SLC39A2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SLC39A2
Entrez Gene ID	29986
Full Name	solute carrier family 39 member 2
Synonyms	6A1,ETI-1,ZIP-2,ZIP2
General protein information	Preferred Names solute carrier family 39 member 2 Names zinc transporter ZIP2 Zrt- and Irt-like protein 2 solute carrier family 39 (zinc transporter), member 2 zinc uptake transporter 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q11.2
Summary	This gene encodes a member of the ZIP family of metal ion transporters. The encoded protein functions as a zinc transporter. Mutations in this gene may be associated with susceptibility to carotid artery disease. Multiple transcript variants have been described. [provided by RefSeq, Mar 2010].
Disorder MIM:	612166

mRNA and Protein(s)

mRNA	Protein	Name
NM_014579.4	NP_055394.2	zinc transporter ZIP2 isoform a
NM_001256588.2	NP_001243517.1	zinc transporter ZIP2 isoform b
NM_001256588.1	NP_001243517.1	zinc transporter ZIP2 isoform b
NM_014579.3	NP_055394.2	zinc transporter ZIP2 isoform a

Pathways from BioSystems

Homologies

Oryza sativa (rice)	Os01g0972200	NP_001045540.1
	SLC39A2	XP_001093488.1
Bos taurus (cattle)	SLC39A2	NP_001192577.1
Pan troglodytes (chimpanzee)	SLC39A2	XP_520676.2
Canis lupus familiaris (dog)	SLC39A2	XP_539681.3
Mus musculus (house mouse)	Slc39a2	NP_001034765.2
Arabidopsis thaliana (thale cress)	ZIP2	NP_200760.1
Homo sapiens (human)	SLC39A2	NP_055394.2
Rattus norvegicus (Norway rat)	Slc39a2	NP_001100730.1
Xenopus tropicalis (tropical clawed frog)	LOC100496006	XP_002934324.1

Gene Ontology
Bibliography

Related articles in PubMed

Zinc Deficiency via a Splice Switch in Zinc Importer ZIP2/SLC39A2 Causes Cystic Fibrosis-Associated MUC5AC Hypersecretion in Airway Epithelial Cells.
Kamei S, Fujikawa H, Nohara H, Ueno-Shuto K, Maruta K, Nakashima R, Kawakami T, Matsumoto C, Sakaguchi Y, Ono T, Suico MA, Boucher RC, Gruenert DC, Takeo T, Nakagata N, Li JD, Kai H, Shuto T
EBioMedicine(2017 Dec)

Zinc deficiency and low enterocyte zinc transporter expression in human patients with autism related mutations in SHANK3.
Pfaender S, Sauer AK, Hagmeyer S, Mangus K, Linta L, Liebau S, Bockmann J, Huguet G, Bourgeron T, Boeckers TM, Grabrucker AM
Scientific reports745190(2017 Mar)

Effect of ZIP2 Gln/Arg/Leu (rs2234632) polymorphism on zinc homeostasis and inflammatory response following zinc supplementation.
Giacconi R, Costarelli L, Malavolta M, Cardelli M, Galeazzi R, Piacenza F, Gasparini N, Basso A, Mariani E, Fulop T, Rink L, Dedoussis G, Herbein G, Jajte J, Provinciali M, Busco F, Mocchegiani E
BioFactors (Oxford, England)41(6)414-23(2015 Nov-Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ZIP2 Gln/Arg/Leu polymorphism involve in proinflammatory mediation and zinc homeostasis in elderly population with a more pronounced anti-inflammatory effect of zinc supplementation in subjects carrying ZIP2 Leu- (Arg43Arg) genotype
Title: Effect of ZIP2 Gln/Arg/Leu (rs2234632) polymorphism on zinc homeostasis and inflammatory response following zinc supplementation.

results of this study suggest that ZIP2, a zinc transporter expressed specifically in the epidermis, and zinc taken up by ZIP2 are necessary for the differentiation of keratinocytes
Title: ZIP2 protein, a zinc transporter, is associated with keratinocyte differentiation.

Data indicate that the average expression level of zinc transporter Zip2 was significantly higher and zinc transporters Zip6, Zip8 mRNA levels were significantly lower in short stature children than in health controls.
Title: Zip1, Zip2, and Zip8 mRNA expressions were associated with growth hormone level during the growth hormone provocation test in children with short stature.

Increased expression of Zip2 gene is closely associated with immunity of pulmonary tuberculosis patients, suggesting that the Zip2 gene may play a key role in initial infection control.
Title: Up-regulation of Slc39A2(Zip2) mRNA in peripheral blood mononuclear cells from patients with pulmonary tuberculosis.

Expression of two Zn2+ influx transporters, ZIP2 and ZIP4, is reduced as a function of retinal pigment epithelium age.
Title: ZIP2 and ZIP4 mediate age-related zinc fluxes across the retinal pigment epithelium.

The following SLC39A2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLC39A2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22751	NM_014579.4 Latest version!	Homo sapiens solute carrier family 39 member 2 (SLC39A2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu22669	NM_001256588.2 Latest version!	Homo sapiens solute carrier family 39 member 2 (SLC39A2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu22669	NM_001256588.1	Homo sapiens solute carrier family 39 member 2 (SLC39A2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu22751	NM_014579.3	Homo sapiens solute carrier family 39 member 2 (SLC39A2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SLC39A2 ( NM_014579.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055394.2 Homo sapiens solute carrier family 39 member 2 (SLC39A2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22751
Clone ID Related Accession (Same CDS sequence)	NM_014579.4 , NM_014579.3
Accession Version	NM_014579.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 930bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-15
Organism	Homo sapiens(human)
Product	zinc transporter ZIP2 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK314974.1 and D83039.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_014579.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF186081.1, D83039.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000298681.5/ ENSP00000298681.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGCAAC TACTAGGAAT AAAACTTGGC TGCCTGTTTG CCCTGTTGGC TCTCACTCTG 
GGCTGTGGCC TTACTCCCAT CTGCTTCAAA TGGTTCCAGA TTGATGCAGC CAGAGGTCAT 
CACCGGCTAG TCCTCAGACT CCTGGGCTGT ATTTCTGCTG GTGTTTTCCT GGGAGCAGGG 
TTCATGCATA TGACTGCTGA AGCCCTGGAG GAAATTGAAT CACAGATTCA GAAGTTCATG 
GTGCAGAACA GATCAGCAAG TGAGAGAAAT TCTTCTGGTG ATGCTGATTC AGCTCATATG 
GAGTATCCCT ATGGAGAGCT CATCATCTCC CTGGGCTTCT TTTTTGTCTT CTTTTTGGAG 
TCGCTGGCAT TGCAGTGCTG TCCTGGGGCT GCTGGAGGAT CGACAGTGCA GGACGAAGAA 
TGGGGTGGGG CTCATATCTT CGAACTCCAC AGCCATGGAC ATTTACCCTC ACCCTCAAAG 
GGTCCCCTCC GAGCCCTTGT CCTCTTGCTG TCACTCTCCT TTCACTCAGT GTTTGAAGGG 
CTAGCTGTGG GGCTGCAGCC GACAGTAGCA GCTACCGTGC AGCTCTGCCT TGCTGTCCTG 
GCTCATAAGG GGCTTGTGGT GTTTGGTGTA GGAATGCGGC TAGTGCATTT AGGTACCAGC 
TCACGATGGG CAGTGTTCTC CATACTATTA TTAGCTCTCA TGTCCCCCCT GGGCCTAGCC 
GTAGGGCTGG CTGTGACTGG AGGGGACTCT GAAGGAGGGC GGGGCTTAGC CCAGGCTGTG 
TTAGAGGGTG TGGCAGCTGG TACCTTCCTG TATGTCACCT TCCTAGAAAT TCTTCCACGG 
GAGCTAGCTA GTCCTGAGGC CCCTCTAGCT AAGTGGAGCT GTGTAGCCGC TGGTTTTGCC 
TTCATGGCCT TTATTGCCTT GTGGGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055394.2
CDS	155..1084
Translation	MEQLLGIKLGCLFALLALTLGCGLTPICFKWFQIDAARGHHRLVLRLLGCISAGVFLGAGFMHMTAEALEEIESQIQKFMVQNRSASERNSSGDADSAHMEYPYGELIISLGFFFVFFLESLALQCCPGAAGGSTVQDEEWGGAHIFELHSHGHLPSPSKGPLRALVLLLSLSFHSVFEGLAVGLQPTVAATVQLCLAVLAHKGLVVFGVGMRLVHLGTSSRWAVFSILLLALMSPLGLAVGLAVTGGDSEGGRGLAQAVLEGVAAGTFLYVTFLEILPRELASPEAPLAKWSCVAAGFAFMAFIALWA

Target ORF information:

RefSeq Version	NM_014579.4
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 39 member 2 (SLC39A2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014579.4

ORF Insert Sequence:

ATGGAGCAAC TACTAGGAAT AAAACTTGGC TGCCTGTTTG CCCTGTTGGC TCTCACTCTG 
GGCTGTGGCC TTACTCCCAT CTGCTTCAAA TGGTTCCAGA TTGATGCAGC CAGAGGTCAT 
CACCGGCTAG TCCTCAGACT CCTGGGCTGT ATTTCTGCTG GTGTTTTCCT GGGAGCAGGG 
TTCATGCATA TGACTGCTGA AGCCCTGGAG GAAATTGAAT CACAGATTCA GAAGTTCATG 
GTGCAGAACA GATCAGCAAG TGAGAGAAAT TCTTCTGGTG ATGCTGATTC AGCTCATATG 
GAGTATCCCT ATGGAGAGCT CATCATCTCC CTGGGCTTCT TTTTTGTCTT CTTTTTGGAG 
TCGCTGGCAT TGCAGTGCTG TCCTGGGGCT GCTGGAGGAT CGACAGTGCA GGACGAAGAA 
TGGGGTGGGG CTCATATCTT CGAACTCCAC AGCCATGGAC ATTTACCCTC ACCCTCAAAG 
GGTCCCCTCC GAGCCCTTGT CCTCTTGCTG TCACTCTCCT TTCACTCAGT GTTTGAAGGG 
CTAGCTGTGG GGCTGCAGCC GACAGTAGCA GCTACCGTGC AGCTCTGCCT TGCTGTCCTG 
GCTCATAAGG GGCTTGTGGT GTTTGGTGTA GGAATGCGGC TAGTGCATTT AGGTACCAGC 
TCACGATGGG CAGTGTTCTC CATACTATTA TTAGCTCTCA TGTCCCCCCT GGGCCTAGCC 
GTAGGGCTGG CTGTGACTGG AGGGGACTCT GAAGGAGGGC GGGGCTTAGC CCAGGCTGTG 
TTAGAGGGTG TGGCAGCTGG TACCTTCCTG TATGTCACCT TCCTAGAAAT TCTTCCACGG 
GAGCTAGCTA GTCCTGAGGC CCCTCTAGCT AAGTGGAGCT GTGTAGCCGC TGGTTTTGCC 
TTCATGGCCT TTATTGCCTT GTGGGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLC39A2 ( NM_014579.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055394.2 Homo sapiens solute carrier family 39 member 2 (SLC39A2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22751
Clone ID Related Accession (Same CDS sequence)	NM_014579.4 , NM_014579.3
Accession Version	NM_014579.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 930bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	zinc transporter ZIP2 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL355922.4, AK314974.1 and D83039.1. This sequence is a reference standard in the RefSeqGene project. On Mar 27, 2010 this sequence version replaced NM_014579.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D83039.1, AF186081.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCAAC TACTAGGAAT AAAACTTGGC TGCCTGTTTG CCCTGTTGGC TCTCACTCTG 
GGCTGTGGCC TTACTCCCAT CTGCTTCAAA TGGTTCCAGA TTGATGCAGC CAGAGGTCAT 
CACCGGCTAG TCCTCAGACT CCTGGGCTGT ATTTCTGCTG GTGTTTTCCT GGGAGCAGGG 
TTCATGCATA TGACTGCTGA AGCCCTGGAG GAAATTGAAT CACAGATTCA GAAGTTCATG 
GTGCAGAACA GATCAGCAAG TGAGAGAAAT TCTTCTGGTG ATGCTGATTC AGCTCATATG 
GAGTATCCCT ATGGAGAGCT CATCATCTCC CTGGGCTTCT TTTTTGTCTT CTTTTTGGAG 
TCGCTGGCAT TGCAGTGCTG TCCTGGGGCT GCTGGAGGAT CGACAGTGCA GGACGAAGAA 
TGGGGTGGGG CTCATATCTT CGAACTCCAC AGCCATGGAC ATTTACCCTC ACCCTCAAAG 
GGTCCCCTCC GAGCCCTTGT CCTCTTGCTG TCACTCTCCT TTCACTCAGT GTTTGAAGGG 
CTAGCTGTGG GGCTGCAGCC GACAGTAGCA GCTACCGTGC AGCTCTGCCT TGCTGTCCTG 
GCTCATAAGG GGCTTGTGGT GTTTGGTGTA GGAATGCGGC TAGTGCATTT AGGTACCAGC 
TCACGATGGG CAGTGTTCTC CATACTATTA TTAGCTCTCA TGTCCCCCCT GGGCCTAGCC 
GTAGGGCTGG CTGTGACTGG AGGGGACTCT GAAGGAGGGC GGGGCTTAGC CCAGGCTGTG 
TTAGAGGGTG TGGCAGCTGG TACCTTCCTG TATGTCACCT TCCTAGAAAT TCTTCCACGG 
GAGCTAGCTA GTCCTGAGGC CCCTCTAGCT AAGTGGAGCT GTGTAGCCGC TGGTTTTGCC 
TTCATGGCCT TTATTGCCTT GTGGGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055394.2
CDS	193..1122
Translation	MEQLLGIKLGCLFALLALTLGCGLTPICFKWFQIDAARGHHRLVLRLLGCISAGVFLGAGFMHMTAEALEEIESQIQKFMVQNRSASERNSSGDADSAHMEYPYGELIISLGFFFVFFLESLALQCCPGAAGGSTVQDEEWGGAHIFELHSHGHLPSPSKGPLRALVLLLSLSFHSVFEGLAVGLQPTVAATVQLCLAVLAHKGLVVFGVGMRLVHLGTSSRWAVFSILLLALMSPLGLAVGLAVTGGDSEGGRGLAQAVLEGVAAGTFLYVTFLEILPRELASPEAPLAKWSCVAAGFAFMAFIALWA

Target ORF information:

RefSeq Version	NM_014579.3
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 39 member 2 (SLC39A2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014579.3

ORF Insert Sequence:

ATGGAGCAAC TACTAGGAAT AAAACTTGGC TGCCTGTTTG CCCTGTTGGC TCTCACTCTG 
GGCTGTGGCC TTACTCCCAT CTGCTTCAAA TGGTTCCAGA TTGATGCAGC CAGAGGTCAT 
CACCGGCTAG TCCTCAGACT CCTGGGCTGT ATTTCTGCTG GTGTTTTCCT GGGAGCAGGG 
TTCATGCATA TGACTGCTGA AGCCCTGGAG GAAATTGAAT CACAGATTCA GAAGTTCATG 
GTGCAGAACA GATCAGCAAG TGAGAGAAAT TCTTCTGGTG ATGCTGATTC AGCTCATATG 
GAGTATCCCT ATGGAGAGCT CATCATCTCC CTGGGCTTCT TTTTTGTCTT CTTTTTGGAG 
TCGCTGGCAT TGCAGTGCTG TCCTGGGGCT GCTGGAGGAT CGACAGTGCA GGACGAAGAA 
TGGGGTGGGG CTCATATCTT CGAACTCCAC AGCCATGGAC ATTTACCCTC ACCCTCAAAG 
GGTCCCCTCC GAGCCCTTGT CCTCTTGCTG TCACTCTCCT TTCACTCAGT GTTTGAAGGG 
CTAGCTGTGG GGCTGCAGCC GACAGTAGCA GCTACCGTGC AGCTCTGCCT TGCTGTCCTG 
GCTCATAAGG GGCTTGTGGT GTTTGGTGTA GGAATGCGGC TAGTGCATTT AGGTACCAGC 
TCACGATGGG CAGTGTTCTC CATACTATTA TTAGCTCTCA TGTCCCCCCT GGGCCTAGCC 
GTAGGGCTGG CTGTGACTGG AGGGGACTCT GAAGGAGGGC GGGGCTTAGC CCAGGCTGTG 
TTAGAGGGTG TGGCAGCTGG TACCTTCCTG TATGTCACCT TCCTAGAAAT TCTTCCACGG 
GAGCTAGCTA GTCCTGAGGC CCCTCTAGCT AAGTGGAGCT GTGTAGCCGC TGGTTTTGCC 
TTCATGGCCT TTATTGCCTT GTGGGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLC39A2 ( NM_001256588.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001243517.1 Homo sapiens solute carrier family 39 member 2 (SLC39A2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu22669
Clone ID Related Accession (Same CDS sequence)	NM_001256588.2 , NM_001256588.1
Accession Version	NM_001256588.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 258bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-15
Organism	Homo sapiens(human)
Product	zinc transporter ZIP2 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP359281.1, BC098274.1, CN306082.1 and AI382710.1. On Jun 1, 2019 this sequence version replaced NM_001256588.1. Transcript Variant: This variant (2) uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct and significantly shorter C-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC098274.1, CN306082.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCAAC TACTAGGAAT AAAACTTGGC TGCCTGTTTG CCCTGTTGGC TCTCACTCTG 
GGCTGTGGCC TTACTCCCAT CTGCTTCAAA TGGTTCCAGA TTGATGCAGC CAGAGGTCAT 
CACCGGCTAG TCCTCAGACT CCTGGGCTGT ATTTCTGCTG GTGTTTTCCT GGGAGCAGGG 
TTCATGCATA TGACTGCTGA AGCCCTGGAG GAAATTGAAT CACAGATTCA GAAGTTCATG 
GTGCAGATCA GCAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001243517.1
CDS	155..412
Translation	MEQLLGIKLGCLFALLALTLGCGLTPICFKWFQIDAARGHHRLVLRLLGCISAGVFLGAGFMHMTAEALEEIESQIQKFMVQISK

Target ORF information:

RefSeq Version	NM_001256588.2
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 39 member 2 (SLC39A2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001256588.2

ORF Insert Sequence:

ATGGAGCAAC TACTAGGAAT AAAACTTGGC TGCCTGTTTG CCCTGTTGGC TCTCACTCTG 
GGCTGTGGCC TTACTCCCAT CTGCTTCAAA TGGTTCCAGA TTGATGCAGC CAGAGGTCAT 
CACCGGCTAG TCCTCAGACT CCTGGGCTGT ATTTCTGCTG GTGTTTTCCT GGGAGCAGGG 
TTCATGCATA TGACTGCTGA AGCCCTGGAG GAAATTGAAT CACAGATTCA GAAGTTCATG 
GTGCAGATCA GCAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLC39A2 ( NM_001256588.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001243517.1 Homo sapiens solute carrier family 39 member 2 (SLC39A2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu22669
Clone ID Related Accession (Same CDS sequence)	NM_001256588.2 , NM_001256588.1
Accession Version	NM_001256588.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 258bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	zinc transporter ZIP2 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP359281.1, AL355922.4, BC098274.1, CN306082.1 and AI382710.1. On Feb 11, 2012 this sequence version replaced NR_033419.1. Transcript Variant: This variant (2) uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct and significantly shorter C-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC098274.1, CN306082.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCAAC TACTAGGAAT AAAACTTGGC TGCCTGTTTG CCCTGTTGGC TCTCACTCTG 
GGCTGTGGCC TTACTCCCAT CTGCTTCAAA TGGTTCCAGA TTGATGCAGC CAGAGGTCAT 
CACCGGCTAG TCCTCAGACT CCTGGGCTGT ATTTCTGCTG GTGTTTTCCT GGGAGCAGGG 
TTCATGCATA TGACTGCTGA AGCCCTGGAG GAAATTGAAT CACAGATTCA GAAGTTCATG 
GTGCAGATCA GCAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001243517.1
CDS	193..450
Translation	MEQLLGIKLGCLFALLALTLGCGLTPICFKWFQIDAARGHHRLVLRLLGCISAGVFLGAGFMHMTAEALEEIESQIQKFMVQISK

Target ORF information:

RefSeq Version	NM_001256588.1
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 39 member 2 (SLC39A2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001256588.1

ORF Insert Sequence:

ATGGAGCAAC TACTAGGAAT AAAACTTGGC TGCCTGTTTG CCCTGTTGGC TCTCACTCTG 
GGCTGTGGCC TTACTCCCAT CTGCTTCAAA TGGTTCCAGA TTGATGCAGC CAGAGGTCAT 
CACCGGCTAG TCCTCAGACT CCTGGGCTGT ATTTCTGCTG GTGTTTTCCT GGGAGCAGGG 
TTCATGCATA TGACTGCTGA AGCCCTGGAG GAAATTGAAT CACAGATTCA GAAGTTCATG 
GTGCAGATCA GCAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Zinc Deficiency via a Splice Switch in Zinc Importer ZIP2/SLC39A2 Causes Cystic Fibrosis-Associated MUC5AC Hypersecretion in Airway Epithelial Cells.
EBioMedicine(2017 Dec)
Kamei S,Fujikawa H,Nohara H,Ueno-Shuto K,Maruta K,Nakashima R,Kawakami T,Matsumoto C,Sakaguchi Y,Ono T,Suico MA,Boucher RC,Gruenert DC,Takeo T,Nakagata N,Li JD,Kai H,Shuto T

Zinc deficiency and low enterocyte zinc transporter expression in human patients with autism related mutations in SHANK3.
Scientific reports745190(2017 Mar)
Pfaender S,Sauer AK,Hagmeyer S,Mangus K,Linta L,Liebau S,Bockmann J,Huguet G,Bourgeron T,Boeckers TM,Grabrucker AM

Effect of ZIP2 Gln/Arg/Leu (rs2234632) polymorphism on zinc homeostasis and inflammatory response following zinc supplementation.
BioFactors (Oxford, England)41(6)414-23(2015 Nov-Dec)
Giacconi R,Costarelli L,Malavolta M,Cardelli M,Galeazzi R,Piacenza F,Gasparini N,Basso A,Mariani E,Fulop T,Rink L,Dedoussis G,Herbein G,Jajte J,Provinciali M,Busco F,Mocchegiani E

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SLC39A2 cDNA ORF clone, Homo sapiens(human)

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