ABO cDNA ORF clone, Homo sapiens(human)
Gene Symbol | ABO |
Entrez Gene ID | 28 |
Full Name | ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase |
Synonyms | A3GALNT,A3GALT1,GTB,NAGAT |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes proteins related to the first discovered blood group system, ABO. Which allele is present in an individual determines the blood group. The 'O' blood group is caused by a deletion of guanine-258 near the N-terminus of the protein which results in a frameshift and translation of an almost entirely different protein. Individuals with the A, B, and AB alleles express glycosyltransferase activities that convert the H antigen into the A or B antigen. Other minor alleles have been found for this gene. [provided by RefSeq, Jul 2008]. |
Disorder MIM: | |
Disorder Html: | [Blood group, ABO system], 616093 (3) |
mRNA and Protein(s)
mRNA | Protein | Name |
---|---|---|
NM_020469.3 | NP_065202.2 | histo-blood group ABO system transferase |
NM_020469.2 | NP_065202.2 | histo-blood group ABO system transferase |

Rattus norvegicus (Norway rat) | Abo | NP_001153735.1 |
Rattus norvegicus (Norway rat) | Abo2 | NP_001258227.1 |
Mus musculus (house mouse) | Abo | NP_109643.3 |
Homo sapiens (human) | ABO | NP_065202.2 |
ABO | XP_001118424.2 | |
Canis lupus familiaris (dog) | ABO | XP_005625199.1 |
Bos taurus (cattle) | ABO | NP_001071394.1 |
Pan troglodytes (chimpanzee) | ABO | NP_001181854.1 |
Rattus norvegicus (Norway rat) | Gbgt1 | NP_075582.3 |

Related articles in PubMed
ABO transcript levels in peripheral blood and erythropoietic culture show different allele-related patterns independent of the CBF/NF-Y enhancer motif and multiple novel allele-specific variations in the 5'- and 3'-noncoding regions.
Thuresson B, Chester MA, Storry JR, Olsson ML
Transfusion48(3)493-504(2008 Mar)
Weak blood group B phenotypes may be caused by variations in the CCAAT-binding factor/NF-Y enhancer region of the ABO gene.
Seltsam A, Wagner FF, Gr?ger D, Gupta CD, Bade-Doeding C, Blasczyk R
Transfusion47(12)2330-5(2007 Dec)
Expression of the histo-blood group B gene predominates in AB-genotype cells.
Twu YC, Hsieh CY, Yu LC
Transfusion46(11)1988-96(2006 Nov)
ABO blood group determines plasma von Willebrand factor levels: a biologic function after all?
Jenkins PV, O'Donnell JS
Transfusion46(10)1836-44(2006 Oct)
Evolution of the O alleles of the human ABO blood group gene.
Roubinet F, Despiau S, Calafell F, Jin F, Bertranpetit J, Saitou N, Blancher A, Bertanpetit J
Transfusion44(5)707-15(2004 May)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
an ABO exonic missense mutation affects B-antigen expression by decreasing the mRNA level of the ABO gene
Title: An exonic missense mutation c.28G>A is associated with weak B blood group by affecting RNA splicing of the ABO gene.
Binding either of the donor substrate UDP-Gal or of UDP induces a semiclosed conformation of blood group glycosyltransferases A and B.
Title: Protein NMR Studies of Substrate Binding to Human Blood Group?A and B Glycosyltransferases.
Kinetic analysis of GTA and GTB point mutants E303C, E303D, E303Q and E303A shows that despite the enzymes having nearly identical sequences, the corresponding mutants of GTA/GTB have up to a 13-fold difference in their residual activities relative to wild type
Title: Glycosyltransfer in mutants of putative catalytic residue Glu303 of the human ABO(H) A and B blood group glycosyltransferases GTA and GTB proceeds through a labile active site.
These results support the contention that ABO expression is dependent upon a downstream positive regulatory element functioning through a tissue-restricted transcription factor, Elf5, in epithelial cells.
Title: Epithelial Expression of Human ABO Blood Group Genes Is Dependent upon a Downstream Regulatory Element Functioning through an Epithelial Cell-specific Transcription Factor, Elf5.
Our findings indicated that genetic variations of ABO gene may contribute to susceptibility of large artery atherosclerosis but not ischemic stroke and small vessel diseases in the Chinese population
Title: Association study of polymorphisms in the ABO gene with ischemic stroke in the Chinese population.
The following ABO gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ABO cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OHu18243![]() |
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Clone ID Related Accession (Same CDS sequence) | NM_020469.3 , NM_020469.2 | |
Accession Version | NM_020469.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1065bp) Protein sequence SNP |
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Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-17 | |
Organism | Homo sapiens(human) | |
Product | histo-blood group ABO system transferase | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AV761252.1, AF134412.1, U15197.1 and AL772161.10. This sequence is a reference standard in the RefSeqGene project. On Sep 25, 2018 this sequence version replaced NM_020469.2. Sequence Note: This RefSeq record represents the ABO*A1.01 allele. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: JX519570.1, JX519569.1 [ECO:0000331] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## |
1 | ATGGCCGAGG TGTTGCGGAC GCTGGCCGGA AAACCAAAAT GCCACGCACT TCGACCTATG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_065202.2 |
CDS | 13..1077 |
Translation |

Target ORF information:
Target ORF information:
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ORF Insert Sequence:
1 | ATGGCCGAGG TGTTGCGGAC GCTGGCCGGA AAACCAAAAT GCCACGCACT TCGACCTATG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu18243![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_020469.3 , NM_020469.2 | |
Accession Version | NM_020469.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1065bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-28 | |
Organism | Homo sapiens(human) | |
Product | histo-blood group ABO system transferase | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AV761252.1, AF134412.1 and U15197.1. This sequence is a reference standard in the RefSeqGene project. On Jan 29, 2005 this sequence version replaced NM_020469.1. Sequence Note: This RefSeq record represents the ABO*A1.01.1.1 allele. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: JX519569.1, JX519570.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGGCCGAGG TGTTGCGGAC GCTGGCCGGA AAACCAAAAT GCCACGCACT TCGACCTATG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_065202.2 |
CDS | 26..1090 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGCCGAGG TGTTGCGGAC GCTGGCCGGA AAACCAAAAT GCCACGCACT TCGACCTATG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
![]() |
ABO transcript levels in peripheral blood and erythropoietic culture show different allele-related patterns independent of the CBF/NF-Y enhancer motif and multiple novel allele-specific variations in the 5'- and 3'-noncoding regions. |
![]() |
Weak blood group B phenotypes may be caused by variations in the CCAAT-binding factor/NF-Y enhancer region of the ABO gene. |
![]() |
Expression of the histo-blood group B gene predominates in AB-genotype cells. |
![]() |
ABO blood group determines plasma von Willebrand factor levels: a biologic function after all? |
![]() |
Evolution of the O alleles of the human ABO blood group gene. |