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POLR3A cDNA ORF clone, Homo sapiens (human)

Gene Symbol POLR3A
Entrez Gene ID 11128
Full Name polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
Synonyms ADDH, HLD7, RPC1, RPC155, hRPC155
General protein information
Preferred Names
DNA-directed RNA polymerase III subunit RPC1
Names
DNA-directed RNA polymerase III subunit RPC1
RNA polymerase III subunit C1
RNA polymerase III subunit C160
RNA polymerase III 155 kDa subunit
RNA polymerase III subunit RPC155-D
DNA-directed RNA polymerase III subunit A
DNA-directed RNA polymerase III largest subunit
NP_008986.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

10

10q22.3

Summary The protein encoded by this gene is the catalytic component of RNA polymerase III, which synthesizes small RNAs. The encoded protein also acts as a sensor to detect foreign DNA and trigger an innate immune response. [provided by RefSeq, Aug 2011]. lac of sum
Disorder MIM:

614258


mRNA and Protein(s)

mRNA Protein Name
NM_007055 NP_008986 DNA-directed RNA polymerase III subunit RPC1



Homo sapiens (human) POLR3A NP_008986.2
Pan troglodytes (chimpanzee) POLR3A XP_507865.4
Macaca mulatta (Rhesus monkey) POLR3A XP_002805710.1
Canis lupus familiaris (dog) POLR3A XP_536399.2
Bos taurus (cattle) POLR3A NP_001077219.1
Mus musculus (house mouse) Polr3a NP_001074716.1
Rattus norvegicus (Norway rat) Polr3a XP_341389.5
Gallus gallus (chicken) POLR3A NP_001006500.1
Danio rerio (zebrafish) polr3a NP_001263425.1
Drosophila melanogaster (fruit fly) CG17209 NP_001096987.2
Caenorhabditis elegans rpc-1 NP_501127.2
Arabidopsis thaliana (thale cress) NRPC1 NP_200812.2
Xenopus (Silurana) tropicalis (western clawed frog) polr3a NP_001096178.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following POLR3A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the POLR3A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu27038
NM_007055 Homo sapiens polymerase (RNA) III (DNA directed) polypeptide A, 155kDa (POLR3A), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$274.50-$384.30
$549.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu27038
Clone ID Related Accession (Same CDS sequence) NM_007055
Accession Version NM_007055.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 4173bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product DNA-directed RNA polymerase III subunit RPC1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA103416.1, AY091459.1, BC041089.1, AK024744.1, DA353439.1 and CA449326.1. This sequence is a reference standard in the RefSeqGene project. On May 13, 2010 this sequence version replaced gi:39725937. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC041089.1, AF021351.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
3661
3721
3781
3841
3901
3961
4021
4081
4141
ATGGTGAAGG AGCAGTTCCG GGAGACGGAT GTGGCCAAGA AAATAAGCCA CATCTGTTTT 
GGAATGAAGT CACCTGAGGA GATGCGCCAG CAGGCGCACA TCCAAGTTGT GAGTAAGAAC
CTGTACAGCC AGGACAACCA ACATGCCCCC TTGCTATATG GGGTGCTCGA CCATAGGATG
GGTACGAGTG AGAAGGATCG TCCATGTGAA ACCTGTGGGA AAAACTTGGC TGACTGTCTA
GGCCACTATG GGTATATCGA CCTGGAGTTG CCGTGTTTTC ATGTAGGGTA CTTCAGAGCA
GTCATAGGCA TCTTACAGAT GATCTGCAAA ACCTGCTGCC ACATCATGCT GTCCCAAGAG
GAGAAGAAGC AGTTTCTGGA CTATCTAAAG AGGCCCGGCC TGACCTACCT TCAGAAGCGA
GGACTGAAAA AGAAAATCTC TGACAAGTGC CGGAAGAAAA ACATCTGCCA TCACTGTGGC
GCTTTTAATG GTACCGTAAA GAAGTGTGGA CTGCTGAAAA TAATTCATGA GAAATACAAG
ACCAACAAAA AAGTGGTGGA TCCCATTGTA TCAAATTTCC TTCAGTCTTT TGAAACAGCC
ATTGAACATA ATAAAGAAGT GGAGCCTCTG CTGGGAAGGG CACAGGAAAA CTTGAATCCC
TTAGTAGTTC TGAATTTATT TAAACGAATC CCAGCTGAAG ATGTTCCTCT ACTTCTGATG
AACCCAGAAG CCGGAAAGCC GTCTGATTTG ATTCTCACAC GACTTTTGGT GCCTCCTTTG
TGTATCAGAC CCTCCGTTGT GAGTGATTTG AAGTCTGGCA CCAATGAAGA TGATCTGACA
ATGAAACTGA CAGAAATCAT TTTCCTAAAC GATGTTATTA AAAAGCATCG GATCTCAGGA
GCCAAGACCC AGATGATCAT GGAGGACTGG GATTTCCTGC AGCTGCAGTG TGCCCTCTAC
ATTAACAGTG AGCTCTCGGG CATTCCCCTC AACATGGCAC CCAAGAAGTG GACCAGAGGC
TTCGTCCAAC GCCTGAAGGG AAAACAGGGT CGATTTAGAG GAAATCTCTC AGGAAAGAGA
GTGGATTTTT CTGGCAGAAC AGTCATCTCG CCCGACCCCA ACCTCCGGAT TGATGAGGTA
GCTGTGCCAG TTCATGTGGC CAAAATTCTA ACTTTTCCTG AGAAGGTAAA CAAAGCAAAC
ATCAATTTCT TGAGGAAACT GGTTCAAAAC GGCCCTGAGG TTCACCCAGG AGCAAACTTC
ATTCAGCAGA GACATACGCA GATGAAAAGG TTTTTGAAAT ACGGAAATCG AGAAAAGATG
GCTCAAGAGC TCAAGTATGG TGACATCGTA GAGAGACACC TCATCGATGG AGATGTGGTG
CTGTTCAATC GGCAGCCCTC GCTGCACAAA TTGAGCATTA TGGCTCATCT GGCCAGGGTC
AAGCCCCACC GGACCTTCAG ATTTAATGAG TGTGTCTGTA CACCCTATAA TGCTGACTTT
GATGGTGATG AAATGAACCT TCATCTTCCT CAAACAGAAG AAGCTAAAGC AGAGGCCCTT
GTTCTGATGG GGACTAAAGC AAATCTTGTA ACCCCGAGGA ATGGGGAACC GCTGATTGCT
GCTATTCAGG ATTTTCTAAC AGGTGCCTAT CTCCTCACTC TCAAGGACAC TTTCTTTGAT
CGAGCCAAGG CTTGCCAAAT CATTGCTTCA ATACTGGTTG GCAAGGATGA GAAAATTAAA
GTTCGCCTCC CACCGCCTAC AATCCTAAAG CCTGTCACCC TGTGGACGGG AAAGCAGATC
TTCAGTGTCA TCCTCAGGCC TAGCGATGAC AATCCAGTGA GGGCCAACCT GCGAACCAAG
GGCAAGCAGT ACTGTGGCAA AGGGGAAGAT CTCTGTGCCA ATGATTCCTA TGTTACAATC
CAGAACAGTG AGTTGATGAG TGGCAGCATG GACAAAGGAA CCCTAGGGTC AGGATCCAAG
AACAATATTT TTTACATTTT GCTGCGAGAC TGGGGACAGA ATGAAGCTGC AGATGCCATG
TCACGGCTCG CCAGGCTGGC TCCTGTCTAC CTGTCTAACC GTGGTTTCTC AATTGGGATC
GGTGATGTCA CACCTGGCCA AGGACTGCTG AAGGCCAAGT ATGAGTTGCT GAATGCCGGC
TACAAGAAAT GTGATGAGTA CATCGAAGCC CTGAACACGG GCAAGCTGCA GCAGCAGCCT
GGCTGCACTG CTGAGGAGAC CCTGGAGGCA CTGATCCTGA AGGAGCTGTC TGTGATCCGT
GACCACGCTG GCAGTGCCTG CCTCCGGGAG CTGGACAAGA GCAACAGCCC CCTCACCATG
GCTCTGTGCG GCTCCAAAGG TTCCTTCATT AACATATCAC AGATGATTGC CTGTGTGGGA
CAGCAGGCCA TCAGTGGCTC TCGAGTGCCA GACGGCTTTG AAAACAGGTC CTTGCCTCAT
TTTGAAAAAC ACTCAAAGCT CCCAGCTGCC AAAGGCTTTG TGGCTAATAG CTTTTATTCC
GGTTTGACAC CAACTGAGTT TTTCTTCCAC ACAATGGCCG GCCGGGAAGG TCTAGTCGAC
ACGGCTGTAA AGACAGCTGA AACGGGATAC ATGCAGCGAA GGCTTGTCAA ATCTCTTGAA
GATCTTTGCT CCCAGTATGA TCTGACAGTC CGAAGCTCTA CTGGCGATAT TATCCAGTTC
ATTTATGGAG GAGATGGCTT AGATCCTGCA GCTATGGAGG GAAAAGATGA ACCTTTGGAG
TTTAAAAGGG TTCTGGACAA CATCAAAGCA GTCTTCCCGT GTCCCAGTGA GCCTGCTCTC
AGCAAAAACG AGCTGATCCT GACCACAGAG TCCATCATGA AGAAGAGTGA GTTCCTCTGC
TGCCAGGACA GCTTCCTGCA GGAAATAAAA AAATTCATTA AGGGGGTCTC TGAGAAGATC
AAGAAAACCA GAGATAAATA TGGCATCAAT GATAACGGCA CAACAGAGCC CCGTGTGCTG
TACCAGCTGG ACCGCATCAC CCCCACCCAA GTAGAAAAGT TTCTGGAGAC CTGTAGGGAC
AAGTACATGA GGGCACAGAT GGAGCCAGGT TCTGCAGTGG GTGCTCTGTG TGCCCAGAGC
ATTGGTGAGC CAGGCACCCA GATGACCCTG AAGACTTTCC ACTTTGCAGG TGTGGCCTCC
ATGAACATCA CCCTGGGCGT GCCCCGGATT AAAGAGATCA TCAACGCTTC CAAGGCCATC
AGCACTCCAA TTATCACAGC ACAGCTAGAC AAGGATGACG ACGCGGATTA TGCTCGCCTC
GTGAAAGGGA GAATTGAGAA AACCCTCTTG GGAGAGATTT CCGAGTATAT TGAAGAAGTG
TTTCTTCCTG ATGACTGCTT TATTCTCGTC AAGCTCTCCC TGGAACGGAT TAGGCTTCTG
AGACTGGAAG TGAACGCTGA GACAGTGAGA TATTCCATCT GCACATCCAA GCTCCGTGTG
AAGCCCGGTG ATGTGGCTGT TCATGGTGAG GCTGTGGTGT GTGTCACCCC CAGAGAGAAC
AGCAAGAGCT CCATGTACTA CGTGCTGCAG TTCCTGAAAG AGGATCTCCC CAAGGTGGTG
GTGCAGGGCA TTCCAGAGGT GTCCAGAGCT GTCATCCACA TTGACGAGCA GAGTGGAAAG
GAGAAGTACA AGCTTCTGGT GGAAGGTGAT AACCTGCGGG CAGTCATGGC CACACACGGT
GTGAAGGGCA CCCGAACCAC CTCCAATAAC ACCTATGAGG TGGAGAAAAC TCTGGGCATC
GAGGCCGCCC GGACAACGAT CATCAATGAA ATCCAGTACA CCATGGTGAA CCACGGCATG
AGCATCGACA GGAGGCACGT GATGCTGCTC TCCGACCTCA TGACCTACAA GGGTGAAGTC
CTGGGCATCA CTAGGTTTGG CCTGGCCAAG ATGAAGGAGA GTGTGCTGAT GCTGGCCTCC
TTTGAGAAGA CGGCTGACCA TCTCTTTGAC GCTGCCTACT TCGGGCAGAA GGACTCTGTG
TGTGGGGTGT CTGAGTGCAT CATCATGGGA ATCCCAATGA ACATTGGAAC CGGGCTCTTC
AAGCTGCTTC ACAAGGCTGA CAGGGACCCG AACCCTCCCA AGAGGCCCCT GATCTTCGAC
ACAAATGAAT TCCACATCCC CCTTGTCACA TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_008986.2
CDS134..4306
Misc Feature(1)152..2923(+)
Misc Feature(2)203..2806(+)
Misc Feature(3)338..379(+)
Misc Feature(4)1175..1231(+)
Misc Feature(5)1466..1468(+)
Misc Feature(6)1628..1642(+)
Misc Feature(7)2654..4087(+)
Misc Feature(8)2663..2701(+)
Misc Feature(9)3194..4213(+)
Misc Feature(10)3200..4213(+)
Misc Feature(11)3215..4075(+)
Misc Feature(12)3227..4204(+)
Misc Feature(13)3362..4111(+)
Misc Feature(14)3842..4027(+)
Misc Feature(15)4073..4198(+)
Exon (1)1..177
Gene:POLR3A
Gene Synonym:
Exon (2)178..313
Gene:POLR3A
Gene Synonym:
Exon (3)314..451
Gene:POLR3A
Gene Synonym:
Exon (4)452..623
Gene:POLR3A
Gene Synonym:
Exon (5)624..778
Gene:POLR3A
Gene Synonym:
Exon (6)779..1018
Gene:POLR3A
Gene Synonym:
Exon (7)1019..1181
Gene:POLR3A
Gene Synonym:
Exon (8)1182..1318
Gene:POLR3A
Gene Synonym:
Exon (9)1319..1422
Gene:POLR3A
Gene Synonym:
Exon (10)1423..1564
Gene:POLR3A
Gene Synonym:
Exon (11)1565..1705
Gene:POLR3A
Gene Synonym:
Exon (12)1706..1775
Gene:POLR3A
Gene Synonym:
Exon (13)1776..1903
Gene:POLR3A
Gene Synonym:
Exon (14)1904..2042
Gene:POLR3A
Gene Synonym:
Exon (15)2043..2207
Gene:POLR3A
Gene Synonym:
Exon (16)2208..2380
Gene:POLR3A
Gene Synonym:
Exon (17)2381..2492
Gene:POLR3A
Gene Synonym:
Exon (18)2493..2611
Gene:POLR3A
Gene Synonym:
Exon (19)2612..2749
Gene:POLR3A
Gene Synonym:
Exon (20)2750..2920
Gene:POLR3A
Gene Synonym:
Exon (21)2921..3034
Gene:POLR3A
Gene Synonym:
Exon (22)3035..3121
Gene:POLR3A
Gene Synonym:
Exon (23)3122..3204
Gene:POLR3A
Gene Synonym:
Exon (24)3205..3375
Gene:POLR3A
Gene Synonym:
Exon (25)3376..3469
Gene:POLR3A
Gene Synonym:
Exon (26)3470..3562
Gene:POLR3A
Gene Synonym:
Exon (27)3563..3727
Gene:POLR3A
Gene Synonym:
Exon (28)3728..3892
Gene:POLR3A
Gene Synonym:
Exon (29)3893..4024
Gene:POLR3A
Gene Synonym:
Exon (30)4025..4157
Gene:POLR3A
Gene Synonym:
Exon (31)4158..6635
Gene:POLR3A
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_007055
Organism Homo sapiens (human)
Definition Homo sapiens polymerase (RNA) III (DNA directed) polypeptide A, 155kDa (POLR3A), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_007055

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
3661
3721
3781
3841
3901
3961
4021
4081
4141
ATGGTGAAGG AGCAGTTCCG GGAGACGGAT GTGGCCAAGA AAATAAGCCA CATCTGTTTT 
GGAATGAAGT CACCTGAGGA GATGCGCCAG CAGGCGCACA TCCAAGTTGT GAGTAAGAAC
CTGTACAGCC AGGACAACCA ACATGCCCCC TTGCTATATG GGGTGCTCGA CCATAGGATG
GGTACGAGTG AGAAGGATCG TCCATGTGAA ACCTGTGGGA AAAACTTGGC TGACTGTCTA
GGCCACTATG GGTATATCGA CCTGGAGTTG CCGTGTTTTC ATGTAGGGTA CTTCAGAGCA
GTCATAGGCA TCTTACAGAT GATCTGCAAA ACCTGCTGCC ACATCATGCT GTCCCAAGAG
GAGAAGAAGC AGTTTCTGGA CTATCTAAAG AGGCCCGGCC TGACCTACCT TCAGAAGCGA
GGACTGAAAA AGAAAATCTC TGACAAGTGC CGGAAGAAAA ACATCTGCCA TCACTGTGGC
GCTTTTAATG GTACCGTAAA GAAGTGTGGA CTGCTGAAAA TAATTCATGA GAAATACAAG
ACCAACAAAA AAGTGGTGGA TCCCATTGTA TCAAATTTCC TTCAGTCTTT TGAAACAGCC
ATTGAACATA ATAAAGAAGT GGAGCCTCTG CTGGGAAGGG CACAGGAAAA CTTGAATCCC
TTAGTAGTTC TGAATTTATT TAAACGAATC CCAGCTGAAG ATGTTCCTCT ACTTCTGATG
AACCCAGAAG CCGGAAAGCC GTCTGATTTG ATTCTCACAC GACTTTTGGT GCCTCCTTTG
TGTATCAGAC CCTCCGTTGT GAGTGATTTG AAGTCTGGCA CCAATGAAGA TGATCTGACA
ATGAAACTGA CAGAAATCAT TTTCCTAAAC GATGTTATTA AAAAGCATCG GATCTCAGGA
GCCAAGACCC AGATGATCAT GGAGGACTGG GATTTCCTGC AGCTGCAGTG TGCCCTCTAC
ATTAACAGTG AGCTCTCGGG CATTCCCCTC AACATGGCAC CCAAGAAGTG GACCAGAGGC
TTCGTCCAAC GCCTGAAGGG AAAACAGGGT CGATTTAGAG GAAATCTCTC AGGAAAGAGA
GTGGATTTTT CTGGCAGAAC AGTCATCTCG CCCGACCCCA ACCTCCGGAT TGATGAGGTA
GCTGTGCCAG TTCATGTGGC CAAAATTCTA ACTTTTCCTG AGAAGGTAAA CAAAGCAAAC
ATCAATTTCT TGAGGAAACT GGTTCAAAAC GGCCCTGAGG TTCACCCAGG AGCAAACTTC
ATTCAGCAGA GACATACGCA GATGAAAAGG TTTTTGAAAT ACGGAAATCG AGAAAAGATG
GCTCAAGAGC TCAAGTATGG TGACATCGTA GAGAGACACC TCATCGATGG AGATGTGGTG
CTGTTCAATC GGCAGCCCTC GCTGCACAAA TTGAGCATTA TGGCTCATCT GGCCAGGGTC
AAGCCCCACC GGACCTTCAG ATTTAATGAG TGTGTCTGTA CACCCTATAA TGCTGACTTT
GATGGTGATG AAATGAACCT TCATCTTCCT CAAACAGAAG AAGCTAAAGC AGAGGCCCTT
GTTCTGATGG GGACTAAAGC AAATCTTGTA ACCCCGAGGA ATGGGGAACC GCTGATTGCT
GCTATTCAGG ATTTTCTAAC AGGTGCCTAT CTCCTCACTC TCAAGGACAC TTTCTTTGAT
CGAGCCAAGG CTTGCCAAAT CATTGCTTCA ATACTGGTTG GCAAGGATGA GAAAATTAAA
GTTCGCCTCC CACCGCCTAC AATCCTAAAG CCTGTCACCC TGTGGACGGG AAAGCAGATC
TTCAGTGTCA TCCTCAGGCC TAGCGATGAC AATCCAGTGA GGGCCAACCT GCGAACCAAG
GGCAAGCAGT ACTGTGGCAA AGGGGAAGAT CTCTGTGCCA ATGATTCCTA TGTTACAATC
CAGAACAGTG AGTTGATGAG TGGCAGCATG GACAAAGGAA CCCTAGGGTC AGGATCCAAG
AACAATATTT TTTACATTTT GCTGCGAGAC TGGGGACAGA ATGAAGCTGC AGATGCCATG
TCACGGCTCG CCAGGCTGGC TCCTGTCTAC CTGTCTAACC GTGGTTTCTC AATTGGGATC
GGTGATGTCA CACCTGGCCA AGGACTGCTG AAGGCCAAGT ATGAGTTGCT GAATGCCGGC
TACAAGAAAT GTGATGAGTA CATCGAAGCC CTGAACACGG GCAAGCTGCA GCAGCAGCCT
GGCTGCACTG CTGAGGAGAC CCTGGAGGCA CTGATCCTGA AGGAGCTGTC TGTGATCCGT
GACCACGCTG GCAGTGCCTG CCTCCGGGAG CTGGACAAGA GCAACAGCCC CCTCACCATG
GCTCTGTGCG GCTCCAAAGG TTCCTTCATT AACATATCAC AGATGATTGC CTGTGTGGGA
CAGCAGGCCA TCAGTGGCTC TCGAGTGCCA GACGGCTTTG AAAACAGGTC CTTGCCTCAT
TTTGAAAAAC ACTCAAAGCT CCCAGCTGCC AAAGGCTTTG TGGCTAATAG CTTTTATTCC
GGTTTGACAC CAACTGAGTT TTTCTTCCAC ACAATGGCCG GCCGGGAAGG TCTAGTCGAC
ACGGCTGTAA AGACAGCTGA AACGGGATAC ATGCAGCGAA GGCTTGTCAA ATCTCTTGAA
GATCTTTGCT CCCAGTATGA TCTGACAGTC CGAAGCTCTA CTGGCGATAT TATCCAGTTC
ATTTATGGAG GAGATGGCTT AGATCCTGCA GCTATGGAGG GAAAAGATGA ACCTTTGGAG
TTTAAAAGGG TTCTGGACAA CATCAAAGCA GTCTTCCCGT GTCCCAGTGA GCCTGCTCTC
AGCAAAAACG AGCTGATCCT GACCACAGAG TCCATCATGA AGAAGAGTGA GTTCCTCTGC
TGCCAGGACA GCTTCCTGCA GGAAATAAAA AAATTCATTA AGGGGGTCTC TGAGAAGATC
AAGAAAACCA GAGATAAATA TGGCATCAAT GATAACGGCA CAACAGAGCC CCGTGTGCTG
TACCAGCTGG ACCGCATCAC CCCCACCCAA GTAGAAAAGT TTCTGGAGAC CTGTAGGGAC
AAGTACATGA GGGCACAGAT GGAGCCAGGT TCTGCAGTGG GTGCTCTGTG TGCCCAGAGC
ATTGGTGAGC CAGGCACCCA GATGACCCTG AAGACTTTCC ACTTTGCAGG TGTGGCCTCC
ATGAACATCA CCCTGGGCGT GCCCCGGATT AAAGAGATCA TCAACGCTTC CAAGGCCATC
AGCACTCCAA TTATCACAGC ACAGCTAGAC AAGGATGACG ACGCGGATTA TGCTCGCCTC
GTGAAAGGGA GAATTGAGAA AACCCTCTTG GGAGAGATTT CCGAGTATAT TGAAGAAGTG
TTTCTTCCTG ATGACTGCTT TATTCTCGTC AAGCTCTCCC TGGAACGGAT TAGGCTTCTG
AGACTGGAAG TGAACGCTGA GACAGTGAGA TATTCCATCT GCACATCCAA GCTCCGTGTG
AAGCCCGGTG ATGTGGCTGT TCATGGTGAG GCTGTGGTGT GTGTCACCCC CAGAGAGAAC
AGCAAGAGCT CCATGTACTA CGTGCTGCAG TTCCTGAAAG AGGATCTCCC CAAGGTGGTG
GTGCAGGGCA TTCCAGAGGT GTCCAGAGCT GTCATCCACA TTGACGAGCA GAGTGGAAAG
GAGAAGTACA AGCTTCTGGT GGAAGGTGAT AACCTGCGGG CAGTCATGGC CACACACGGT
GTGAAGGGCA CCCGAACCAC CTCCAATAAC ACCTATGAGG TGGAGAAAAC TCTGGGCATC
GAGGCCGCCC GGACAACGAT CATCAATGAA ATCCAGTACA CCATGGTGAA CCACGGCATG
AGCATCGACA GGAGGCACGT GATGCTGCTC TCCGACCTCA TGACCTACAA GGGTGAAGTC
CTGGGCATCA CTAGGTTTGG CCTGGCCAAG ATGAAGGAGA GTGTGCTGAT GCTGGCCTCC
TTTGAGAAGA CGGCTGACCA TCTCTTTGAC GCTGCCTACT TCGGGCAGAA GGACTCTGTG
TGTGGGGTGT CTGAGTGCAT CATCATGGGA ATCCCAATGA ACATTGGAAC CGGGCTCTTC
AAGCTGCTTC ACAAGGCTGA CAGGGACCCG AACCCTCCCA AGAGGCCCCT GATCTTCGAC
ACAAATGAAT TCCACATCCC CCTTGTCACA TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Clinical spectrum of 4H leukodystrophy caused by POLR3A and POLR3B mutations
Neurology 83 (21), 1898-1905 (2014)
Wolf NI, Vanderver A, van Spaendonk RM, Schiffmann R, Brais B, Bugiani M, Sistermans E, Catsman-Berrevoets C, Kros JM, Pinto PS, Pohl D, Tirupathi S, Stromme P, de Grauw T, Fribourg S, Demos M, Pizzino A, Naidu S, Guerrero K, van der Knaap MS and Bernard G.


book

Different patterns of cerebellar abnormality and hypomyelination between POLR3A and POLR3B mutations
Brain Dev. 36 (3), 259-263 (2014)
Takanashi J, Osaka H, Saitsu H, Sasaki M, Mori H, Shibayama H, Tanaka M, Nomura Y, Terao Y, Inoue K, Matsumoto N and Barkovich AJ.


book

Gene duplication and neofunctionalization: POLR3G and POLR3GL
Genome Res. 24 (1), 37-51 (2014)
Renaud M, Praz V, Vieu E, Florens L, Washburn MP, l'Hote P and Hernandez N.


book

Mutations in POLR3A and POLR3B are a major cause of hypomyelinating leukodystrophies with or without dental abnormalities and/or hypogonadotropic hypogonadism
J. Med. Genet. 50 (3), 194-197 (2013)
Daoud H, Tetreault M, Gibson W, Guerrero K, Cohen A, Gburek-Augustat J, Synofzik M, Brais B, Stevens CA, Sanchez-Carpintero R, Goizet C, Naidu S, Vanderver A and Bernard G.


book

Identification of an immunodominant epitope on RNA polymerase III recognized by systemic sclerosis sera: application to enzyme-linked immunosorbent assay
Arthritis Rheum. 46 (10), 2742-2747 (2002)
Kuwana M, Kimura K and Kawakami Y.


book

Nuclear particles containing RNA polymerase III complexes associated with the junctional plaque protein plakophilin 2
Proc. Natl. Acad. Sci. U.S.A. 98 (14), 7795-7800 (2001)
Mertens C, Hofmann I, Wang Z, Teichmann M, Sepehri Chong S, Schnolzer M and Franke WW.


book

The largest subunit of human RNA polymerase III is closely related to the largest subunit of yeast and trypanosome RNA polymerase III
Genome Res. 7 (10), 1006-1019 (1997)
Sepehri S and Hernandez N.


book

Leukodystrophy Overview
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Vanderver,A., Tonduti,D., Schiffmann,R., Schmidt,J. and van der Knaap,M.S.


book

Pol III-Related Leukodystrophies
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Bernard,G. and Vanderver,A.


book

The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC
J. Acquir. Immune Defic. Syndr. 5 (11), 1142-1147 (1992)
Jang KL, Collins MK and Latchman DS.


 
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