PLA2G2E cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PLA2G2E
Entrez Gene ID	30814
Full Name	phospholipase A2 group IIE
Synonyms	GIIE sPLA2,sPLA2-IIE
General protein information	Preferred Names phospholipase A2 group IIE Names group IIE secretory phospholipase A2 phosphatidylcholine 2-acylhydrolase 2E
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p36.13

mRNA and Protein(s)

mRNA	Protein	Name
NM_014589.3	NP_055404.1	group IIE secretory phospholipase A2 precursor
NM_014589.2	NP_055404.1	group IIE secretory phospholipase A2 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Pla2g2e	NP_036174.1
Canis lupus familiaris (dog)	PLA2G2E	XP_544525.3
Xenopus tropicalis (tropical clawed frog)	LOC101735122	XP_004920461.1
	PLA2G2E	XP_001094364.1
Xenopus tropicalis (tropical clawed frog)	LOC100496855	XP_002938654.1
Homo sapiens (human)	PLA2G2E	NP_055404.1
Pan troglodytes (chimpanzee)	PLA2G2E	XP_001163677.1
Bos taurus (cattle)	PLA2G2E	NP_001179015.1
Gallus gallus (chicken)	PLA2G2E	NP_001171878.1

Gene Ontology
Bibliography

Related articles in PubMed

Structural basis for functional selectivity and ligand recognition revealed by crystal structures of human secreted phospholipase A
Hou S, Xu T, Xu J, Qu L, Xu Y, Chen L, Liu J
Scientific reports7(1)10815(2017 Sep)

Group IIE secretory phospholipase A2 regulates lipolysis in adipocytes.
Zhi H, Qu L, Wu F, Chen L, Tao J
Obesity (Silver Spring, Md.)23(4)760-8(2015 Apr)

The expression of groups IIE and V phospholipase A2 is associated with an increased expression of osteogenic molecules in human calcified aortic valves.
Suzuki K, Takahashi S, Watanabe K, Fujioka D, Nakamura T, Obata JE, Kawabata K, Katoh R, Matsumoto M, Kugiyama K
Journal of atherosclerosis and thrombosis21(12)1308-25(2014)

Genome-wide association study of ulcerative colitis in Koreans suggests extensive overlapping of genetic susceptibility with Caucasians.
Yang SK, Hong M, Zhao W, Jung Y, Tayebi N, Ye BD, Kim KJ, Park SH, Lee I, Shin HD, Cheong HS, Kim LH, Kim HJ, Jung SA, Kang D, Youn HS, Liu J, Song K
Inflammatory bowel diseases19(5)954-66(2013 Apr)

Genome-wide association identifies multiple ulcerative colitis susceptibility loci.
McGovern DP, Gardet A, T?rkvist L, Goyette P, Essers J, Taylor KD, Neale BM, Ong RT, Lagac? C, Li C, Green T, Stevens CR, Beauchamp C, Fleshner PR, Carlson M, D'Amato M, Halfvarson J, Hibberd ML, L?rdal M, Padyukov L, Andriulli A, Colombo E, Latiano A, Palmieri O, Bernard EJ, Deslandres C, Hommes DW, de Jong DJ, Stokkers PC, Weersma RK, , Sharma Y, Silverberg MS, Cho JH, Wu J, Roeder K, Brant SR, Schumm LP, Duerr RH, Dubinsky MC, Glazer NL, Haritunians T, Ippoliti A, Melmed GY, Siscovick DS, Vasiliauskas EA, Targan SR, Annese V, Wijmenga C, Pettersson S, Rotter JI, Xavier RJ, Daly MJ, Rioux JD, Seielstad M
Nature genetics42(4)332-7(2010 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

sPLA(2) -IIE regulates lipolysis in adipocytes, likely through the ERK/HSL signaling pathway
Title: Group IIE secretory phospholipase A2 regulates lipolysis in adipocytes.

expression of PLA2s-IIE and -V correlates with the development of calcification as well as the expression of pro-osteogenic molecules in human aortic valves
Title: The expression of groups IIE and V phospholipase A2 is associated with an increased expression of osteogenic molecules in human calcified aortic valves.

Single-nucleotide polymorphism in PLA2G2E gene is associated with ulcerative colitis.
Title: Genome-wide association study of ulcerative colitis in Koreans suggests extensive overlapping of genetic susceptibility with Caucasians.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.

promotes stimulus-induced arachidonic acid release and prostaglandin (PG) production similar to those elicited by HSPG-dependent sPLA(2)s, suggesting that this enzyme plays a role in the inflammatory process.
Title: Arachidonate release and eicosanoid generation by group IIE phospholipase A(2).

The following PLA2G2E gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PLA2G2E cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu01793	NM_014589.3 Latest version!	Homo sapiens phospholipase A2 group IIE (PLA2G2E), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu01793	NM_014589.2	Homo sapiens phospholipase A2 group IIE (PLA2G2E), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PLA2G2E ( NM_014589.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055404.1 Homo sapiens phospholipase A2 group IIE (PLA2G2E), mRNA.

Price & Availability↑

CloneID	OHu01793
Clone ID Related Accession (Same CDS sequence)	NM_014589.3 , NM_014589.2
Accession Version	NM_014589.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	group IIE secretory phospholipase A2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF189279.1 and AL358253.16. On May 17, 2019 this sequence version replaced NM_014589.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. An in-frame AUG is located 12 codons upstream of the annotated translation start site but is not being annotated as a start site since it is poorly conserved and is in a weak Kozak sequence context. ##Evidence-Data-START## Transcript exon combination :: AF189279.1, BC069116.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved MANE Ensembl match :: ENST00000375116.3/ ENSP00000364257.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGAAATCTC CCCACGTGCT GGTGTTCCTT TGCCTCCTGG TGGCTCTGGT CACCGGGAAC 
CTGGTTCAGT TTGGGGTGAT GATCGAGAAG ATGACAGGCA AGTCCGCCCT GCAGTACAAC 
GACTATGGCT GTTACTGCGG CATCGGTGGC TCCCACTGGC CGGTGGACCA GACTGACTGG 
TGCTGCCACG CCCACGACTG CTGCTACGGG CGTCTGGAGA AGCTGGGCTG TGAGCCCAAA 
CTGGAAAAGT ATCTTTTCTC TGTCAGCGAA CGTGGCATTT TCTGCGCCGG CAGGACCACC 
TGCCAGCGGC TGACCTGCGA GTGTGACAAG AGGGCTGCCC TCTGCTTTCG CCGCAACCTG 
GGCACCTACA ACCGCAAATA TGCCCATTAT CCCAACAAGC TGTGCACCGG GCCCACCCCG 
CCCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055404.1
CDS	59..487
Translation	MKSPHVLVFLCLLVALVTGNLVQFGVMIEKMTGKSALQYNDYGCYCGIGGSHWPVDQTDWCCHAHDCCYGRLEKLGCEPKLEKYLFSVSERGIFCAGRTTCQRLTCECDKRAALCFRRNLGTYNRKYAHYPNKLCTGPTPPC

Target ORF information:

RefSeq Version	NM_014589.3
Organism	Homo sapiens(human)
Definition	Homo sapiens phospholipase A2 group IIE (PLA2G2E), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014589.3

ORF Insert Sequence:

ATGAAATCTC CCCACGTGCT GGTGTTCCTT TGCCTCCTGG TGGCTCTGGT CACCGGGAAC 
CTGGTTCAGT TTGGGGTGAT GATCGAGAAG ATGACAGGCA AGTCCGCCCT GCAGTACAAC 
GACTATGGCT GTTACTGCGG CATCGGTGGC TCCCACTGGC CGGTGGACCA GACTGACTGG 
TGCTGCCACG CCCACGACTG CTGCTACGGG CGTCTGGAGA AGCTGGGCTG TGAGCCCAAA 
CTGGAAAAGT ATCTTTTCTC TGTCAGCGAA CGTGGCATTT TCTGCGCCGG CAGGACCACC 
TGCCAGCGGC TGACCTGCGA GTGTGACAAG AGGGCTGCCC TCTGCTTTCG CCGCAACCTG 
GGCACCTACA ACCGCAAATA TGCCCATTAT CCCAACAAGC TGTGCACCGG GCCCACCCCG 
CCCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PLA2G2E ( NM_014589.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_055404.1 Homo sapiens phospholipase A2 group IIE (PLA2G2E), mRNA.

Price & Availability↑

CloneID	OHu01793
Clone ID Related Accession (Same CDS sequence)	NM_014589.3 , NM_014589.2
Accession Version	NM_014589.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-08
Organism	Homo sapiens(human)
Product	group IIE secretory phospholipase A2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF189279.1 and AL358253.16. On Nov 17, 2012 this sequence version replaced NM_014589.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. An in-frame AUG is located 12 codons upstream of the annotated translation start site but is not being annotated as a start site since it is poorly conserved and is in a weak Kozak sequence context. ##Evidence-Data-START## Transcript exon combination :: AF189279.1, BC069116.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END##

ATGAAATCTC CCCACGTGCT GGTGTTCCTT TGCCTCCTGG TGGCTCTGGT CACCGGGAAC 
CTGGTTCAGT TTGGGGTGAT GATCGAGAAG ATGACAGGCA AGTCCGCCCT GCAGTACAAC 
GACTATGGCT GTTACTGCGG CATCGGTGGC TCCCACTGGC CGGTGGACCA GACTGACTGG 
TGCTGCCACG CCCACGACTG CTGCTACGGG CGTCTGGAGA AGCTGGGCTG TGAGCCCAAA 
CTGGAAAAGT ATCTTTTCTC TGTCAGCGAA CGTGGCATTT TCTGCGCCGG CAGGACCACC 
TGCCAGCGGC TGACCTGCGA GTGTGACAAG AGGGCTGCCC TCTGCTTTCG CCGCAACCTG 
GGCACCTACA ACCGCAAATA TGCCCATTAT CCCAACAAGC TGTGCACCGG GCCCACCCCG 
CCCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055404.1
CDS	59..487
Translation	MKSPHVLVFLCLLVALVTGNLVQFGVMIEKMTGKSALQYNDYGCYCGIGGSHWPVDQTDWCCHAHDCCYGRLEKLGCEPKLEKYLFSVSERGIFCAGRTTCQRLTCECDKRAALCFRRNLGTYNRKYAHYPNKLCTGPTPPC

Target ORF information:

RefSeq Version	NM_014589.2
Organism	Homo sapiens(human)
Definition	Homo sapiens phospholipase A2 group IIE (PLA2G2E), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014589.2

ORF Insert Sequence:

ATGAAATCTC CCCACGTGCT GGTGTTCCTT TGCCTCCTGG TGGCTCTGGT CACCGGGAAC 
CTGGTTCAGT TTGGGGTGAT GATCGAGAAG ATGACAGGCA AGTCCGCCCT GCAGTACAAC 
GACTATGGCT GTTACTGCGG CATCGGTGGC TCCCACTGGC CGGTGGACCA GACTGACTGG 
TGCTGCCACG CCCACGACTG CTGCTACGGG CGTCTGGAGA AGCTGGGCTG TGAGCCCAAA 
CTGGAAAAGT ATCTTTTCTC TGTCAGCGAA CGTGGCATTT TCTGCGCCGG CAGGACCACC 
TGCCAGCGGC TGACCTGCGA GTGTGACAAG AGGGCTGCCC TCTGCTTTCG CCGCAACCTG 
GGCACCTACA ACCGCAAATA TGCCCATTAT CCCAACAAGC TGTGCACCGG GCCCACCCCG 
CCCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structural basis for functional selectivity and ligand recognition revealed by crystal structures of human secreted phospholipase A
Scientific reports7(1)10815(2017 Sep)
Hou S,Xu T,Xu J,Qu L,Xu Y,Chen L,Liu J

Group IIE secretory phospholipase A2 regulates lipolysis in adipocytes.
Obesity (Silver Spring, Md.)23(4)760-8(2015 Apr)
Zhi H,Qu L,Wu F,Chen L,Tao J

The expression of groups IIE and V phospholipase A2 is associated with an increased expression of osteogenic molecules in human calcified aortic valves.
Journal of atherosclerosis and thrombosis21(12)1308-25(2014)
Suzuki K,Takahashi S,Watanabe K,Fujioka D,Nakamura T,Obata JE,Kawabata K,Katoh R,Matsumoto M,Kugiyama K

Genome-wide association study of ulcerative colitis in Koreans suggests extensive overlapping of genetic susceptibility with Caucasians.
Inflammatory bowel diseases19(5)954-66(2013 Apr)
Yang SK,Hong M,Zhao W,Jung Y,Tayebi N,Ye BD,Kim KJ,Park SH,Lee I,Shin HD,Cheong HS,Kim LH,Kim HJ,Jung SA,Kang D,Youn HS,Liu J,Song K

Genome-wide association identifies multiple ulcerative colitis susceptibility loci.
Nature genetics42(4)332-7(2010 Apr)
McGovern DP,Gardet A,T?rkvist L,Goyette P,Essers J,Taylor KD,Neale BM,Ong RT,Lagac? C,Li C,Green T,Stevens CR,Beauchamp C,Fleshner PR,Carlson M,D'Amato M,Halfvarson J,Hibberd ML,L?rdal M,Padyukov L,Andriulli A,Colombo E,Latiano A,Palmieri O,Bernard EJ,Deslandres C,Hommes DW,de Jong DJ,Stokkers PC,Weersma RK,,Sharma Y,Silverberg MS,Cho JH,Wu J,Roeder K,Brant SR,Schumm LP,Duerr RH,Dubinsky MC,Glazer NL,Haritunians T,Ippoliti A,Melmed GY,Siscovick DS,Vasiliauskas EA,Targan SR,Annese V,Wijmenga C,Pettersson S,Rotter JI,Xavier RJ,Daly MJ,Rioux JD,Seielstad M

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PLA2G2E cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

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Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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