Katna1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Katna1
Entrez Gene ID	292464
Full Name	katanin catalytic subunit A1
General protein information	Preferred Names katanin catalytic subunit A1 Names katanin p60 ATPase-containing subunit A1 katanin p60 subunit A 1 katanin p60 subunit A1 microtubule severing protein p60 katanin
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1p13
Summary	p60 ATPase-containing subunit of katanin, a heterodimeric enzyme (together with p80 subunit Katnb1) responsible for severing microtubules from the centrosome [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001004217.4	NP_001004217.2	katanin p60 ATPase-containing subunit A1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	KATNA1	XP_001173304.1
Canis lupus familiaris (dog)	KATNA1	XP_533445.1
Gallus gallus (chicken)	KATNA1	NP_001038113.1
Homo sapiens (human)	KATNA1	NP_008975.1
Arabidopsis thaliana (thale cress)	ERH3	NP_178151.1
Xenopus tropicalis (tropical clawed frog)	katna1	NP_001072433.1
Bos taurus (cattle)	KATNA1	NP_001179032.1
Rattus norvegicus (Norway rat)	Katna1	NP_001004217.2
Oryza sativa (rice)	Os01g0683100	NP_001043887.1
Mus musculus (house mouse)	Katna1	NP_035965.2
Danio rerio (zebrafish)	katna1	NP_001018440.1

Gene Ontology
Bibliography

Related articles in PubMed

Proteomic Analysis of the Mammalian Katanin Family of Microtubule-severing Enzymes Defines Katanin p80 subunit B-like 1 (KATNBL1) as a Regulator of Mammalian Katanin Microtubule-severing.
Cheung K, Senese S, Kuang J, Bui N, Ongpipattanakul C, Gholkar A, Cohn W, Capri J, Whitelegge JP, Torres JZ
Molecular & cellular proteomics : MCP15(5)1658-69(2016 05)

Katanin p60 contributes to microtubule instability around the midbody and facilitates cytokinesis in rat cells.
Matsuo M, Shimodaira T, Kasama T, Hata Y, Echigo A, Okabe M, Arai K, Makino Y, Niwa S, Saya H, Kishimoto T
PloS one8(11)e80392(2013)

Tubulin polyglutamylation stimulates spastin-mediated microtubule severing.
Lacroix B, van Dijk J, Gold ND, Guizetti J, Aldrian-Herrada G, Rogowski K, Gerlich DW, Janke C
The Journal of cell biology189(6)945-54(2010 Jun)

The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells.
Cummings CM, Bentley CA, Perdue SA, Baas PW, Singer JD
The Journal of biological chemistry284(17)11663-75(2009 Apr)

The microtubule-severing proteins spastin and katanin participate differently in the formation of axonal branches.
Yu W, Qiang L, Solowska JM, Karabay A, Korulu S, Baas PW
Molecular biology of the cell19(4)1485-98(2008 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Katanin p60 contributes to microtubule instability around the midbody and facilitates cytokinesis in rat cells.
Title: Katanin p60 contributes to microtubule instability around the midbody and facilitates cytokinesis in rat cells.

two modes by which microtubule severing occurs during axonal branch formation, based on the concentration of spastin at branch sites and on local detachment from microtubules of molecules such as tau that regulate the severing properties of P60-katanin
Title: The microtubule-severing proteins spastin and katanin participate differently in the formation of axonal branches.

When katanin is overexpressed in fibroblasts, the microtubules are severed into short pieces, but this phenomenon is suppressed by the coexpression of tau.
Title: Tau protects microtubules in the axon from severing by katanin.

the ratio of P60 to P80 varies markedly in different tissues, at different phases of development, and regionally within the neuron. Suggested that the effects on neuronal morphology are dependent on the degree of microtubule severing and loss of polymer
Title: Regulation of microtubule severing by katanin subunits during neuronal development.

The following Katna1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Katna1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa10102	NM_001004217.4 Latest version!	Rattus norvegicus katanin catalytic subunit A1 (Katna1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Katna1 ( NM_001004217.4 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001004217.2 Rattus norvegicus katanin catalytic subunit A1 (Katna1), mRNA.

Price & Availability↑

CloneID	ORa10102
Clone ID Related Accession (Same CDS sequence)	NM_001004217.4
Accession Version	NM_001004217.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1482bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Rattus norvegicus(Norway rat)
Product	katanin p60 ATPase-containing subunit A1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC097929.1 and BI302698.1. On Aug 11, 2009 this sequence version replaced NM_001004217.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC097929.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCATGA GTCTTCTAAT GATTACTGAG AATGTAAAAT TGGCTCGTGA GTATGCATTG 
CTGGGAAACT ATGACTCTGC AATGGTCTAT TATCAGGGAG TTCTTGACCA AATTAACAAG 
TATCTATACT CAGTCAAAGA TACACACCTC CATCAGAAAT GGCAACAGGT TTGGCAGGAA 
ATAAACGTGG AAGCTAAGCA TGTTAAGGAG ATCATGAAAA CACTGGAGAG CTTTAAACTG 
GACAGCACTT CTTTGAAAGC TGCACAGCAT GAGCTTCCGT CCTCGGAAGG AGAAGTCTGG 
TCTTTGCCGG TACCTGTTGA AAGGAGACCC TTACCAGGAC CTAGGAAGCG CCAGTCTACT 
CAGCACAGTG ACCCTAAGCC ACACAGTAAC CGGCCAGGCG CAGTCGTCAG AGCTCATCGA 
CCATCTGCAC AGAGTCTGCA CAGCGACAGA GGCAAAGCTG TTCGTAGTCG TGAAAAGAAA 
GAGCAGAGTA AGGGCAGAGA GGAAAAGAAC AAATTACCTG CTGCAGTTAC AGAACCAGAG 
GCAAATAAAT TTGATAGCAC GGGGTATGAC AAGGACTTAG TAGAAGCTTT GGAAAGAGAT 
ATAATTTCTC AGAATCCCAA CGTTCGGTGG TATGATATTG CTGATTTAGT AGAAGCTAAA 
AAGTTGCTTC AGGAAGCAGT GGTGTTACCA ATGTGGATGC CAGAATTCTT TAAGGGCATT 
AGGAGACCAT GGAAAGGTGT GCTGATGGTT GGCCCACCTG GCACTGGAAA GACCCTCCTT 
GCTAAAGCAG TTGCCACAGA ATGCAAGACA ACGTTCTTCA ATGTCTCTTC ATCCACTCTG 
ACTTCCAAAT ACAGAGGAGA GTCTGAGAAG CTTGTCCGTC TTCTGTTTGA AATGGCTCGG 
TTTTACTCCC CAGCTACCAT ATTTATTGAT GAGATAGATT CCATCTGCAG CCGCCGAGGA 
ACTTCTGAAG AGCATGAAGC AAGCCGAAGG GTGAAAGCTG AGCTGCTGGT TCAGATGGAT 
GGTGTTGGAG GTGCCTCAGA AAATGACGAC CCTTCCAAGA TGGTCATGGT TCTGGCGGCC 
ACTAATTTCC CATGGGACAT AGATGAGGCT TTAAGGCGTC GTCTGGAGAA AAGAATCTAT 
ATTCCGTTAC CATCAGCAAA AGGCAGAGAA GAACTGTTAA GAATAAGTCT ACGAGAGCTG 
GAATTGGCTG ATGATGTTAA CCTTGCAAGC ATAGCAGAAA ACATGGAAGG CTACTCAGGT 
GCAGACATTA CCAATGTATG CAGGGATGCG TCCTTGATGG CCATGAGACG CCGTATTGAG 
GGTCTAACCC CAGAAGAAAT CCGGAACCTT TCAAGAGAAG AAATGCACAT GCCTACCACC 
ATGGAGGATT TTGAAATGGC TTTAAAGAAG GTCTCCAAAT CAGTATCAGC TGCAGACATT 
GAGAGATACG AGAAATGGAT AGTTGAGTTT GGATCATGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001004217.2
CDS	191..1672
Translation	MSMSLLMITENVKLAREYALLGNYDSAMVYYQGVLDQINKYLYSVKDTHLHQKWQQVWQEINVEAKHVKEIMKTLESFKLDSTSLKAAQHELPSSEGEVWSLPVPVERRPLPGPRKRQSTQHSDPKPHSNRPGAVVRAHRPSAQSLHSDRGKAVRSREKKEQSKGREEKNKLPAAVTEPEANKFDSTGYDKDLVEALERDIISQNPNVRWYDIADLVEAKKLLQEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGASENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLRISLRELELADDVNLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSREEMHMPTTMEDFEMALKKVSKSVSAADIERYEKWIVEFGSC

Target ORF information:

RefSeq Version	NM_001004217.4
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus katanin catalytic subunit A1 (Katna1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001004217.4

ORF Insert Sequence:

ATGAGCATGA GTCTTCTAAT GATTACTGAG AATGTAAAAT TGGCTCGTGA GTATGCATTG 
CTGGGAAACT ATGACTCTGC AATGGTCTAT TATCAGGGAG TTCTTGACCA AATTAACAAG 
TATCTATACT CAGTCAAAGA TACACACCTC CATCAGAAAT GGCAACAGGT TTGGCAGGAA 
ATAAACGTGG AAGCTAAGCA TGTTAAGGAG ATCATGAAAA CACTGGAGAG CTTTAAACTG 
GACAGCACTT CTTTGAAAGC TGCACAGCAT GAGCTTCCGT CCTCGGAAGG AGAAGTCTGG 
TCTTTGCCGG TACCTGTTGA AAGGAGACCC TTACCAGGAC CTAGGAAGCG CCAGTCTACT 
CAGCACAGTG ACCCTAAGCC ACACAGTAAC CGGCCAGGCG CAGTCGTCAG AGCTCATCGA 
CCATCTGCAC AGAGTCTGCA CAGCGACAGA GGCAAAGCTG TTCGTAGTCG TGAAAAGAAA 
GAGCAGAGTA AGGGCAGAGA GGAAAAGAAC AAATTACCTG CTGCAGTTAC AGAACCAGAG 
GCAAATAAAT TTGATAGCAC GGGGTATGAC AAGGACTTAG TAGAAGCTTT GGAAAGAGAT 
ATAATTTCTC AGAATCCCAA CGTTCGGTGG TATGATATTG CTGATTTAGT AGAAGCTAAA 
AAGTTGCTTC AGGAAGCAGT GGTGTTACCA ATGTGGATGC CAGAATTCTT TAAGGGCATT 
AGGAGACCAT GGAAAGGTGT GCTGATGGTT GGCCCACCTG GCACTGGAAA GACCCTCCTT 
GCTAAAGCAG TTGCCACAGA ATGCAAGACA ACGTTCTTCA ATGTCTCTTC ATCCACTCTG 
ACTTCCAAAT ACAGAGGAGA GTCTGAGAAG CTTGTCCGTC TTCTGTTTGA AATGGCTCGG 
TTTTACTCCC CAGCTACCAT ATTTATTGAT GAGATAGATT CCATCTGCAG CCGCCGAGGA 
ACTTCTGAAG AGCATGAAGC AAGCCGAAGG GTGAAAGCTG AGCTGCTGGT TCAGATGGAT 
GGTGTTGGAG GTGCCTCAGA AAATGACGAC CCTTCCAAGA TGGTCATGGT TCTGGCGGCC 
ACTAATTTCC CATGGGACAT AGATGAGGCT TTAAGGCGTC GTCTGGAGAA AAGAATCTAT 
ATTCCGTTAC CATCAGCAAA AGGCAGAGAA GAACTGTTAA GAATAAGTCT ACGAGAGCTG 
GAATTGGCTG ATGATGTTAA CCTTGCAAGC ATAGCAGAAA ACATGGAAGG CTACTCAGGT 
GCAGACATTA CCAATGTATG CAGGGATGCG TCCTTGATGG CCATGAGACG CCGTATTGAG 
GGTCTAACCC CAGAAGAAAT CCGGAACCTT TCAAGAGAAG AAATGCACAT GCCTACCACC 
ATGGAGGATT TTGAAATGGC TTTAAAGAAG GTCTCCAAAT CAGTATCAGC TGCAGACATT 
GAGAGATACG AGAAATGGAT AGTTGAGTTT GGATCATGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Proteomic Analysis of the Mammalian Katanin Family of Microtubule-severing Enzymes Defines Katanin p80 subunit B-like 1 (KATNBL1) as a Regulator of Mammalian Katanin Microtubule-severing.
Molecular & cellular proteomics : MCP15(5)1658-69(2016 05)
Cheung K,Senese S,Kuang J,Bui N,Ongpipattanakul C,Gholkar A,Cohn W,Capri J,Whitelegge JP,Torres JZ

Katanin p60 contributes to microtubule instability around the midbody and facilitates cytokinesis in rat cells.
PloS one8(11)e80392(2013)
Matsuo M,Shimodaira T,Kasama T,Hata Y,Echigo A,Okabe M,Arai K,Makino Y,Niwa S,Saya H,Kishimoto T

Tubulin polyglutamylation stimulates spastin-mediated microtubule severing.
The Journal of cell biology189(6)945-54(2010 Jun)
Lacroix B,van Dijk J,Gold ND,Guizetti J,Aldrian-Herrada G,Rogowski K,Gerlich DW,Janke C

The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells.
The Journal of biological chemistry284(17)11663-75(2009 Apr)
Cummings CM,Bentley CA,Perdue SA,Baas PW,Singer JD

The microtubule-severing proteins spastin and katanin participate differently in the formation of axonal branches.
Molecular biology of the cell19(4)1485-98(2008 Apr)
Yu W,Qiang L,Solowska JM,Karabay A,Korulu S,Baas PW

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Katna1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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