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GNB3 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol GNB3
Entrez Gene ID 2784
Full Name G protein subunit beta 3
Synonyms CSNB1H
General protein information
Preferred Names

G protein subunit beta 3

Names

guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
G protein, beta-3 subunit
GTP-binding regulatory protein beta-3 chain
guanine nucleotide binding protein (G protein), beta polypeptide 3
guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 3
hypertension associated protein
transducin beta chain 3

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

12

12p13.31

Summary Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit which belongs to the WD repeat G protein beta family. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014].
Disorder MIM:

139130

Disorder Html: {Hypertension, essential, susceptibility to}, 145500 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_002075.3 NP_002066.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform 1
NM_001297571.1 NP_001284500.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform 2
XM_011520953.2 XP_011519255.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1



Pan troglodytes (chimpanzee) GNB3 XP_003313511.1
Danio rerio (zebrafish) gnb3a NP_001002437.1
Rattus norvegicus (Norway rat) Gnb3 NP_068630.1
Macaca mulatta (rhesus monkey) GNB3 XP_001110494.1
Xenopus tropicalis (tropical clawed frog) gnb3 NP_001011107.1
Homo sapiens (human) GNB3 NP_002066.1
Canis lupus familiaris (dog) GNB3 NP_001003004.1
Bos taurus (cattle) GNB3 NP_001179276.1
Mus musculus (house mouse) Gnb3 NP_038558.1
Gallus gallus (chicken) GNB3 XP_004938175.1


Related articles in PubMed

Association of G-protein beta3 subunit gene C825T polymorphism with cardiac and cerebrovascular events in Chinese hypertensive patients.
Zhu W, Li J, Sun X, Hua Q
Clinical and experimental hypertension (New York, N.Y. : 1993)39(1)80-84(2017)

GNB3 C825T Polymorphism and Myocardial Recovery in Peripartum Cardiomyopathy: Results of the Multicenter Investigations of Pregnancy-Associated Cardiomyopathy Study.
Sheppard R, Hsich E, Damp J, Elkayam U, Kealey A, Ramani G, Zucker M, Alexis JD, Horne BD, Hanley-Yanez K, Pisarcik J, Halder I, Fett JD, McNamara DM,
Circulation. Heart failure9(3)e002683(2016 Mar)

Synergistic Effects of ACE Insertion/Deletion and GNB3 C825T Polymorphisms on the Efficacy of PDE-5 Inhibitor in Patients with Pulmonary Hypertension.
Nishimura R, Tanabe N, Sekine A, Kasai H, Suda R, Kato F, Jujo T, Sugiura T, Shigeta A, Sakao S, Tatsumi K
Respiration; international review of thoracic diseases91(2)132-40(2016)

Beta 3 subunit of G-protein and its influence on autonomic nervous system in patients with vasovagal syncope.
Evin L, Mitro P, Habalova V, Simurda M, Muller E, Murin P
Bratislavske lekarske listy117(3)142-7(2016)

Characterization of the splice variant Gbeta3v of the human G-protein Gbeta3 subunit.
Rosskopf D, Kielbik M, Manthey I, Bilmen G, Eisenhardt A, Siffert W
Biochimica et biophysica acta1626(1-3)33-42(2003 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Bipolar patients with the TT genotype had a lower BMI, smaller waist circumference, and lower levels of lipids and leptin than those with the CT or CC genotypes undergoing the valproic acid treatment course.
Title: A longitudinal study of the association between the GNB3 C825T polymorphism and metabolic disturbance in bipolar II patients treated with valproate.

Expressed in cone photoreceptors and ON-bipolar cells, Gbeta3 is essential in phototransduction and ON-bipolar cell signaling.
Title: Recessive Retinopathy Consequent on Mutant G-Protein β Subunit 3 (GNB3).

GNB3 TT genotype was associated with lower left ventricular ejection fraction at 6 and 12 months in women with peripartum cardiomyopathy.
Title: GNB3 C825T Polymorphism and Myocardial Recovery in Peripartum Cardiomyopathy: Results of the Multicenter Investigations of Pregnancy-Associated Cardiomyopathy Study.

The present review illustrates that the C825T polymorphism is associated with increased cardiovascular risk of death and disease in Caucasian patients, independently of other established cardiovascular risk factors.
Title: G-Protein β3-Subunit Gene C825T Polymorphism and Cardiovascular Risk: An Updated Review.

The T-allele of GNbeta3 C825Tcan increase susceptibility to depression. After stratification by ethnicity, the same association was found in the Asian subpopulation, but not the Caucasian subpopulation.
Title: The C825T Polymorphism of the G-Protein β3 Gene as a Risk Factor for Depression: A Meta-Analysis.

The following GNB3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GNB3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu28823 NM_002075.3
Latest version!
Homo sapiens G protein subunit beta 3 (GNB3), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
OHu28836 NM_001297571.1
Latest version!
Homo sapiens G protein subunit beta 3 (GNB3), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $223.30
$319.00
OHu58008 XM_011520953.2
Latest version!
Homo sapiens G protein subunit beta 3 (GNB3), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $223.30
$319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu28823
Clone ID Related Accession (Same CDS sequence) NM_002075.3
Accession Version NM_002075.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1023bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-15
Organism Homo sapiens(Human)
Product guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AU143349.1, BC002454.2, U47924.1 and BC015920.1. This sequence is a reference standard in the RefSeqGene project. On Jul 3, 2014 this sequence version replaced NM_002075.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC002454.2, AB593098.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGGGGGAGA TGGAGCAACT GCGTCAGGAA GCGGAGCAGC TCAAGAAGCA GATTGCAGAT 
GCCAGGAAAG CCTGTGCTGA CGTTACTCTG GCAGAGCTGG TGTCTGGCCT AGAGGTGGTG
GGACGAGTCC AGATGCGGAC GCGGCGGACG TTAAGGGGAC ACCTGGCCAA GATTTACGCC
ATGCACTGGG CCACTGATTC TAAGCTGCTG GTAAGTGCCT CGCAAGATGG GAAGCTGATC
GTGTGGGACA GCTACACCAC CAACAAGGTG CACGCCATCC CACTGCGCTC CTCCTGGGTC
ATGACCTGTG CCTATGCCCC ATCAGGGAAC TTTGTGGCAT GTGGGGGGCT GGACAACATG
TGTTCCATCT ACAACCTCAA ATCCCGTGAG GGCAATGTCA AGGTCAGCCG GGAGCTTTCT
GCTCACACAG GTTATCTCTC CTGCTGCCGC TTCCTGGATG ACAACAATAT TGTGACCAGC
TCGGGGGACA CCACGTGTGC CTTGTGGGAC ATTGAGACTG GGCAGCAGAA GACTGTATTT
GTGGGACACA CGGGTGACTG CATGAGCCTG GCTGTGTCTC CTGACTTCAA TCTCTTCATT
TCGGGGGCCT GTGATGCCAG TGCCAAGCTC TGGGATGTGC GAGAGGGGAC CTGCCGTCAG
ACTTTCACTG GCCACGAGTC GGACATCAAC GCCATCTGTT TCTTCCCCAA TGGAGAGGCC
ATCTGCACGG GCTCGGATGA CGCTTCCTGC CGCTTGTTTG ACCTGCGGGC AGACCAGGAG
CTGATCTGCT TCTCCCACGA GAGCATCATC TGCGGCATCA CGTCCGTGGC CTTCTCCCTC
AGTGGCCGCC TACTATTCGC TGGCTACGAC GACTTCAACT GCAATGTCTG GGACTCCATG
AAGTCTGAGC GTGTGGGCAT CCTCTCTGGC CACGATAACA GGGTGAGCTG CCTGGGAGTC
ACAGCTGACG GGATGGCTGT GGCCACAGGT TCCTGGGACA GCTTCCTCAA AATCTGGAAC
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_002066.1
CDS211..1233
Misc Feature(1)190..192
Misc Feature(2)352..1230
Misc Feature(3)<355..1230
Misc Feature(4)367..459
Misc Feature(5)order(370..372,424..426,436..438,454..459,478..483,550..552,562..564,580..585,631..636,685..687,697..699,715..720,757..759,811..813,823..825,841..846,880..885,937..939,949..951,967..972,1003..1008,1066..1068,1081..1083,1099..1104,1138..1143,1195..1197,1207..1209,1225..1230)
Misc Feature(6)382..495
Misc Feature(7)493..585
Misc Feature(8)511..633
Misc Feature(9)595..597
Misc Feature(10)631..720
Misc Feature(11)646..753
Misc Feature(12)754..846
Misc Feature(13)772..879
Misc Feature(14)880..972
Misc Feature(15)895..1005
Misc Feature(16)1012..1104
Misc Feature(17)1027..1137
Misc Feature(18)1138..1230
Misc Feature(19)1153..1227
Exon (1)1..180
Exon (2)181..267
Exon (3)268..306
Exon (4)307..413
Exon (5)414..477
Exon (6)478..640
Exon (7)641..707
Exon (8)708..909
Exon (9)910..1126
Exon (10)1127..1730
Translation

Target ORF information:

RefSeq Version NM_002075.3
Organism Homo sapiens(Human)
Definition Homo sapiens G protein subunit beta 3 (GNB3), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002075.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGGGGGAGA TGGAGCAACT GCGTCAGGAA GCGGAGCAGC TCAAGAAGCA GATTGCAGAT 
GCCAGGAAAG CCTGTGCTGA CGTTACTCTG GCAGAGCTGG TGTCTGGCCT AGAGGTGGTG
GGACGAGTCC AGATGCGGAC GCGGCGGACG TTAAGGGGAC ACCTGGCCAA GATTTACGCC
ATGCACTGGG CCACTGATTC TAAGCTGCTG GTAAGTGCCT CGCAAGATGG GAAGCTGATC
GTGTGGGACA GCTACACCAC CAACAAGGTG CACGCCATCC CACTGCGCTC CTCCTGGGTC
ATGACCTGTG CCTATGCCCC ATCAGGGAAC TTTGTGGCAT GTGGGGGGCT GGACAACATG
TGTTCCATCT ACAACCTCAA ATCCCGTGAG GGCAATGTCA AGGTCAGCCG GGAGCTTTCT
GCTCACACAG GTTATCTCTC CTGCTGCCGC TTCCTGGATG ACAACAATAT TGTGACCAGC
TCGGGGGACA CCACGTGTGC CTTGTGGGAC ATTGAGACTG GGCAGCAGAA GACTGTATTT
GTGGGACACA CGGGTGACTG CATGAGCCTG GCTGTGTCTC CTGACTTCAA TCTCTTCATT
TCGGGGGCCT GTGATGCCAG TGCCAAGCTC TGGGATGTGC GAGAGGGGAC CTGCCGTCAG
ACTTTCACTG GCCACGAGTC GGACATCAAC GCCATCTGTT TCTTCCCCAA TGGAGAGGCC
ATCTGCACGG GCTCGGATGA CGCTTCCTGC CGCTTGTTTG ACCTGCGGGC AGACCAGGAG
CTGATCTGCT TCTCCCACGA GAGCATCATC TGCGGCATCA CGTCCGTGGC CTTCTCCCTC
AGTGGCCGCC TACTATTCGC TGGCTACGAC GACTTCAACT GCAATGTCTG GGACTCCATG
AAGTCTGAGC GTGTGGGCAT CCTCTCTGGC CACGATAACA GGGTGAGCTG CCTGGGAGTC
ACAGCTGACG GGATGGCTGT GGCCACAGGT TCCTGGGACA GCTTCCTCAA AATCTGGAAC
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu28836
Clone ID Related Accession (Same CDS sequence) NM_001297571.1
Accession Version NM_001297571.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1020bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-15
Organism Homo sapiens(Human)
Product guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AU143349.1, AK313091.1, U47924.1 and BC015920.1. On Jul 3, 2014 this sequence version replaced XM_005253680.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site, in the central coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK313091.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGGGGGAGA TGGAGCAACT GCGTCAGGAA GCGGAGCAGC TCAAGAAGCA GATTGCAGAT 
GCCAGGAAAG CCTGTGCTGA CGTTACTCTG GCAGAGCTGG TGTCTGGCCT AGAGGTGGTG
GGACGAGTCC AGATGCGGAC GCGGCGGACG TTAAGGGGAC ACCTGGCCAA GATTTACGCC
ATGCACTGGG CCACTGATTC TAAGCTGCTG GTAAGTGCCT CGCAAGATGG GAAGCTGATC
GTGTGGGACA GCTACACCAC CAACAAGGTG CACGCCATCC CACTGCGCTC CTCCTGGGTC
ATGACCTGTG CCTATGCCCC ATCAGGGAAC TTTGTGGCAT GTGGGGGGCT GGACAACATG
TGTTCCATCT ACAACCTCAA ATCCCGTGAG GGCAATGTCA AGGTCAGCCG GGAGCTTTCT
GCTCACACAG GTTATCTCTC CTGCTGCCGC TTCCTGGATG ACAACAATAT TGTGACCAGC
TCGGGGGACA CCACTGCCTT GTGGGACATT GAGACTGGGC AGCAGAAGAC TGTATTTGTG
GGACACACGG GTGACTGCAT GAGCCTGGCT GTGTCTCCTG ACTTCAATCT CTTCATTTCG
GGGGCCTGTG ATGCCAGTGC CAAGCTCTGG GATGTGCGAG AGGGGACCTG CCGTCAGACT
TTCACTGGCC ACGAGTCGGA CATCAACGCC ATCTGTTTCT TCCCCAATGG AGAGGCCATC
TGCACGGGCT CGGATGACGC TTCCTGCCGC TTGTTTGACC TGCGGGCAGA CCAGGAGCTG
ATCTGCTTCT CCCACGAGAG CATCATCTGC GGCATCACGT CCGTGGCCTT CTCCCTCAGT
GGCCGCCTAC TATTCGCTGG CTACGACGAC TTCAACTGCA ATGTCTGGGA CTCCATGAAG
TCTGAGCGTG TGGGCATCCT CTCTGGCCAC GATAACAGGG TGAGCTGCCT GGGAGTCACA
GCTGACGGGA TGGCTGTGGC CACAGGTTCC TGGGACAGCT TCCTCAAAAT CTGGAACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001284500.1
CDS211..1230
Misc Feature(1)190..192
Misc Feature(2)352..1227
Misc Feature(3)<355..1227
Misc Feature(4)367..459
Misc Feature(5)order(370..372,424..426,436..438,454..459,478..483,550..552,562..564,580..585,631..636,685..687,712..717,754..756,808..810,820..822,838..843,877..882,934..936,946..948,964..969,1000..1005,1063..1065,1078..1080,1096..1101,1135..1140,1192..1194,1204..1206,1222..1227)
Misc Feature(6)382..495
Misc Feature(7)493..585
Misc Feature(8)511..633
Misc Feature(9)646..750
Misc Feature(10)751..843
Misc Feature(11)769..876
Misc Feature(12)877..969
Misc Feature(13)892..1002
Misc Feature(14)1009..1101
Misc Feature(15)1024..1134
Misc Feature(16)1135..1227
Misc Feature(17)1150..1224
Exon (1)1..180
Exon (2)181..267
Exon (3)268..306
Exon (4)307..413
Exon (5)414..477
Exon (6)478..640
Exon (7)641..704
Exon (8)705..906
Exon (9)907..1123
Exon (10)1124..1727
Translation

Target ORF information:

RefSeq Version NM_001297571.1
Organism Homo sapiens(Human)
Definition Homo sapiens G protein subunit beta 3 (GNB3), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001297571.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGGGGGAGA TGGAGCAACT GCGTCAGGAA GCGGAGCAGC TCAAGAAGCA GATTGCAGAT 
GCCAGGAAAG CCTGTGCTGA CGTTACTCTG GCAGAGCTGG TGTCTGGCCT AGAGGTGGTG
GGACGAGTCC AGATGCGGAC GCGGCGGACG TTAAGGGGAC ACCTGGCCAA GATTTACGCC
ATGCACTGGG CCACTGATTC TAAGCTGCTG GTAAGTGCCT CGCAAGATGG GAAGCTGATC
GTGTGGGACA GCTACACCAC CAACAAGGTG CACGCCATCC CACTGCGCTC CTCCTGGGTC
ATGACCTGTG CCTATGCCCC ATCAGGGAAC TTTGTGGCAT GTGGGGGGCT GGACAACATG
TGTTCCATCT ACAACCTCAA ATCCCGTGAG GGCAATGTCA AGGTCAGCCG GGAGCTTTCT
GCTCACACAG GTTATCTCTC CTGCTGCCGC TTCCTGGATG ACAACAATAT TGTGACCAGC
TCGGGGGACA CCACTGCCTT GTGGGACATT GAGACTGGGC AGCAGAAGAC TGTATTTGTG
GGACACACGG GTGACTGCAT GAGCCTGGCT GTGTCTCCTG ACTTCAATCT CTTCATTTCG
GGGGCCTGTG ATGCCAGTGC CAAGCTCTGG GATGTGCGAG AGGGGACCTG CCGTCAGACT
TTCACTGGCC ACGAGTCGGA CATCAACGCC ATCTGTTTCT TCCCCAATGG AGAGGCCATC
TGCACGGGCT CGGATGACGC TTCCTGCCGC TTGTTTGACC TGCGGGCAGA CCAGGAGCTG
ATCTGCTTCT CCCACGAGAG CATCATCTGC GGCATCACGT CCGTGGCCTT CTCCCTCAGT
GGCCGCCTAC TATTCGCTGG CTACGACGAC TTCAACTGCA ATGTCTGGGA CTCCATGAAG
TCTGAGCGTG TGGGCATCCT CTCTGGCCAC GATAACAGGG TGAGCTGCCT GGGAGTCACA
GCTGACGGGA TGGCTGTGGC CACAGGTTCC TGGGACAGCT TCCTCAAAAT CTGGAACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu58008
Clone ID Related Accession (Same CDS sequence) XM_011520953.2
Accession Version XM_011520953.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1083bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011520953.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGGGGGAGA TGGAGCAACT GCGTCAGGAA GCGGAGCAGC TCAAGAAGCA GATTGCAGAT 
GCCAGGAAAG CCTGTGCTGA CGTTACTCTG GCAGAGCTGG TGTCTGGCCT AGAGGTGGTG
GGACGAGTCC AGATGCGGAC GCGGCGGACG TTAAGGGGAC ACCTGGCCAA GATTTACGCC
ATGCACTGGG CCACTGATTC TAAGCTGCTG GTAAGTGCCT CGCAAGATGG GAAGCTGATC
GTGTGGGACA GCTACACCAC CAACAAGGTG CACGCCATCC CACTGCGCTC CTCCTGGGTC
ATGACCTGTG CCTATGCCCC ATCAGGGAAC TTTGTGGCAT GTGGGGGGCT GGACAACATG
TGTTCCATCT ACAACCTCAA ATCCCGTGAG GGCAATGTCA AGGTCAGCCG GGAGCTTTCT
GCTCACACAG GTTATCTCTC CTGCTGCCGC TTCCTGGATG ACAACAATAT TGTGACCAGC
TCGGGGGACA CCACGTGTGC CTTGTGGGAC ATTGAGACTG GGCAGCAGAA GACTGTATTT
GTGGGACACA CGGGTGACTG CATGAGCCTG GCTGTGTCTC CTGACTTCAA TCTCTTCATT
TCGGGGGCCT GTGATGCCAG TGCCAAGCTC TGGGATGTGC GAGAGGGGAC CTGCCGTCAG
ACTTTCACTG GCCACGAGTC GGACATCAAC GCCATCTGTT TCTTCCCCAA TGGAGAGGCC
ATCTGCACGG GCTCGGATGA CGCTTCCTGC CGCTTGTTTG ACCTGCGGGC AGACCAGGAG
CTGATCTGCT TCTCCCACGA GAGCATCATC TGCGGCATCA CGTCCGTGGC CTTCTCCCTC
AGTGGCCGCC TACTATTCGC TGGCTACGAC GACTTCAACT GCAATGTCTG GGACTCCATG
AAGTCTGAGC GTGTGGGTAA GGGCCAGCCC TGGCTGCTGC TTCCTCAGCT GGAAGGACCC
TCCCCAGCCC TCCCTCCCCA TTCTGTACCC CCCATCAGCT CCCATTTCGG ACTCTCTTAC
TGCTGTCCCT TGTCACTGGG TGACTCCACC CCTGGAATCC AGTACCCCTT GGTTCCCAAC
TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011519255.1
CDS143..1225
Misc Feature(1)284..1063
Misc Feature(2)<287..1063
Misc Feature(3)order(302..304,356..358,368..370,386..391,410..415,482..484,494..496,512..517,563..568,617..619,629..631,647..652,689..691,743..745,755..757,773..778,812..817,869..871,881..883,899..904,935..940,998..1000,1013..1015,1031..1036)
Misc Feature(4)314..427
Misc Feature(5)443..565
Misc Feature(6)578..685
Misc Feature(7)704..811
Misc Feature(8)827..937
Misc Feature(9)959..1096
Translation

Target ORF information:

RefSeq Version XM_011520953.2
Organism Homo sapiens(Human)
Definition Homo sapiens G protein subunit beta 3 (GNB3), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011520953.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGGGGGAGA TGGAGCAACT GCGTCAGGAA GCGGAGCAGC TCAAGAAGCA GATTGCAGAT 
GCCAGGAAAG CCTGTGCTGA CGTTACTCTG GCAGAGCTGG TGTCTGGCCT AGAGGTGGTG
GGACGAGTCC AGATGCGGAC GCGGCGGACG TTAAGGGGAC ACCTGGCCAA GATTTACGCC
ATGCACTGGG CCACTGATTC TAAGCTGCTG GTAAGTGCCT CGCAAGATGG GAAGCTGATC
GTGTGGGACA GCTACACCAC CAACAAGGTG CACGCCATCC CACTGCGCTC CTCCTGGGTC
ATGACCTGTG CCTATGCCCC ATCAGGGAAC TTTGTGGCAT GTGGGGGGCT GGACAACATG
TGTTCCATCT ACAACCTCAA ATCCCGTGAG GGCAATGTCA AGGTCAGCCG GGAGCTTTCT
GCTCACACAG GTTATCTCTC CTGCTGCCGC TTCCTGGATG ACAACAATAT TGTGACCAGC
TCGGGGGACA CCACGTGTGC CTTGTGGGAC ATTGAGACTG GGCAGCAGAA GACTGTATTT
GTGGGACACA CGGGTGACTG CATGAGCCTG GCTGTGTCTC CTGACTTCAA TCTCTTCATT
TCGGGGGCCT GTGATGCCAG TGCCAAGCTC TGGGATGTGC GAGAGGGGAC CTGCCGTCAG
ACTTTCACTG GCCACGAGTC GGACATCAAC GCCATCTGTT TCTTCCCCAA TGGAGAGGCC
ATCTGCACGG GCTCGGATGA CGCTTCCTGC CGCTTGTTTG ACCTGCGGGC AGACCAGGAG
CTGATCTGCT TCTCCCACGA GAGCATCATC TGCGGCATCA CGTCCGTGGC CTTCTCCCTC
AGTGGCCGCC TACTATTCGC TGGCTACGAC GACTTCAACT GCAATGTCTG GGACTCCATG
AAGTCTGAGC GTGTGGGTAA GGGCCAGCCC TGGCTGCTGC TTCCTCAGCT GGAAGGACCC
TCCCCAGCCC TCCCTCCCCA TTCTGTACCC CCCATCAGCT CCCATTTCGG ACTCTCTTAC
TGCTGTCCCT TGTCACTGGG TGACTCCACC CCTGGAATCC AGTACCCCTT GGTTCCCAAC
TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Association of G-protein beta3 subunit gene C825T polymorphism with cardiac and cerebrovascular events in Chinese hypertensive patients.
Clinical and experimental hypertension (New York, N.Y. : 1993)39(1)80-84(2017)
Zhu W,Li J,Sun X,Hua Q


book

GNB3 C825T Polymorphism and Myocardial Recovery in Peripartum Cardiomyopathy: Results of the Multicenter Investigations of Pregnancy-Associated Cardiomyopathy Study.
Circulation. Heart failure9(3)e002683(2016 Mar)
Sheppard R,Hsich E,Damp J,Elkayam U,Kealey A,Ramani G,Zucker M,Alexis JD,Horne BD,Hanley-Yanez K,Pisarcik J,Halder I,Fett JD,McNamara DM,


book

Synergistic Effects of ACE Insertion/Deletion and GNB3 C825T Polymorphisms on the Efficacy of PDE-5 Inhibitor in Patients with Pulmonary Hypertension.
Respiration; international review of thoracic diseases91(2)132-40(2016)
Nishimura R,Tanabe N,Sekine A,Kasai H,Suda R,Kato F,Jujo T,Sugiura T,Shigeta A,Sakao S,Tatsumi K


book

Beta 3 subunit of G-protein and its influence on autonomic nervous system in patients with vasovagal syncope.
Bratislavske lekarske listy117(3)142-7(2016)
Evin L,Mitro P,Habalova V,Simurda M,Muller E,Murin P


book

Characterization of the splice variant Gbeta3v of the human G-protein Gbeta3 subunit.
Biochimica et biophysica acta1626(1-3)33-42(2003 Apr)
Rosskopf D,Kielbik M,Manthey I,Bilmen G,Eisenhardt A,Siffert W


 
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