Gene Symbol | Asl |
Entrez Gene ID | 59085 |
Full Name | argininosuccinate lyase |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Asl cDNA ORF clone
gRNAs
Gene Symbol | Asl |
Entrez Gene ID | 59085 |
Full Name | argininosuccinate lyase |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006249247.3 | XP_006249309.1 | argininosuccinate lyase isoform X1 |
XM_006249245.3 | XP_006249307.1 | argininosuccinate lyase isoform X1 |
NM_021577.3 | NP_067588.2 | argininosuccinate lyase |
Bos taurus (cattle) | ASL | NP_001029600.1 |
Gallus gallus (chicken) | ASL2 | NP_001025885.1 |
Saccharomyces cerevisiae (baker's yeast) | ARG4 | NP_011882.1 |
Rattus norvegicus (Norway rat) | Asl | NP_067588.2 |
Drosophila melanogaster (fruit fly) | CG9510 | NP_001027234.1 |
Eremothecium gossypii | AGOS_AEL019W | NP_984842.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_17278 | XP_003717639.1 |
Homo sapiens (human) | ASL | NP_000039.2 |
Pan troglodytes (chimpanzee) | ASL | XP_519125.3 |
Mus musculus (house mouse) | Asl | NP_598529.1 |
Oryza sativa (rice) | Os03g0305500 | NP_001049883.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP008141 | XP_317320.4 |
Canis lupus familiaris (dog) | LOC479704 | XP_536832.2 |
Gallus gallus (chicken) | ASL1 | NP_990832.1 |
Danio rerio (zebrafish) | asl | NP_956745.1 |
Kluyveromyces lactis | KLLA0A08404g | XP_451371.1 |
Schizosaccharomyces pombe (fission yeast) | SPBC1539.03c | NP_596817.1 |
Schizosaccharomyces pombe (fission yeast) | arg7 | NP_595129.1 |
Neurospora crassa | NCU08162 | XP_959654.1 |
Arabidopsis thaliana (thale cress) | AT5G10920 | NP_196653.1 |
Xenopus tropicalis (tropical clawed frog) | asl | NP_001106586.1 |
Argininosuccinate lyase in enterocytes protects from development of necrotizing enterocolitis.
Premkumar MH, Sule G, Nagamani SC, Chakkalakal S, Nordin A, Jain M, Ruan MZ, Bertin T, Dawson B, Zhang J, Schady D, Bryan NS, Campeau PM, Erez A, Lee B
American journal of physiology. Gastrointestinal and liver physiology307(3)G347-54(2014 Aug)
Toward an understanding of the protein interaction network of the human liver.
Wang J, Huo K, Ma L, Tang L, Li D, Huang X, Yuan Y, Li C, Wang W, Guan W, Chen H, Jin C, Wei J, Zhang W, Yang Y, Liu Q, Zhou Y, Zhang C, Wu Z, Xu W, Zhang Y, Liu T, Yu D, Zhang Y, Chen L, Zhu D, Zhong X, Kang L, Gan X, Yu X, Ma Q, Yan J, Zhou L, Liu Z, Zhu Y, Zhou T, He F, Yang X
Molecular systems biology7536(2011 Oct)
L-citrulline attenuates arrested alveolar growth and pulmonary hypertension in oxygen-induced lung injury in newborn rats.
Vadivel A, Aschner JL, Rey-Parra GJ, Magarik J, Zeng H, Summar M, Eaton F, Th?baud B
Pediatric research68(6)519-25(2010 Dec)
Urea cycle gene expression is suppressed by PFOA treatment in rats.
Walters MW, Wallace KB
Toxicology letters197(1)46-50(2010 Aug)
Nitric oxide (no), citrulline - no cycle enzymes, glutamine synthetase and oxidative stress in anoxia (hypobaric hypoxia) and reperfusion in rat brain.
Swamy M, Salleh MJ, Sirajudeen KN, Yusof WR, Chandran G
International journal of medical sciences7(3)147-54(2010 May)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Enterocyte-derived ASL has a protective role in necrotizing enterocolitis.
Title: Argininosuccinate lyase in enterocytes protects from development of necrotizing enterocolitis.
Local factors such as the NO produced by nNOS/ASS/ASL-positive neurons, could influence ASS/ASL-positive microglia cells avoiding or allowing the induction, in these cells, of iNOS.
Title: Activated microglia cells express argininosuccinate synthetase and argininosuccinate lyase in the rat brain after transient ischemia.
24 h after reperfusion, number of nNOS-positive neurons and tpercentage of those co-expressing ASS and ASL were significantly increased in the animals with a longer survival. 144 h after ischemia there was almost complete restore of these neurons.
Title: Transient ischemia increases neuronal nitric oxide synthase, argininosuccinate synthetase and argininosuccinate lyase co-expression in rat striatal neurons.
The following Asl gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Asl cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa04845 | |
Clone ID Related Accession (Same CDS sequence) | XM_006249247.3 , XM_006249245.3 , NM_021577.3 | |
Accession Version | NM_021577.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1386bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-20 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | argininosuccinate lyase | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC097270.1. On Jun 10, 2007 this sequence version replaced NM_021577.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC097270.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCATCGG AGAGCGGGAA GCTATGGGGT GGCCGATTTG CAGGCTCGGT CGACCCCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_067588.2 |
CDS | 620..2005 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCATCGG AGAGCGGGAA GCTATGGGGT GGCCGATTTG CAGGCTCGGT CGACCCCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa04845 | |
Clone ID Related Accession (Same CDS sequence) | XM_006249247.3 , XM_006249245.3 , NM_021577.3 | |
Accession Version | XM_006249247.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1386bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | argininosuccinate lyase isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006249247.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCATCGG AGAGCGGGAA GCTATGGGGT GGCCGATTTG CAGGCTCGGT CGACCCCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006249309.1 |
CDS | 388..1773 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCATCGG AGAGCGGGAA GCTATGGGGT GGCCGATTTG CAGGCTCGGT CGACCCCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa04845 | |
Clone ID Related Accession (Same CDS sequence) | XM_006249247.3 , XM_006249245.3 , NM_021577.3 | |
Accession Version | XM_006249245.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1386bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | argininosuccinate lyase isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006249245.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCATCGG AGAGCGGGAA GCTATGGGGT GGCCGATTTG CAGGCTCGGT CGACCCCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006249307.1 |
CDS | 445..1830 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCATCGG AGAGCGGGAA GCTATGGGGT GGCCGATTTG CAGGCTCGGT CGACCCCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Argininosuccinate lyase in enterocytes protects from development of necrotizing enterocolitis. |
Toward an understanding of the protein interaction network of the human liver. |
L-citrulline attenuates arrested alveolar growth and pulmonary hypertension in oxygen-induced lung injury in newborn rats. |
Urea cycle gene expression is suppressed by PFOA treatment in rats. |
Nitric oxide (no), citrulline - no cycle enzymes, glutamine synthetase and oxidative stress in anoxia (hypobaric hypoxia) and reperfusion in rat brain. |