Irp-1A cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	Irp-1A
Entrez Gene ID	42689
Full Name	Iron regulatory protein 1A
Synonyms	C-Acon,CG4900,Dmel\CG4900,IRF,IRP,IRP-1,IRP-1A,IRP1,c-Acon,cACON,cAcon,dIRP,irp1A
General protein information	Preferred Names Iron regulatory protein 1A Names CG4900 gene product from transcript CG4900-RA CG4900-PA Irp-1A-PA c-aconitase cytoplasmic aconitase cytosolic aconitase iron regulatory factor iron regulatory protein iron regulatory protein 1A
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 3R Map Location: 94C3-94C3

mRNA and Protein(s)

mRNA	Protein	Name
NM_058023.5	NP_477371.1	iron regulatory protein 1A

Pathways from BioSystems

Homologies

Homo sapiens (human)	ACO1	NP_002188.1
Pan troglodytes (chimpanzee)	ACO1	XP_001156102.1
Drosophila melanogaster (fruit fly)	Irp-1A	NP_477371.1
Arabidopsis thaliana (thale cress)	ACO1	NP_195308.1
	ACO1	XP_001103761.1
Bos taurus (cattle)	ACO1	NP_001069059.1
Arabidopsis thaliana (thale cress)	ACO3	NP_178634.2
Caenorhabditis elegans (roundworm)	aco-1	NP_509898.1
Oryza sativa (rice)	Os03g0136900	NP_001048898.1
Canis lupus familiaris (dog)	ACO1	XP_538698.2
Rattus norvegicus (Norway rat)	Aco1	NP_059017.1
Danio rerio (zebrafish)	aco1	NP_001030155.1
Drosophila melanogaster (fruit fly)	Irp-1B	NP_524303.2
Xenopus tropicalis (tropical clawed frog)	aco1	NP_001135643.1
Mus musculus (house mouse)	Aco1	NP_031412.2
Gallus gallus (chicken)	ACO1	NP_001025707.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007258	XP_308544.4

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

muscle-specific overexpression of IRP-1A, but not of IRP-1B, resulted in pre-adult lethality, underscoring the importance of the biochemical difference between the two proteins;only IRP-1A can bind to iron-responsive elements
Title: Of two cytosolic aconitases expressed in Drosophila, only one functions as an iron-regulatory protein.

The following Irp-1A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Irp-1A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa08686	NM_058023.5 Latest version!	Drosophila melanogaster iron regulatory protein 1A (Irp-1A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$510.30 $729.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Irp-1A ( NM_058023.5 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_477371.1 Drosophila melanogaster iron regulatory protein 1A (Irp-1A), mRNA.

Price & Availability↑

CloneID	OFa08686
Clone ID Related Accession (Same CDS sequence)	NM_058023.5
Accession Version	NM_058023.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2709bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	iron regulatory protein 1A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033777). On Jan 16, 2013 this sequence version replaced NM_058023.4. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGTCCGGCT CCGGCGCCAA TCCCTTTGCC CAGTTCCAGG AGTCATTCAC CCAGGACGGC 
AACGTCTACA AGTATTTTGA TCTGCCCTCC ATCGACAGCA AATATGAGTC ACTGCCCTTT 
TCCATTCGCG TTCTGCTGGA ATCAGCGGTG CGCAACTGTG ACAACTTTCA TGTGCTGGAG 
AAGGATGTGC AGAGCATCCT GGGATGGACT CCATCGCTGA AGCAGGAAAC CAGCGATGTG 
GAAGTCTCCT TCAAGCCAGC TCGTGTTATA TTGCAGGACT TTACTGGCGT TCCCGCCGTC 
GTGGATTTTG CTGCCATGCG GGATGCTGTC CGCGAGCTGG GCGGCAATCC TGAGAAAATC 
AATCCCATCT GCCCTGCCGA CCTGGTCATC GACCATTCCG TTCAGGTGGA TTTCGTTCGC 
TCCTCGGACG CATTGACCAA GAACGAGTCA CTAGAGTTCC AGCGCAACAA GGAACGATTC 
ACCTTCCTCA AATGGGGAGC TCGCGCTTTT GACAATATGC TAATTGTGCC ACCCGGCTCT 
GGCATTGTGC ACCAGGTTAA CCTGGAGTAT CTGGCCCGAG TGGTTTTCGA AAGCGACAGT 
TCAGCGGACG GATCTAAGAT CCTTTATCCG GATAGCGTTG TGGGCACTGA CTCCCACACT 
ACAATGATCA ATGGATTAGG TGTTCTCGGC TGGGGTGTTG GCGGTATCGA GGCGGAGGCC 
GTAATGTTGG GCCAGTCCAT TTCCATGCTG TTGCCAGAGG TGATTGGCTA CAGGCTGGAG 
GGCAAACTGG GCCCTCTGGC CACATCCACC GATCTGGTGC TGACCATTAC CAAGCATTTG 
CGTCAGCTTG GTGTCGTCGG CAAGTTCGTG GAGTTTTACG GCCCCGGAGT GGCAGAGCTC 
AGCATCGCGG ATCGCGCCAC CATCAGCAAC ATGTGTCCGG AATATGGAGC CACTGTGGGT 
TACTTCCCAA TCGATGAAAA CACGCTGAGT TACATGCGCC AAACCAATCG CTCCGAGAAG 
AAAATCGATA TTATCCGGAA GTATTTGAAG GCCACTCGAC AACTTCGTGA CTATTCCCTT 
GTGGATCAGG ATCCCCAATA CACGGAGTCT GTAACTTTGG ACTTATCCAC CGTGGTGACC 
TCGGTTTCGG GGCCCAAGCG ACCGCACGAT CGCGTTTCAG TTTCCAGCAT GTGCGAAGAC 
TTCAAGTCGT GCCTCATAAG TCCTGTCGGC TTCAAGGGAT TCGCCATACC ACCGAGTGCA 
TTGGCTGCAA GTGGTGAATT CCAATGGGAC GATGGGAAGA GCTATAAGAT AGGTCATGGA 
TCTGTTGTGA TTGCCGCCAT CACCTCGTGC ACGAACACTT CGAATCCCTC GGTGATGTTG 
GGCGCTGGTC TGCTGGCCAA GAATGCCGTG CAGAAGGGCT TGAGTATTTT GCCGTATATC 
AAGACCTCAT TGTCACCAGG ATCTGGCGTG GTTACCTACT ATCTGAGGGA ATCCGGTGTG 
ATTCCCTATC TGGAGCAGCT GGGCTTCGAC ATTGTGGGCT ATGGCTGTAT GACCTGCATT 
GGCAACTCGG GCCCGCTCGA TGAGAACGTA GTGAACACCA TCGAGAAGAA CGGACTGGTT 
TGCTGTGGCG TCCTGTCGGG CAATCGCAAT TTCGAGGGTC GCATCCATCC CAATACTAGG 
GCCAATTATC TGGCCAGTCC GCTGCTGGTG ATTGCCTACG CGATTGCCGG CCGTGTGGAT 
ATTGATTTCG AGATCGAACC GCTGGGCGTG GATTCCAACG GCAAGGAGGT GTTCCTGCGC 
GATATCTGGC CAACGCGCAG TGAGATTCAG GAGGTAGAGC ATAAGCACGT CATTCCCGCC 
ATGTTCCAGG AGGTGTACAG CAAAATTCAA CTGGGATCCA GGGACTGGCA AACGTTGGAG 
GTGTCGGATA GCAAGTTGTA TCCATGGAGT GAAATATCAA CATACATCAA ACTACCACCG 
TTCTTCGAGG GTATGACTCG TGCGCTGCCC AAACTTAAAG GTATCGAGAA GGCTCGCTGT 
CTGCTGCTTC TCGGTGATTC AGTGACCACC GATCATATCT CGCCAGCCGG ATCCATTGCA 
CGAAAGTCAC CGGCAGCGCG CTATTTGTCG GAAAGGGGTC TAACGCCGCG CGACTTTAAT 
TCGTATGGAT CCAGACGTGG CAATGATGCG GTGATGGCAC GCGGAACCTT TGCCAACATC 
CGTCTGGTCA ATAAACTGGC ATCCAAGACG GGACCCAGCA CACTGCACGT GCCCAGTGGC 
GAGGAGATGG ACATCTTCGA TGCGGCGGAA CGGTATGCGA GCGAAGGAAC ACCTTTGGTT 
CTGGTCGTAG GCAAGGACTA CGGCAGTGGC AGCTCACGTG ATTGGGCCGC CAAGGGGCCA 
TTTCTGCTGG GCATCAAGGC GGTGATTGCT GAATCGTACG AGCGCATTCA CCGCTCAAAT 
CTGGTGGGCA TGGGCATCAT TCCGCTGCAG TTCTTGCCTG GCCAGAGCGC CGATACCCTG 
AAACTGAGTG GCAGGGAGGT GTACAACATT GTCCTGCCCG AGGGCGAACT GAAGCCGGGC 
CAGAGGATTC AGGTCGATGC TGATGGCAAT GTCTTTGAGA CCACGTTGCG TTTCGACACC 
GAGGTGGACA TAACGTACTA CAAGAATGGC GGCATTTTGA ACTATATGAT ACGCAAAATG 
CTGGATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_477371.1
CDS	64..2772
Translation	MSGSGANPFAQFQESFTQDGNVYKYFDLPSIDSKYESLPFSIRVLLESAVRNCDNFHVLEKDVQSILGWTPSLKQETSDVEVSFKPARVILQDFTGVPAVVDFAAMRDAVRELGGNPEKINPICPADLVIDHSVQVDFVRSSDALTKNESLEFQRNKERFTFLKWGARAFDNMLIVPPGSGIVHQVNLEYLARVVFESDSSADGSKILYPDSVVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQSISMLLPEVIGYRLEGKLGPLATSTDLVLTITKHLRQLGVVGKFVEFYGPGVAELSIADRATISNMCPEYGATVGYFPIDENTLSYMRQTNRSEKKIDIIRKYLKATRQLRDYSLVDQDPQYTESVTLDLSTVVTSVSGPKRPHDRVSVSSMCEDFKSCLISPVGFKGFAIPPSALAASGEFQWDDGKSYKIGHGSVVIAAITSCTNTSNPSVMLGAGLLAKNAVQKGLSILPYIKTSLSPGSGVVTYYLRESGVIPYLEQLGFDIVGYGCMTCIGNSGPLDENVVNTIEKNGLVCCGVLSGNRNFEGRIHPNTRANYLASPLLVIAYAIAGRVDIDFEIEPLGVDSNGKEVFLRDIWPTRSEIQEVEHKHVIPAMFQEVYSKIQLGSRDWQTLEVSDSKLYPWSEISTYIKLPPFFEGMTRALPKLKGIEKARCLLLLGDSVTTDHISPAGSIARKSPAARYLSERGLTPRDFNSYGSRRGNDAVMARGTFANIRLVNKLASKTGPSTLHVPSGEEMDIFDAAERYASEGTPLVLVVGKDYGSGSSRDWAAKGPFLLGIKAVIAESYERIHRSNLVGMGIIPLQFLPGQSADTLKLSGREVYNIVLPEGELKPGQRIQVDADGNVFETTLRFDTEVDITYYKNGGILNYMIRKMLD

Target ORF information:

RefSeq Version	NM_058023.5
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster iron regulatory protein 1A (Irp-1A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_058023.5

ORF Insert Sequence:

ATGTCCGGCT CCGGCGCCAA TCCCTTTGCC CAGTTCCAGG AGTCATTCAC CCAGGACGGC 
AACGTCTACA AGTATTTTGA TCTGCCCTCC ATCGACAGCA AATATGAGTC ACTGCCCTTT 
TCCATTCGCG TTCTGCTGGA ATCAGCGGTG CGCAACTGTG ACAACTTTCA TGTGCTGGAG 
AAGGATGTGC AGAGCATCCT GGGATGGACT CCATCGCTGA AGCAGGAAAC CAGCGATGTG 
GAAGTCTCCT TCAAGCCAGC TCGTGTTATA TTGCAGGACT TTACTGGCGT TCCCGCCGTC 
GTGGATTTTG CTGCCATGCG GGATGCTGTC CGCGAGCTGG GCGGCAATCC TGAGAAAATC 
AATCCCATCT GCCCTGCCGA CCTGGTCATC GACCATTCCG TTCAGGTGGA TTTCGTTCGC 
TCCTCGGACG CATTGACCAA GAACGAGTCA CTAGAGTTCC AGCGCAACAA GGAACGATTC 
ACCTTCCTCA AATGGGGAGC TCGCGCTTTT GACAATATGC TAATTGTGCC ACCCGGCTCT 
GGCATTGTGC ACCAGGTTAA CCTGGAGTAT CTGGCCCGAG TGGTTTTCGA AAGCGACAGT 
TCAGCGGACG GATCTAAGAT CCTTTATCCG GATAGCGTTG TGGGCACTGA CTCCCACACT 
ACAATGATCA ATGGATTAGG TGTTCTCGGC TGGGGTGTTG GCGGTATCGA GGCGGAGGCC 
GTAATGTTGG GCCAGTCCAT TTCCATGCTG TTGCCAGAGG TGATTGGCTA CAGGCTGGAG 
GGCAAACTGG GCCCTCTGGC CACATCCACC GATCTGGTGC TGACCATTAC CAAGCATTTG 
CGTCAGCTTG GTGTCGTCGG CAAGTTCGTG GAGTTTTACG GCCCCGGAGT GGCAGAGCTC 
AGCATCGCGG ATCGCGCCAC CATCAGCAAC ATGTGTCCGG AATATGGAGC CACTGTGGGT 
TACTTCCCAA TCGATGAAAA CACGCTGAGT TACATGCGCC AAACCAATCG CTCCGAGAAG 
AAAATCGATA TTATCCGGAA GTATTTGAAG GCCACTCGAC AACTTCGTGA CTATTCCCTT 
GTGGATCAGG ATCCCCAATA CACGGAGTCT GTAACTTTGG ACTTATCCAC CGTGGTGACC 
TCGGTTTCGG GGCCCAAGCG ACCGCACGAT CGCGTTTCAG TTTCCAGCAT GTGCGAAGAC 
TTCAAGTCGT GCCTCATAAG TCCTGTCGGC TTCAAGGGAT TCGCCATACC ACCGAGTGCA 
TTGGCTGCAA GTGGTGAATT CCAATGGGAC GATGGGAAGA GCTATAAGAT AGGTCATGGA 
TCTGTTGTGA TTGCCGCCAT CACCTCGTGC ACGAACACTT CGAATCCCTC GGTGATGTTG 
GGCGCTGGTC TGCTGGCCAA GAATGCCGTG CAGAAGGGCT TGAGTATTTT GCCGTATATC 
AAGACCTCAT TGTCACCAGG ATCTGGCGTG GTTACCTACT ATCTGAGGGA ATCCGGTGTG 
ATTCCCTATC TGGAGCAGCT GGGCTTCGAC ATTGTGGGCT ATGGCTGTAT GACCTGCATT 
GGCAACTCGG GCCCGCTCGA TGAGAACGTA GTGAACACCA TCGAGAAGAA CGGACTGGTT 
TGCTGTGGCG TCCTGTCGGG CAATCGCAAT TTCGAGGGTC GCATCCATCC CAATACTAGG 
GCCAATTATC TGGCCAGTCC GCTGCTGGTG ATTGCCTACG CGATTGCCGG CCGTGTGGAT 
ATTGATTTCG AGATCGAACC GCTGGGCGTG GATTCCAACG GCAAGGAGGT GTTCCTGCGC 
GATATCTGGC CAACGCGCAG TGAGATTCAG GAGGTAGAGC ATAAGCACGT CATTCCCGCC 
ATGTTCCAGG AGGTGTACAG CAAAATTCAA CTGGGATCCA GGGACTGGCA AACGTTGGAG 
GTGTCGGATA GCAAGTTGTA TCCATGGAGT GAAATATCAA CATACATCAA ACTACCACCG 
TTCTTCGAGG GTATGACTCG TGCGCTGCCC AAACTTAAAG GTATCGAGAA GGCTCGCTGT 
CTGCTGCTTC TCGGTGATTC AGTGACCACC GATCATATCT CGCCAGCCGG ATCCATTGCA 
CGAAAGTCAC CGGCAGCGCG CTATTTGTCG GAAAGGGGTC TAACGCCGCG CGACTTTAAT 
TCGTATGGAT CCAGACGTGG CAATGATGCG GTGATGGCAC GCGGAACCTT TGCCAACATC 
CGTCTGGTCA ATAAACTGGC ATCCAAGACG GGACCCAGCA CACTGCACGT GCCCAGTGGC 
GAGGAGATGG ACATCTTCGA TGCGGCGGAA CGGTATGCGA GCGAAGGAAC ACCTTTGGTT 
CTGGTCGTAG GCAAGGACTA CGGCAGTGGC AGCTCACGTG ATTGGGCCGC CAAGGGGCCA 
TTTCTGCTGG GCATCAAGGC GGTGATTGCT GAATCGTACG AGCGCATTCA CCGCTCAAAT 
CTGGTGGGCA TGGGCATCAT TCCGCTGCAG TTCTTGCCTG GCCAGAGCGC CGATACCCTG 
AAACTGAGTG GCAGGGAGGT GTACAACATT GTCCTGCCCG AGGGCGAACT GAAGCCGGGC 
CAGAGGATTC AGGTCGATGC TGATGGCAAT GTCTTTGAGA CCACGTTGCG TTTCGACACC 
GAGGTGGACA TAACGTACTA CAAGAATGGC GGCATTTTGA ACTATATGAT ACGCAAAATG 
CTGGATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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Irp-1A cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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