AGRP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	AGRP
Entrez Gene ID	181
Full Name	agouti related neuropeptide
Synonyms	AGRT,ART,ASIP2
General protein information	Preferred Names agouti related neuropeptide Names agouti-related protein agouti related protein homolog
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16q22.1
Summary	This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. [provided by RefSeq, Dec 2009].
Disorder MIM:	602311
Disorder Html:	{Obesity, late-onset}, 601665 (3); {Leanness, inherited} (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001138.1	NP_001129.1	agouti-related protein precursor
XM_011522927.1	XP_011521229.1	agouti-related protein isoform X1
NM_001138.2	NP_001129.1	agouti-related protein precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	AGRP	XP_853932.1
Pan troglodytes (chimpanzee)	AGRP	XP_001164015.1
	AGRP	XP_001091740.1
Bos taurus (cattle)	AGRP	NP_776408.1
Mus musculus (house mouse)	Agrp	NP_001258735.1
Homo sapiens (human)	AGRP	NP_001129.1
Rattus norvegicus (Norway rat)	Agrp	NP_387499.1
Gallus gallus (chicken)	AGRP	NP_001026628.1
Gallus gallus (chicken)	LOC100859622	XP_004951049.1

Gene Ontology
Bibliography

Related articles in PubMed

The agouti-related peptide binds heparan sulfate through segments critical for its orexigenic effects.
Palomino R, Lee HW, Millhauser GL
The Journal of biological chemistry292(18)7651-7661(2017 05)

Regulation of plasma agouti-related protein and its relationship with hunger in lean and obese men.
Hazell TJ, Sawula L, Edgett BA, Walsh JJ, Gurd BJ
Appetite107166-170(2016 Dec)

Biased signaling initiated by agouti-related peptide through human melanocortin-3 and -4 receptors.
Yang Z, Tao YX
Biochimica et biophysica acta1862(9)1485-94(2016 Sep)

Analysis of MC4R rs17782313, POMC rs1042571, APOE-Hha1 and AGRP rs3412352 genetic variants with susceptibility to obesity risk in North Indians.
Srivastava A, Mittal B, Prakash J, Srivastava P, Srivastava N
Annals of human biology43(3)285-8(2016 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

data provide compelling evidence that AgRP is a heparan sulfate-binding protein and localizes critical regions in the AgRP structure required for this interaction.
Title: The agouti-related peptide binds heparan sulfate through segments critical for its orexigenic effects.

AgRP is not associated with changes in hunger or satiety, and can change without corresponding changes in leptin. This suggests that AgRP may not be involved in the episodic control of appetite and the release of AgRP may involve signals other than leptin.
Title: Regulation of plasma agouti-related protein and its relationship with hunger in lean and obese men.

The aim of this survey is to evaluate the association of genetic variants of melanocortin-4-receptor (MC4R), pro-opiomelanocortin (POMC), apolipoprotein E (APOE) and agouti-related protein (AGRP) with obesity in the North Indian population.
Title: Analysis of MC4R rs17782313, POMC rs1042571, APOE-Hha1 and AGRP rs3412352 genetic variants with susceptibility to obesity risk in North Indians.

CSF AgRP was not different in lean vs. overweight/obese subjects; however, plasma AgRP was higher in lean subjects.
Title: Proopiomelanocortin, agouti-related protein, and leptin in human cerebrospinal fluid: correlations with body weight and adiposity.

human agouti-related protein has a role in enhancing expression and stability of human melanocortin-4 receptor
Title: Co-expression of human agouti-related protein enhances expression and stability of human melanocortin-4 receptor.

The following AGRP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the AGRP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17959	NM_001138.2 Latest version!	Homo sapiens agouti related neuropeptide (AGRP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu17959	XM_011522927.1 Latest version!	Homo sapiens agouti related neuropeptide (AGRP), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu17959	NM_001138.1	Homo sapiens agouti related neuropeptide (AGRP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

AGRP ( NM_001138.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001129.1 Homo sapiens agouti related neuropeptide (AGRP), mRNA.

Price & Availability↑

CloneID	OHu17959
Clone ID Related Accession (Same CDS sequence)	NM_001138.1 , XM_011522927.1 , NM_001138.2
Accession Version	NM_001138.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 399bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-30
Organism	Homo sapiens(human)
Product	agouti-related protein precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U88063.1. This sequence is a reference standard in the RefSeqGene project. On Dec 17, 2009 this sequence version replaced NM_007316.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U88063.1, CD369732.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145544, SAMEA2146411 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTGACCG CAGCGGTGCT GAGCTGTGCC CTGCTGCTGG CACTGCCTGC CACGCGAGGA 
GCCCAGATGG GCTTGGCCCC CATGGAGGGC ATCAGAAGGC CTGACCAGGC CCTGCTCCCA 
GAGCTCCCAG GCCTGGGCCT GCGGGCCCCA CTGAAGAAGA CAACTGCAGA ACAGGCAGAA 
GAGGATCTGT TGCAGGAGGC TCAGGCCTTG GCAGAGGTAC TAGACCTGCA GGACCGCGAG 
CCCCGCTCCT CACGTCGCTG CGTAAGGCTG CATGAGTCCT GCCTGGGACA GCAGGTGCCT 
TGCTGTGACC CATGTGCCAC GTGCTACTGC CGCTTCTTCA ATGCCTTCTG CTACTGCCGC 
AAGCTGGGTA CTGCCATGAA TCCCTGCAGC CGCACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001129.1
CDS	301..699
Translation	MLTAAVLSCALLLALPATRGAQMGLAPMEGIRRPDQALLPELPGLGLRAPLKKTTAEQAEEDLLQEAQALAEVLDLQDREPRSSRRCVRLHESCLGQQVPCCDPCATCYCRFFNAFCYCRKLGTAMNPCSRT

Target ORF information:

RefSeq Version	NM_001138.1
Organism	Homo sapiens(human)
Definition	Homo sapiens agouti related neuropeptide (AGRP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001138.1

ORF Insert Sequence:

ATGCTGACCG CAGCGGTGCT GAGCTGTGCC CTGCTGCTGG CACTGCCTGC CACGCGAGGA 
GCCCAGATGG GCTTGGCCCC CATGGAGGGC ATCAGAAGGC CTGACCAGGC CCTGCTCCCA 
GAGCTCCCAG GCCTGGGCCT GCGGGCCCCA CTGAAGAAGA CAACTGCAGA ACAGGCAGAA 
GAGGATCTGT TGCAGGAGGC TCAGGCCTTG GCAGAGGTAC TAGACCTGCA GGACCGCGAG 
CCCCGCTCCT CACGTCGCTG CGTAAGGCTG CATGAGTCCT GCCTGGGACA GCAGGTGCCT 
TGCTGTGACC CATGTGCCAC GTGCTACTGC CGCTTCTTCA ATGCCTTCTG CTACTGCCGC 
AAGCTGGGTA CTGCCATGAA TCCCTGCAGC CGCACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AGRP ( NM_001138.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001129.1 Homo sapiens agouti related neuropeptide (AGRP), mRNA.

Price & Availability↑

CloneID	OHu17959
Clone ID Related Accession (Same CDS sequence)	NM_001138.1 , XM_011522927.1 , NM_001138.2
Accession Version	NM_001138.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 399bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	agouti-related protein precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC009061.10. This sequence is a reference standard in the RefSeqGene project. On Aug 13, 2019 this sequence version replaced NM_001138.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U88063.1, CD369732.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTGACCG CAGCGGTGCT GAGCTGTGCC CTGCTGCTGG CACTGCCTGC CACGCGAGGA 
GCCCAGATGG GCTTGGCCCC CATGGAGGGC ATCAGAAGGC CTGACCAGGC CCTGCTCCCA 
GAGCTCCCAG GCCTGGGCCT GCGGGCCCCA CTGAAGAAGA CAACTGCAGA ACAGGCAGAA 
GAGGATCTGT TGCAGGAGGC TCAGGCCTTG GCAGAGGTAC TAGACCTGCA GGACCGCGAG 
CCCCGCTCCT CACGTCGCTG CGTAAGGCTG CATGAGTCCT GCCTGGGACA GCAGGTGCCT 
TGCTGTGACC CATGTGCCAC GTGCTACTGC CGCTTCTTCA ATGCCTTCTG CTACTGCCGC 
AAGCTGGGTA CTGCCATGAA TCCCTGCAGC CGCACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001129.1
CDS	35..433
Translation	MLTAAVLSCALLLALPATRGAQMGLAPMEGIRRPDQALLPELPGLGLRAPLKKTTAEQAEEDLLQEAQALAEVLDLQDREPRSSRRCVRLHESCLGQQVPCCDPCATCYCRFFNAFCYCRKLGTAMNPCSRT

Target ORF information:

RefSeq Version	NM_001138.2
Organism	Homo sapiens(human)
Definition	Homo sapiens agouti related neuropeptide (AGRP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001138.2

ORF Insert Sequence:

ATGCTGACCG CAGCGGTGCT GAGCTGTGCC CTGCTGCTGG CACTGCCTGC CACGCGAGGA 
GCCCAGATGG GCTTGGCCCC CATGGAGGGC ATCAGAAGGC CTGACCAGGC CCTGCTCCCA 
GAGCTCCCAG GCCTGGGCCT GCGGGCCCCA CTGAAGAAGA CAACTGCAGA ACAGGCAGAA 
GAGGATCTGT TGCAGGAGGC TCAGGCCTTG GCAGAGGTAC TAGACCTGCA GGACCGCGAG 
CCCCGCTCCT CACGTCGCTG CGTAAGGCTG CATGAGTCCT GCCTGGGACA GCAGGTGCCT 
TGCTGTGACC CATGTGCCAC GTGCTACTGC CGCTTCTTCA ATGCCTTCTG CTACTGCCGC 
AAGCTGGGTA CTGCCATGAA TCCCTGCAGC CGCACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AGRP ( XM_011522927.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011521229.1 Homo sapiens agouti related neuropeptide (AGRP), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu17959
Clone ID Related Accession (Same CDS sequence)	NM_001138.1 , XM_011522927.1 , NM_001138.2
Accession Version	XM_011522927.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 399bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	agouti-related protein isoform X1
Comment

ATGCTGACCG CAGCGGTGCT GAGCTGTGCC CTGCTGCTGG CACTGCCTGC CACGCGAGGA 
GCCCAGATGG GCTTGGCCCC CATGGAGGGC ATCAGAAGGC CTGACCAGGC CCTGCTCCCA 
GAGCTCCCAG GCCTGGGCCT GCGGGCCCCA CTGAAGAAGA CAACTGCAGA ACAGGCAGAA 
GAGGATCTGT TGCAGGAGGC TCAGGCCTTG GCAGAGGTAC TAGACCTGCA GGACCGCGAG 
CCCCGCTCCT CACGTCGCTG CGTAAGGCTG CATGAGTCCT GCCTGGGACA GCAGGTGCCT 
TGCTGTGACC CATGTGCCAC GTGCTACTGC CGCTTCTTCA ATGCCTTCTG CTACTGCCGC 
AAGCTGGGTA CTGCCATGAA TCCCTGCAGC CGCACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011521229.1
Translation	MLTAAVLSCALLLALPATRGAQMGLAPMEGIRRPDQALLPELPGLGLRAPLKKTTAEQAEEDLLQEAQALAEVLDLQDREPRSSRRCVRLHESCLGQQVPCCDPCATCYCRFFNAFCYCRKLGTAMNPCSRT

Target ORF information:

RefSeq Version	XM_011522927.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens agouti related neuropeptide (AGRP), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011522927.1

ORF Insert Sequence:

ATGCTGACCG CAGCGGTGCT GAGCTGTGCC CTGCTGCTGG CACTGCCTGC CACGCGAGGA 
GCCCAGATGG GCTTGGCCCC CATGGAGGGC ATCAGAAGGC CTGACCAGGC CCTGCTCCCA 
GAGCTCCCAG GCCTGGGCCT GCGGGCCCCA CTGAAGAAGA CAACTGCAGA ACAGGCAGAA 
GAGGATCTGT TGCAGGAGGC TCAGGCCTTG GCAGAGGTAC TAGACCTGCA GGACCGCGAG 
CCCCGCTCCT CACGTCGCTG CGTAAGGCTG CATGAGTCCT GCCTGGGACA GCAGGTGCCT 
TGCTGTGACC CATGTGCCAC GTGCTACTGC CGCTTCTTCA ATGCCTTCTG CTACTGCCGC 
AAGCTGGGTA CTGCCATGAA TCCCTGCAGC CGCACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The agouti-related peptide binds heparan sulfate through segments critical for its orexigenic effects.
The Journal of biological chemistry292(18)7651-7661(2017 05)
Palomino R,Lee HW,Millhauser GL

Regulation of plasma agouti-related protein and its relationship with hunger in lean and obese men.
Appetite107166-170(2016 Dec)
Hazell TJ,Sawula L,Edgett BA,Walsh JJ,Gurd BJ

Biased signaling initiated by agouti-related peptide through human melanocortin-3 and -4 receptors.
Biochimica et biophysica acta1862(9)1485-94(2016 Sep)
Yang Z,Tao YX

Analysis of MC4R rs17782313, POMC rs1042571, APOE-Hha1 and AGRP rs3412352 genetic variants with susceptibility to obesity risk in North Indians.
Annals of human biology43(3)285-8(2016 May)
Srivastava A,Mittal B,Prakash J,Srivastava P,Srivastava N