Technique where gene encoding the human target protein is inserted into the locus encoding the mouse target ortholog within the mouse genome. These "knock-in/knock-out" mice will only express the human target protein but not the endogenous mouse ortholog.
Related Biology Tools
GenSmart™ Codon Optimization
GenSmart Optimization is a free online tool for performing codon optimization to improve gene expression. GenScript's patented algorithms are integrated into the tool to optimize the computing capability of high-performance sequence generation.
DNA Construct Design Tool
GenSmart™ Design is a free online DNA construct design tool developed by GenScript. GenSmart™ Design has two design modules, the Create Construct module for individual plasmid design and the Create Library module for DNA library design.
Codon Frequency Tables
This online tool shows commonly used genetic codon frequency table in expression host organisms including Escherichia coli and other common host organisms.
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If you know of any terms that have been omitted from this glossary that you feel would be useful to include, please send detail to the Editorial Office at GenScript: [email protected]