ID2 cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	ID2
Entrez Gene ID	395852
Full Name	inhibitor of DNA binding 2, HLH protein
General protein information	Preferred Names inhibitor of DNA binding 2, HLH protein Names DNA-binding protein inhibitor ID-2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein transcriptional regulator Id2
Gene Type	protein-coding
Organism	Gallus gallus(chicken)

mRNA and Protein(s)

mRNA	Protein	Name
NM_205002.1	NP_990333.1	DNA-binding protein inhibitor ID-2

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	id2a	NP_958448.1
Pan troglodytes (chimpanzee)	ID2	XP_003308921.1
Mus musculus (house mouse)	Id2	NP_034626.1
Xenopus tropicalis (tropical clawed frog)	id2	NP_988885.1
Homo sapiens (human)	ID2	NP_002157.2
	ID2	XP_001081982.2
Gallus gallus (chicken)	ID2	NP_990333.1
Bos taurus (cattle)	ID2	NP_001029403.1
Rattus norvegicus (Norway rat)	Id2	NP_037192.1

Gene Ontology
Bibliography

Related articles in PubMed

Ligand- and stage-dependent divergent functions of BMP signaling in the differentiation of embryonic skeletogenic progenitors in vitro.
Lorda-Diez CI, Montero JA, Choe S, Garcia-Porrero JA, Hurle JM
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research29(3)735-48(2014 Mar)

Id gene regulation and function in the prosensory domains of the chicken inner ear: a link between Bmp signaling and Atoh1.
Kamaid A, Neves J, Gir?ldez F
The Journal of neuroscience : the official journal of the Society for Neuroscience30(34)11426-34(2010 Aug)

Expression of Id2 in the developing limb is associated with zones of active BMP signaling and marks the regions of growth and differentiation of the developing digits.
Lorda-Diez CI, Torre-P?rez N, Garc?a-Porrero JA, Hurle JM, Montero JA
The International journal of developmental biology53(8-10)1495-502(2009)

Id sustains Hes1 expression to inhibit precocious neurogenesis by releasing negative autoregulation of Hes1.
Bai G, Sheng N, Xie Z, Bian W, Yokota Y, Benezra R, Kageyama R, Guillemot F, Jing N
Developmental cell13(2)283-97(2007 Aug)

Dynamic Id2 expression in the medial and lateral domains of avian dermamyotome.
Krishan K, McKinnell I, Patel K, Dhoot GK
Developmental dynamics : an official publication of the American Association of Anatomists234(2)363-70(2005 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Gene-silencing experiments indicate that Id2 is one of the factors limiting the profibrogenic influence of BMPs in the developing digits.
Title: Ligand- and stage-dependent divergent functions of BMP signaling in the differentiation of embryonic skeletogenic progenitors in vitro.

Increased bone morphogenetic protein signaling induces expression of Id1, Id2, and Id3 along with the inhibition of atonal homolog 1 (Atoh1).
Title: Id gene regulation and function in the prosensory domains of the chicken inner ear: a link between Bmp signaling and Atoh1.

Data show that the Expression of Id2 both in vivo and in vitro was up-regulated in BMP-gain-of-function.
Title: Expression of Id2 in the developing limb is associated with zones of active BMP signaling and marks the regions of growth and differentiation of the developing digits.

These results indicate that Id proteins participate in NSC maintenance through sustaining Hes1 expression in early embryos.
Title: Id sustains Hes1 expression to inhibit precocious neurogenesis by releasing negative autoregulation of Hes1.

Id2 expression in somites requires positive signalling from not only axial structures and lateral plate mesoderm but also surface ectoderm
Title: Dynamic Id2 expression in the medial and lateral domains of avian dermamyotome.

The following ID2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ID2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa00274	NM_205002.1 Latest version!	Gallus gallus inhibitor of DNA binding 2, HLH protein (ID2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ID2 ( NM_205002.1 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_990333.1 Gallus gallus inhibitor of DNA binding 2, HLH protein (ID2), mRNA.

Price & Availability↑

CloneID	OGa00274
Clone ID Related Accession (Same CDS sequence)	NM_205002.1
Accession Version	NM_205002.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 405bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-20
Organism	Gallus gallus(chicken)
Product	DNA-binding protein inhibitor ID-2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF068831.1. ##Evidence-Data-START## Transcript exon combination :: AF068831.1, CO773471.1 [ECO:0000332] ##Evidence-Data-END##

ATGAAAGCTT TCAGCCCCGT GCGGTCCGTG CGGAAGAACG GCCTTTCGGA GCACAACCTG 
GGCATCTCCC GCAGCAAGAC CCCGGTGGAC GACCCCATGA GCCTGCTGTA CAACATGAAC 
GACTGCTACT CCAAGCTGAA GGAGCTGGTG CCCAGCATCC CGCAGAACAA GAAGGTCAGC 
AAGATGGAAA TCCTGCAGCA CGTCATCGAC TACATCCTGG ACCTGCAGAT CGCGCTGGAC 
TCGCACCCGT CCATCGTCAG CCTCCACCAC CAGCGGCCGG GGCAGAACGC CGCCTCCCGG 
ACCCCGCTGA CCACGCTCAA CACAGACATC AGCATCCTCT CCCTACAGGC AGCCGAGTTC 
CCCTCAGAAC TAATGGCGAG TGACAGCAAA GCGCTCTGTG GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_990333.1
CDS	76..480
Translation	MKAFSPVRSVRKNGLSEHNLGISRSKTPVDDPMSLLYNMNDCYSKLKELVPSIPQNKKVSKMEILQHVIDYILDLQIALDSHPSIVSLHHQRPGQNAASRTPLTTLNTDISILSLQAAEFPSELMASDSKALCG

Target ORF information:

RefSeq Version	NM_205002.1
Organism	Gallus gallus(chicken)
Definition	Gallus gallus inhibitor of DNA binding 2, HLH protein (ID2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_205002.1

ORF Insert Sequence:

ATGAAAGCTT TCAGCCCCGT GCGGTCCGTG CGGAAGAACG GCCTTTCGGA GCACAACCTG 
GGCATCTCCC GCAGCAAGAC CCCGGTGGAC GACCCCATGA GCCTGCTGTA CAACATGAAC 
GACTGCTACT CCAAGCTGAA GGAGCTGGTG CCCAGCATCC CGCAGAACAA GAAGGTCAGC 
AAGATGGAAA TCCTGCAGCA CGTCATCGAC TACATCCTGG ACCTGCAGAT CGCGCTGGAC 
TCGCACCCGT CCATCGTCAG CCTCCACCAC CAGCGGCCGG GGCAGAACGC CGCCTCCCGG 
ACCCCGCTGA CCACGCTCAA CACAGACATC AGCATCCTCT CCCTACAGGC AGCCGAGTTC 
CCCTCAGAAC TAATGGCGAG TGACAGCAAA GCGCTCTGTG GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ligand- and stage-dependent divergent functions of BMP signaling in the differentiation of embryonic skeletogenic progenitors in vitro.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research29(3)735-48(2014 Mar)
Lorda-Diez CI,Montero JA,Choe S,Garcia-Porrero JA,Hurle JM

Id gene regulation and function in the prosensory domains of the chicken inner ear: a link between Bmp signaling and Atoh1.
The Journal of neuroscience : the official journal of the Society for Neuroscience30(34)11426-34(2010 Aug)
Kamaid A,Neves J,Gir?ldez F

Expression of Id2 in the developing limb is associated with zones of active BMP signaling and marks the regions of growth and differentiation of the developing digits.
The International journal of developmental biology53(8-10)1495-502(2009)
Lorda-Diez CI,Torre-P?rez N,Garc?a-Porrero JA,Hurle JM,Montero JA

Id sustains Hes1 expression to inhibit precocious neurogenesis by releasing negative autoregulation of Hes1.
Developmental cell13(2)283-97(2007 Aug)
Bai G,Sheng N,Xie Z,Bian W,Yokota Y,Benezra R,Kageyama R,Guillemot F,Jing N

Dynamic Id2 expression in the medial and lateral domains of avian dermamyotome.
Developmental dynamics : an official publication of the American Association of Anatomists234(2)363-70(2005 Oct)
Krishan K,McKinnell I,Patel K,Dhoot GK

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ID2 cDNA ORF clone, Gallus gallus(chicken)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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