PSORS1C2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PSORS1C2
Entrez Gene ID	170680
Full Name	psoriasis susceptibility 1 candidate 2
Synonyms	C6orf17,SPR1
General protein information	Preferred Names psoriasis susceptibility 1 candidate 2 Names psoriasis susceptibility 1 candidate gene 2 protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p21.33
Disorder MIM:	613526

mRNA and Protein(s)

mRNA	Protein	Name
NM_014069.2	NP_054788.2	psoriasis susceptibility 1 candidate gene 2 protein precursor
NM_014069.3	NP_054788.2	psoriasis susceptibility 1 candidate gene 2 protein precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	PSORS1C2	NP_054788.2
	PSORS1C2	NP_001108426.1
Pan troglodytes (chimpanzee)	PSORS1C2	NP_001038970.1
Mus musculus (house mouse)	Psors1c2	NP_065601.2
Canis lupus familiaris (dog)	PSORS1C2	XP_003431779.1
Rattus norvegicus (Norway rat)	Psors1c2	NP_001159488.1

Gene Ontology
Bibliography

Related articles in PubMed

Phylogenetic profiling and gene expression studies implicate a primary role of PSORS1C2 in terminal differentiation of keratinocytes.
Abbas Zadeh S, Mlitz V, Lachner J, Golabi B, Mildner M, Pammer J, Tschachler E, Eckhart L
Experimental dermatology26(4)352-358(2017 Apr)

Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk.
Chubb D, Weinhold N, Broderick P, Chen B, Johnson DC, F?rsti A, Vijayakrishnan J, Migliorini G, Dobbins SE, Holroyd A, Hose D, Walker BA, Davies FE, Gregory WA, Jackson GH, Irving JA, Pratt G, Fegan C, Fenton JA, Neben K, Hoffmann P, N?then MM, M?hleisen TW, Eisele L, Ross FM, Straka C, Einsele H, Langer C, D?rner E, Allan JM, Jauch A, Morgan GJ, Hemminki K, Houlston RS, Goldschmidt H
Nature genetics45(10)1221-1225(2013 Oct)

The HLA-Cw*06 allele and -1149 G/T polymorphism of extrapituitary promoter of PRL gene as a possible common genetic predisposing factors to psoriasis vulgaris and psoriatic arthritis in Czech population.
Cibulova A, Zajacova M, Fojtikova M, Stolfa J, Sedova L, Cejkova P, Lippert J, Arenberger P, Cerna M
Rheumatology international33(4)913-9(2013 Apr)

GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children.
Li J, Glessner JT, Zhang H, Hou C, Wei Z, Bradfield JP, Mentch FD, Guo Y, Kim C, Xia Q, Chiavacci RM, Thomas KA, Qiu H, Grant SF, Furth SL, Hakonarson H, Sleiman PM
Human molecular genetics22(7)1457-64(2013 Apr)

Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.
Kim DK, Cho MH, Hersh CP, Lomas DA, Miller BE, Kong X, Bakke P, Gulsvik A, Agust? A, Wouters E, Celli B, Coxson H, Vestbo J, MacNee W, Yates JC, Rennard S, Litonjua A, Qiu W, Beaty TH, Crapo JD, Riley JH, Tal-Singer R, Silverman EK,
American journal of respiratory and critical care medicine186(12)1238-47(2012 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In Czech population, association between HLA-Cw*06 and psoriatic arthritis was low and restricted to psoriatic arthritis patients with early psoriasis onset
Title: The HLA-Cw*06 allele and -1149 G/T polymorphism of extrapituitary promoter of PRL gene as a possible common genetic predisposing factors to psoriasis vulgaris and psoriatic arthritis in Czech population.

Observational study of gene-disease association. (HuGE Navigator)
Title: High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.

HLA-Cw*06 allele frequency is associated with psoriasis
Title: Correlation of HLA-Cw*06 allele frequency with some clinical features of psoriasis vulgaris in the population of northern Poland.

In a case-control study, five of the nine single nucleotide polymorphisms (SNPs) found in SEEK1 were associated with psoriasis, while one of the four SNPs found in SPR1 showed association.
Title: Polymorphisms in the SEEK1 and SPR1 genes on 6p21.3 associate with psoriasis in the Swedish population.

HLA-Cw6 remains the major risk allele in Chinese psoriatics, and that the SPR1 gene might not play an important role in the causation of PV.
Title: SPR1 gene near HLA-C is unlikely to be a psoriasis susceptibility gene.

The following PSORS1C2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PSORS1C2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu10122	NM_014069.3 Latest version!	Homo sapiens psoriasis susceptibility 1 candidate 2 (PSORS1C2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu10122	NM_014069.2	Homo sapiens psoriasis susceptibility 1 candidate 2 (PSORS1C2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PSORS1C2 ( NM_014069.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_054788.2 Homo sapiens psoriasis susceptibility 1 candidate 2 (PSORS1C2), mRNA.

Price & Availability↑

CloneID	OHu10122
Clone ID Related Accession (Same CDS sequence)	NM_014069.2 , NM_014069.3
Accession Version	NM_014069.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 411bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-23
Organism	Homo sapiens(human)
Product	psoriasis susceptibility 1 candidate gene 2 protein precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF484420.1 and AL662844.12. On Sep 7, 2007 this sequence version replaced NM_014069.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF484420.1, AB031480.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2147596 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATCCTCA ACTGGAAGCT CCTGGGGATC CTGGTCCTTT GCCTGCACAC CAGAGGCATC 
TCAGGCAGCG AGGGCCACCC CTCTCACCCA CCCGCAGAGG ACCGAGAGGA GGCAGGCTCC 
CCAACATTGC CTCAGGGCCC CCCAGTCCCC GGTGACCCTT GGCCAGGGGC ACCCCCTCTC 
TTTGAAGATC CTCCGCCTAC CCGCCCCAGT CGTCCCTGGA GAGACCTGCC TGAAACTGGA 
GTCTGGCTCC CTGAACCGCC TAGAACGGAT CCTCCTCAAC CTCCCCGGCC TGACGACCCT 
TGGCCGGCAG GACCCCAGCC CCCAGAAAAC CCCTGGCCTC CTGCCCCTGA GGTGGACAAC 
CGACCTCAGG AGGAGCCAGA CCTAGACCCA CCCCGGGAAG AGTACAGATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_054788.2
CDS	325..735
Translation	MILNWKLLGILVLCLHTRGISGSEGHPSHPPAEDREEAGSPTLPQGPPVPGDPWPGAPPLFEDPPPTRPSRPWRDLPETGVWLPEPPRTDPPQPPRPDDPWPAGPQPPENPWPPAPEVDNRPQEEPDLDPPREEYR

Target ORF information:

RefSeq Version	NM_014069.2
Organism	Homo sapiens(human)
Definition	Homo sapiens psoriasis susceptibility 1 candidate 2 (PSORS1C2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014069.2

ORF Insert Sequence:

ATGATCCTCA ACTGGAAGCT CCTGGGGATC CTGGTCCTTT GCCTGCACAC CAGAGGCATC 
TCAGGCAGCG AGGGCCACCC CTCTCACCCA CCCGCAGAGG ACCGAGAGGA GGCAGGCTCC 
CCAACATTGC CTCAGGGCCC CCCAGTCCCC GGTGACCCTT GGCCAGGGGC ACCCCCTCTC 
TTTGAAGATC CTCCGCCTAC CCGCCCCAGT CGTCCCTGGA GAGACCTGCC TGAAACTGGA 
GTCTGGCTCC CTGAACCGCC TAGAACGGAT CCTCCTCAAC CTCCCCGGCC TGACGACCCT 
TGGCCGGCAG GACCCCAGCC CCCAGAAAAC CCCTGGCCTC CTGCCCCTGA GGTGGACAAC 
CGACCTCAGG AGGAGCCAGA CCTAGACCCA CCCCGGGAAG AGTACAGATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PSORS1C2 ( NM_014069.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_054788.2 Homo sapiens psoriasis susceptibility 1 candidate 2 (PSORS1C2), mRNA.

Price & Availability↑

CloneID	OHu10122
Clone ID Related Accession (Same CDS sequence)	NM_014069.2 , NM_014069.3
Accession Version	NM_014069.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 411bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	psoriasis susceptibility 1 candidate gene 2 protein precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF484420.1 and AL662844.12. On Nov 22, 2018 this sequence version replaced NM_014069.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB031480.1, AF484420.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2147596 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000259845.5/ ENSP00000259845.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGATCCTCA ACTGGAAGCT CCTGGGGATC CTGGTCCTTT GCCTGCACAC CAGAGGCATC 
TCAGGCAGCG AGGGCCACCC CTCTCACCCA CCCGCAGAGG ACCGAGAGGA GGCAGGCTCC 
CCAACATTGC CTCAGGGCCC CCCAGTCCCC GGTGACCCTT GGCCAGGGGC ACCCCCTCTC 
TTTGAAGATC CTCCGCCTAC CCGCCCCAGT CGTCCCTGGA GAGACCTGCC TGAAACTGGA 
GTCTGGCTCC CTGAACCGCC TAGAACGGAT CCTCCTCAAC CTCCCCGGCC TGACGACCCT 
TGGCCGGCAG GACCCCAGCC CCCAGAAAAC CCCTGGCCTC CTGCCCCTGA GGTGGACAAC 
CGACCTCAGG AGGAGCCAGA CCTAGACCCA CCCCGGGAAG AGTACAGATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_054788.2
CDS	41..451
Translation	MILNWKLLGILVLCLHTRGISGSEGHPSHPPAEDREEAGSPTLPQGPPVPGDPWPGAPPLFEDPPPTRPSRPWRDLPETGVWLPEPPRTDPPQPPRPDDPWPAGPQPPENPWPPAPEVDNRPQEEPDLDPPREEYR

Target ORF information:

RefSeq Version	NM_014069.3
Organism	Homo sapiens(human)
Definition	Homo sapiens psoriasis susceptibility 1 candidate 2 (PSORS1C2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014069.3

ORF Insert Sequence:

ATGATCCTCA ACTGGAAGCT CCTGGGGATC CTGGTCCTTT GCCTGCACAC CAGAGGCATC 
TCAGGCAGCG AGGGCCACCC CTCTCACCCA CCCGCAGAGG ACCGAGAGGA GGCAGGCTCC 
CCAACATTGC CTCAGGGCCC CCCAGTCCCC GGTGACCCTT GGCCAGGGGC ACCCCCTCTC 
TTTGAAGATC CTCCGCCTAC CCGCCCCAGT CGTCCCTGGA GAGACCTGCC TGAAACTGGA 
GTCTGGCTCC CTGAACCGCC TAGAACGGAT CCTCCTCAAC CTCCCCGGCC TGACGACCCT 
TGGCCGGCAG GACCCCAGCC CCCAGAAAAC CCCTGGCCTC CTGCCCCTGA GGTGGACAAC 
CGACCTCAGG AGGAGCCAGA CCTAGACCCA CCCCGGGAAG AGTACAGATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Phylogenetic profiling and gene expression studies implicate a primary role of PSORS1C2 in terminal differentiation of keratinocytes.
Experimental dermatology26(4)352-358(2017 Apr)
Abbas Zadeh S,Mlitz V,Lachner J,Golabi B,Mildner M,Pammer J,Tschachler E,Eckhart L

Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk.
Nature genetics45(10)1221-1225(2013 Oct)
Chubb D,Weinhold N,Broderick P,Chen B,Johnson DC,F?rsti A,Vijayakrishnan J,Migliorini G,Dobbins SE,Holroyd A,Hose D,Walker BA,Davies FE,Gregory WA,Jackson GH,Irving JA,Pratt G,Fegan C,Fenton JA,Neben K,Hoffmann P,N?then MM,M?hleisen TW,Eisele L,Ross FM,Straka C,Einsele H,Langer C,D?rner E,Allan JM,Jauch A,Morgan GJ,Hemminki K,Houlston RS,Goldschmidt H

The HLA-Cw*06 allele and -1149 G/T polymorphism of extrapituitary promoter of PRL gene as a possible common genetic predisposing factors to psoriasis vulgaris and psoriatic arthritis in Czech population.
Rheumatology international33(4)913-9(2013 Apr)
Cibulova A,Zajacova M,Fojtikova M,Stolfa J,Sedova L,Cejkova P,Lippert J,Arenberger P,Cerna M

GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children.
Human molecular genetics22(7)1457-64(2013 Apr)
Li J,Glessner JT,Zhang H,Hou C,Wei Z,Bradfield JP,Mentch FD,Guo Y,Kim C,Xia Q,Chiavacci RM,Thomas KA,Qiu H,Grant SF,Furth SL,Hakonarson H,Sleiman PM

Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine186(12)1238-47(2012 Dec)
Kim DK,Cho MH,Hersh CP,Lomas DA,Miller BE,Kong X,Bakke P,Gulsvik A,Agust? A,Wouters E,Celli B,Coxson H,Vestbo J,MacNee W,Yates JC,Rennard S,Litonjua A,Qiu W,Beaty TH,Crapo JD,Riley JH,Tal-Singer R,Silverman EK,

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PSORS1C2 cDNA ORF clone, Homo sapiens(human)

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Related articles in PubMed

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Target ORF information:

ORF Insert Sequence:

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