Gene Symbol | EDC4 |
Entrez Gene ID | 23644 |
Full Name | enhancer of mRNA decapping 4 |
Synonyms | GE1,Ge-1,HEDL5,HEDLS,RCD-8,RCD8 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » EDC4 cDNA ORF clone
Gene Symbol | EDC4 |
Entrez Gene ID | 23644 |
Full Name | enhancer of mRNA decapping 4 |
Synonyms | GE1,Ge-1,HEDL5,HEDLS,RCD-8,RCD8 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_014329.4 | NP_055144.3 | enhancer of mRNA-decapping protein 4 |
NM_014329.5 | NP_055144.3 | enhancer of mRNA-decapping protein 4 |
Xenopus tropicalis (tropical clawed frog) | edc4 | XP_002935417.2 |
Pan troglodytes (chimpanzee) | EDC4 | XP_003315200.1 |
Canis lupus familiaris (dog) | EDC4 | XP_546871.3 |
Danio rerio (zebrafish) | edc4 | NP_001038550.1 |
Bos taurus (cattle) | EDC4 | XP_002694948.2 |
Mus musculus (house mouse) | Edc4 | NP_853625.1 |
Gallus gallus (chicken) | EDC4 | XP_414022.4 |
Homo sapiens (human) | EDC4 | NP_055144.3 |
Rattus norvegicus (Norway rat) | Edc4 | NP_001028240.3 |
Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)
A human microprotein that interacts with the mRNA decapping complex.
D'Lima NG, Ma J, Winkler L, Chu Q, Loh KH, Corpuz EO, Budnik BA, Lykke-Andersen J, Saghatelian A, Slavoff SA
Nature chemical biology13(2)174-180(2017 02)
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M
Cell163(3)712-23(2015 Oct)
The Assembly of EDC4 and Dcp1a into Processing Bodies Is Critical for the Translational Regulation of IL-6.
Seto E, Yoshida-Sugitani R, Kobayashi T, Toyama-Sorimachi N
PloS one10(5)e0123223(2015)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The assembly of EDC4 and Dcp1a into processing bodies is critical for the translational regulation of IL-6.
Title: The Assembly of EDC4 and Dcp1a into Processing Bodies Is Critical for the Translational Regulation of IL-6.
EDC4 is a processing body (P-body) component.
Title: CCHCR1 interacts with EDC4, suggesting its localization in P-bodies.
The data indicates that DCP2 activation by DCP1 occurs preferentially on the EDC4 scaffold, which may serve to couple DCP2 activation by DCP1 with 5'-to-3' mRNA degradation by XRN1 in human cells.
Title: The activation of the decapping enzyme DCP2 by DCP1 occurs on the EDC4 scaffold and involves a conserved loop in DCP1.
LMKB is the first protein identified to date that interacts with this portion of Ge-1. LMKB was expressed in human B and T lymphocyte cell lines; depletion of LMKB increased expression of IFI44L.
Title: LMKB/MARF1 localizes to mRNA processing bodies, interacts with Ge-1, and regulates IFI44L gene expression.
EDC4 might contribute to regulation of CoA biosynthesis in addition to its scaffold function in processing bodies
Title: EDC4 interacts with and regulates the dephospho-CoA kinase activity of CoA synthase.
The following EDC4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EDC4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu06313 | |
Clone ID Related Accession (Same CDS sequence) | NM_014329.4 , NM_014329.5 | |
Accession Version | NM_014329.4 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 4206bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-01 | |
Organism | Homo sapiens(human) | |
Product | enhancer of mRNA-decapping protein 4 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DC403765.1, BC064567.1 and AI631525.1. On Nov 5, 2011 this sequence version replaced NM_014329.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.133095.1, SRR1803617.183345.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCCTCCT GCGCGAGCAT CGACATCGAG GACGCCACGC AGCACCTGCG GGACATCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_055144.3 |
CDS | 240..4445 |
Translation |
Target ORF information:
Target ORF information:
|
NM_014329.4 |
1 | ATGGCCTCCT GCGCGAGCAT CGACATCGAG GACGCCACGC AGCACCTGCG GGACATCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu06313 | |
Clone ID Related Accession (Same CDS sequence) | NM_014329.4 , NM_014329.5 | |
Accession Version | NM_014329.5 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 4206bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-09 | |
Organism | Homo sapiens(human) | |
Product | enhancer of mRNA-decapping protein 4 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DC403765.1 and BC064567.1. On Nov 23, 2018 this sequence version replaced NM_014329.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC043616.1, SRR1803615.133095.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000358933.10/ ENSP00000351811.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGGCCTCCT GCGCGAGCAT CGACATCGAG GACGCCACGC AGCACCTGCG GGACATCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_055144.3 |
CDS | 211..4416 |
Translation |
Target ORF information:
Target ORF information:
|
NM_014329.5 |
1 | ATGGCCTCCT GCGCGAGCAT CGACATCGAG GACGCCACGC AGCACCTGCG GGACATCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Architecture of the human interactome defines protein communities and disease networks. |
A human microprotein that interacts with the mRNA decapping complex. |
A human interactome in three quantitative dimensions organized by stoichiometries and abundances. |
The Assembly of EDC4 and Dcp1a into Processing Bodies Is Critical for the Translational Regulation of IL-6. |