HTR5A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HTR5A
Entrez Gene ID	3361
Full Name	5-hydroxytryptamine receptor 5A
Synonyms	5-HT5A
General protein information	Preferred Names 5-hydroxytryptamine receptor 5A Names 5-hydroxytryptamine receptor 5A 5-HT-5 5-HT-5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q36.2
Summary	The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization. [provided by RefSeq, Jul 2008].
Disorder MIM:	601305

mRNA and Protein(s)

mRNA	Protein	Name
NM_024012.3	NP_076917.1	5-hydroxytryptamine receptor 5A

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	HTR5A	XP_519477.3
Danio rerio (zebrafish)	htr5al	NP_001007122.1
Homo sapiens (human)	HTR5A	NP_076917.1
Canis lupus familiaris (dog)	HTR5A	XP_539929.2
Danio rerio (zebrafish)	htr5a	NP_001119882.2
Xenopus tropicalis (tropical clawed frog)	htr5a	XP_002932543.2
Bos taurus (cattle)	HTR5A	NP_001179771.1
Rattus norvegicus (Norway rat)	Htr5a	NP_037280.1
Gallus gallus (chicken)	HTR5A	XP_425970.1
	HTR5A	XP_001105989.1
Mus musculus (house mouse)	Htr5a	NP_032340.2

Gene Ontology
Bibliography

Related articles in PubMed

Evaluation of association of common variants in HTR1A and HTR5A with schizophrenia and executive function.
Guan F, Lin H, Chen G, Li L, Chen T, Liu X, Han J, Li T
Scientific reports638048(2016 Nov)

Genome-wide interaction study of smoking and bladder cancer risk.
Figueroa JD, Han SS, Garcia-Closas M, Baris D, Jacobs EJ, Kogevinas M, Schwenn M, Malats N, Johnson A, Purdue MP, Caporaso N, Landi MT, Prokunina-Olsson L, Wang Z, Hutchinson A, Burdette L, Wheeler W, Vineis P, Siddiq A, Cortessis VK, Kooperberg C, Cussenot O, Benhamou S, Prescott J, Porru S, Bueno-de-Mesquita HB, Trichopoulos D, Ljungberg B, Clavel-Chapelon F, Weiderpass E, Krogh V, Dorronsoro M, Travis R, Tj?nneland A, Brenan P, Chang-Claude J, Riboli E, Conti D, Gago-Dominguez M, Stern MC, Pike MC, Van Den Berg D, Yuan JM, Hohensee C, Rodabough R, Cancel-Tassin G, Roupret M, Comperat E, Chen C, De Vivo I, Giovannucci E, Hunter DJ, Kraft P, Lindstrom S, Carta A, Pavanello S, Arici C, Mastrangelo G, Karagas MR, Schned A, Armenti KR, Hosain GM, Haiman CA, Fraumeni JF Jr, Chanock SJ, Chatterjee N, Rothman N, Silverman DT
Carcinogenesis35(8)1737-44(2014 Aug)

Serotonin-related polymorphisms in TPH1 and HTR5A genes are not associated with escitalopram treatment response in Korean patients with major depression.
Kim YG, Chang HS, Won ES, Ham BJ, Lee MS
Neuropsychobiology69(4)210-9(2014)

Genome-wide association study of the five-factor model of personality in young Korean women.
Kim HN, Roh SJ, Sung YA, Chung HW, Lee JY, Cho J, Shin H, Kim HL
Journal of human genetics58(10)667-74(2013 Oct)

Association study of 182 candidate genes in anorexia nervosa.
Pinheiro AP, Bulik CM, Thornton LM, Sullivan PF, Root TL, Bloss CS, Berrettini WH, Schork NJ, Kaye WH, Bergen AW, Magistretti P, Brandt H, Crawford S, Crow S, Fichter MM, Goldman D, Halmi KA, Johnson C, Kaplan AS, Keel PK, Klump KL, La Via M, Mitchell JE, Strober M, Rotondo A, Treasure J, Woodside DB
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics153B(5)1070-80(2010 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results suggest that TPH1 218A/C and HTR5A 12A/T polymorphisms cannot predict treatment response in major depression
Title: Serotonin-related polymorphisms in TPH1 and HTR5A genes are not associated with escitalopram treatment response in Korean patients with major depression.

Observational study of gene-disease association. (HuGE Navigator)
Title: A large-scale candidate gene association study of age at menarche and age at natural menopause.

Observational study of gene-disease association. (HuGE Navigator)
Title: Association study of 182 candidate genes in anorexia nervosa.

Observational study of gene-disease association. (HuGE Navigator)
Title: Serotonin (5-HT) receptor 5A sequence variants affect human plasma triglyceride levels.

Observational study of gene-disease association. (HuGE Navigator)
Title: Association study of the serotoninergic system in migraine in the Spanish population.

The following HTR5A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HTR5A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu22813	NM_024012.3 Latest version!	Homo sapiens 5-hydroxytryptamine receptor 5A (HTR5A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HTR5A ( NM_024012.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_076917.1 Homo sapiens 5-hydroxytryptamine receptor 5A (HTR5A), mRNA.

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CloneID	OHu22813
Clone ID Related Accession (Same CDS sequence)	NM_024012.3
Accession Version	NM_024012.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1074bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	5-hydroxytryptamine receptor 5A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC093726.3, BC112021.1, AC092628.3 and BX538209.1. This sequence is a reference standard in the RefSeqGene project. On Feb 18, 2012 this sequence version replaced NM_024012.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.49656.1, SRR1803615.18151.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2148874 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGATTTAC CTGTGAACCT AACCTCCTTT TCCCTCTCCA CCCCCTCCCC TTTGGAGACC 
AACCACAGCC TCGGCAAAGA CGACCTGCGC CCCAGCTCGC CCCTGCTCTC GGTCTTCGGA 
GTGCTTATTC TCACCTTGCT GGGCTTTCTG GTGGCGGCGA CGTTCGCCTG GAACCTGCTG 
GTGCTGGCGA CCATCCTCCG TGTACGCACC TTCCACCGCG TGCCCCACAA CCTGGTGGCA 
TCCATGGCCG TCTCGGATGT CCTGGTGGCC GCGCTGGTCA TGCCGCTGAG CCTGGTGCAC 
GAGCTGTCCG GGCGCCGCTG GCAGCTAGGT CGGAGGCTGT GCCAGCTTTG GATCGCGTGC 
GACGTGCTTT GCTGCACGGC CAGCATCTGG AACGTGACGG CCATAGCCCT GGACCGCTAC 
TGGTCCATCA CGCGCCACAT GGAATACACG CTCCGCACCC GCAAGTGCGT CTCCAACGTC 
ATGATCGCGC TCACCTGGGC ACTCTCCGCT GTCATCTCTC TGGCCCCGCT GCTTTTTGGC 
TGGGGAGAGA CGTACTCTGA GGGCAGCGAG GAGTGCCAGG TAAGCCGCGA GCCTTCCTAC 
GCCGTGTTCT CCACCGTAGG CGCCTTCTAC CTGCCGCTCT GTGTGGTGCT CTTCGTGTAC 
TGGAAGATCT ACAAGGCTGC CAAGTTCCGC GTGGGCTCCA GGAAGACCAA TAGCGTCTCA 
CCCATATCCG AAGCTGTGGA GGTGAAGGAC TCTGCCAAAC AGCCCCAGAT GGTGTTCACG 
GTCCGCCACG CCACCGTCAC CTTCCAGCCA GAAGGGGACA CGTGGCGGGA GCAGAAGGAG 
CAGCGGGCCG CCCTCATGGT GGGCATCCTC ATTGGCGTGT TCGTGCTCTG CTGGATCCCC 
TTCTTTCTCA CCGAGCTCAT CAGTCCCCTC TGCTCCTGTG ACATCCCCGC CATCTGGAAA 
AGCATCTTCC TGTGGCTTGG CTACTCCAAC TCCTTCTTTA ACCCCCTGAT CTATACGGCT 
TTCAACAAGA ACTACAACAG CGCCTTCAAG AACTTCTTTT CTAGGCAACA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_076917.1
CDS	577..1650
Translation	MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH

Target ORF information:

RefSeq Version	NM_024012.3
Organism	Homo sapiens(human)
Definition	Homo sapiens 5-hydroxytryptamine receptor 5A (HTR5A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024012.3

ORF Insert Sequence:

ATGGATTTAC CTGTGAACCT AACCTCCTTT TCCCTCTCCA CCCCCTCCCC TTTGGAGACC 
AACCACAGCC TCGGCAAAGA CGACCTGCGC CCCAGCTCGC CCCTGCTCTC GGTCTTCGGA 
GTGCTTATTC TCACCTTGCT GGGCTTTCTG GTGGCGGCGA CGTTCGCCTG GAACCTGCTG 
GTGCTGGCGA CCATCCTCCG TGTACGCACC TTCCACCGCG TGCCCCACAA CCTGGTGGCA 
TCCATGGCCG TCTCGGATGT CCTGGTGGCC GCGCTGGTCA TGCCGCTGAG CCTGGTGCAC 
GAGCTGTCCG GGCGCCGCTG GCAGCTAGGT CGGAGGCTGT GCCAGCTTTG GATCGCGTGC 
GACGTGCTTT GCTGCACGGC CAGCATCTGG AACGTGACGG CCATAGCCCT GGACCGCTAC 
TGGTCCATCA CGCGCCACAT GGAATACACG CTCCGCACCC GCAAGTGCGT CTCCAACGTC 
ATGATCGCGC TCACCTGGGC ACTCTCCGCT GTCATCTCTC TGGCCCCGCT GCTTTTTGGC 
TGGGGAGAGA CGTACTCTGA GGGCAGCGAG GAGTGCCAGG TAAGCCGCGA GCCTTCCTAC 
GCCGTGTTCT CCACCGTAGG CGCCTTCTAC CTGCCGCTCT GTGTGGTGCT CTTCGTGTAC 
TGGAAGATCT ACAAGGCTGC CAAGTTCCGC GTGGGCTCCA GGAAGACCAA TAGCGTCTCA 
CCCATATCCG AAGCTGTGGA GGTGAAGGAC TCTGCCAAAC AGCCCCAGAT GGTGTTCACG 
GTCCGCCACG CCACCGTCAC CTTCCAGCCA GAAGGGGACA CGTGGCGGGA GCAGAAGGAG 
CAGCGGGCCG CCCTCATGGT GGGCATCCTC ATTGGCGTGT TCGTGCTCTG CTGGATCCCC 
TTCTTTCTCA CCGAGCTCAT CAGTCCCCTC TGCTCCTGTG ACATCCCCGC CATCTGGAAA 
AGCATCTTCC TGTGGCTTGG CTACTCCAAC TCCTTCTTTA ACCCCCTGAT CTATACGGCT 
TTCAACAAGA ACTACAACAG CGCCTTCAAG AACTTCTTTT CTAGGCAACA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Evaluation of association of common variants in HTR1A and HTR5A with schizophrenia and executive function.
Scientific reports638048(2016 Nov)
Guan F,Lin H,Chen G,Li L,Chen T,Liu X,Han J,Li T

Genome-wide interaction study of smoking and bladder cancer risk.
Carcinogenesis35(8)1737-44(2014 Aug)
Figueroa JD,Han SS,Garcia-Closas M,Baris D,Jacobs EJ,Kogevinas M,Schwenn M,Malats N,Johnson A,Purdue MP,Caporaso N,Landi MT,Prokunina-Olsson L,Wang Z,Hutchinson A,Burdette L,Wheeler W,Vineis P,Siddiq A,Cortessis VK,Kooperberg C,Cussenot O,Benhamou S,Prescott J,Porru S,Bueno-de-Mesquita HB,Trichopoulos D,Ljungberg B,Clavel-Chapelon F,Weiderpass E,Krogh V,Dorronsoro M,Travis R,Tj?nneland A,Brenan P,Chang-Claude J,Riboli E,Conti D,Gago-Dominguez M,Stern MC,Pike MC,Van Den Berg D,Yuan JM,Hohensee C,Rodabough R,Cancel-Tassin G,Roupret M,Comperat E,Chen C,De Vivo I,Giovannucci E,Hunter DJ,Kraft P,Lindstrom S,Carta A,Pavanello S,Arici C,Mastrangelo G,Karagas MR,Schned A,Armenti KR,Hosain GM,Haiman CA,Fraumeni JF Jr,Chanock SJ,Chatterjee N,Rothman N,Silverman DT

Serotonin-related polymorphisms in TPH1 and HTR5A genes are not associated with escitalopram treatment response in Korean patients with major depression.
Neuropsychobiology69(4)210-9(2014)
Kim YG,Chang HS,Won ES,Ham BJ,Lee MS

Genome-wide association study of the five-factor model of personality in young Korean women.
Journal of human genetics58(10)667-74(2013 Oct)
Kim HN,Roh SJ,Sung YA,Chung HW,Lee JY,Cho J,Shin H,Kim HL

Association study of 182 candidate genes in anorexia nervosa.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics153B(5)1070-80(2010 Jul)
Pinheiro AP,Bulik CM,Thornton LM,Sullivan PF,Root TL,Bloss CS,Berrettini WH,Schork NJ,Kaye WH,Bergen AW,Magistretti P,Brandt H,Crawford S,Crow S,Fichter MM,Goldman D,Halmi KA,Johnson C,Kaplan AS,Keel PK,Klump KL,La Via M,Mitchell JE,Strober M,Rotondo A,Treasure J,Woodside DB

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HTR5A cDNA ORF clone, Homo sapiens(human)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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