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HLA-DQA1 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol HLA-DQA1
Entrez Gene ID 3117
Full Name major histocompatibility complex, class II, DQ alpha 1
Synonyms CELIAC1,DQ-A1,HLA-DQA
General protein information
Preferred Names

major histocompatibility complex, class II, DQ alpha 1

Names

HLA class II histocompatibility antigen, DQ alpha 1 chain
DC-1 alpha chain
DC-alpha
HLA-DCA
MHC HLA-DQ alpha
MHC class II DQA1
MHC class II HLA-DQ-alpha-1

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

6

6p21.32

Summary HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq, Jul 2008].
Disorder MIM:

146880

Disorder Html: {Celiac disease, susceptibility to}, 212750 (3)

mRNA and Protein(s)

mRNA Protein Name
XM_006715079.3 XP_006715142.1 HLA class II histocompatibility antigen, DQ alpha 1 chain isoform X1
NM_002122.3 NP_002113.2 HLA class II histocompatibility antigen, DQ alpha 1 chain precursor



Homo sapiens (human) HLA-DQA1 NP_002113.2
Mus musculus (house mouse) H2-Aa NP_034508.2
Bos taurus (cattle) LOC100848815 XP_003587740.1
Macaca mulatta (rhesus monkey) MAMU-DQA1 NP_001127767.1
Pan troglodytes (chimpanzee) PATR-DQA1 XP_003950844.1
Macaca mulatta (rhesus monkey) HLA-DQA1 XP_001115365.1
Rattus norvegicus (Norway rat) RT1-Ba NP_001008831.1


Related articles in PubMed

HLA-DQA1 and HLA-DQB1 allele diversity and its extended haplotypes in Madeira Island (Portugal).
Spínola H, Lemos A, Couto AR, Parreira B, Soares M, Dutra I, Bruges-Armas J, Brehm A
International journal of immunogenetics44(1)27-31(2017 Feb)

A childhood acute lymphoblastic leukemia genome-wide association study identifies novel sex-specific risk variants.
Singh SK, Lupo PJ, Scheurer ME, Saxena A, Kennedy AE, Ibrahimou B, Barbieri MA, Mills KI, McCauley JL, Okcu MF, Dorak MT
Medicine95(46)e5300(2016 Nov)

 Association of HLA-DQ and IFNL4 polymorphisms with susceptibility to hepatitis B virus infection and clearance.
Fan JH, Hou SH, Qing-Ling L, Hu J, Peng H, Guo JJ
Annals of hepatology15(4)532-9(2016 Jul-Aug)

Maternal and fetal human leukocyte antigen class Ia and II alleles in severe preeclampsia and eclampsia.
Emmery J, Hachmon R, Pyo CW, Nelson WC, Geraghty DE, Andersen AM, Melbye M, Hviid TV
Genes and immunity17(4)251-60(2016 06)

[The association of the severe clinical course of respiratory papillomatosis with certain HLA-DQ alleles].
Kolesnikova OM
Vestnik otorinolaringologii81(4)31-33(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

HLA-DQA1 alleles contribute to the susceptibility of unexplained recurrent spontaneous abortion among ethnic Han Chinese.
Title: [Analysis of the association of human leukocyte antigen DQ gene polymorphisms with unexplained recurrent spontaneous abortion among ethnic Han Chinese from Wenzhou region].

A significant correlation was found between worldwide wheat consumption and HLA DQ2 (p=0.01) and the sum of DQ2 and DQ8 (p=0.01) frequencies. Wheat consumption and HLA-DQ2 tend to co-localize in different continents.
Title: Co-localization of gluten consumption and HLA-DQ2 and -DQ8 genotypes, a clue to the history of celiac disease.

analysis of distribution of HLA-DQ genotypes in a group of pediatric celiac patients
Title: HLA genotyping in pediatric celiac disease patients.

our findings clearly support that CNV of the HLA-DQA1 are associated with susceptibility to RA in Chinese Han population.
Title: Association between HLA-DQA1 gene copy number polymorphisms and susceptibility to rheumatoid arthritis in Chinese Han population.

HLA-DQA1*03:02 HLA-DRB1*08:01 and DRB1*08:03 occurred more frequently in patients with drug resistant tuberculosis than in controls.
Title: HLA-class II alleles in patients with drug-resistant pulmonary tuberculosis in Kazakhstan.

The following HLA-DQA1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HLA-DQA1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu18636
NM_002122.3
Latest version!
Homo sapiens major histocompatibility complex, class II, DQ alpha 1 (HLA-DQA1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
OHu40288 XM_006715079.3
Latest version!
Homo sapiens major histocompatibility complex, class II, DQ alpha 1 (HLA-DQA1), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $139.30
$199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu18636
Clone ID Related Accession (Same CDS sequence) NM_002122.3
Accession Version NM_002122.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 768bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-07
Organism Homo sapiens(Human)
Product HLA class II histocompatibility antigen, DQ alpha 1 chain precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK130811.1, M20431.1, BU617246.1 and AF533896.1. This sequence is a reference standard in the RefSeqGene project. On or before Aug 31, 2013 this sequence version replaced XM_003846467.2, NM_002122.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK130838.1, SRR1163658.388665.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGATCCTAA ACAAAGCTCT GCTGCTGGGG GCCCTCGCTC TGACCACCGT GATGAGCCCC 
TGTGGAGGTG AAGACATTGT GGCTGACCAC GTTGCCTCTT GTGGTGTAAA CTTGTACCAG
TTTTACGGTC CCTCTGGCCA GTACACCCAT GAATTTGATG GAGATGAGCA GTTCTACGTG
GACCTGGAGA GGAAGGAGAC TGCCTGGCGG TGGCCTGAGT TCAGCAAATT TGGAGGTTTT
GACCCGCAGG GTGCACTGAG AAACATGGCT GTGGCAAAAC ACAACTTGAA CATCATGATT
AAACGCTACA ACTCTACCGC TGCTACCAAT GAGGTTCCTG AGGTCACAGT GTTTTCCAAG
TCTCCCGTGA CACTGGGTCA GCCCAACACC CTCATTTGTC TTGTGGACAA CATCTTTCCT
CCTGTGGTCA ACATCACATG GCTGAGCAAT GGGCAGTCAG TCACAGAAGG TGTTTCTGAG
ACCAGCTTCC TCTCCAAGAG TGATCATTCC TTCTTCAAGA TCAGTTACCT CACCTTCCTC
CCTTCTGCTG ATGAGATTTA TGACTGCAAG GTGGAGCACT GGGGCCTGGA CCAGCCTCTT
CTGAAACACT GGGAGCCTGA GATTCCAGCC CCTATGTCAG AGCTCACAGA GACTGTGGTC
TGTGCCCTGG GGTTGTCTGT GGGCCTCATG GGCATTGTGG TGGGCACTGT CTTCATCATC
CAAGGCCTGC GTTCAGTTGG TGCTTCCAGA CACCAAGGGC CATTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_002113.2
CDS54..821
Misc Feature(1)33..35
Misc Feature(2)141..377
Misc Feature(3)387..668
Misc Feature(4)order(399..401,405..413,417..419,573..575,579..581)
Misc Feature(5)order(471..479,537..548,561..566,579..581)
Misc Feature(6)660..815
Exon (1)1..135
Exon (2)136..384
Exon (3)385..666
Exon (4)667..841
Exon (5)842..1542
Translation

Target ORF information:

RefSeq Version NM_002122.3
Organism Homo sapiens(Human)
Definition Homo sapiens major histocompatibility complex, class II, DQ alpha 1 (HLA-DQA1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002122.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGATCCTAA ACAAAGCTCT GCTGCTGGGG GCCCTCGCTC TGACCACCGT GATGAGCCCC 
TGTGGAGGTG AAGACATTGT GGCTGACCAC GTTGCCTCTT GTGGTGTAAA CTTGTACCAG
TTTTACGGTC CCTCTGGCCA GTACACCCAT GAATTTGATG GAGATGAGCA GTTCTACGTG
GACCTGGAGA GGAAGGAGAC TGCCTGGCGG TGGCCTGAGT TCAGCAAATT TGGAGGTTTT
GACCCGCAGG GTGCACTGAG AAACATGGCT GTGGCAAAAC ACAACTTGAA CATCATGATT
AAACGCTACA ACTCTACCGC TGCTACCAAT GAGGTTCCTG AGGTCACAGT GTTTTCCAAG
TCTCCCGTGA CACTGGGTCA GCCCAACACC CTCATTTGTC TTGTGGACAA CATCTTTCCT
CCTGTGGTCA ACATCACATG GCTGAGCAAT GGGCAGTCAG TCACAGAAGG TGTTTCTGAG
ACCAGCTTCC TCTCCAAGAG TGATCATTCC TTCTTCAAGA TCAGTTACCT CACCTTCCTC
CCTTCTGCTG ATGAGATTTA TGACTGCAAG GTGGAGCACT GGGGCCTGGA CCAGCCTCTT
CTGAAACACT GGGAGCCTGA GATTCCAGCC CCTATGTCAG AGCTCACAGA GACTGTGGTC
TGTGCCCTGG GGTTGTCTGT GGGCCTCATG GGCATTGTGG TGGGCACTGT CTTCATCATC
CAAGGCCTGC GTTCAGTTGG TGCTTCCAGA CACCAAGGGC CATTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu40288
Clone ID Related Accession (Same CDS sequence) XM_006715079.3
Accession Version XM_006715079.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 621bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product HLA class II histocompatibility antigen, DQ alpha 1 chain isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006715079.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
ATGATCCTAA ACAAAGCTCT GCTGCTGGGG GCCCTCGCTC TGACCACCGT GATGAGCCCC 
TGTGGAGGTG AAGACATTGT GGCTGACCAC GTTGCCTCTT GTGGTGTAAA CTTGTACCAG
TTTTACGGTC CCTCTGGCCA GTACACCCAT GAATTTGATG GAGATGAGCA GTTCTACGTG
GACCTGGAGA GGAAGGAGAC TGCCTGGCGG TGGCCTGAGT TCAGCAAATT TGGAGGTTTT
GACCCGCAGG GTGCACTGAG AAACATGGCT GTGGCAAAAC ACAACTTGAA CATCATGATT
AAACGCTACA ACTCTACCGC TGCTACCAAT GAGGTTCCTG AGGTCACAGT GTTTTCCAAG
TCTCCCGTGA CACTGGGTCA GCCCAACACC CTCATTTGTC TTGTGGACAA CATCTTTCCT
CCTGTGGTCA ACATCACATG GCTGAGCAAT GGGCAGTCAG TCACAGAAGG TGTTTCTGAG
ACCAGCTTCC TCTCCAAGAG TGATCATTCC TTCTTCAAGA TCAGTTACCT CACCTTCCTC
CCTTCTGCTG ATGAGATTTA TGACTGCAAG GTGGAGCACT GGGGCCTGGA CCAGCCTCTT
CTGAAACACT GGGTTGAATG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_006715142.1
CDS57..677
Misc Feature(1)144..380
Misc Feature(2)390..671
Misc Feature(3)order(402..404,408..416,420..422,576..578,582..584)
Misc Feature(4)order(474..482,540..551,564..569,582..584)
Translation

Target ORF information:

RefSeq Version XM_006715079.3
Organism Homo sapiens(Human)
Definition Homo sapiens major histocompatibility complex, class II, DQ alpha 1 (HLA-DQA1), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_006715079.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
ATGATCCTAA ACAAAGCTCT GCTGCTGGGG GCCCTCGCTC TGACCACCGT GATGAGCCCC 
TGTGGAGGTG AAGACATTGT GGCTGACCAC GTTGCCTCTT GTGGTGTAAA CTTGTACCAG
TTTTACGGTC CCTCTGGCCA GTACACCCAT GAATTTGATG GAGATGAGCA GTTCTACGTG
GACCTGGAGA GGAAGGAGAC TGCCTGGCGG TGGCCTGAGT TCAGCAAATT TGGAGGTTTT
GACCCGCAGG GTGCACTGAG AAACATGGCT GTGGCAAAAC ACAACTTGAA CATCATGATT
AAACGCTACA ACTCTACCGC TGCTACCAAT GAGGTTCCTG AGGTCACAGT GTTTTCCAAG
TCTCCCGTGA CACTGGGTCA GCCCAACACC CTCATTTGTC TTGTGGACAA CATCTTTCCT
CCTGTGGTCA ACATCACATG GCTGAGCAAT GGGCAGTCAG TCACAGAAGG TGTTTCTGAG
ACCAGCTTCC TCTCCAAGAG TGATCATTCC TTCTTCAAGA TCAGTTACCT CACCTTCCTC
CCTTCTGCTG ATGAGATTTA TGACTGCAAG GTGGAGCACT GGGGCCTGGA CCAGCCTCTT
CTGAAACACT GGGTTGAATG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

HLA-DQA1 and HLA-DQB1 allele diversity and its extended haplotypes in Madeira Island (Portugal).
International journal of immunogenetics44(1)27-31(2017 Feb)
Spínola H,Lemos A,Couto AR,Parreira B,Soares M,Dutra I,Bruges-Armas J,Brehm A


book

A childhood acute lymphoblastic leukemia genome-wide association study identifies novel sex-specific risk variants.
Medicine95(46)e5300(2016 Nov)
Singh SK,Lupo PJ,Scheurer ME,Saxena A,Kennedy AE,Ibrahimou B,Barbieri MA,Mills KI,McCauley JL,Okcu MF,Dorak MT


book

 Association of HLA-DQ and IFNL4 polymorphisms with susceptibility to hepatitis B virus infection and clearance.
Annals of hepatology15(4)532-9(2016 Jul-Aug)
Fan JH,Hou SH,Qing-Ling L,Hu J,Peng H,Guo JJ


book

Maternal and fetal human leukocyte antigen class Ia and II alleles in severe preeclampsia and eclampsia.
Genes and immunity17(4)251-60(2016 06)
Emmery J,Hachmon R,Pyo CW,Nelson WC,Geraghty DE,Andersen AM,Melbye M,Hviid TV


book

[The association of the severe clinical course of respiratory papillomatosis with certain HLA-DQ alleles].
Vestnik otorinolaringologii81(4)31-33(2016)
Kolesnikova OM


 
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