTTGCAGCCA GGATGGGCCA 
CTTCTTCTCA TTGTGGAGTA TGCAAAGTAT GGATCCCTGC GGGGGTTCCT GCGGGACAGC 
CGCAAGATCG GGCCTGCCTA TGTGAGCAGT GGAGGCAGCC GCAATTCCAG CTCCCTGGAC 
CACCCAGACG AAAGGGTGCT GACCATGGGC GACCTCATCT CCTTCGCCTG GCAGATCTCG 
AGGGGTATGC AGTACTTGGC TGAAATGAAG CTCGTACATC GAGACTTAGC TGCCAGAAAC 
ATCTTGGTGG CAGAGGGACG GAAGATGAAG ATCTCTGACT TTGGGCTGTC CCGAGATGTT 
TATGAAGAAG ATTCCTATGT GAAGAAAAGC AAGGGCCGGA TTCCCGTCAA ATGGATGGCA 
ATCGAGTCTC TCTTCGATCA CATCTATACC ACTCAAAGTG ATGTGTGGTC CTTTGGAGTG 
CTGCTATGGG AGATTGTGAC CCTGGGAGGC AACCCCTACC CTGGAATTCC TCCTGAACGA 
CTCTTCAACC TTCTGAAGAC AGGCCACAGG ATGGAGAGGC CAGACAACTG CAGCGAGGAA 
ATGTACCGCC TGATGCTGCA GTGCTGGAAG CAGGAGCCGG ACAAGAGGCC AGTATTTGCT 
GACATCAGCA AGGATCTGGA GAAGATGATG GTCAAAAGCA GAGACTACTT GGACCTGGCT 
GCATCCACCC CTTCGGACTC ACTGCTCTAT GACGATGGGC TCTCGGAAGA GGAGACGCCC 
CTGGTGGACT GTAACAGTGC TCCCCTCCCG CGCTCCCTCC CTTCCACATG GATTGAAAAC 
AAACTCTATG GCATGTCAGA CCCGAACTGG CCTGGAGAGA GTCCTGTACC ACTCACGAGA 
GCCGATGGCA CTAGCACTGG GTTCCCAAGA TATGCAAATG ATAGTGTATA TGCTAACTGG 
ATGGTTTCAC CCTCAGCGGC AAAATTAATG GACACATTTG ATAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017447959.1
CDS	391..3738
Translation	MAKARSGAAGLGLKLFLLLPLLGEAPLGLYFSRDAYWERLYVDQPAGTPLLYVHALRDAPGEVPSFRLGQYLYGVYRTRLHENDWIHIDSGTGLLYLNQSLDHSSWEQLSIRNGGFPLLTVFLQVFLGSTAQREGECHWPGCARVYFSFINDTFPNCSSFKARDLCTPETGVSFRIRENRPPGTFYQFRMLPVQFLCPNISVKYKLLEGDGLPFRCDPDCLEVSTRWALDRELQEKYVLEAECAVAGPGANKEKVAVSFPVTVYDEDDSPPTFSGGVGTASAVVEFKRKEGTVVATLQVFDADVVPASGELVRRYTSTLLSGDSWAQQTFRVEHTPNETLVQSNNNSVRATMHNYKLVLNRSLSISESRVLQLVVLVNDSDFQGPGSGVLFLHFNVSVLPVTLNLPMAYSFPVNRRARRYAQIGKVCVENCQEFSGVSIQYKLQPSSTNCSALGVVTSTEDTSGTLYVNDTEALRRPECTELQYTVVATDRQTRRQTQASLVVTVEGTYIAEEVGCPKSCAVNKRRPECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTRTCPDGHCDALESRDINICPQDCLRGPIVGGHERGERQGIKAGYGICNCFPDEKKCFCEPEDSQGPLCDELCRTVITAAVLFSFIISVLLSTFCIHRYHKHAHKPPIASAEMTFCRPAQGFPISYSSSGTRRPSLDSMENQVSVDSFKIPEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKGRAGYTTVAVKMLKENASQSELRDLLSEFNLLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRDSRKIGPAYVSSGGSRNSSSLDHPDERVLTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKKSKGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKSRDYLDLAASTPSDSLLYDDGLSEEETPLVDCNSAPLPRSLPSTWIENKLYGMSDPNWPGESPVPLTRADGTSTGFPRYANDSVYANWMVSPSAAKLMDTFDS

Target ORF information:

RefSeq Version	XM_017592470.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ret proto-oncogene (Ret), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017592470.1

ORF Insert Sequence:

ATGGCGAAAG CGAGGTCCGG CGCCGCAGGG CTGGGGCTGA AGCTGTTTTT GCTGCTGCCG 
CTACTGGGAG AAGCCCCGCT GGGTCTCTAC TTCTCAAGGG ATGCTTACTG GGAGAGGCTG 
TATGTGGACC AGCCAGCTGG CACACCTCTG CTCTATGTCC ATGCCCTACG GGATGCCCCT 
GGAGAAGTGC CCAGCTTCCG CCTGGGCCAG TATCTCTATG GCGTCTACCG CACGCGTCTG 
CATGAGAATG ACTGGATCCA CATCGATTCG GGCACTGGCC TCCTCTACCT CAATCAGAGC 
CTGGACCATA GTTCCTGGGA GCAGCTCAGC ATCCGCAATG GCGGCTTCCC CTTGCTCACC 
GTCTTCCTCC AGGTCTTCCT GGGGTCCACA GCCCAGAGAG AGGGAGAGTG TCATTGGCCA 
GGCTGTGCCC GTGTGTACTT CTCCTTCATC AACGACACCT TCCCAAATTG TAGCTCCTTC 
AAAGCCCGGG ATCTCTGCAC CCCGGAGACG GGTGTGTCCT TCCGCATCAG GGAGAACAGG 
CCCCCTGGCA CCTTCTACCA GTTCCGCATG CTACCTGTGC AGTTCCTTTG TCCTAACATC 
AGTGTGAAGT ACAAACTCTT AGAAGGGGAC GGTCTGCCCT TCCGTTGTGA CCCCGACTGT 
CTGGAGGTGA GCACGCGGTG GGCGCTGGAT CGGGAGCTTC AGGAGAAGTA TGTGCTGGAG 
GCTGAGTGCG CAGTGGCAGG CCCTGGAGCC AACAAGGAGA AGGTGGCCGT GTCCTTCCCG 
GTGACGGTGT ATGATGAAGA CGACTCCCCG CCCACCTTCT CCGGAGGTGT GGGCACCGCC 
AGTGCTGTGG TGGAGTTTAA GCGGAAGGAG GGCACTGTGG TAGCCACTCT GCAGGTGTTT 
GATGCAGATG TGGTGCCAGC ATCTGGGGAG CTGGTGAGGC GGTACACAAG CACACTACTC 
TCAGGGGATT CCTGGGCCCA GCAGACCTTC CGGGTGGAGC ACACACCCAA CGAGACCTTG 
GTCCAGTCCA ACAACAACTC CGTGCGGGCA ACCATGCACA ATTACAAGCT GGTTCTCAAC 
AGGAGCCTGT CCATCTCAGA GAGCCGAGTC CTGCAGCTAG TAGTCCTGGT CAATGACTCA 
GACTTCCAGG GGCCTGGGTC AGGTGTTCTC TTCCTCCATT TCAACGTGTC TGTGCTGCCT 
GTCACCCTGA ACCTACCCAT GGCCTACTCC TTCCCAGTGA ATAGGAGAGC CCGCCGTTAT 
GCCCAGATTG GGAAAGTTTG CGTGGAGAAC TGCCAGGAGT TCAGCGGTGT CTCCATCCAG 
TACAAGCTGC AGCCCTCCAG CACCAACTGC AGTGCCCTAG GTGTGGTCAC CTCAACAGAA 
GACACCTCAG GGACCCTATA TGTAAATGAC ACGGAGGCCC TGCGGCGACC TGAGTGTACC 
GAGCTTCAGT ACACAGTGGT AGCCACTGAC CGGCAGACCC GCAGGCAGAC CCAGGCTTCG 
TTAGTCGTCA CAGTGGAGGG GACATACATT GCAGAAGAAG TGGGCTGCCC CAAGTCCTGT 
GCAGTAAACA AGAGGCGACC TGAGTGTGAG GAGTGTGGTG GCCTGGGTTC TCCAACTGGC 
AGATGTGAGT GGCGTCAGGG AGATGGTAAA GGGATCACCA GGAACTTCTC CACCTGTTCT 
CCTAGCACCA GGACCTGTCC TGATGGCCAC TGTGATGCTC TGGAGAGCCG GGATATCAAC 
ATTTGCCCCC AGGACTGTCT CCGTGGCCCC ATTGTTGGCG GGCATGAGCG AGGGGAGCGC 
CAGGGGATTA AAGCCGGCTA TGGCATCTGC AACTGTTTCC CTGATGAGAA GAAGTGCTTC 
TGCGAGCCAG AGGACAGCCA GGGCCCATTG TGCGATGAGC TGTGCCGTAC GGTCATCACA 
GCCGCTGTCC TCTTCTCCTT CATAATCTCT GTCCTGCTGT CCACCTTCTG CATCCACCGC 
TACCACAAGC ATGCGCACAA GCCACCCATC GCGTCAGCCG AAATGACCTT CTGCCGGCCG 
GCCCAGGGCT TCCCAATCAG CTATTCTTCC TCGGGCACCC GCCGGCCCTC ACTGGACTCC 
ATGGAGAACC AGGTCTCTGT GGACTCTTTC AAGATCCCGG AGGATCCGAA GTGGGAATTT 
CCTCGGAAGA ACTTAGTTCT TGGGAAAACC CTGGGAGAAG GCGAGTTTGG AAAAGTAGTC 
AAGGCCACAG CCTTCCGTCT GAAAGGCCGG GCAGGATACA CCACAGTGGC TGTGAAAATG 
CTGAAAGAAA ACGCCTCCCA GAGTGAACTA CGAGACCTGC TCTCTGAGTT CAACCTTCTG 
AAACAAGTCA ACCATCCACA TGTCATCAAG TTGTACGGGG CTTGCAGCCA GGATGGGCCA 
CTTCTTCTCA TTGTGGAGTA TGCAAAGTAT GGATCCCTGC GGGGGTTCCT GCGGGACAGC 
CGCAAGATCG GGCCTGCCTA TGTGAGCAGT GGAGGCAGCC GCAATTCCAG CTCCCTGGAC 
CACCCAGACG AAAGGGTGCT GACCATGGGC GACCTCATCT CCTTCGCCTG GCAGATCTCG 
AGGGGTATGC AGTACTTGGC TGAAATGAAG CTCGTACATC GAGACTTAGC TGCCAGAAAC 
ATCTTGGTGG CAGAGGGACG GAAGATGAAG ATCTCTGACT TTGGGCTGTC CCGAGATGTT 
TATGAAGAAG ATTCCTATGT GAAGAAAAGC AAGGGCCGGA TTCCCGTCAA ATGGATGGCA 
ATCGAGTCTC TCTTCGATCA CATCTATACC ACTCAAAGTG ATGTGTGGTC CTTTGGAGTG 
CTGCTATGGG AGATTGTGAC CCTGGGAGGC AACCCCTACC CTGGAATTCC TCCTGAACGA 
CTCTTCAACC TTCTGAAGAC AGGCCACAGG ATGGAGAGGC CAGACAACTG CAGCGAGGAA 
ATGTACCGCC TGATGCTGCA GTGCTGGAAG CAGGAGCCGG ACAAGAGGCC AGTATTTGCT 
GACATCAGCA AGGATCTGGA GAAGATGATG GTCAAAAGCA GAGACTACTT GGACCTGGCT 
GCATCCACCC CTTCGGACTC ACTGCTCTAT GACGATGGGC TCTCGGAAGA GGAGACGCCC 
CTGGTGGACT GTAACAGTGC TCCCCTCCCG CGCTCCCTCC CTTCCACATG GATTGAAAAC 
AAACTCTATG GCATGTCAGA CCCGAACTGG CCTGGAGAGA GTCCTGTACC ACTCACGAGA 
GCCGATGGCA CTAGCACTGG GTTCCCAAGA TATGCAAATG ATAGTGTATA TGCTAACTGG 
ATGGTTTCAC CCTCAGCGGC AAAATTAATG GACACATTTG ATAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand.
Nature medicine23(10)1158-1166(2017 Oct)
Yang L,Chang CC,Sun Z,Madsen D,Zhu H,Padkj?r SB,Wu X,Huang T,Hultman K,Paulsen SJ,Wang J,Bugge A,Frantzen JB,N?rgaard P,Jeppesen JF,Yang Z,Secher A,Chen H,Li X,John LM,Shan B,He Z,Gao X,Su J,Hansen KT,Yang W,J?rgensen SB

GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates.
Nature medicine23(10)1150-1157(2017 Oct)
Mullican SE,Lin-Schmidt X,Chin CN,Chavez JA,Furman JL,Armstrong AA,Beck SC,South VJ,Dinh TQ,Cash-Mason TD,Cavanaugh CR,Nelson S,Huang C,Hunter MJ,Rangwala SM

Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.
Nature550(7675)255-259(2017 Oct)
Hsu JY,Crawley S,Chen M,Ayupova DA,Lindhout DA,Higbee J,Kutach A,Joo W,Gao Z,Fu D,To C,Mondal K,Li B,Kekatpure A,Wang M,Laird T,Horner G,Chan J,McEntee M,Lopez M,Lakshminarasimhan D,White A,Wang SP,Yao J,Yie J,Matern H,Solloway M,Haldankar R,Parsons T,Tang J,Shen WD,Alice Chen Y,Tian H,Allan BB

Vitamin D regulation of GDNF/Ret signaling in dopaminergic neurons.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology(2017 Oct)
Pertile RAN,Cui X,Hammond L,Eyles DW

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Ret cDNA ORF clone, Rattus norvegicus(Norway rat)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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