HBEGF cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Gene Symbol	HBEGF
Entrez Gene ID	522921
Full Name	heparin binding EGF like growth factor
Synonyms	DTR,HB-EGF
General protein information	Preferred Names heparin binding EGF like growth factor Names proheparin-binding EGF-like growth factor diphtheria toxin receptor heparin-binding epidermal growth factor-like growth factor
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA Protein Name

NM_001144090.1 NP_001137562.1 proheparin-binding EGF-like growth factor precursor
Pathways from BioSystems

mRNA	Protein	Name
NM_001144090.1	NP_001137562.1	proheparin-binding EGF-like growth factor precursor

Homologies

Pan troglodytes (chimpanzee)	HBEGF	XP_001137119.1
	HBEGF	XP_001085848.1
Canis lupus familiaris (dog)	HBEGF	XP_005617336.1
Homo sapiens (human)	HBEGF	NP_001936.1
Bos taurus (cattle)	HBEGF	NP_001137562.1
Rattus norvegicus (Norway rat)	Hbegf	NP_037077.1
Gallus gallus (chicken)	HBEGF	NP_990180.1
Mus musculus (house mouse)	Hbegf	NP_034545.1

Gene Ontology
Bibliography

Related articles in PubMed

Expression of Heparin-Binding EGF-Like Growth Factor (HB-EGF) in Bovine Endometrium: Effects of HB-EGF and Interferon-? on Prostaglandin Production.
Takatsu K, Acosta TJ
Reproduction in domestic animals = Zuchthygiene50(3)458-64(2015 Jun)

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

Heparin-binding epidermal growth factor-like growth factor: a component in chromaffin granules which promotes the survival of nigrostriatal dopaminergic neurones in vitro and in vivo.
Hanke M, Farkas LM, Jakob M, Ries R, Pohl J, Sullivan AM
Neuroscience124(4)757-66(2004)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results indicate that HB-EGF and its receptors expression changed in bovine endometrium throughout the oestrous cycle; IFN-tau increased their expression in cultured endometrial cells.
Title: Expression of Heparin-Binding EGF-Like Growth Factor (HB-EGF) in Bovine Endometrium: Effects of HB-EGF and Interferon-? on Prostaglandin Production.

Heparin-binding EGF-like growth factor is main component in chromaffin granules responsible for neurotrophic effect on dopaminergic neurones. Protective effects on nigrostriatal dopaminergic neurones. Candidate for treatment of Parkinson's disease.
Title: Heparin-binding epidermal growth factor-like growth factor: a component in chromaffin granules which promotes the survival of nigrostriatal dopaminergic neurones in vitro and in vivo.

The following HBEGF gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HBEGF cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa38990	NM_001144090.1 Latest version!	Bos taurus heparin binding EGF like growth factor (HBEGF), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HBEGF ( NM_001144090.1 ) cDNA ORF clone, Bos taurus(cattle) -> NP_001137562.1 Bos taurus heparin binding EGF like growth factor (HBEGF), mRNA.

Price & Availability↑

CloneID	OBa38990
Clone ID Related Accession (Same CDS sequence)	NM_001144090.1
Accession Version	NM_001144090.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 627bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-28
Organism	Bos taurus(cattle)
Product	proheparin-binding EGF-like growth factor precursor
Comment	Comment: INFERRED REFSEQ: This record is predicted by genome sequence analysis and is not yet supported by experimental evidence. The reference sequence was derived from NKLS02000007.1. On Jan 22, 2009 this sequence version replaced XM_601210.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR5571254.19314.1, SRR5571263.30449.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN03145412, SAMN03145413 [ECO:0000350] ##Evidence-Data-END##

ATGAAGCTGC TGCCGTCGGT GGTGCTGAAG CTCTTTCTTG CTGCAGTGCT TTCGGCGTTG 
GTGACTGGCG AGAGCCTGGA GCGGCTTCGG AGAGGCCTGG CTGCTGGAAC CAGCAATCTG 
GACACCCCTA CTCAATCTAC GGACCAGCTG CTGCCCGCGG GAGGTGGCCA AGGCCGGGAA 
GTCCTGGACT TGGAAGAGGC AAACCTGGAC CTTTTCAGAG CTGCTTTCTC CTCCAAGCCA 
CAAGCTCTGG CCACACCAAG CAAGGAGGAG CGTGGGAAAA GAAAGAAGAA AGGCAAGGGG 
TTAGGGAAGA AGAGAAACCC ATGTCTTCGG AGATACAAGG ACTTCTGCAT CCACGGAGAA 
TGCAAATACG TGAAGGAGCT CCGGGTTCCA ACCTGCATCT GCCACCCAGG TTATCACGGA 
GAGAGGTGCC ATGGGCTGAG CCTCCCGGTG AAAAATCGCT TATATACGTA CGATCACACA 
ACCATCCTGG TTGTGGTGGC TGTGGTGCTA TCATCCGTCT GTCTGCTGGT CATCATGGGG 
CTTCTCATGT TTTGGTACCA CAGAAGAGGA GGTTATGACG TGGAAAATGA AGAGAAAGTG 
AAGTTGGGCA TGACTACGTC CCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001137562.1
CDS	282..908
Translation	MKLLPSVVLKLFLAAVLSALVTGESLERLRRGLAAGTSNLDTPTQSTDQLLPAGGGQGREVLDLEEANLDLFRAAFSSKPQALATPSKEERGKRKKKGKGLGKKRNPCLRRYKDFCIHGECKYVKELRVPTCICHPGYHGERCHGLSLPVKNRLYTYDHTTILVVVAVVLSSVCLLVIMGLLMFWYHRRGGYDVENEEKVKLGMTTSH

Target ORF information:

RefSeq Version	NM_001144090.1
Organism	Bos taurus(cattle)
Definition	Bos taurus heparin binding EGF like growth factor (HBEGF), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001144090.1

ORF Insert Sequence:

ATGAAGCTGC TGCCGTCGGT GGTGCTGAAG CTCTTTCTTG CTGCAGTGCT TTCGGCGTTG 
GTGACTGGCG AGAGCCTGGA GCGGCTTCGG AGAGGCCTGG CTGCTGGAAC CAGCAATCTG 
GACACCCCTA CTCAATCTAC GGACCAGCTG CTGCCCGCGG GAGGTGGCCA AGGCCGGGAA 
GTCCTGGACT TGGAAGAGGC AAACCTGGAC CTTTTCAGAG CTGCTTTCTC CTCCAAGCCA 
CAAGCTCTGG CCACACCAAG CAAGGAGGAG CGTGGGAAAA GAAAGAAGAA AGGCAAGGGG 
TTAGGGAAGA AGAGAAACCC ATGTCTTCGG AGATACAAGG ACTTCTGCAT CCACGGAGAA 
TGCAAATACG TGAAGGAGCT CCGGGTTCCA ACCTGCATCT GCCACCCAGG TTATCACGGA 
GAGAGGTGCC ATGGGCTGAG CCTCCCGGTG AAAAATCGCT TATATACGTA CGATCACACA 
ACCATCCTGG TTGTGGTGGC TGTGGTGCTA TCATCCGTCT GTCTGCTGGT CATCATGGGG 
CTTCTCATGT TTTGGTACCA CAGAAGAGGA GGTTATGACG TGGAAAATGA AGAGAAAGTG 
AAGTTGGGCA TGACTACGTC CCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression of Heparin-Binding EGF-Like Growth Factor (HB-EGF) in Bovine Endometrium: Effects of HB-EGF and Interferon-? on Prostaglandin Production.
Reproduction in domestic animals = Zuchthygiene50(3)458-64(2015 Jun)
Takatsu K,Acosta TJ

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

Heparin-binding epidermal growth factor-like growth factor: a component in chromaffin granules which promotes the survival of nigrostriatal dopaminergic neurones in vitro and in vivo.
Neuroscience124(4)757-66(2004)
Hanke M,Farkas LM,Jakob M,Ries R,Pohl J,Sullivan AM

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HBEGF cDNA ORF clone, Bos taurus(cattle)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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