Gene Symbol | CADM4 |
Entrez Gene ID | 199731 |
Full Name | cell adhesion molecule 4 |
Synonyms | IGSF4C,NECL4,Necl-4,TSLL2,synCAM4 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » CADM4 cDNA ORF clone
Gene Symbol | CADM4 |
Entrez Gene ID | 199731 |
Full Name | cell adhesion molecule 4 |
Synonyms | IGSF4C,NECL4,Necl-4,TSLL2,synCAM4 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
XM_017026452.1 | XP_016881941.1 | cell adhesion molecule 4 isoform X1 |
NM_145296.1 | NP_660339.1 | cell adhesion molecule 4 precursor |
XM_005258620.1 | XP_005258677.1 | cell adhesion molecule 4 isoform X1 |
XM_005258620.2 | XP_005258677.1 | cell adhesion molecule 4 isoform X2 |
NM_145296.2 | NP_660339.1 | cell adhesion molecule 4 precursor |
Danio rerio (zebrafish) | cadm4 | NP_001007429.1 |
Pan troglodytes (chimpanzee) | CADM4 | XP_512719.4 |
Canis lupus familiaris (dog) | CADM4 | XP_541580.3 |
Bos taurus (cattle) | CADM4 | XP_002695203.2 |
Rattus norvegicus (Norway rat) | Cadm4 | NP_001040572.1 |
Homo sapiens (human) | CADM4 | NP_660339.1 |
Mus musculus (house mouse) | Cadm4 | NP_694752.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100488420 | XP_002939173.1 |
Neuroblastoma cells undergo transcriptomic alterations upon dissemination into the bone marrow and subsequent tumor progression.
Rifatbegovic F, Frech C, Abbasi MR, Taschner-Mandl S, Weiss T, Schmidt WM, Schmidt I, Ladenstein R, Ambros IM, Ambros PF
International journal of cancer142(2)297-307(2018 Jan)
Necl-4 enhances the PLC?-c-Raf-MEK-ERK pathway without affecting internalization of VEGFR2.
Yamana S, Tokiyama A, Fujita H, Terao Y, Horibe S, Sasaki N, Satomi-Kobayashi S, Hirata KI, Rikitake Y
Biochemical and biophysical research communications490(2)169-175(2017 08)
Necl 4 and RNase 5 Are Important Biomarkers for Gastric and Colon Adenocarcinomas.
Sayar ?, G?k?e A, Demirtas L, Eken H, ?imen FK, ?imen O
Medical science monitor : international medical journal of experimental and clinical research232654-2659(2017 May)
The Cell Adhesion Molecule Necl-4/CADM4 Serves as a Novel Regulator for Contact Inhibition of Cell Movement and Proliferation.
Yamana S, Tokiyama A, Mizutani K, Hirata K, Takai Y, Rikitake Y
PloS one10(4)e0124259(2015)
Genetic deletion of Cadm4 results in myelin abnormalities resembling Charcot-Marie-Tooth neuropathy.
Golan N, Kartvelishvily E, Spiegel I, Salomon D, Sabanay H, Rechav K, Vainshtein A, Frechter S, Maik-Rachline G, Eshed-Eisenbach Y, Momoi T, Peles E
The Journal of neuroscience : the official journal of the Society for Neuroscience33(27)10950-61(2013 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Low CADM4 expression is associated with bone marrow metastasis in neuroblastoma.
Title: Neuroblastoma cells undergo transcriptomic alterations upon dissemination into the bone marrow and subsequent tumor progression.
The results suggest that Necl-4 enhances VEGF-induced activation of PLCgamma-c-Raf-MEK-ERK pathway without affecting the phosphorylation and internalization of VEGFR2.
Title: Necl-4 enhances the PLC?-c-Raf-MEK-ERK pathway without affecting internalization of VEGFR2.
Necl-4 serves as a novel regulator for contact inhibition of cell movement and proliferation cooperatively with the VEGF receptor and PTPN13
Title: The Cell Adhesion Molecule Necl-4/CADM4 Serves as a Novel Regulator for Contact Inhibition of Cell Movement and Proliferation.
Cadm4 regulates the growth of the myelin unit and the organization of the underlying axonal membrane.
Title: Genetic deletion of Cadm4 results in myelin abnormalities resembling Charcot-Marie-Tooth neuropathy.
results indicate that Necl-4 serves as a tumor suppressor by inhibiting the ErbB2/ErbB3 signaling and hemidesmosome disassembly
Title: Interaction of Necl-4/CADM4 with ErbB3 and integrin ?6 ?4 and inhibition of ErbB2/ErbB3 signaling and hemidesmosome disassembly.
The following CADM4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CADM4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu06532 | |
Clone ID Related Accession (Same CDS sequence) | NM_145296.1 , NM_145296.2 | |
Accession Version | NM_145296.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1167bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-12-17 | |
Organism | Homo sapiens(human) | |
Product | cell adhesion molecule 4 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF363368.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF363368.1, BC068457.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGGGCCGGG CCCGGCGCTT CCAGTGGCCG CTGCTGCTGC TGTGGGCGGC CGCGGCGGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_660339.1 |
CDS | 50..1216 |
Translation |
Target ORF information:
Target ORF information:
|
NM_145296.1 |
1 | ATGGGCCGGG CCCGGCGCTT CCAGTGGCCG CTGCTGCTGC TGTGGGCGGC CGCGGCGGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu06532 | |
Clone ID Related Accession (Same CDS sequence) | NM_145296.1 , NM_145296.2 | |
Accession Version | NM_145296.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1167bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-30 | |
Organism | Homo sapiens(human) | |
Product | cell adhesion molecule 4 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC005525.2 and AF363368.1. On Nov 22, 2018 this sequence version replaced NM_145296.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC068457.1, AF363368.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000222374.3/ ENSP00000222374.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGGGCCGGG CCCGGCGCTT CCAGTGGCCG CTGCTGCTGC TGTGGGCGGC CGCGGCGGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_660339.1 |
CDS | 61..1227 |
Translation |
Target ORF information:
Target ORF information:
|
NM_145296.2 |
1 | ATGGGCCGGG CCCGGCGCTT CCAGTGGCCG CTGCTGCTGC TGTGGGCGGC CGCGGCGGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu52094 | |
Clone ID Related Accession (Same CDS sequence) | XM_005258620.1 , XM_005258620.2 | |
Accession Version | XM_005258620.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1038bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-03-11 | |
Organism | Homo sapiens(Human) | |
Product | cell adhesion molecule 4 isoform X1 | |
Comment |
1 | ATGGGCCGGG CCCGGCGCTT CCAGTGGCCG CTGCTGCTGC TGTGGGCGGC CGCGGCGGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005258677.1 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005258620.1 |
1 | ATGGGCCGGG CCCGGCGCTT CCAGTGGCCG CTGCTGCTGC TGTGGGCGGC CGCGGCGGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu52094 | |
Clone ID Related Accession (Same CDS sequence) | XM_005258620.1 , XM_005258620.2 | |
Accession Version | XM_005258620.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1038bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | cell adhesion molecule 4 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005258620.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGGCCGGG CCCGGCGCTT CCAGTGGCCG CTGCTGCTGC TGTGGGCGGC CGCGGCGGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005258677.1 |
CDS | 32..1069 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005258620.2 |
1 | ATGGGCCGGG CCCGGCGCTT CCAGTGGCCG CTGCTGCTGC TGTGGGCGGC CGCGGCGGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu88296 | |
Clone ID Related Accession (Same CDS sequence) | XM_017026452.1 | |
Accession Version | XM_017026452.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1110bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | cell adhesion molecule 4 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGACAGGGG CAGGACAGGA AGTACAGACA GAGAACGTGA CAGTGGCTGA GGGTGGGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016881941.1 |
CDS | 16..1125 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017026452.1 |
1 | ATGACAGGGG CAGGACAGGA AGTACAGACA GAGAACGTGA CAGTGGCTGA GGGTGGGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Neuroblastoma cells undergo transcriptomic alterations upon dissemination into the bone marrow and subsequent tumor progression. |
Necl-4 enhances the PLC?-c-Raf-MEK-ERK pathway without affecting internalization of VEGFR2. |
Necl 4 and RNase 5 Are Important Biomarkers for Gastric and Colon Adenocarcinomas. |
The Cell Adhesion Molecule Necl-4/CADM4 Serves as a Novel Regulator for Contact Inhibition of Cell Movement and Proliferation. |
Genetic deletion of Cadm4 results in myelin abnormalities resembling Charcot-Marie-Tooth neuropathy. |