Map3k12 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Map3k12
Entrez Gene ID	25579
Full Name	mitogen activated protein kinase kinase kinase 12
Synonyms	DLK,MUK,PK,Zpk
General protein information	Preferred Names mitogen activated protein kinase kinase kinase 12 Names mitogen-activated protein kinase kinase kinase 12 MAPK-upstream kinase Mitogen activated protein kinase 12 (Zipper (leucine) protein kinase) Zipper (leucine) protein kinase dual leucine zipper bearing kinase dual leucine zipper kinase leucine-zipper protein kinase mixed lineage kinase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q36
Summary	kinase which is an activator of the JNK-pathway [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006242381.3	XP_006242443.1	mitogen-activated protein kinase kinase kinase 12 isoform X1
NM_013055.1	NP_037187.1	mitogen-activated protein kinase kinase kinase 12
XM_006242382.3	XP_006242444.1	mitogen-activated protein kinase kinase kinase 12 isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MAP3K12	XP_509099.3
Bos taurus (cattle)	MAP3K12	NP_001192220.1
Homo sapiens (human)	MAP3K12	NP_001180440.1
Canis lupus familiaris (dog)	MAP3K12	XP_848815.1
Danio rerio (zebrafish)	map3k12	NP_996977.1
Mus musculus (house mouse)	Map3k12	NP_001157115.1
Rattus norvegicus (Norway rat)	Map3k12	NP_037187.1
	MAP3K12	XP_001105474.1
Xenopus tropicalis (tropical clawed frog)	map3k12	XP_004911999.1

Gene Ontology
Bibliography

Related articles in PubMed

ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and A? Secretion.
Huang YA, Zhou B, Wernig M, S?dhof TC
Cell168(3)427-441.e21(2017 Jan)

Leucine Zipper-bearing Kinase promotes axon growth in mammalian central nervous system neurons.
Chen M, Geoffroy CG, Wong HN, Tress O, Nguyen MT, Holzman LB, Jin Y, Zheng B
Scientific reports631482(2016 Aug)

ZPK/DLK and MKK4 form the critical gateway to axotomy-induced motoneuron death in neonates.
Itoh T, Horiuchi M, Ikeda RH Jr, Xu J, Bannerman P, Pleasure D, Penninger JM, Tournier C, Itoh A
The Journal of neuroscience : the official journal of the Society for Neuroscience34(32)10729-42(2014 Aug)

Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death.
Welsbie DS, Yang Z, Ge Y, Mitchell KL, Zhou X, Martin SE, Berlinicke CA, Hackler L Jr, Fuller J, Fu J, Cao LH, Han B, Auld D, Xue T, Hirai S, Germain L, Simard-Bisson C, Blouin R, Nguyen JV, Davis CH, Enke RA, Boye SL, Merbs SL, Marsh-Armstrong N, Hauswirth WW, DiAntonio A, Nickells RW, Inglese J, Hanes J, Yau KW, Quigley HA, Zack DJ
Proceedings of the National Academy of Sciences of the United States of America110(10)4045-50(2013 Mar)

CEP11004, a novel inhibitor of the mixed lineage kinases, suppresses apoptotic death in dopamine neurons of the substantia nigra induced by 6-hydroxydopamine.
Ganguly A, Oo TF, Rzhetskaya M, Pratt R, Yarygina O, Momoi T, Kholodilov N, Burke RE
Journal of neurochemistry88(2)469-80(2004 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These findings explain how DLK specifically mediates nerve injury responses and reveal a novel cellular mechanism that ensures the specificity of neuronal kinase signaling.
Title: Palmitoylation controls DLK localization, interactions and activity to ensure effective axonal injury signaling.

DLK is required for RGC JNK activation and cell death in a rodent model of optic neuropathy
Title: Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death.

Src-dependent tyrosine phosphorylation of recombinant rat DLK was important for regulation of its activity. DLK may have a role in PDGF signaling.
Title: The mixed-lineage kinase DLK undergoes Src-dependent tyrosine phosphorylation and activation in cells exposed to vanadate or platelet-derived growth factor (PDGF).

Dlk is expressed in a subpopulation of oval cells and that Dlk(+) cells represent intermediate cells between Dlk(-) oval cells and mature hepatocytes.
Title: Expression of Dlk/Pref-1 defines a subpopulation in the oval cell compartment of rat liver.

MUK/DLK/ZPK, and JNK activity increase potently and temporally in newly generated neurons in developing mouse telencephalon during radial migration
Title: MAPK-upstream protein kinase (MUK) regulates the radial migration of immature neurons in telencephalon of mouse embryo.

The following Map3k12 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Map3k12 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa01799	NM_013055.1 Latest version!	Rattus norvegicus mitogen activated protein kinase kinase kinase 12 (Map3k12), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$524.30 $749.00
ORa30760	XM_006242382.3 Latest version!	Rattus norvegicus mitogen activated protein kinase kinase kinase 12 (Map3k12), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
ORa30760	XM_006242381.3 Latest version!	Rattus norvegicus mitogen activated protein kinase kinase kinase 12 (Map3k12), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Map3k12 ( NM_013055.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037187.1 Rattus norvegicus mitogen activated protein kinase kinase kinase 12 (Map3k12), mRNA.

Price & Availability↑

CloneID	ORa01799
Clone ID Related Accession (Same CDS sequence)	NM_013055.1
Accession Version	NM_013055.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2667bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	mitogen-activated protein kinase kinase kinase 12
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D49785.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D49785.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN01906348 [ECO:0000350] ##Evidence-Data-END##

ATGGCCTGCC TCCATGAAAC CCGAACACCC TCCCCTTCCT TTGGAGGCTT TGTGTCTACT 
CTAAGTGAGG CCTCCATGCG AAAGCTGGAT CCAGACACTT CAGACTGCAC CCCTGAGAAG 
GACCTGACAC CTACCCAATG TGTACTTCGA GATGTTGTGC CTCTCGGTGG GCAGGGTGGA 
GGAGGGCCCA GCCCCTCCCC AGGTGGAGAG CCTCCTCCAG AGCCTTTTGC CAATAGTGTC 
CTGCAGCTAC ATGAGCAGGA TACAGGTGGG CCAGGGGGAG CCACCGGGTC ACCTGAGAGT 
CGAGCATCTA GGGTTCGAGC TGATGAGGTA CGTCTGCAGT GCCAGAGTGG CAGTGGCTTC 
CTTGAAGGTC TTTTTGGCTG CCTGCGCCCT GTCTGGACAA TGATTGGCAA AGCCTACTCC 
ACAGAGCACA AGCAACAGCA GGAAGACCTT TGGGAAGTCC CCTTTGAGGA AATCCTGGAC 
CTGCAGTGGG TAGGCTCAGG GGCTCAGGGT GCCGTTTTCC TGGGACGCTT TCATGGGGAG 
GAGGTAGCTG TGAAGAAGGT TCGAGACCTC AAGGAGACCG ACATCAAGCA TCTTCGAAAA 
CTGAAGCACC CCAACATCAT CACTTTCAAG GGTGTTTGCA CACAGGCCCC GTGCTACTGC 
ATCCTCATGG AGTTCTGTGC CCAAGGACAG CTGTATGAGG TGCTCAGGGC GGGCCGCCCC 
GTTACCCCCT CCTTGCTGGT TGACTGGTCC ATGGGCATCG CTGGAGGCAT GAATTACCTA 
CACCTGCACA AAATCATCCA CAGAGACCTG AAGTCACCCA ACATGCTAAT CACATACGAC 
GATGTGGTGA AGATCTCAGA CTTTGGCACT TCCAAGGAGC TGAGTGACAA GAGCACCAAG 
ATGTCCTTTG CAGGGACAGT AGCCTGGATG GCTCCTGAAG TGATCAGAAA TGAACCTGTG 
TCTGAGAAGG TTGACATCTG GTCCTTTGGG GTGGTGCTTT GGGAATTACT GACTGGAGAG 
ATTCCCTACA AAGATGTAGA CTCCTCAGCC ATCATCTGGG GTGTGGGAAG CAACAGTCTT 
CACCTGCCTG TACCCTCTAG CTGCCCAGAC GGCTTTAAAA TTCTGCTTCG CCAGTGCTGG 
AACAGAAAAC CTCGGAACCG CCCATCATTC CGACAGATCT TGCTGCACCT GGACATCGCC 
TCGGCTGATG TGCTCTCTAC ACCCCAGGAG ACTTACTTTA AATCCCAGGC AGAGTGGCGG 
GAAGAAGTAA AACTGCACTT TGAAAAGATT AAGTCAGAAG GGACCTGTCT GCACCGCCTA 
GAAGAGGAAC TGGTGATGCG GAGAAGGGAG GAGCTCAGAC ATGCCCTGGA CATCAGGGAG 
CACTATGAGC GCAAGTTGGA GAGAGCTAAC AACTTGTACA TGGAACTGAA TGCCCTCATG 
TTGCAACTAG AACTCAAAGA GAGGGAATTG CTCAGGCGAG AGCAAGCTTT AGAAAGGAGG 
TGTCCTGGTC TACTGAAGTC ACACACGTCC CGAAGCCTCC TACATGGAAA CACGATGGAG 
AAGCTCATCA AGAAAAGGAA TGTGCCACAG AAACTGTCAC CCCATAGCAA AAGGCCAGAT 
ATTCTCAAGA CAGAGTCTTT GCTACCTAAA CTAGATGCAG CCCTAAGTGG GGTGGGGCTT 
CCTGGTTGTC CTAAGGCCCC CCCTTCACCT GGGAGGAGTC GTCGTGGCAA GACCCGTCAC 
CGAAAGGCCA GCGCCAAGGG CAGCTGTGGA GACCTGCCTG GGCTTCGTGC AGCTTTGCCA 
CCCCATGAGC CTGGAGGACT AGGAAGCCCA GGAGGCCTAG GAGTGGGCCC TACAGCTTGG 
GATGCCTCCC CCCCTGCTCT CCGTGGACTC CACCATGACC TTCTACTTCG GAAGATGTCT 
TCATCATCCC CAGACCTGTT ATCAGCAGCA CTGGGAGCCC GAGGCCGAGG GGCAACAGGG 
GGAGCTCGGG ATCCTGGCTC ACCACCTCCA CCCCAGGGTG ATACTCCTCC AAGTGAGGGA 
TCAGCTCCTG GTTCCACCAG CCCAGATTCA CCTGGGGGAG CTAAAGGGGA ACCACCTCCA 
CCAGTAGGGC CTGGAGAAGG TGTGGGGCTG CTGGGAACTG GAAGGGAAGG GACTACAGGC 
CGGGGAGGAA GCCGGGCTGG GTACCAGCAC TTGACCCCCG CTGCGCTGCT GTACAGGGCT 
GCTGTGACTC GTAGTCAGAA ACGTGGTATC TCATCTGAAG AGGAAGAAGG AGAGGTCGAC 
AGTGAAGTAG AGCTACCCCC AAGTCAAAGG TGGCCTCAGG GCCCGAACAT GCGTCAGTCA 
CTATCTACGT TCAGCTCAGA GAACCCATCA GATGTGGAGG AAGGTACAGC TAGTGAGCCT 
TCCCCAAGTG GCACACCGGA AGTTGGCAGC ACCAACACTG ATGAGCGACC AGATGAACGG 
TCTGATGACA TGTGCTCACA GGGTTCAGAA ATCCCACTGG ACCTACCTAC TTCAGAGGTG 
GTCCCTGAAC GTGAAACCAG CTCCTTGCCC ATGCAACACC AGGATGACCA GGGCCCCAAT 
CCTGAGGACT CAGACTGTGA CAGCACTGAA TTGGACAACT CCAACAGCAT TGATGCCTTG 
CCGCCCCCAG CCTCCCTTCC TCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037187.1
CDS	451..3117
Translation	MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTQCVLRDVVPLGGQGGGGPSPSPGGEPPPEPFANSVLQLHEQDTGGPGGATGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNRKPRNRPSFRQILLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKSHTSRSLLHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKAPPSPGRSRRGKTRHRKASAKGSCGDLPGLRAALPPHEPGGLGSPGGLGVGPTAWDASPPALRGLHHDLLLRKMSSSSPDLLSAALGARGRGATGGARDPGSPPPPQGDTPPSEGSAPGSTSPDSPGGAKGEPPPPVGPGEGVGLLGTGREGTTGRGGSRAGYQHLTPAALLYRAAVTRSQKRGISSEEEEGEVDSEVELPPSQRWPQGPNMRQSLSTFSSENPSDVEEGTASEPSPSGTPEVGSTNTDERPDERSDDMCSQGSEIPLDLPTSEVVPERETSSLPMQHQDDQGPNPEDSDCDSTELDNSNSIDALPPPASLPP

Target ORF information:

RefSeq Version	NM_013055.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus mitogen activated protein kinase kinase kinase 12 (Map3k12), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013055.1

ORF Insert Sequence:

ATGGCCTGCC TCCATGAAAC CCGAACACCC TCCCCTTCCT TTGGAGGCTT TGTGTCTACT 
CTAAGTGAGG CCTCCATGCG AAAGCTGGAT CCAGACACTT CAGACTGCAC CCCTGAGAAG 
GACCTGACAC CTACCCAATG TGTACTTCGA GATGTTGTGC CTCTCGGTGG GCAGGGTGGA 
GGAGGGCCCA GCCCCTCCCC AGGTGGAGAG CCTCCTCCAG AGCCTTTTGC CAATAGTGTC 
CTGCAGCTAC ATGAGCAGGA TACAGGTGGG CCAGGGGGAG CCACCGGGTC ACCTGAGAGT 
CGAGCATCTA GGGTTCGAGC TGATGAGGTA CGTCTGCAGT GCCAGAGTGG CAGTGGCTTC 
CTTGAAGGTC TTTTTGGCTG CCTGCGCCCT GTCTGGACAA TGATTGGCAA AGCCTACTCC 
ACAGAGCACA AGCAACAGCA GGAAGACCTT TGGGAAGTCC CCTTTGAGGA AATCCTGGAC 
CTGCAGTGGG TAGGCTCAGG GGCTCAGGGT GCCGTTTTCC TGGGACGCTT TCATGGGGAG 
GAGGTAGCTG TGAAGAAGGT TCGAGACCTC AAGGAGACCG ACATCAAGCA TCTTCGAAAA 
CTGAAGCACC CCAACATCAT CACTTTCAAG GGTGTTTGCA CACAGGCCCC GTGCTACTGC 
ATCCTCATGG AGTTCTGTGC CCAAGGACAG CTGTATGAGG TGCTCAGGGC GGGCCGCCCC 
GTTACCCCCT CCTTGCTGGT TGACTGGTCC ATGGGCATCG CTGGAGGCAT GAATTACCTA 
CACCTGCACA AAATCATCCA CAGAGACCTG AAGTCACCCA ACATGCTAAT CACATACGAC 
GATGTGGTGA AGATCTCAGA CTTTGGCACT TCCAAGGAGC TGAGTGACAA GAGCACCAAG 
ATGTCCTTTG CAGGGACAGT AGCCTGGATG GCTCCTGAAG TGATCAGAAA TGAACCTGTG 
TCTGAGAAGG TTGACATCTG GTCCTTTGGG GTGGTGCTTT GGGAATTACT GACTGGAGAG 
ATTCCCTACA AAGATGTAGA CTCCTCAGCC ATCATCTGGG GTGTGGGAAG CAACAGTCTT 
CACCTGCCTG TACCCTCTAG CTGCCCAGAC GGCTTTAAAA TTCTGCTTCG CCAGTGCTGG 
AACAGAAAAC CTCGGAACCG CCCATCATTC CGACAGATCT TGCTGCACCT GGACATCGCC 
TCGGCTGATG TGCTCTCTAC ACCCCAGGAG ACTTACTTTA AATCCCAGGC AGAGTGGCGG 
GAAGAAGTAA AACTGCACTT TGAAAAGATT AAGTCAGAAG GGACCTGTCT GCACCGCCTA 
GAAGAGGAAC TGGTGATGCG GAGAAGGGAG GAGCTCAGAC ATGCCCTGGA CATCAGGGAG 
CACTATGAGC GCAAGTTGGA GAGAGCTAAC AACTTGTACA TGGAACTGAA TGCCCTCATG 
TTGCAACTAG AACTCAAAGA GAGGGAATTG CTCAGGCGAG AGCAAGCTTT AGAAAGGAGG 
TGTCCTGGTC TACTGAAGTC ACACACGTCC CGAAGCCTCC TACATGGAAA CACGATGGAG 
AAGCTCATCA AGAAAAGGAA TGTGCCACAG AAACTGTCAC CCCATAGCAA AAGGCCAGAT 
ATTCTCAAGA CAGAGTCTTT GCTACCTAAA CTAGATGCAG CCCTAAGTGG GGTGGGGCTT 
CCTGGTTGTC CTAAGGCCCC CCCTTCACCT GGGAGGAGTC GTCGTGGCAA GACCCGTCAC 
CGAAAGGCCA GCGCCAAGGG CAGCTGTGGA GACCTGCCTG GGCTTCGTGC AGCTTTGCCA 
CCCCATGAGC CTGGAGGACT AGGAAGCCCA GGAGGCCTAG GAGTGGGCCC TACAGCTTGG 
GATGCCTCCC CCCCTGCTCT CCGTGGACTC CACCATGACC TTCTACTTCG GAAGATGTCT 
TCATCATCCC CAGACCTGTT ATCAGCAGCA CTGGGAGCCC GAGGCCGAGG GGCAACAGGG 
GGAGCTCGGG ATCCTGGCTC ACCACCTCCA CCCCAGGGTG ATACTCCTCC AAGTGAGGGA 
TCAGCTCCTG GTTCCACCAG CCCAGATTCA CCTGGGGGAG CTAAAGGGGA ACCACCTCCA 
CCAGTAGGGC CTGGAGAAGG TGTGGGGCTG CTGGGAACTG GAAGGGAAGG GACTACAGGC 
CGGGGAGGAA GCCGGGCTGG GTACCAGCAC TTGACCCCCG CTGCGCTGCT GTACAGGGCT 
GCTGTGACTC GTAGTCAGAA ACGTGGTATC TCATCTGAAG AGGAAGAAGG AGAGGTCGAC 
AGTGAAGTAG AGCTACCCCC AAGTCAAAGG TGGCCTCAGG GCCCGAACAT GCGTCAGTCA 
CTATCTACGT TCAGCTCAGA GAACCCATCA GATGTGGAGG AAGGTACAGC TAGTGAGCCT 
TCCCCAAGTG GCACACCGGA AGTTGGCAGC ACCAACACTG ATGAGCGACC AGATGAACGG 
TCTGATGACA TGTGCTCACA GGGTTCAGAA ATCCCACTGG ACCTACCTAC TTCAGAGGTG 
GTCCCTGAAC GTGAAACCAG CTCCTTGCCC ATGCAACACC AGGATGACCA GGGCCCCAAT 
CCTGAGGACT CAGACTGTGA CAGCACTGAA TTGGACAACT CCAACAGCAT TGATGCCTTG 
CCGCCCCCAG CCTCCCTTCC TCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Map3k12 ( XM_006242381.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006242443.1 Rattus norvegicus mitogen activated protein kinase kinase kinase 12 (Map3k12), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa30760
Clone ID Related Accession (Same CDS sequence)	XM_006242381.3 , XM_006242382.3
Accession Version	XM_006242381.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2667bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	mitogen-activated protein kinase kinase kinase 12 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005106.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006242381.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCTGCC TCCATGAAAC CCGAACACCC TCCCCTTCCT TTGGAGGCTT TGTGTCTACT 
CTAAGTGAGG CCTCCATGCG AAAGCTGGAT CCAGACACTT CAGACTGCAC CCCTGAGAAG 
GACCTGACAC CTACCCAATG TGTACTTCGA GATGTTGTGC CTCTCGGTGG GCAGGGTGGA 
GGAGGGCCCA GCCCCTCCCC AGGTGGAGAG CCTCCTCCAG AGCCTTTTGC CAATAGTGTC 
CTGCAGCTAC ATGAGCAGGA TACAGGTGGG CCAGGGGGAG CCACCGGGTC ACCTGAGAGT 
CGAGCATCTA GGGTTCGAGC TGATGAGGTA CGTCTGCAGT GCCAGAGTGG CAGTGGCTTC 
CTTGAAGGTC TTTTTGGCTG CCTGCGCCCT GTCTGGACAA TGATTGGCAA AGCCTACTCC 
ACAGAGCACA AGCAACAGCA GGAAGACCTT TGGGAAGTCC CCTTTGAGGA AATCCTGGAC 
CTGCAGTGGG TAGGCTCAGG GGCTCAGGGT GCCGTTTTCC TGGGACGCTT TCATGGGGAG 
GAGGTAGCTG TGAAGAAGGT TCGAGACCTC AAGGAGACCG ACATCAAGCA TCTTCGAAAA 
CTGAAGCACC CCAACATCAT CACTTTCAAG GGTGTTTGCA CACAGGCCCC GTGCTACTGC 
ATCCTCATGG AGTTCTGTGC CCAAGGACAG CTGTATGAGG TGCTCAGGGC GGGCCGCCCC 
GTTACCCCCT CCTTGCTGGT TGACTGGTCC ATGGGCATCG CTGGAGGCAT GAATTACCTA 
CACCTGCACA AAATCATCCA TAGAGACCTG AAGTCACCCA ACATGCTAAT CACATACGAC 
GATGTGGTGA AGATCTCAGA CTTTGGCACT TCCAAGGAGC TGAGTGACAA GAGCACCAAG 
ATGTCCTTTG CAGGGACAGT AGCCTGGATG GCTCCTGAAG TGATCAGAAA TGAACCTGTG 
TCTGAGAAGG TTGACATCTG GTCCTTTGGG GTGGTGCTTT GGGAATTACT GACTGGAGAG 
ATTCCCTACA AAGATGTAGA CTCCTCAGCC ATCATCTGGG GTGTGGGAAG CAACAGTCTT 
CACCTGCCTG TACCCTCTAG CTGCCCAGAC GGCTTTAAAA TTCTGCTTCG CCAGTGCTGG 
AACAGCAAAC CTCGGAACCG CCCATCATTC CGACAGATCT TGCTGCACCT GGACATCGCC 
TCGGCTGATG TGCTCTCTAC ACCCCAGGAG ACTTACTTTA AATCCCAGGC AGAGTGGCGG 
GAAGAAGTAA AACTGCACTT TGAAAAGATT AAGTCAGAAG GGACCTGTCT GCACCGCCTA 
GAAGAGGAAC TGGTGATGCG GAGAAGGGAG GAGCTCAGAC ATGCCCTGGA CATCAGGGAG 
CACTATGAGC GCAAGTTGGA GAGAGCTAAC AACTTGTACA TGGAACTGAA TGCCCTCATG 
TTGCAACTAG AACTCAAAGA GAGGGAATTG CTCAGGCGAG AGCAAGCTTT AGAAAGGAGG 
TGTCCTGGTC TACTGAAGTC ACACACGTCC CGAAGCCTCC TACATGGAAA CACGATGGAG 
AAGCTCATCA AGAAAAGGAA TGTGCCACAG AAACTGTCAC CCCATAGCAA AAGGCCAGAT 
ATTCTCAAGA CAGAGTCTTT GCTACCTAAA CTAGATGCAG CCCTAAGTGG GGTGGGGCTT 
CCTGGGTGTC CTAAGGGCCC CCCTTCACCT GGGAGGAGTC GTCGTGGCAA GACCCGTCAC 
CGAAAGGCCA GCGCCAAGGG CAGCTGTGGA GACCTGCCTG GGCTTCGTGC AGCTTTGCCA 
CCCCATGAGC CTGGAGGACT AGGAAGCCCA GGAGGCCTAG GAGTGGGCCC TACAGCTTGG 
GATGCCTGCC CCCCTGCTCT CCGTGGACTC CACCATGACC TTCTACTTCG GAAGATGTCT 
TCATCATCCC CAGACCTGTT ATCAGCAGCA CTGGGAGCCC GAGGCCGAGG GGCAACAGGG 
GGAGCTCGGG ATCCTGGCTC ACCACCTCCA CCCCAGGGTG ATACTCCTCC AAGTGAGGGA 
TCAGCTCCTG GTTCCACCAG CCCAGATTCA CCTGGGGGAG CTAAAGGGGA ACCACCTCCA 
CCAGTAGGGC CTGGAGAAGG TGTGGGGCTG CTGGGAACTG GAAGGGAAGG GACTACAGGC 
CGGGGAGGAA GCCGGGCTGG GTACCAGCAC TTGACCCCCG CTGCGCTGCT GTACAGGGCT 
GCTGTGACTC GTAGTCAGAA ACGTGGTATC TCATCTGAAG AGGAAGAAGG AGAGGTCGAC 
AGTGAAGTAG AGCTACCCCC AAGTCAAAGG TGGCCTCAGG GCCCGAACAT GCGTCAGTCA 
CTATCTACGT TCAGCTCAGA GAACCCATCA GATGTGGAGG AAGGTACAGC TAGTGAGCCT 
TCCCCAAGTG GCACACCGGA AGTTGGCAGC ACCAACACTG ATGAGCGACC AGATGAACGG 
TCTGATGACA TGTGCTCACA GGGTTCAGAA ATCCCACTGG ACCTACCTAC TTCAGAGGTG 
GTCCCTGAAC GTGAAACCAG CTCCTTGCCC ATGCAACACC AGGATGACCA GGGCCCCAAT 
CCTGAGGACT CAGACTGTGA CAGCACTGAA TTGGACAACT CCAACAGCAT TGATGCCTTG 
CGGCCCCCAG CCTCCCTTCC TCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006242443.1
CDS	1833..4499
Translation	MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTQCVLRDVVPLGGQGGGGPSPSPGGEPPPEPFANSVLQLHEQDTGGPGGATGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKSHTSRSLLHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPSPGRSRRGKTRHRKASAKGSCGDLPGLRAALPPHEPGGLGSPGGLGVGPTAWDACPPALRGLHHDLLLRKMSSSSPDLLSAALGARGRGATGGARDPGSPPPPQGDTPPSEGSAPGSTSPDSPGGAKGEPPPPVGPGEGVGLLGTGREGTTGRGGSRAGYQHLTPAALLYRAAVTRSQKRGISSEEEEGEVDSEVELPPSQRWPQGPNMRQSLSTFSSENPSDVEEGTASEPSPSGTPEVGSTNTDERPDERSDDMCSQGSEIPLDLPTSEVVPERETSSLPMQHQDDQGPNPEDSDCDSTELDNSNSIDALRPPASLPP

Target ORF information:

RefSeq Version	XM_006242381.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus mitogen activated protein kinase kinase kinase 12 (Map3k12), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006242381.3

ORF Insert Sequence:

ATGGCCTGCC TCCATGAAAC CCGAACACCC TCCCCTTCCT TTGGAGGCTT TGTGTCTACT 
CTAAGTGAGG CCTCCATGCG AAAGCTGGAT CCAGACACTT CAGACTGCAC CCCTGAGAAG 
GACCTGACAC CTACCCAATG TGTACTTCGA GATGTTGTGC CTCTCGGTGG GCAGGGTGGA 
GGAGGGCCCA GCCCCTCCCC AGGTGGAGAG CCTCCTCCAG AGCCTTTTGC CAATAGTGTC 
CTGCAGCTAC ATGAGCAGGA TACAGGTGGG CCAGGGGGAG CCACCGGGTC ACCTGAGAGT 
CGAGCATCTA GGGTTCGAGC TGATGAGGTA CGTCTGCAGT GCCAGAGTGG CAGTGGCTTC 
CTTGAAGGTC TTTTTGGCTG CCTGCGCCCT GTCTGGACAA TGATTGGCAA AGCCTACTCC 
ACAGAGCACA AGCAACAGCA GGAAGACCTT TGGGAAGTCC CCTTTGAGGA AATCCTGGAC 
CTGCAGTGGG TAGGCTCAGG GGCTCAGGGT GCCGTTTTCC TGGGACGCTT TCATGGGGAG 
GAGGTAGCTG TGAAGAAGGT TCGAGACCTC AAGGAGACCG ACATCAAGCA TCTTCGAAAA 
CTGAAGCACC CCAACATCAT CACTTTCAAG GGTGTTTGCA CACAGGCCCC GTGCTACTGC 
ATCCTCATGG AGTTCTGTGC CCAAGGACAG CTGTATGAGG TGCTCAGGGC GGGCCGCCCC 
GTTACCCCCT CCTTGCTGGT TGACTGGTCC ATGGGCATCG CTGGAGGCAT GAATTACCTA 
CACCTGCACA AAATCATCCA TAGAGACCTG AAGTCACCCA ACATGCTAAT CACATACGAC 
GATGTGGTGA AGATCTCAGA CTTTGGCACT TCCAAGGAGC TGAGTGACAA GAGCACCAAG 
ATGTCCTTTG CAGGGACAGT AGCCTGGATG GCTCCTGAAG TGATCAGAAA TGAACCTGTG 
TCTGAGAAGG TTGACATCTG GTCCTTTGGG GTGGTGCTTT GGGAATTACT GACTGGAGAG 
ATTCCCTACA AAGATGTAGA CTCCTCAGCC ATCATCTGGG GTGTGGGAAG CAACAGTCTT 
CACCTGCCTG TACCCTCTAG CTGCCCAGAC GGCTTTAAAA TTCTGCTTCG CCAGTGCTGG 
AACAGCAAAC CTCGGAACCG CCCATCATTC CGACAGATCT TGCTGCACCT GGACATCGCC 
TCGGCTGATG TGCTCTCTAC ACCCCAGGAG ACTTACTTTA AATCCCAGGC AGAGTGGCGG 
GAAGAAGTAA AACTGCACTT TGAAAAGATT AAGTCAGAAG GGACCTGTCT GCACCGCCTA 
GAAGAGGAAC TGGTGATGCG GAGAAGGGAG GAGCTCAGAC ATGCCCTGGA CATCAGGGAG 
CACTATGAGC GCAAGTTGGA GAGAGCTAAC AACTTGTACA TGGAACTGAA TGCCCTCATG 
TTGCAACTAG AACTCAAAGA GAGGGAATTG CTCAGGCGAG AGCAAGCTTT AGAAAGGAGG 
TGTCCTGGTC TACTGAAGTC ACACACGTCC CGAAGCCTCC TACATGGAAA CACGATGGAG 
AAGCTCATCA AGAAAAGGAA TGTGCCACAG AAACTGTCAC CCCATAGCAA AAGGCCAGAT 
ATTCTCAAGA CAGAGTCTTT GCTACCTAAA CTAGATGCAG CCCTAAGTGG GGTGGGGCTT 
CCTGGGTGTC CTAAGGGCCC CCCTTCACCT GGGAGGAGTC GTCGTGGCAA GACCCGTCAC 
CGAAAGGCCA GCGCCAAGGG CAGCTGTGGA GACCTGCCTG GGCTTCGTGC AGCTTTGCCA 
CCCCATGAGC CTGGAGGACT AGGAAGCCCA GGAGGCCTAG GAGTGGGCCC TACAGCTTGG 
GATGCCTGCC CCCCTGCTCT CCGTGGACTC CACCATGACC TTCTACTTCG GAAGATGTCT 
TCATCATCCC CAGACCTGTT ATCAGCAGCA CTGGGAGCCC GAGGCCGAGG GGCAACAGGG 
GGAGCTCGGG ATCCTGGCTC ACCACCTCCA CCCCAGGGTG ATACTCCTCC AAGTGAGGGA 
TCAGCTCCTG GTTCCACCAG CCCAGATTCA CCTGGGGGAG CTAAAGGGGA ACCACCTCCA 
CCAGTAGGGC CTGGAGAAGG TGTGGGGCTG CTGGGAACTG GAAGGGAAGG GACTACAGGC 
CGGGGAGGAA GCCGGGCTGG GTACCAGCAC TTGACCCCCG CTGCGCTGCT GTACAGGGCT 
GCTGTGACTC GTAGTCAGAA ACGTGGTATC TCATCTGAAG AGGAAGAAGG AGAGGTCGAC 
AGTGAAGTAG AGCTACCCCC AAGTCAAAGG TGGCCTCAGG GCCCGAACAT GCGTCAGTCA 
CTATCTACGT TCAGCTCAGA GAACCCATCA GATGTGGAGG AAGGTACAGC TAGTGAGCCT 
TCCCCAAGTG GCACACCGGA AGTTGGCAGC ACCAACACTG ATGAGCGACC AGATGAACGG 
TCTGATGACA TGTGCTCACA GGGTTCAGAA ATCCCACTGG ACCTACCTAC TTCAGAGGTG 
GTCCCTGAAC GTGAAACCAG CTCCTTGCCC ATGCAACACC AGGATGACCA GGGCCCCAAT 
CCTGAGGACT CAGACTGTGA CAGCACTGAA TTGGACAACT CCAACAGCAT TGATGCCTTG 
CGGCCCCCAG CCTCCCTTCC TCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Map3k12 ( XM_006242382.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006242444.1 Rattus norvegicus mitogen activated protein kinase kinase kinase 12 (Map3k12), transcript variant X2, mRNA.

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CloneID	ORa30760
Clone ID Related Accession (Same CDS sequence)	XM_006242381.3 , XM_006242382.3
Accession Version	XM_006242382.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2667bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	mitogen-activated protein kinase kinase kinase 12 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005106.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006242382.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCTGCC TCCATGAAAC CCGAACACCC TCCCCTTCCT TTGGAGGCTT TGTGTCTACT 
CTAAGTGAGG CCTCCATGCG AAAGCTGGAT CCAGACACTT CAGACTGCAC CCCTGAGAAG 
GACCTGACAC CTACCCAATG TGTACTTCGA GATGTTGTGC CTCTCGGTGG GCAGGGTGGA 
GGAGGGCCCA GCCCCTCCCC AGGTGGAGAG CCTCCTCCAG AGCCTTTTGC CAATAGTGTC 
CTGCAGCTAC ATGAGCAGGA TACAGGTGGG CCAGGGGGAG CCACCGGGTC ACCTGAGAGT 
CGAGCATCTA GGGTTCGAGC TGATGAGGTA CGTCTGCAGT GCCAGAGTGG CAGTGGCTTC 
CTTGAAGGTC TTTTTGGCTG CCTGCGCCCT GTCTGGACAA TGATTGGCAA AGCCTACTCC 
ACAGAGCACA AGCAACAGCA GGAAGACCTT TGGGAAGTCC CCTTTGAGGA AATCCTGGAC 
CTGCAGTGGG TAGGCTCAGG GGCTCAGGGT GCCGTTTTCC TGGGACGCTT TCATGGGGAG 
GAGGTAGCTG TGAAGAAGGT TCGAGACCTC AAGGAGACCG ACATCAAGCA TCTTCGAAAA 
CTGAAGCACC CCAACATCAT CACTTTCAAG GGTGTTTGCA CACAGGCCCC GTGCTACTGC 
ATCCTCATGG AGTTCTGTGC CCAAGGACAG CTGTATGAGG TGCTCAGGGC GGGCCGCCCC 
GTTACCCCCT CCTTGCTGGT TGACTGGTCC ATGGGCATCG CTGGAGGCAT GAATTACCTA 
CACCTGCACA AAATCATCCA TAGAGACCTG AAGTCACCCA ACATGCTAAT CACATACGAC 
GATGTGGTGA AGATCTCAGA CTTTGGCACT TCCAAGGAGC TGAGTGACAA GAGCACCAAG 
ATGTCCTTTG CAGGGACAGT AGCCTGGATG GCTCCTGAAG TGATCAGAAA TGAACCTGTG 
TCTGAGAAGG TTGACATCTG GTCCTTTGGG GTGGTGCTTT GGGAATTACT GACTGGAGAG 
ATTCCCTACA AAGATGTAGA CTCCTCAGCC ATCATCTGGG GTGTGGGAAG CAACAGTCTT 
CACCTGCCTG TACCCTCTAG CTGCCCAGAC GGCTTTAAAA TTCTGCTTCG CCAGTGCTGG 
AACAGCAAAC CTCGGAACCG CCCATCATTC CGACAGATCT TGCTGCACCT GGACATCGCC 
TCGGCTGATG TGCTCTCTAC ACCCCAGGAG ACTTACTTTA AATCCCAGGC AGAGTGGCGG 
GAAGAAGTAA AACTGCACTT TGAAAAGATT AAGTCAGAAG GGACCTGTCT GCACCGCCTA 
GAAGAGGAAC TGGTGATGCG GAGAAGGGAG GAGCTCAGAC ATGCCCTGGA CATCAGGGAG 
CACTATGAGC GCAAGTTGGA GAGAGCTAAC AACTTGTACA TGGAACTGAA TGCCCTCATG 
TTGCAACTAG AACTCAAAGA GAGGGAATTG CTCAGGCGAG AGCAAGCTTT AGAAAGGAGG 
TGTCCTGGTC TACTGAAGTC ACACACGTCC CGAAGCCTCC TACATGGAAA CACGATGGAG 
AAGCTCATCA AGAAAAGGAA TGTGCCACAG AAACTGTCAC CCCATAGCAA AAGGCCAGAT 
ATTCTCAAGA CAGAGTCTTT GCTACCTAAA CTAGATGCAG CCCTAAGTGG GGTGGGGCTT 
CCTGGGTGTC CTAAGGGCCC CCCTTCACCT GGGAGGAGTC GTCGTGGCAA GACCCGTCAC 
CGAAAGGCCA GCGCCAAGGG CAGCTGTGGA GACCTGCCTG GGCTTCGTGC AGCTTTGCCA 
CCCCATGAGC CTGGAGGACT AGGAAGCCCA GGAGGCCTAG GAGTGGGCCC TACAGCTTGG 
GATGCCTGCC CCCCTGCTCT CCGTGGACTC CACCATGACC TTCTACTTCG GAAGATGTCT 
TCATCATCCC CAGACCTGTT ATCAGCAGCA CTGGGAGCCC GAGGCCGAGG GGCAACAGGG 
GGAGCTCGGG ATCCTGGCTC ACCACCTCCA CCCCAGGGTG ATACTCCTCC AAGTGAGGGA 
TCAGCTCCTG GTTCCACCAG CCCAGATTCA CCTGGGGGAG CTAAAGGGGA ACCACCTCCA 
CCAGTAGGGC CTGGAGAAGG TGTGGGGCTG CTGGGAACTG GAAGGGAAGG GACTACAGGC 
CGGGGAGGAA GCCGGGCTGG GTACCAGCAC TTGACCCCCG CTGCGCTGCT GTACAGGGCT 
GCTGTGACTC GTAGTCAGAA ACGTGGTATC TCATCTGAAG AGGAAGAAGG AGAGGTCGAC 
AGTGAAGTAG AGCTACCCCC AAGTCAAAGG TGGCCTCAGG GCCCGAACAT GCGTCAGTCA 
CTATCTACGT TCAGCTCAGA GAACCCATCA GATGTGGAGG AAGGTACAGC TAGTGAGCCT 
TCCCCAAGTG GCACACCGGA AGTTGGCAGC ACCAACACTG ATGAGCGACC AGATGAACGG 
TCTGATGACA TGTGCTCACA GGGTTCAGAA ATCCCACTGG ACCTACCTAC TTCAGAGGTG 
GTCCCTGAAC GTGAAACCAG CTCCTTGCCC ATGCAACACC AGGATGACCA GGGCCCCAAT 
CCTGAGGACT CAGACTGTGA CAGCACTGAA TTGGACAACT CCAACAGCAT TGATGCCTTG 
CGGCCCCCAG CCTCCCTTCC TCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006242444.1
CDS	111..2777
Translation	MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTQCVLRDVVPLGGQGGGGPSPSPGGEPPPEPFANSVLQLHEQDTGGPGGATGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKSHTSRSLLHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPSPGRSRRGKTRHRKASAKGSCGDLPGLRAALPPHEPGGLGSPGGLGVGPTAWDACPPALRGLHHDLLLRKMSSSSPDLLSAALGARGRGATGGARDPGSPPPPQGDTPPSEGSAPGSTSPDSPGGAKGEPPPPVGPGEGVGLLGTGREGTTGRGGSRAGYQHLTPAALLYRAAVTRSQKRGISSEEEEGEVDSEVELPPSQRWPQGPNMRQSLSTFSSENPSDVEEGTASEPSPSGTPEVGSTNTDERPDERSDDMCSQGSEIPLDLPTSEVVPERETSSLPMQHQDDQGPNPEDSDCDSTELDNSNSIDALRPPASLPP

Target ORF information:

RefSeq Version	XM_006242382.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus mitogen activated protein kinase kinase kinase 12 (Map3k12), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006242382.3

ORF Insert Sequence:

ATGGCCTGCC TCCATGAAAC CCGAACACCC TCCCCTTCCT TTGGAGGCTT TGTGTCTACT 
CTAAGTGAGG CCTCCATGCG AAAGCTGGAT CCAGACACTT CAGACTGCAC CCCTGAGAAG 
GACCTGACAC CTACCCAATG TGTACTTCGA GATGTTGTGC CTCTCGGTGG GCAGGGTGGA 
GGAGGGCCCA GCCCCTCCCC AGGTGGAGAG CCTCCTCCAG AGCCTTTTGC CAATAGTGTC 
CTGCAGCTAC ATGAGCAGGA TACAGGTGGG CCAGGGGGAG CCACCGGGTC ACCTGAGAGT 
CGAGCATCTA GGGTTCGAGC TGATGAGGTA CGTCTGCAGT GCCAGAGTGG CAGTGGCTTC 
CTTGAAGGTC TTTTTGGCTG CCTGCGCCCT GTCTGGACAA TGATTGGCAA AGCCTACTCC 
ACAGAGCACA AGCAACAGCA GGAAGACCTT TGGGAAGTCC CCTTTGAGGA AATCCTGGAC 
CTGCAGTGGG TAGGCTCAGG GGCTCAGGGT GCCGTTTTCC TGGGACGCTT TCATGGGGAG 
GAGGTAGCTG TGAAGAAGGT TCGAGACCTC AAGGAGACCG ACATCAAGCA TCTTCGAAAA 
CTGAAGCACC CCAACATCAT CACTTTCAAG GGTGTTTGCA CACAGGCCCC GTGCTACTGC 
ATCCTCATGG AGTTCTGTGC CCAAGGACAG CTGTATGAGG TGCTCAGGGC GGGCCGCCCC 
GTTACCCCCT CCTTGCTGGT TGACTGGTCC ATGGGCATCG CTGGAGGCAT GAATTACCTA 
CACCTGCACA AAATCATCCA TAGAGACCTG AAGTCACCCA ACATGCTAAT CACATACGAC 
GATGTGGTGA AGATCTCAGA CTTTGGCACT TCCAAGGAGC TGAGTGACAA GAGCACCAAG 
ATGTCCTTTG CAGGGACAGT AGCCTGGATG GCTCCTGAAG TGATCAGAAA TGAACCTGTG 
TCTGAGAAGG TTGACATCTG GTCCTTTGGG GTGGTGCTTT GGGAATTACT GACTGGAGAG 
ATTCCCTACA AAGATGTAGA CTCCTCAGCC ATCATCTGGG GTGTGGGAAG CAACAGTCTT 
CACCTGCCTG TACCCTCTAG CTGCCCAGAC GGCTTTAAAA TTCTGCTTCG CCAGTGCTGG 
AACAGCAAAC CTCGGAACCG CCCATCATTC CGACAGATCT TGCTGCACCT GGACATCGCC 
TCGGCTGATG TGCTCTCTAC ACCCCAGGAG ACTTACTTTA AATCCCAGGC AGAGTGGCGG 
GAAGAAGTAA AACTGCACTT TGAAAAGATT AAGTCAGAAG GGACCTGTCT GCACCGCCTA 
GAAGAGGAAC TGGTGATGCG GAGAAGGGAG GAGCTCAGAC ATGCCCTGGA CATCAGGGAG 
CACTATGAGC GCAAGTTGGA GAGAGCTAAC AACTTGTACA TGGAACTGAA TGCCCTCATG 
TTGCAACTAG AACTCAAAGA GAGGGAATTG CTCAGGCGAG AGCAAGCTTT AGAAAGGAGG 
TGTCCTGGTC TACTGAAGTC ACACACGTCC CGAAGCCTCC TACATGGAAA CACGATGGAG 
AAGCTCATCA AGAAAAGGAA TGTGCCACAG AAACTGTCAC CCCATAGCAA AAGGCCAGAT 
ATTCTCAAGA CAGAGTCTTT GCTACCTAAA CTAGATGCAG CCCTAAGTGG GGTGGGGCTT 
CCTGGGTGTC CTAAGGGCCC CCCTTCACCT GGGAGGAGTC GTCGTGGCAA GACCCGTCAC 
CGAAAGGCCA GCGCCAAGGG CAGCTGTGGA GACCTGCCTG GGCTTCGTGC AGCTTTGCCA 
CCCCATGAGC CTGGAGGACT AGGAAGCCCA GGAGGCCTAG GAGTGGGCCC TACAGCTTGG 
GATGCCTGCC CCCCTGCTCT CCGTGGACTC CACCATGACC TTCTACTTCG GAAGATGTCT 
TCATCATCCC CAGACCTGTT ATCAGCAGCA CTGGGAGCCC GAGGCCGAGG GGCAACAGGG 
GGAGCTCGGG ATCCTGGCTC ACCACCTCCA CCCCAGGGTG ATACTCCTCC AAGTGAGGGA 
TCAGCTCCTG GTTCCACCAG CCCAGATTCA CCTGGGGGAG CTAAAGGGGA ACCACCTCCA 
CCAGTAGGGC CTGGAGAAGG TGTGGGGCTG CTGGGAACTG GAAGGGAAGG GACTACAGGC 
CGGGGAGGAA GCCGGGCTGG GTACCAGCAC TTGACCCCCG CTGCGCTGCT GTACAGGGCT 
GCTGTGACTC GTAGTCAGAA ACGTGGTATC TCATCTGAAG AGGAAGAAGG AGAGGTCGAC 
AGTGAAGTAG AGCTACCCCC AAGTCAAAGG TGGCCTCAGG GCCCGAACAT GCGTCAGTCA 
CTATCTACGT TCAGCTCAGA GAACCCATCA GATGTGGAGG AAGGTACAGC TAGTGAGCCT 
TCCCCAAGTG GCACACCGGA AGTTGGCAGC ACCAACACTG ATGAGCGACC AGATGAACGG 
TCTGATGACA TGTGCTCACA GGGTTCAGAA ATCCCACTGG ACCTACCTAC TTCAGAGGTG 
GTCCCTGAAC GTGAAACCAG CTCCTTGCCC ATGCAACACC AGGATGACCA GGGCCCCAAT 
CCTGAGGACT CAGACTGTGA CAGCACTGAA TTGGACAACT CCAACAGCAT TGATGCCTTG 
CGGCCCCCAG CCTCCCTTCC TCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and A? Secretion.
Cell168(3)427-441.e21(2017 Jan)
Huang YA,Zhou B,Wernig M,S?dhof TC

Leucine Zipper-bearing Kinase promotes axon growth in mammalian central nervous system neurons.
Scientific reports631482(2016 Aug)
Chen M,Geoffroy CG,Wong HN,Tress O,Nguyen MT,Holzman LB,Jin Y,Zheng B

ZPK/DLK and MKK4 form the critical gateway to axotomy-induced motoneuron death in neonates.
The Journal of neuroscience : the official journal of the Society for Neuroscience34(32)10729-42(2014 Aug)
Itoh T,Horiuchi M,Ikeda RH Jr,Xu J,Bannerman P,Pleasure D,Penninger JM,Tournier C,Itoh A

Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death.
Proceedings of the National Academy of Sciences of the United States of America110(10)4045-50(2013 Mar)
Welsbie DS,Yang Z,Ge Y,Mitchell KL,Zhou X,Martin SE,Berlinicke CA,Hackler L Jr,Fuller J,Fu J,Cao LH,Han B,Auld D,Xue T,Hirai S,Germain L,Simard-Bisson C,Blouin R,Nguyen JV,Davis CH,Enke RA,Boye SL,Merbs SL,Marsh-Armstrong N,Hauswirth WW,DiAntonio A,Nickells RW,Inglese J,Hanes J,Yau KW,Quigley HA,Zack DJ

CEP11004, a novel inhibitor of the mixed lineage kinases, suppresses apoptotic death in dopamine neurons of the substantia nigra induced by 6-hydroxydopamine.
Journal of neurochemistry88(2)469-80(2004 Jan)
Ganguly A,Oo TF,Rzhetskaya M,Pratt R,Yarygina O,Momoi T,Kholodilov N,Burke RE

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Map3k12 cDNA ORF clone, Rattus norvegicus(Norway rat)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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