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NKX2-3 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol NKX2-3
Entrez Gene ID 159296
Full Name NK2 homeobox 3
Synonyms CSX3,NK2.3,NKX2.3,NKX2C,NKX4-3
General protein information
Preferred Names

NK2 homeobox 3

Names

homeobox protein Nkx-2.3
NK2 transcription factor related, locus 3
homeobox protein NK-2 homolog C

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

10

10q24.2

Summary This gene encodes a homeodomain-containing transcription factor. The encoded protein is a member of the NKX family of homeodomain transcription factors. Studies of similar proteins in mouse and rat have indicated a potential role in cellular differentiation.[provided by RefSeq, Mar 2010].
Disorder MIM:

606727


mRNA and Protein(s)

mRNA Protein Name
XM_011539370.1 XP_011537672.1 homeobox protein Nkx-2.3 isoform X1
NM_145285.2 NP_660328.2 homeobox protein Nkx-2.3



Canis lupus familiaris (dog) NKX2-3 XP_003640037.1
Xenopus tropicalis (tropical clawed frog) nkx2-3 XP_002937234.1
Rattus norvegicus (Norway rat) Nkx2-3 NP_001101064.1
Homo sapiens (human) NKX2-3 NP_660328.2
Danio rerio (zebrafish) nkx2.3 NP_571498.1
Macaca mulatta (rhesus monkey) NKX2-3 XP_001106216.2
Pan troglodytes (chimpanzee) NKX2-3 XP_001166828.2
Bos taurus (cattle) NKX2-3 NP_001029848.1
Mus musculus (house mouse) Nkx2-3 NP_032725.1


Related articles in PubMed

GWAS of dental caries patterns in the permanent dentition.
Shaffer JR, Feingold E, Wang X, Lee M, Tcuenco K, Weeks DE, Weyant RJ, Crout R, McNeil DW, Marazita ML
Journal of dental research92(1)38-44(2013 Jan)

Seventy-five genetic loci influencing the human red blood cell.
van der Harst P, Zhang W, Mateo Leach I, Rendon A, Verweij N, Sehmi J, Paul DS, Elling U, Allayee H, Li X, Radhakrishnan A, Tan ST, Voss K, Weichenberger CX, Albers CA, Al-Hussani A, Asselbergs FW, Ciullo M, Danjou F, Dina C, Esko T, Evans DM, Franke L, Gögele M, Hartiala J, Hersch M, Holm H, Hottenga JJ, Kanoni S, Kleber ME, Lagou V, Langenberg C, Lopez LM, Lyytikäinen LP, Melander O, Murgia F, Nolte IM, O'Reilly PF, Padmanabhan S, Parsa A, Pirastu N, Porcu E, Portas L, Prokopenko I, Ried JS, Shin SY, Tang CS, Teumer A, Traglia M, Ulivi S, Westra HJ, Yang J, Zhao JH, Anni F, Abdellaoui A, Attwood A, Balkau B, Bandinelli S, Bastardot F, Benyamin B, Boehm BO, Cookson WO, Das D, de Bakker PI, de Boer RA, de Geus EJ, de Moor MH, Dimitriou M, Domingues FS, Döring A, Engström G, Eyjolfsson GI, Ferrucci L, Fischer K, Galanello R, Garner SF, Genser B, Gibson QD, Girotto G, Gudbjartsson DF, Harris SE, Hartikainen AL, Hastie CE, Hedblad B, Illig T, Jolley J, Kähönen M, Kema IP, Kemp JP, Liang L, Lloyd-Jones H, Loos RJ, Meacham S, Medland SE, Meisinger C, Memari Y, Mihailov E, Miller K, Moffatt MF, Nauck M, Novatchkova M, Nutile T, Olafsson I, Onundarson PT, Parracciani D, Penninx BW, Perseu L, Piga A, Pistis G, Pouta A, Puc U, Raitakari O, Ring SM, Robino A, Ruggiero D, Ruokonen A, Saint-Pierre A, Sala C, Salumets A, Sambrook J, Schepers H, Schmidt CO, Silljé HH, Sladek R, Smit JH, Starr JM, Stephens J, Sulem P, Tanaka T, Thorsteinsdottir U, Tragante V, van Gilst WH, van Pelt LJ, van Veldhuisen DJ, Völker U, Whitfield JB, Willemsen G, Winkelmann BR, Wirnsberger G, Algra A, Cucca F, d'Adamo AP, Danesh J, Deary IJ, Dominiczak AF, Elliott P, Fortina P, Froguel P, Gasparini P, Greinacher A, Hazen SL, Jarvelin MR, Khaw KT, Lehtimäki T, Maerz W, Martin NG, Metspalu A, Mitchell BD, Montgomery GW, Moore C, Navis G, Pirastu M, Pramstaller PP, Ramirez-Solis R, Schadt E, Scott J, Shuldiner AR, Smith GD, Smith JG, Snieder H, Sorice R, Spector TD, Stefansson K, Stumvoll M, Tang WH, Toniolo D, Tönjes A, Visscher PM, Vollenweider P, Wareham NJ, Wolffenbuttel BH, Boomsma DI, Beckmann JS, Dedoussis GV, Deloukas P, Ferreira MA, Sanna S, Uda M, Hicks AA, Penninger JM, Gieger C, Kooner JS, Ouwehand WH, Soranzo N, Chambers JC
Nature492(7429)369-75(2012 Dec)

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, Hui KY, Lee JC, Schumm LP, Sharma Y, Anderson CA, Essers J, Mitrovic M, Ning K, Cleynen I, Theatre E, Spain SL, Raychaudhuri S, Goyette P, Wei Z, Abraham C, Achkar JP, Ahmad T, Amininejad L, Ananthakrishnan AN, Andersen V, Andrews JM, Baidoo L, Balschun T, Bampton PA, Bitton A, Boucher G, Brand S, Büning C, Cohain A, Cichon S, D'Amato M, De Jong D, Devaney KL, Dubinsky M, Edwards C, Ellinghaus D, Ferguson LR, Franchimont D, Fransen K, Gearry R, Georges M, Gieger C, Glas J, Haritunians T, Hart A, Hawkey C, Hedl M, Hu X, Karlsen TH, Kupcinskas L, Kugathasan S, Latiano A, Laukens D, Lawrance IC, Lees CW, Louis E, Mahy G, Mansfield J, Morgan AR, Mowat C, Newman W, Palmieri O, Ponsioen CY, Potocnik U, Prescott NJ, Regueiro M, Rotter JI, Russell RK, Sanderson JD, Sans M, Satsangi J, Schreiber S, Simms LA, Sventoraityte J, Targan SR, Taylor KD, Tremelling M, Verspaget HW, De Vos M, Wijmenga C, Wilson DC, Winkelmann J, Xavier RJ, Zeissig S, Zhang B, Zhang CK, Zhao H, , Silverberg MS, Annese V, Hakonarson H, Brant SR, Radford-Smith G, Mathew CG, Rioux JD, Schadt EE, Daly MJ, Franke A, Parkes M, Vermeire S, Barrett JC, Cho JH
Nature491(7422)119-24(2012 Nov)

A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
Kenny EE, Pe'er I, Karban A, Ozelius L, Mitchell AA, Ng SM, Erazo M, Ostrer H, Abraham C, Abreu MT, Atzmon G, Barzilai N, Brant SR, Bressman S, Burns ER, Chowers Y, Clark LN, Darvasi A, Doheny D, Duerr RH, Eliakim R, Giladi N, Gregersen PK, Hakonarson H, Jones MR, Marder K, McGovern DP, Mulle J, Orr-Urtreger A, Proctor DD, Pulver A, Rotter JI, Silverberg MS, Ullman T, Warren ST, Waterman M, Zhang W, Bergman A, Mayer L, Katz S, Desnick RJ, Cho JH, Peter I
PLoS genetics8(3)e1002559(2012)

PTPN2 is associated with Crohn's disease and its expression is regulated by NKX2-3.
Yu W, Hegarty JP, Berg A, Kelly AA, Wang Y, Poritz LS, Franke A, Schreiber S, Koltun WA, Lin Z
Disease markers32(2)83-91(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

NKX2-3 is a key mediator for maintaining myofibroblast characteristics, and our results show that colorectal myofibroblasts, as defined by the expression of AOC3, NKX2-3, and other markers, are a distinctly different cell type from TGFbeta-activated fibroblasts
Title: Myofibroblasts are distinguished from activated skin fibroblasts by the expression of AOC3 and other associated markers.

The persons with a NKX2-3 G or T allele may have a moderately increased risk of CD.
Title: Contribution of NKX2-3 polymorphisms to inflammatory bowel diseases: a meta-analysis of 35358 subjects.

NKX2-3 may play different roles in ulcerative colitis and Crohn's disease pathogenesis by differential regulation of EGR1.
Title: Genes differentially regulated by NKX2-3 in B cells between ulcerative colitis and Crohn's disease patients and possible involvement of EGR1.

A positive correlation was observed between mRNA expression of PTPN2 and NKX2-3 in B cells and in intestinal tissues from both Crohn's disease and ulcerative colitis patients.
Title: PTPN2 is associated with Crohn's disease and its expression is regulated by NKX2-3.

The binding of NFAT1 to the NKX2-3 promoter region with rs1190140 was confirmed by chromatin immunoprecipitation assay.
Title: NKX2-3 variant rs11190140 is associated with IBD and alters binding of NFAT.

The following NKX2-3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NKX2-3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu18132 NM_145285.2
Latest version!
Homo sapiens NK2 homeobox 3 (NKX2-3), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$159.50-$223.30
$319.00
OHu77045 XM_011539370.1
Latest version!
Homo sapiens NK2 homeobox 3 (NKX2-3), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu18132
Clone ID Related Accession (Same CDS sequence) NM_145285.2
Accession Version NM_145285.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1095bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2015-03-15
Organism Homo sapiens(Human)
Product homeobox protein Nkx-2.3
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI764885.1, BC025788.1 and AL353719.10. This sequence is a reference standard in the RefSeqGene project. On Jun 9, 2007 this sequence version replaced NM_145285.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by orthologous data and transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BI764885.1, AK300856.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGATGTTAC CAAGCCCGGT CACCTCCACC CCTTTCTCAG TCAAAGACAT TTTGAATCTG 
GAGCAGCAGC ACCAGCACTT CCATGGTGCG CACTTGCAGG CGGACTTGGA GCACCACTTC
CACTCTGCGC CCTGCATGCT GGCCGCCGCT GAGGGGACGC AATTTTCTGA CGGAGGGGAG
GAGGACGAGG AAGACGAGGG CGAGAAATTG TCCTATTTGA ACTCACTAGC CGCAGCAGAC
GGCCACGGGG ATTCAGGGCT GTGTCCCCAG GGCTATGTCC ACACGGTCCT GCGAGACTCG
TGCAGCGAGC CCAAGGAACA TGAAGAGGAG CCCGAGGTCG TGAGGGACCG GAGCCAAAAA
AGCTGCCAGC TGAAGAAGTC TCTAGAGACG GCCGGAGACT GCAAGGCGGC GGAGGAGAGC
GAGAGGCCGA AGCCACGCAG CCGCCGGAAG CCCCGGGTCC TCTTCTCGCA AGCCCAGGTC
TTCGAGCTGG AACGCAGGTT CAAGCAGCAG CGGTACCTGT CGGCACCCGA GCGCGAGCAC
CTCGCCAGCA GCCTGAAGCT CACATCCACT CAGGTGAAAA TCTGGTTCCA GAATCGCAGG
TACAAGTGCA AGAGACAGCG GCAGGACAAG TCTCTGGAGC TTGGCGCACA CGCGCCCCCG
CCGCCGCCGC GCCGCGTGGC TGTCCCGGTG CTGGTGCGGG ACGGCAAGCC GTGCGTCACG
CCCAGCGCGC AGGCCTACGG CGCGCCCTAC AGCGTGGGCG CCAGCGCCTA CTCCTACAAC
AGCTTCCCCG CCTACGGCTA TGGGAACTCG GCCGCGGCCG CCGCCGCCGC CGCCGCCGCC
GCCGCAGCAG CGGCGGCCTA CAGCAGCAGC TATGGCTGTG CGTACCCGGC GGGCGGCGGC
GGCGGCGGCG GCGGGACCTC CGCGGCGACC ACTGCCATGC AGCCCGCCTG CAGCGCGGCC
GGAGGCGGCC CCTTTGTGAA CGTGAGCAAC CTAGGAGGCT TCGGCAGCGG CGGCAGCGCA
CAGCCGTTGC ACCAGGGTAC TGCAGCCGGG GCCGCGTGCG CTCAGGGCAC CTTGCAGGGC
ATCCGGGCCT GGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_660328.2
CDS200..1294
Misc Feature(1)188..190
Misc Feature(2)641..811
Misc Feature(3)order(644..658,662..664,713..715,731..733,770..772,776..781,788..793,797..805,809..814)
Misc Feature(4)order(650..652,659..661,779..781,788..793,800..802)
Exon (1)1..557
Exon (2)558..2097
Translation

Target ORF information:

RefSeq Version NM_145285.2
Organism Homo sapiens(Human)
Definition Homo sapiens NK2 homeobox 3 (NKX2-3), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_145285.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGATGTTAC CAAGCCCGGT CACCTCCACC CCTTTCTCAG TCAAAGACAT TTTGAATCTG 
GAGCAGCAGC ACCAGCACTT CCATGGTGCG CACTTGCAGG CGGACTTGGA GCACCACTTC
CACTCTGCGC CCTGCATGCT GGCCGCCGCT GAGGGGACGC AATTTTCTGA CGGAGGGGAG
GAGGACGAGG AAGACGAGGG CGAGAAATTG TCCTATTTGA ACTCACTAGC CGCAGCAGAC
GGCCACGGGG ATTCAGGGCT GTGTCCCCAG GGCTATGTCC ACACGGTCCT GCGAGACTCG
TGCAGCGAGC CCAAGGAACA TGAAGAGGAG CCCGAGGTCG TGAGGGACCG GAGCCAAAAA
AGCTGCCAGC TGAAGAAGTC TCTAGAGACG GCCGGAGACT GCAAGGCGGC GGAGGAGAGC
GAGAGGCCGA AGCCACGCAG CCGCCGGAAG CCCCGGGTCC TCTTCTCGCA AGCCCAGGTC
TTCGAGCTGG AACGCAGGTT CAAGCAGCAG CGGTACCTGT CGGCACCCGA GCGCGAGCAC
CTCGCCAGCA GCCTGAAGCT CACATCCACT CAGGTGAAAA TCTGGTTCCA GAATCGCAGG
TACAAGTGCA AGAGACAGCG GCAGGACAAG TCTCTGGAGC TTGGCGCACA CGCGCCCCCG
CCGCCGCCGC GCCGCGTGGC TGTCCCGGTG CTGGTGCGGG ACGGCAAGCC GTGCGTCACG
CCCAGCGCGC AGGCCTACGG CGCGCCCTAC AGCGTGGGCG CCAGCGCCTA CTCCTACAAC
AGCTTCCCCG CCTACGGCTA TGGGAACTCG GCCGCGGCCG CCGCCGCCGC CGCCGCCGCC
GCCGCAGCAG CGGCGGCCTA CAGCAGCAGC TATGGCTGTG CGTACCCGGC GGGCGGCGGC
GGCGGCGGCG GCGGGACCTC CGCGGCGACC ACTGCCATGC AGCCCGCCTG CAGCGCGGCC
GGAGGCGGCC CCTTTGTGAA CGTGAGCAAC CTAGGAGGCT TCGGCAGCGG CGGCAGCGCA
CAGCCGTTGC ACCAGGGTAC TGCAGCCGGG GCCGCGTGCG CTCAGGGCAC CTTGCAGGGC
ATCCGGGCCT GGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu77045
Clone ID Related Accession (Same CDS sequence) XM_011539370.1
Accession Version XM_011539370.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 585bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product homeobox protein Nkx-2.3 isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
ATGATGTTAC CAAGCCCGGT CACCTCCACC CCTTTCTCAG TCAAAGACAT TTTGAATCTG 
GAGCAGCAGC ACCAGCACTT CCATGGTGCG CACTTGCAGG CGGACTTGGA GCACCACTTC
CACTCTGCGC CCTGCATGCT GGCCGCCGCT GAGGGGACGC AATTTTCTGA CGGAGGGGAG
GAGGACGAGG AAGACGAGGG CGAGAAATTG TCCTATTTGA ACTCACTAGC CGCAGCAGAC
GGCCACGGGG ATTCAGGGCT GTGTCCCCAG GGCTATGTCC ACACGGTCCT GCGAGACTCG
TGCAGCGAGC CCAAGGAACA TGAAGAGGAG CCCGAGGTCG TGAGGGACCG GAGCCAAAAT
GCTCAAGATC CAAATAAACA CGCACTAACT ACCCCTCTCC ACGAAACGCG CCTCCGCCTG
CTAAGGGCGT TCTTTGGGTA CTGGGGCTGT CTCAGGGTCC CACAGCGCCA GGAGCCACAA
ACGTTCCCAA AAGTCCAGCC ATTTACTACC GCACGCTCTG CGCAGCCACC AAAAAGGGTC
ACGGTGCTCC AGGACAGGAG CCGCGGTGCG GCCGGGAACA GCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011537672.1
CDS191..775
Translation

Target ORF information:

RefSeq Version XM_011539370.1
Organism Homo sapiens(Human)
Definition Homo sapiens NK2 homeobox 3 (NKX2-3), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011539370.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGATGTTAC CAAGCCCGGT CACCTCCACC CCTTTCTCAG TCAAAGACAT TTTGAATCTG 
GAGCAGCAGC ACCAGCACTT CCATGGTGCG CACTTGCAGG CGGACTTGGA GCACCACTTC
CACTCTGCGC CCTGCATGCT GGCCGCCGCT GAGGGGACGC AATTTTCTGA CGGAGGGGAG
GAGGACGAGG AAGACGAGGG CGAGAAATTG TCCTATTTGA ACTCACTAGC CGCAGCAGAC
GGCCACGGGG ATTCAGGGCT GTGTCCCCAG GGCTATGTCC ACACGGTCCT GCGAGACTCG
TGCAGCGAGC CCAAGGAACA TGAAGAGGAG CCCGAGGTCG TGAGGGACCG GAGCCAAAAT
GCTCAAGATC CAAATAAACA CGCACTAACT ACCCCTCTCC ACGAAACGCG CCTCCGCCTG
CTAAGGGCGT TCTTTGGGTA CTGGGGCTGT CTCAGGGTCC CACAGCGCCA GGAGCCACAA
ACGTTCCCAA AAGTCCAGCC ATTTACTACC GCACGCTCTG CGCAGCCACC AAAAAGGGTC
ACGGTGCTCC AGGACAGGAG CCGCGGTGCG GCCGGGAACA GCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

GWAS of dental caries patterns in the permanent dentition.
Journal of dental research92(1)38-44(2013 Jan)
Shaffer JR,Feingold E,Wang X,Lee M,Tcuenco K,Weeks DE,Weyant RJ,Crout R,McNeil DW,Marazita ML


book

Seventy-five genetic loci influencing the human red blood cell.
Nature492(7429)369-75(2012 Dec)
van der Harst P,Zhang W,Mateo Leach I,Rendon A,Verweij N,Sehmi J,Paul DS,Elling U,Allayee H,Li X,Radhakrishnan A,Tan ST,Voss K,Weichenberger CX,Albers CA,Al-Hussani A,Asselbergs FW,Ciullo M,Danjou F,Dina C,Esko T,Evans DM,Franke L,Gögele M,Hartiala J,Hersch M,Holm H,Hottenga JJ,Kanoni S,Kleber ME,Lagou V,Langenberg C,Lopez LM,Lyytikäinen LP,Melander O,Murgia F,Nolte IM,O'Reilly PF,Padmanabhan S,Parsa A,Pirastu N,Porcu E,Portas L,Prokopenko I,Ried JS,Shin SY,Tang CS,Teumer A,Traglia M,Ulivi S,Westra HJ,Yang J,Zhao JH,Anni F,Abdellaoui A,Attwood A,Balkau B,Bandinelli S,Bastardot F,Benyamin B,Boehm BO,Cookson WO,Das D,de Bakker PI,de Boer RA,de Geus EJ,de Moor MH,Dimitriou M,Domingues FS,Döring A,Engström G,Eyjolfsson GI,Ferrucci L,Fischer K,Galanello R,Garner SF,Genser B,Gibson QD,Girotto G,Gudbjartsson DF,Harris SE,Hartikainen AL,Hastie CE,Hedblad B,Illig T,Jolley J,Kähönen M,Kema IP,Kemp JP,Liang L,Lloyd-Jones H,Loos RJ,Meacham S,Medland SE,Meisinger C,Memari Y,Mihailov E,Miller K,Moffatt MF,Nauck M,Novatchkova M,Nutile T,Olafsson I,Onundarson PT,Parracciani D,Penninx BW,Perseu L,Piga A,Pistis G,Pouta A,Puc U,Raitakari O,Ring SM,Robino A,Ruggiero D,Ruokonen A,Saint-Pierre A,Sala C,Salumets A,Sambrook J,Schepers H,Schmidt CO,Silljé HH,Sladek R,Smit JH,Starr JM,Stephens J,Sulem P,Tanaka T,Thorsteinsdottir U,Tragante V,van Gilst WH,van Pelt LJ,van Veldhuisen DJ,Völker U,Whitfield JB,Willemsen G,Winkelmann BR,Wirnsberger G,Algra A,Cucca F,d'Adamo AP,Danesh J,Deary IJ,Dominiczak AF,Elliott P,Fortina P,Froguel P,Gasparini P,Greinacher A,Hazen SL,Jarvelin MR,Khaw KT,Lehtimäki T,Maerz W,Martin NG,Metspalu A,Mitchell BD,Montgomery GW,Moore C,Navis G,Pirastu M,Pramstaller PP,Ramirez-Solis R,Schadt E,Scott J,Shuldiner AR,Smith GD,Smith JG,Snieder H,Sorice R,Spector TD,Stefansson K,Stumvoll M,Tang WH,Toniolo D,Tönjes A,Visscher PM,Vollenweider P,Wareham NJ,Wolffenbuttel BH,Boomsma DI,Beckmann JS,Dedoussis GV,Deloukas P,Ferreira MA,Sanna S,Uda M,Hicks AA,Penninger JM,Gieger C,Kooner JS,Ouwehand WH,Soranzo N,Chambers JC


book

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
Nature491(7422)119-24(2012 Nov)
Jostins L,Ripke S,Weersma RK,Duerr RH,McGovern DP,Hui KY,Lee JC,Schumm LP,Sharma Y,Anderson CA,Essers J,Mitrovic M,Ning K,Cleynen I,Theatre E,Spain SL,Raychaudhuri S,Goyette P,Wei Z,Abraham C,Achkar JP,Ahmad T,Amininejad L,Ananthakrishnan AN,Andersen V,Andrews JM,Baidoo L,Balschun T,Bampton PA,Bitton A,Boucher G,Brand S,Büning C,Cohain A,Cichon S,D'Amato M,De Jong D,Devaney KL,Dubinsky M,Edwards C,Ellinghaus D,Ferguson LR,Franchimont D,Fransen K,Gearry R,Georges M,Gieger C,Glas J,Haritunians T,Hart A,Hawkey C,Hedl M,Hu X,Karlsen TH,Kupcinskas L,Kugathasan S,Latiano A,Laukens D,Lawrance IC,Lees CW,Louis E,Mahy G,Mansfield J,Morgan AR,Mowat C,Newman W,Palmieri O,Ponsioen CY,Potocnik U,Prescott NJ,Regueiro M,Rotter JI,Russell RK,Sanderson JD,Sans M,Satsangi J,Schreiber S,Simms LA,Sventoraityte J,Targan SR,Taylor KD,Tremelling M,Verspaget HW,De Vos M,Wijmenga C,Wilson DC,Winkelmann J,Xavier RJ,Zeissig S,Zhang B,Zhang CK,Zhao H,,Silverberg MS,Annese V,Hakonarson H,Brant SR,Radford-Smith G,Mathew CG,Rioux JD,Schadt EE,Daly MJ,Franke A,Parkes M,Vermeire S,Barrett JC,Cho JH


book

A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
PLoS genetics8(3)e1002559(2012)
Kenny EE,Pe'er I,Karban A,Ozelius L,Mitchell AA,Ng SM,Erazo M,Ostrer H,Abraham C,Abreu MT,Atzmon G,Barzilai N,Brant SR,Bressman S,Burns ER,Chowers Y,Clark LN,Darvasi A,Doheny D,Duerr RH,Eliakim R,Giladi N,Gregersen PK,Hakonarson H,Jones MR,Marder K,McGovern DP,Mulle J,Orr-Urtreger A,Proctor DD,Pulver A,Rotter JI,Silverberg MS,Ullman T,Warren ST,Waterman M,Zhang W,Bergman A,Mayer L,Katz S,Desnick RJ,Cho JH,Peter I


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PTPN2 is associated with Crohn's disease and its expression is regulated by NKX2-3.
Disease markers32(2)83-91(2012)
Yu W,Hegarty JP,Berg A,Kelly AA,Wang Y,Poritz LS,Franke A,Schreiber S,Koltun WA,Lin Z


 
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