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CLDN14 cDNA ORF clone, Homo sapiens (human)

Gene Symbol CLDN14
Entrez Gene ID 23562
Full Name claudin 14
Synonyms DFNB29
General protein information
Preferred Names
claudin-14
Names
claudin-14
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

21

21q22.3

Summary Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. It is also reported that four synonymous variants in this gene are associated with kidney stones and reduced bone mineral density. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2010]. lac of sum
Disorder MIM:

605608

Disorder Html: Deafness, autosomal recessive 29 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_012130 NP_036262 claudin-14
XM_011529519 XP_011527821 claudin-14 isoform X1
NM_001146078 NP_001139550 claudin-14
NM_001146077 NP_001139549 claudin-14
NM_144492 NP_652763 claudin-14
NM_001146079 NP_001139551 claudin-14



Homo sapiens (human) CLDN14 NP_001139549.1
Pan troglodytes (chimpanzee) CLDN14 XP_525469.1
Macaca mulatta (Rhesus monkey) CLDN14 XP_002803185.1
Canis lupus familiaris (dog) CLDN14 XP_005638958.1
Bos taurus (cattle) CLDN14 XP_005202183.1
Mus musculus (house mouse) Cldn14 NP_001159398.1
Rattus norvegicus (Norway rat) Cldn14 NP_001013447.1
Gallus gallus (chicken) CLDN14 XP_004934594.1
Danio rerio (zebrafish) cldn2 NP_001004559.2
Xenopus (Silurana) tropicalis (western clawed frog) cldn14 XP_004912176.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following CLDN14 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CLDN14 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu20415
NM_012130 Homo sapiens claudin 14 (CLDN14), transcript variant epsilon, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
OHu20415
XM_011529519 PREDICTED: Homo sapiens claudin 14 (CLDN14), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
OHu20415
NM_001146078 Homo sapiens claudin 14 (CLDN14), transcript variant gamma, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
OHu20415
NM_001146077 Homo sapiens claudin 14 (CLDN14), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
OHu20415
NM_144492 Homo sapiens claudin 14 (CLDN14), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
OHu20415
NM_001146079 Homo sapiens claudin 14 (CLDN14), transcript variant 5, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu20415
Clone ID Related Accession (Same CDS sequence) NM_001146077 , NM_001146078 , NM_001146079 , NM_012130 , NM_144492 , XM_011529519
Accession Version NM_012130.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 720bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 26-MAY-2014
Organism Homo sapiens (human)
Product claudin-14
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY355349.1 and BC012126.1. On Jul 3, 2012 this sequence version replaced gi:21536295. Transcript Variant: This variant (epsilon) differs in the 5' UTR compared to variant 1. All five variants encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC012126.1, BM911659.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
ATGGCCAGCA CGGCCGTGCA GCTTCTGGGC TTCCTGCTCA GCTTCCTGGG CATGGTGGGC 
ACGTTGATCA CCACCATCCT GCCGCACTGG CGGAGGACAG CGCACGTGGG CACCAACATC
CTCACGGCCG TGTCCTACCT GAAAGGGCTC TGGATGGAGT GTGTGTGGCA CAGCACAGGC
ATCTACCAGT GCCAGATCTA CCGATCCCTG CTGGCGCTGC CCCAAGACCT CCAGGCTGCC
CGCGCCCTCA TGGTCATCTC CTGCCTGCTC TCGGGCATAG CCTGCGCCTG CGCCGTCATC
GGGATGAAGT GCACGCGCTG CGCCAAGGGC ACACCCGCCA AGACCACCTT TGCCATCCTC
GGCGGCACCC TCTTCATCCT GGCCGGCCTC CTGTGCATGG TGGCCGTCTC CTGGACCACC
AACGACGTGG TGCAGAACTT CTACAACCCG CTGCTGCCCA GCGGCATGAA GTTTGAGATT
GGCCAGGCCC TGTACCTGGG CTTCATCTCC TCGTCCCTCT CGCTCATTGG TGGCACCCTG
CTTTGCCTGT CCTGCCAGGA CGAGGCACCC TACAGGCCCT ACCAGGCCCC GCCCAGGGCC
ACCACGACCA CTGCAAACAC CGCACCTGCC TACCAGCCAC CAGCTGCCTA CAAAGACAAT
CGGGCCCCCT CAGTGACCTC GGCCACGCAC AGCGGGTACA GGCTGAACGA CTACGTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_036262.1
CDS157..876
Misc Feature(1)139..141(+)
Misc Feature(2)178..240(+)
Misc Feature(3)223..699(+)
Misc Feature(4)400..462(+)
Misc Feature(5)502..564(+)
Misc Feature(6)643..705(+)
Exon (1)1..75
Gene:CLDN14
Gene Synonym:
Exon (2)76..1231
Gene:CLDN14
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_012130
Organism Homo sapiens (human)
Definition Homo sapiens claudin 14 (CLDN14), transcript variant epsilon, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_012130

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGGCCAGCA CGGCCGTGCA GCTTCTGGGC TTCCTGCTCA GCTTCCTGGG CATGGTGGGC 
ACGTTGATCA CCACCATCCT GCCGCACTGG CGGAGGACAG CGCACGTGGG CACCAACATC
CTCACGGCCG TGTCCTACCT GAAAGGGCTC TGGATGGAGT GTGTGTGGCA CAGCACAGGC
ATCTACCAGT GCCAGATCTA CCGATCCCTG CTGGCGCTGC CCCAAGACCT CCAGGCTGCC
CGCGCCCTCA TGGTCATCTC CTGCCTGCTC TCGGGCATAG CCTGCGCCTG CGCCGTCATC
GGGATGAAGT GCACGCGCTG CGCCAAGGGC ACACCCGCCA AGACCACCTT TGCCATCCTC
GGCGGCACCC TCTTCATCCT GGCCGGCCTC CTGTGCATGG TGGCCGTCTC CTGGACCACC
AACGACGTGG TGCAGAACTT CTACAACCCG CTGCTGCCCA GCGGCATGAA GTTTGAGATT
GGCCAGGCCC TGTACCTGGG CTTCATCTCC TCGTCCCTCT CGCTCATTGG TGGCACCCTG
CTTTGCCTGT CCTGCCAGGA CGAGGCACCC TACAGGCCCT ACCAGGCCCC GCCCAGGGCC
ACCACGACCA CTGCAAACAC CGCACCTGCC TACCAGCCAC CAGCTGCCTA CAAAGACAAT
CGGGCCCCCT CAGTGACCTC GGCCACGCAC AGCGGGTACA GGCTGAACGA CTACGTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu20415
Clone ID Related Accession (Same CDS sequence) NM_001146077 , NM_001146078 , NM_001146079 , NM_012130 , NM_144492 , XM_011529519
Accession Version XM_011529519.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 720bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product claudin-14 isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_011512.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
ATGGCCAGCA CGGCCGTGCA GCTTCTGGGC TTCCTGCTCA GCTTCCTGGG CATGGTGGGC 
ACGTTGATCA CCACCATCCT GCCGCACTGG CGGAGGACAG CGCACGTGGG CACCAACATC
CTCACGGCCG TGTCCTACCT GAAAGGGCTC TGGATGGAGT GTGTGTGGCA CAGCACAGGC
ATCTACCAGT GCCAGATCTA CCGATCCCTG CTGGCGCTGC CCCAAGACCT CCAGGCTGCC
CGCGCCCTCA TGGTCATCTC CTGCCTGCTC TCGGGCATAG CCTGCGCCTG CGCCGTCATC
GGGATGAAGT GCACGCGCTG CGCCAAGGGC ACACCCGCCA AGACCACCTT TGCCATCCTC
GGCGGCACCC TCTTCATCCT GGCCGGCCTC CTGTGCATGG TGGCCGTCTC CTGGACCACC
AACGACGTGG TGCAGAACTT CTACAACCCG CTGCTGCCCA GCGGCATGAA GTTTGAGATT
GGCCAGGCCC TGTACCTGGG CTTCATCTCC TCGTCCCTCT CGCTCATTGG TGGCACCCTG
CTTTGCCTGT CCTGCCAGGA CGAGGCACCC TACAGGCCCT ACCAGGCCCC GCCCAGGGCC
ACCACGACCA CTGCAAACAC CGCACCTGCC TACCAGCCAC CAGCTGCCTA CAAAGACAAT
CGGGCCCCCT CAGTGACCTC GGCCACGCAC AGCGGGTACA GGCTGAACGA CTACGTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011527821.1
CDS400..1119
Misc Feature(1)466..942(+)
Translation

Target ORF information:

RefSeq Version XM_011529519
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens claudin 14 (CLDN14), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011529519

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGGCCAGCA CGGCCGTGCA GCTTCTGGGC TTCCTGCTCA GCTTCCTGGG CATGGTGGGC 
ACGTTGATCA CCACCATCCT GCCGCACTGG CGGAGGACAG CGCACGTGGG CACCAACATC
CTCACGGCCG TGTCCTACCT GAAAGGGCTC TGGATGGAGT GTGTGTGGCA CAGCACAGGC
ATCTACCAGT GCCAGATCTA CCGATCCCTG CTGGCGCTGC CCCAAGACCT CCAGGCTGCC
CGCGCCCTCA TGGTCATCTC CTGCCTGCTC TCGGGCATAG CCTGCGCCTG CGCCGTCATC
GGGATGAAGT GCACGCGCTG CGCCAAGGGC ACACCCGCCA AGACCACCTT TGCCATCCTC
GGCGGCACCC TCTTCATCCT GGCCGGCCTC CTGTGCATGG TGGCCGTCTC CTGGACCACC
AACGACGTGG TGCAGAACTT CTACAACCCG CTGCTGCCCA GCGGCATGAA GTTTGAGATT
GGCCAGGCCC TGTACCTGGG CTTCATCTCC TCGTCCCTCT CGCTCATTGG TGGCACCCTG
CTTTGCCTGT CCTGCCAGGA CGAGGCACCC TACAGGCCCT ACCAGGCCCC GCCCAGGGCC
ACCACGACCA CTGCAAACAC CGCACCTGCC TACCAGCCAC CAGCTGCCTA CAAAGACAAT
CGGGCCCCCT CAGTGACCTC GGCCACGCAC AGCGGGTACA GGCTGAACGA CTACGTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu20415
Clone ID Related Accession (Same CDS sequence) NM_001146077 , NM_001146078 , NM_001146079 , NM_012130 , NM_144492 , XM_011529519
Accession Version NM_001146078.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 720bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product claudin-14
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AI655909.1, AJ566765.1 and BC012126.1. On Jul 3, 2012 this sequence version replaced gi:225703139. Transcript Variant: This variant (gamma) differs in the 5' UTR compared to variant 1. All five variants encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ566765.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145774, SAMEA962348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
ATGGCCAGCA CGGCCGTGCA GCTTCTGGGC TTCCTGCTCA GCTTCCTGGG CATGGTGGGC 
ACGTTGATCA CCACCATCCT GCCGCACTGG CGGAGGACAG CGCACGTGGG CACCAACATC
CTCACGGCCG TGTCCTACCT GAAAGGGCTC TGGATGGAGT GTGTGTGGCA CAGCACAGGC
ATCTACCAGT GCCAGATCTA CCGATCCCTG CTGGCGCTGC CCCAAGACCT CCAGGCTGCC
CGCGCCCTCA TGGTCATCTC CTGCCTGCTC TCGGGCATAG CCTGCGCCTG CGCCGTCATC
GGGATGAAGT GCACGCGCTG CGCCAAGGGC ACACCCGCCA AGACCACCTT TGCCATCCTC
GGCGGCACCC TCTTCATCCT GGCCGGCCTC CTGTGCATGG TGGCCGTCTC CTGGACCACC
AACGACGTGG TGCAGAACTT CTACAACCCG CTGCTGCCCA GCGGCATGAA GTTTGAGATT
GGCCAGGCCC TGTACCTGGG CTTCATCTCC TCGTCCCTCT CGCTCATTGG TGGCACCCTG
CTTTGCCTGT CCTGCCAGGA CGAGGCACCC TACAGGCCCT ACCAGGCCCC GCCCAGGGCC
ACCACGACCA CTGCAAACAC CGCACCTGCC TACCAGCCAC CAGCTGCCTA CAAAGACAAT
CGGGCCCCCT CAGTGACCTC GGCCACGCAC AGCGGGTACA GGCTGAACGA CTACGTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001139550.1
CDS475..1194
Misc Feature(1)457..459(+)
Misc Feature(2)496..558(+)
Misc Feature(3)541..1017(+)
Misc Feature(4)718..780(+)
Misc Feature(5)820..882(+)
Misc Feature(6)961..1023(+)
Exon (1)1..255
Gene:CLDN14
Gene Synonym:
Exon (2)256..393
Gene:CLDN14
Gene Synonym:
Exon (3)394..1549
Gene:CLDN14
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001146078
Organism Homo sapiens (human)
Definition Homo sapiens claudin 14 (CLDN14), transcript variant gamma, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001146078

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGGCCAGCA CGGCCGTGCA GCTTCTGGGC TTCCTGCTCA GCTTCCTGGG CATGGTGGGC 
ACGTTGATCA CCACCATCCT GCCGCACTGG CGGAGGACAG CGCACGTGGG CACCAACATC
CTCACGGCCG TGTCCTACCT GAAAGGGCTC TGGATGGAGT GTGTGTGGCA CAGCACAGGC
ATCTACCAGT GCCAGATCTA CCGATCCCTG CTGGCGCTGC CCCAAGACCT CCAGGCTGCC
CGCGCCCTCA TGGTCATCTC CTGCCTGCTC TCGGGCATAG CCTGCGCCTG CGCCGTCATC
GGGATGAAGT GCACGCGCTG CGCCAAGGGC ACACCCGCCA AGACCACCTT TGCCATCCTC
GGCGGCACCC TCTTCATCCT GGCCGGCCTC CTGTGCATGG TGGCCGTCTC CTGGACCACC
AACGACGTGG TGCAGAACTT CTACAACCCG CTGCTGCCCA GCGGCATGAA GTTTGAGATT
GGCCAGGCCC TGTACCTGGG CTTCATCTCC TCGTCCCTCT CGCTCATTGG TGGCACCCTG
CTTTGCCTGT CCTGCCAGGA CGAGGCACCC TACAGGCCCT ACCAGGCCCC GCCCAGGGCC
ACCACGACCA CTGCAAACAC CGCACCTGCC TACCAGCCAC CAGCTGCCTA CAAAGACAAT
CGGGCCCCCT CAGTGACCTC GGCCACGCAC AGCGGGTACA GGCTGAACGA CTACGTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu20415
Clone ID Related Accession (Same CDS sequence) NM_001146077 , NM_001146078 , NM_001146079 , NM_012130 , NM_144492 , XM_011529519
Accession Version NM_001146077.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 720bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product claudin-14
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ566766.1 and BC012126.1. This sequence is a reference standard in the RefSeqGene project. Transcript Variant: This variant (delta) differs in the 5' UTR compared to variant 1. All five variants encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ566766.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968968, SAMEA2145774 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
ATGGCCAGCA CGGCCGTGCA GCTTCTGGGC TTCCTGCTCA GCTTCCTGGG CATGGTGGGC 
ACGTTGATCA CCACCATCCT GCCGCACTGG CGGAGGACAG CGCACGTGGG CACCAACATC
CTCACGGCCG TGTCCTACCT GAAAGGGCTC TGGATGGAGT GTGTGTGGCA CAGCACAGGC
ATCTACCAGT GCCAGATCTA CCGATCCCTG CTGGCGCTGC CCCAAGACCT CCAGGCTGCC
CGCGCCCTCA TGGTCATCTC CTGCCTGCTC TCGGGCATAG CCTGCGCCTG CGCCGTCATC
GGGATGAAGT GCACGCGCTG CGCCAAGGGC ACACCCGCCA AGACCACCTT TGCCATCCTC
GGCGGCACCC TCTTCATCCT GGCCGGCCTC CTGTGCATGG TGGCCGTCTC CTGGACCACC
AACGACGTGG TGCAGAACTT CTACAACCCG CTGCTGCCCA GCGGCATGAA GTTTGAGATT
GGCCAGGCCC TGTACCTGGG CTTCATCTCC TCGTCCCTCT CGCTCATTGG TGGCACCCTG
CTTTGCCTGT CCTGCCAGGA CGAGGCACCC TACAGGCCCT ACCAGGCCCC GCCCAGGGCC
ACCACGACCA CTGCAAACAC CGCACCTGCC TACCAGCCAC CAGCTGCCTA CAAAGACAAT
CGGGCCCCCT CAGTGACCTC GGCCACGCAC AGCGGGTACA GGCTGAACGA CTACGTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001139549.1
CDS379..1098
Misc Feature(1)361..363(+)
Misc Feature(2)400..462(+)
Misc Feature(3)445..921(+)
Misc Feature(4)622..684(+)
Misc Feature(5)724..786(+)
Misc Feature(6)865..927(+)
Exon (1)1..159
Gene:CLDN14
Gene Synonym:
Exon (2)160..297
Gene:CLDN14
Gene Synonym:
Exon (3)298..1453
Gene:CLDN14
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001146077
Organism Homo sapiens (human)
Definition Homo sapiens claudin 14 (CLDN14), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001146077

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGGCCAGCA CGGCCGTGCA GCTTCTGGGC TTCCTGCTCA GCTTCCTGGG CATGGTGGGC 
ACGTTGATCA CCACCATCCT GCCGCACTGG CGGAGGACAG CGCACGTGGG CACCAACATC
CTCACGGCCG TGTCCTACCT GAAAGGGCTC TGGATGGAGT GTGTGTGGCA CAGCACAGGC
ATCTACCAGT GCCAGATCTA CCGATCCCTG CTGGCGCTGC CCCAAGACCT CCAGGCTGCC
CGCGCCCTCA TGGTCATCTC CTGCCTGCTC TCGGGCATAG CCTGCGCCTG CGCCGTCATC
GGGATGAAGT GCACGCGCTG CGCCAAGGGC ACACCCGCCA AGACCACCTT TGCCATCCTC
GGCGGCACCC TCTTCATCCT GGCCGGCCTC CTGTGCATGG TGGCCGTCTC CTGGACCACC
AACGACGTGG TGCAGAACTT CTACAACCCG CTGCTGCCCA GCGGCATGAA GTTTGAGATT
GGCCAGGCCC TGTACCTGGG CTTCATCTCC TCGTCCCTCT CGCTCATTGG TGGCACCCTG
CTTTGCCTGT CCTGCCAGGA CGAGGCACCC TACAGGCCCT ACCAGGCCCC GCCCAGGGCC
ACCACGACCA CTGCAAACAC CGCACCTGCC TACCAGCCAC CAGCTGCCTA CAAAGACAAT
CGGGCCCCCT CAGTGACCTC GGCCACGCAC AGCGGGTACA GGCTGAACGA CTACGTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu20415
Clone ID Related Accession (Same CDS sequence) NM_001146077 , NM_001146078 , NM_001146079 , NM_012130 , NM_144492 , XM_011529519
Accession Version NM_144492.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 720bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product claudin-14
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF314090.1, AP000695.1 and BC012126.1. On Mar 27, 2009 this sequence version replaced gi:21536293. Transcript Variant: This variant (alpha) represents the longest transcript. All five variants encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF314090.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145122, SAMEA2162895 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
ATGGCCAGCA CGGCCGTGCA GCTTCTGGGC TTCCTGCTCA GCTTCCTGGG CATGGTGGGC 
ACGTTGATCA CCACCATCCT GCCGCACTGG CGGAGGACAG CGCACGTGGG CACCAACATC
CTCACGGCCG TGTCCTACCT GAAAGGGCTC TGGATGGAGT GTGTGTGGCA CAGCACAGGC
ATCTACCAGT GCCAGATCTA CCGATCCCTG CTGGCGCTGC CCCAAGACCT CCAGGCTGCC
CGCGCCCTCA TGGTCATCTC CTGCCTGCTC TCGGGCATAG CCTGCGCCTG CGCCGTCATC
GGGATGAAGT GCACGCGCTG CGCCAAGGGC ACACCCGCCA AGACCACCTT TGCCATCCTC
GGCGGCACCC TCTTCATCCT GGCCGGCCTC CTGTGCATGG TGGCCGTCTC CTGGACCACC
AACGACGTGG TGCAGAACTT CTACAACCCG CTGCTGCCCA GCGGCATGAA GTTTGAGATT
GGCCAGGCCC TGTACCTGGG CTTCATCTCC TCGTCCCTCT CGCTCATTGG TGGCACCCTG
CTTTGCCTGT CCTGCCAGGA CGAGGCACCC TACAGGCCCT ACCAGGCCCC GCCCAGGGCC
ACCACGACCA CTGCAAACAC CGCACCTGCC TACCAGCCAC CAGCTGCCTA CAAAGACAAT
CGGGCCCCCT CAGTGACCTC GGCCACGCAC AGCGGGTACA GGCTGAACGA CTACGTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_652763.1
CDS868..1587
Misc Feature(1)850..852(+)
Misc Feature(2)889..951(+)
Misc Feature(3)934..1410(+)
Misc Feature(4)1111..1173(+)
Misc Feature(5)1213..1275(+)
Misc Feature(6)1354..1416(+)
Exon (1)1..596
Gene:CLDN14
Gene Synonym:
Exon (2)597..786
Gene:CLDN14
Gene Synonym:
Exon (3)787..1942
Gene:CLDN14
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_144492
Organism Homo sapiens (human)
Definition Homo sapiens claudin 14 (CLDN14), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_144492

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGGCCAGCA CGGCCGTGCA GCTTCTGGGC TTCCTGCTCA GCTTCCTGGG CATGGTGGGC 
ACGTTGATCA CCACCATCCT GCCGCACTGG CGGAGGACAG CGCACGTGGG CACCAACATC
CTCACGGCCG TGTCCTACCT GAAAGGGCTC TGGATGGAGT GTGTGTGGCA CAGCACAGGC
ATCTACCAGT GCCAGATCTA CCGATCCCTG CTGGCGCTGC CCCAAGACCT CCAGGCTGCC
CGCGCCCTCA TGGTCATCTC CTGCCTGCTC TCGGGCATAG CCTGCGCCTG CGCCGTCATC
GGGATGAAGT GCACGCGCTG CGCCAAGGGC ACACCCGCCA AGACCACCTT TGCCATCCTC
GGCGGCACCC TCTTCATCCT GGCCGGCCTC CTGTGCATGG TGGCCGTCTC CTGGACCACC
AACGACGTGG TGCAGAACTT CTACAACCCG CTGCTGCCCA GCGGCATGAA GTTTGAGATT
GGCCAGGCCC TGTACCTGGG CTTCATCTCC TCGTCCCTCT CGCTCATTGG TGGCACCCTG
CTTTGCCTGT CCTGCCAGGA CGAGGCACCC TACAGGCCCT ACCAGGCCCC GCCCAGGGCC
ACCACGACCA CTGCAAACAC CGCACCTGCC TACCAGCCAC CAGCTGCCTA CAAAGACAAT
CGGGCCCCCT CAGTGACCTC GGCCACGCAC AGCGGGTACA GGCTGAACGA CTACGTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu20415
Clone ID Related Accession (Same CDS sequence) NM_001146077 , NM_001146078 , NM_001146079 , NM_012130 , NM_144492 , XM_011529519
Accession Version NM_001146079.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 720bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product claudin-14
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY355348.1, AP000695.1 and BC012126.1. Transcript Variant: This variant (beta) differs in the 5' UTR compared to variant 1. All five variants encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY355348.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145122, SAMEA2155590 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
ATGGCCAGCA CGGCCGTGCA GCTTCTGGGC TTCCTGCTCA GCTTCCTGGG CATGGTGGGC 
ACGTTGATCA CCACCATCCT GCCGCACTGG CGGAGGACAG CGCACGTGGG CACCAACATC
CTCACGGCCG TGTCCTACCT GAAAGGGCTC TGGATGGAGT GTGTGTGGCA CAGCACAGGC
ATCTACCAGT GCCAGATCTA CCGATCCCTG CTGGCGCTGC CCCAAGACCT CCAGGCTGCC
CGCGCCCTCA TGGTCATCTC CTGCCTGCTC TCGGGCATAG CCTGCGCCTG CGCCGTCATC
GGGATGAAGT GCACGCGCTG CGCCAAGGGC ACACCCGCCA AGACCACCTT TGCCATCCTC
GGCGGCACCC TCTTCATCCT GGCCGGCCTC CTGTGCATGG TGGCCGTCTC CTGGACCACC
AACGACGTGG TGCAGAACTT CTACAACCCG CTGCTGCCCA GCGGCATGAA GTTTGAGATT
GGCCAGGCCC TGTACCTGGG CTTCATCTCC TCGTCCCTCT CGCTCATTGG TGGCACCCTG
CTTTGCCTGT CCTGCCAGGA CGAGGCACCC TACAGGCCCT ACCAGGCCCC GCCCAGGGCC
ACCACGACCA CTGCAAACAC CGCACCTGCC TACCAGCCAC CAGCTGCCTA CAAAGACAAT
CGGGCCCCCT CAGTGACCTC GGCCACGCAC AGCGGGTACA GGCTGAACGA CTACGTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001139551.1
CDS678..1397
Misc Feature(1)660..662(+)
Misc Feature(2)699..761(+)
Misc Feature(3)744..1220(+)
Misc Feature(4)921..983(+)
Misc Feature(5)1023..1085(+)
Misc Feature(6)1164..1226(+)
Exon (1)1..596
Gene:CLDN14
Gene Synonym:
Exon (2)597..1752
Gene:CLDN14
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001146079
Organism Homo sapiens (human)
Definition Homo sapiens claudin 14 (CLDN14), transcript variant 5, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001146079

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGGCCAGCA CGGCCGTGCA GCTTCTGGGC TTCCTGCTCA GCTTCCTGGG CATGGTGGGC 
ACGTTGATCA CCACCATCCT GCCGCACTGG CGGAGGACAG CGCACGTGGG CACCAACATC
CTCACGGCCG TGTCCTACCT GAAAGGGCTC TGGATGGAGT GTGTGTGGCA CAGCACAGGC
ATCTACCAGT GCCAGATCTA CCGATCCCTG CTGGCGCTGC CCCAAGACCT CCAGGCTGCC
CGCGCCCTCA TGGTCATCTC CTGCCTGCTC TCGGGCATAG CCTGCGCCTG CGCCGTCATC
GGGATGAAGT GCACGCGCTG CGCCAAGGGC ACACCCGCCA AGACCACCTT TGCCATCCTC
GGCGGCACCC TCTTCATCCT GGCCGGCCTC CTGTGCATGG TGGCCGTCTC CTGGACCACC
AACGACGTGG TGCAGAACTT CTACAACCCG CTGCTGCCCA GCGGCATGAA GTTTGAGATT
GGCCAGGCCC TGTACCTGGG CTTCATCTCC TCGTCCCTCT CGCTCATTGG TGGCACCCTG
CTTTGCCTGT CCTGCCAGGA CGAGGCACCC TACAGGCCCT ACCAGGCCCC GCCCAGGGCC
ACCACGACCA CTGCAAACAC CGCACCTGCC TACCAGCCAC CAGCTGCCTA CAAAGACAAT
CGGGCCCCCT CAGTGACCTC GGCCACGCAC AGCGGGTACA GGCTGAACGA CTACGTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Frequency of rare allelic variation in candidate genes among individuals with low and high urinary calcium excretion
PLoS ONE 8 (8), E71885 (2013)
Toka HR, Genovese G, Mount DB, Pollak MR and Curhan GC.


book

Analysis of CLDN14 gene in deaf Moroccan patients with non-syndromic hearing loss
Gene 523 (1), 103-105 (2013)
Charif M, Bakhchane A, Abidi O, Boulouiz R, Eloualid A, Roky R, Rouba H, Kandil M, Lenaers G and Barakat A.


book

Phenotypic variability of CLDN14 mutations causing DFNB29 hearing loss in the Pakistani population
J. Hum. Genet. 58 (2), 102-108 (2013)
Bashir ZE, Latief N, Belyantseva IA, Iqbal F, Riazuddin SA, Khan SN, Friedman TB, Riazuddin S and Riazuddin S.


book

Human claudin-8 and -14 are receptors capable of conveying the cytotoxic effects of Clostridium perfringens enterotoxin
MBio 4 (1) (2013)
Shrestha A and McClane BA.


book

Impact of ancestry and common genetic variants on QT interval in African Americans
Circ Cardiovasc Genet 5 (6), 647-655 (2012)
Smith JG, Avery CL, Evans DS, Nalls MA, Meng YA, Smith EN, Palmer C, Tanaka T, Mehra R, Butler AM, Young T, Buxbaum SG, Kerr KF, Berenson GS, Schnabel RB, Li G, Ellinor PT, Magnani JW, Chen W, Bis JC, Curb JD, Hsueh WC, Rotter JI, Liu Y, Newman AB, Limacher MC, North KE, Reiner AP, Quibrera PM, Schork NJ, Singleton AB, Psaty BM, Soliman EZ, Solomon AJ, Srinivasan SR, Alonso A, Wallace R, Redline S, Zhang ZM, Post WS, Zonderman AB, Taylor HA, Murray SS, Ferrucci L, Arking DE, Evans MK, Fox ER, Sotoodehnia N, Heckbert SR, Whitsel EA and Newton-Cheh C.


book

Multifunctional strands in tight junctions
Nat. Rev. Mol. Cell Biol. 2 (4), 285-293 (2001)
Tsukita S, Furuse M and Itoh M.


book

The roles of claudin superfamily proteins in paracellular transport
Traffic 2 (2), 93-98 (2001)
Heiskala M, Peterson PA and Yang Y.


book

Mutations in the gene encoding tight junction claudin-14 cause autosomal recessive deafness DFNB29
Cell 104 (1), 165-172 (2001)
Wilcox ER, Burton QL, Naz S, Riazuddin S, Smith TN, Ploplis B, Belyantseva I, Ben-Yosef T, Liburd NA, Morell RJ, Kachar B, Wu DK, Griffith AJ, Riazuddin S and Friedman TB.


book

Tight junctions of the blood-brain barrier
Cell. Mol. Neurobiol. 20 (1), 57-76 (2000)
Kniesel U and Wolburg H.


book

Deafness and Hereditary Hearing Loss Overview
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Smith,R.J.H., Shearer,A.E., Hildebrand,M.S. and Van Camp,G.


 
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