About the G alpha (i) signalling events pathway
The heterotrimeric G protein Gz, is a member of the Gi family. Unlike other Gi family members it lacks an ADP ribosylation site cysteine four residues from the carboxyl terminus and is thus pertussis toxin-insensitive. It inhibits adenylyl cyclase types I, V and VI. G alpha (z) interacts with the Rap1 GTPase activating protein (Rap1GAP) to attenuate Rap1 signaling. Like all G-proteins Gz has an intrinsic GTPase activity, but this activity tends to be lower for the pertussis toxin insensitive G-proteins, most strikingly so for Gz, whose kcat value for GTP hydrolysis is 200-fold lower than those of Gs or Gi (Grazziano et al. 1989). Gz knockout mice have disrupted platelet aggregation at physiological concentrations of epinephrine and responses to several neuroactive drugs are altered (Yang et al. 2000).
The longest variant of each gene is displayed. Click the see gene variants link to see all gene variants.
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| Gene Symbol | Full Name |
|---|---|
| ADCY1 | adenylate cyclase 1 (brain) |
| ADCY2 | adenylate cyclase 2 (brain) |
| ADCY3 | adenylate cyclase 3 |
| ADCY5 | adenylate cyclase 5 |
| ADCY6 | adenylate cyclase 6 |
| ADCY7 | adenylate cyclase 7 |
| ADCY8 | adenylate cyclase 8 (brain) |
| ADCY9 | adenylate cyclase 9 |
| ADORA1 | adenosine A1 receptor |
| ADORA3 | adenosine A3 receptor |
| ADRA2A | adrenoceptor alpha 2A |
| ADRA2B | adrenoceptor alpha 2B |
| ADRA2C | adrenoceptor alpha 2C |
| AGT | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
| AGTR2 | angiotensin II receptor, type 2 |
| APLNR | apelin receptor |
| ANXA1 | annexin A1 |
| APP | amyloid beta (A4) precursor protein |
| OPN1SW | opsin 1 (cone pigments), short-wave-sensitive |
| BDKRB1 | bradykinin receptor B1 |
| BDKRB2 | bradykinin receptor B2 |
| CXCR5 | chemokine (C-X-C motif) receptor 5 |
| C3 | complement component 3 |
| C3AR1 | complement component 3a receptor 1 |
| C5 | complement component 5 |
| C5AR1 | complement component 5a receptor 1 |
| CASR | calcium-sensing receptor |
| CHRM2 | cholinergic receptor, muscarinic 2 |
| CHRM4 | cholinergic receptor, muscarinic 4 |
| CCR1 | chemokine (C-C motif) receptor 1 |
| CCR3 | chemokine (C-C motif) receptor 3 |
| CCR4 | chemokine (C-C motif) receptor 4 |
| CCR5 | chemokine (C-C motif) receptor 5 (gene/pseudogene) |
| CCR6 | chemokine (C-C motif) receptor 6 |
| CCR7 | chemokine (C-C motif) receptor 7 |
| CCR8 | chemokine (C-C motif) receptor 8 |
| CNR1 | cannabinoid receptor 1 (brain) |
| CNR2 | cannabinoid receptor 2 (macrophage) |
| DRD2 | dopamine receptor D2 |
| DRD3 | dopamine receptor D3 |
| DRD4 | dopamine receptor D4 |
| S1PR1 | sphingosine-1-phosphate receptor 1 |
| LPAR1 | lysophosphatidic acid receptor 1 |
| S1PR3 | sphingosine-1-phosphate receptor 3 |
| FPR1 | formyl peptide receptor 1 |
| FPR2 | formyl peptide receptor 2 |
| FPR3 | formyl peptide receptor 3 |
| GABBR1 | gamma-aminobutyric acid (GABA) B receptor, 1 |
| GALR1 | galanin receptor 1 |
| OPN1MW | opsin 1 (cone pigments), medium-wave-sensitive |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 |
| GNAI2 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 |
| GNAS | GNAS complex locus |
| GNAT1 | guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 |
| GNAT2 | guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 |
| GNAZ | guanine nucleotide binding protein (G protein), alpha z polypeptide |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 |
| GNB2 | guanine nucleotide binding protein (G protein), beta polypeptide 2 |
| GNB3 | guanine nucleotide binding protein (G protein), beta polypeptide 3 |
| GNG3 | guanine nucleotide binding protein (G protein), gamma 3 |
| GNG4 | guanine nucleotide binding protein (G protein), gamma 4 |
| GNG5 | guanine nucleotide binding protein (G protein), gamma 5 |
| GNG7 | guanine nucleotide binding protein (G protein), gamma 7 |
| GNG10 | guanine nucleotide binding protein (G protein), gamma 10 |
| GNG11 | guanine nucleotide binding protein (G protein), gamma 11 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 |
| GNGT2 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 |
| CCR10 | chemokine (C-C motif) receptor 10 |
| NPBWR1 | neuropeptides B/W receptor 1 |
| NPBWR2 | neuropeptides B/W receptor 2 |
| CXCR3 | chemokine (C-X-C motif) receptor 3 |
| GPR17 | G protein-coupled receptor 17 |
| GPR18 | G protein-coupled receptor 18 |
| MCHR1 | melanin-concentrating hormone receptor 1 |
| GPER1 | G protein-coupled estrogen receptor 1 |
| GRM2 | glutamate receptor, metabotropic 2 |
| GRM3 | glutamate receptor, metabotropic 3 |
| GRM4 | glutamate receptor, metabotropic 4 |
| GRM6 | glutamate receptor, metabotropic 6 |
| GRM7 | glutamate receptor, metabotropic 7 |
| GRM8 | glutamate receptor, metabotropic 8 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) |
| CXCL2 | chemokine (C-X-C motif) ligand 2 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 |
| HTR1A | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled |
| HTR1B | 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled |
| HTR1D | 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled |
| HTR1E | 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled |
| HTR1F | 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled |
| HTR5A | 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled |
| CXCL8 | chemokine (C-X-C motif) ligand 8 |
| CXCR1 | chemokine (C-X-C motif) receptor 1 |
| CXCR2 | chemokine (C-X-C motif) receptor 2 |
| CXCL10 | chemokine (C-X-C motif) ligand 10 |
| KNG1 | kininogen 1 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 |
| MTNR1A | melatonin receptor 1A |
| MTNR1B | melatonin receptor 1B |
| NPY | neuropeptide Y |
