H2-Aa cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	H2-Aa
Entrez Gene ID	14960
Full Name	histocompatibility 2, class II antigen A, alpha
Synonyms	Aalpha,H-2Aa,H2Aa,I-Aalpha,IAalpha,Ia-1,Ia1
General protein information	Preferred Names histocompatibility 2, class II antigen A, alpha Names histocompatibility 2, class II antigen A, alpha A alpha H-2 class II histocompatibility antigen, A-B alpha chain H-2 class II histocompatibility antigen, A-F alpha chain H-2 class II histocompatibility antigen, A-K alpha chain H-2 class II histocompatibility antigen, A-Q alpha chain H-2 class II histocompatibility antigen, A-R alpha chain H-2 class II histocompatibility antigen, A-S alpha chain H-2 class II histocompatibility antigen, A-U alpha chain MHC class II antigen A alpha isoform-004 MHC class II antigen alpha chain MHC-II I-A(d) alpha major histocompatibility protein class II alpha chain
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17 B1\|17 17.98 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010378.2	NP_034508.2	histocompatibility 2, class II antigen A, alpha precursor
NM_010378.3	NP_034508.2	histocompatibility 2, class II antigen A, alpha precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	HLA-DQA1	NP_002113.2
Mus musculus (house mouse)	H2-Aa	NP_034508.2
	MAMU-DQA1	NP_001127767.1
Bos taurus (cattle)	LOC100848815	XP_003587740.1
Pan troglodytes (chimpanzee)	PATR-DQA1	XP_003950844.1
	HLA-DQA1	XP_001115365.1
Rattus norvegicus (Norway rat)	RT1-Ba	NP_001008831.1

Gene Ontology
Bibliography

Related articles in PubMed

A triad of molecular regions contribute to the formation of two distinct MHC class II conformers.
Drake LA, Drake JR
Molecular immunology7459-70(2016 06)

The QTL within the H2 Complex Involved in the Control of Tuberculosis Infection in Mice Is the Classical Class II H2-Ab1 Gene.
Logunova N, Korotetskaya M, Polshakov V, Apt A
PLoS genetics11(11)e1005672(2015 Nov)

Ag-presenting CpG-activated pDCs prime Th17 cells that induce tumor regression.
Gu?ry L, Dubrot J, Lippens C, Brighouse D, Malinge P, Irla M, Pot C, Reith W, Waldburger JM, Hugues S
Cancer research74(22)6430-40(2014 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate an alternative mechanism where lymph node stromal cells (LNSCs) tolerize CD4(+) T cells through the presentation of self-antigens via transferred peptide-MHCII complexes of dendritic cell origin.
Title: Lymph node stromal cells acquire peptide-MHCII complexes from dendritic cells and induce antigen-specific CD4? T cell tolerance.

Data show that MHC class II(+)Fas(+) BM cells were closely associated with CD4(+) T cells in the BM of affected animals.
Title: MHC class II upregulation and colocalization with Fas in experimental models of immune-mediated bone marrow failure.

Analysis of CD8(+) T-cell-specific responses in A2xneu mice indicated that the priming activity of old A2xneu mice to induce an immune response was diminished compared with young animals.
Title: Implications of aging and self-tolerance on the generation of immune and antitumor immune responses.

The following H2-Aa gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the H2-Aa cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu18536	NM_010378.3 Latest version!	Mus musculus histocompatibility 2, class II antigen A, alpha (H2-Aa), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
View Old Accession Versions >>
OMu18536	NM_010378.2	Mus musculus histocompatibility 2, class II antigen A, alpha (H2-Aa), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

H2-Aa ( NM_010378.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034508.2 Mus musculus histocompatibility 2, class II antigen A, alpha (H2-Aa), mRNA.

Price & Availability↑

CloneID	OMu18536
Clone ID Related Accession (Same CDS sequence)	NM_010378.2 , NM_010378.3
Accession Version	NM_010378.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 771bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Mus musculus(house mouse)
Product	histocompatibility 2, class II antigen A, alpha precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC019721.1. On Jun 19, 2003 this sequence version replaced NM_010378.1. Sequence Note: This record matches the C57BL/6J reference assembly sequence and represents the b haplotype of this gene. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC019721.1, BC043925.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849380 [ECO:0000348] ##Evidence-Data-END##

ATGCCGCGCA GCAGAGCTCT GATTCTGGGG GTCCTCGCCC TGACCACCAT GCTCAGCCTC 
TGTGGAGGTG AAGACGACAT TGAGGCCGAC CACGTAGGCA CCTATGGTAT AAGTGTATAT 
CAGTCTCCTG GAGACATTGG CCAGTACACA TTTGAATTTG ATGGTGATGA GTTGTTCTAT 
GTGGACTTGG ATAAGAAGGA GACTGTCTGG ATGCTTCCTG AGTTTGGCCA ATTGGCAAGC 
TTTGACCCCC AAGGTGGACT GCAAAACATA GCTGTAGTAA AACACAACTT GGGAGTCTTG 
ACTAAGAGGT CAAATTCCAC CCCAGCTACC AATGAGGCTC CTCAAGCGAC TGTGTTCCCC 
AAGTCCCCTG TGCTGCTGGG TCAGCCCAAC ACCCTCATCT GCTTTGTGGA CAACATCTTC 
CCTCCTGTGA TCAACATCAC ATGGCTCAGA AATAGCAAGT CAGTCGCAGA CGGTGTTTAT 
GAGACCAGCT TCTTCGTCAA CCGTGACTAT TCCTTCCACA AGCTGTCTTA TCTCACCTTC 
ATCCCTTCTG ACGATGACAT TTATGACTGC AAGGTGGAAC ACTGGGGCCT GGAGGAGCCG 
GTTCTGAAAC ACTGGGAACC TGAGATTCCA GCCCCCATGT CAGAGCTGAC AGAGACTGTG 
GTCTGTGCCC TGGGGTTGTC TGTGGGCCTT GTGGGCATCG TGGTGGGCAC CATCTTCATC 
ATTCAAGGCC TGCGATCAGG TGGCACCTCC AGACACCCAG GGCCTTTATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034508.2
CDS	6..776
Translation	MPRSRALILGVLALTTMLSLCGGEDDIEADHVGTYGISVYQSPGDIGQYTFEFDGDELFYVDLDKKETVWMLPEFGQLASFDPQGGLQNIAVVKHNLGVLTKRSNSTPATNEAPQATVFPKSPVLLGQPNTLICFVDNIFPPVINITWLRNSKSVADGVYETSFFVNRDYSFHKLSYLTFIPSDDDIYDCKVEHWGLEEPVLKHWEPEIPAPMSELTETVVCALGLSVGLVGIVVGTIFIIQGLRSGGTSRHPGPL

Target ORF information:

RefSeq Version	NM_010378.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus histocompatibility 2, class II antigen A, alpha (H2-Aa), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010378.2

ORF Insert Sequence:

ATGCCGCGCA GCAGAGCTCT GATTCTGGGG GTCCTCGCCC TGACCACCAT GCTCAGCCTC 
TGTGGAGGTG AAGACGACAT TGAGGCCGAC CACGTAGGCA CCTATGGTAT AAGTGTATAT 
CAGTCTCCTG GAGACATTGG CCAGTACACA TTTGAATTTG ATGGTGATGA GTTGTTCTAT 
GTGGACTTGG ATAAGAAGGA GACTGTCTGG ATGCTTCCTG AGTTTGGCCA ATTGGCAAGC 
TTTGACCCCC AAGGTGGACT GCAAAACATA GCTGTAGTAA AACACAACTT GGGAGTCTTG 
ACTAAGAGGT CAAATTCCAC CCCAGCTACC AATGAGGCTC CTCAAGCGAC TGTGTTCCCC 
AAGTCCCCTG TGCTGCTGGG TCAGCCCAAC ACCCTCATCT GCTTTGTGGA CAACATCTTC 
CCTCCTGTGA TCAACATCAC ATGGCTCAGA AATAGCAAGT CAGTCGCAGA CGGTGTTTAT 
GAGACCAGCT TCTTCGTCAA CCGTGACTAT TCCTTCCACA AGCTGTCTTA TCTCACCTTC 
ATCCCTTCTG ACGATGACAT TTATGACTGC AAGGTGGAAC ACTGGGGCCT GGAGGAGCCG 
GTTCTGAAAC ACTGGGAACC TGAGATTCCA GCCCCCATGT CAGAGCTGAC AGAGACTGTG 
GTCTGTGCCC TGGGGTTGTC TGTGGGCCTT GTGGGCATCG TGGTGGGCAC CATCTTCATC 
ATTCAAGGCC TGCGATCAGG TGGCACCTCC AGACACCCAG GGCCTTTATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

H2-Aa ( NM_010378.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034508.2 Mus musculus histocompatibility 2, class II antigen A, alpha (H2-Aa), mRNA.

Price & Availability↑

CloneID	OMu18536
Clone ID Related Accession (Same CDS sequence)	NM_010378.2 , NM_010378.3
Accession Version	NM_010378.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 771bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Mus musculus(house mouse)
Product	histocompatibility 2, class II antigen A, alpha precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CR974422.14, AK002532.1 and BY604245.1. On Jul 13, 2018 this sequence version replaced NM_010378.2. Sequence Note: This record matches the C57BL/6J reference assembly sequence and represents the b haplotype of this gene. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC031711.1, AK002532.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCGCGCA GCAGAGCTCT GATTCTGGGG GTCCTCGCCC TGACCACCAT GCTCAGCCTC 
TGTGGAGGTG AAGACGACAT TGAGGCCGAC CACGTAGGCA CCTATGGTAT AAGTGTATAT 
CAGTCTCCTG GAGACATTGG CCAGTACACA TTTGAATTTG ATGGTGATGA GTTGTTCTAT 
GTGGACTTGG ATAAGAAGGA GACTGTCTGG ATGCTTCCTG AGTTTGGCCA ATTGGCAAGC 
TTTGACCCCC AAGGTGGACT GCAAAACATA GCTGTAGTAA AACACAACTT GGGAGTCTTG 
ACTAAGAGGT CAAATTCCAC CCCAGCTACC AATGAGGCTC CTCAAGCGAC TGTGTTCCCC 
AAGTCCCCTG TGCTGCTGGG TCAGCCCAAC ACCCTCATCT GCTTTGTGGA CAACATCTTC 
CCTCCTGTGA TCAACATCAC ATGGCTCAGA AATAGCAAGT CAGTCGCAGA CGGTGTTTAT 
GAGACCAGCT TCTTCGTCAA CCGTGACTAT TCCTTCCACA AGCTGTCTTA TCTCACCTTC 
ATCCCTTCTG ACGATGACAT TTATGACTGC AAGGTGGAAC ACTGGGGCCT GGAGGAGCCG 
GTTCTGAAAC ACTGGGAACC TGAGATTCCA GCCCCCATGT CAGAGCTGAC AGAGACTGTG 
GTCTGTGCCC TGGGGTTGTC TGTGGGCCTT GTGGGCATCG TGGTGGGCAC CATCTTCATC 
ATTCAAGGCC TGCGATCAGG TGGCACCTCC AGACACCCAG GGCCTTTATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034508.2
CDS	58..828
Translation	MPRSRALILGVLALTTMLSLCGGEDDIEADHVGTYGISVYQSPGDIGQYTFEFDGDELFYVDLDKKETVWMLPEFGQLASFDPQGGLQNIAVVKHNLGVLTKRSNSTPATNEAPQATVFPKSPVLLGQPNTLICFVDNIFPPVINITWLRNSKSVADGVYETSFFVNRDYSFHKLSYLTFIPSDDDIYDCKVEHWGLEEPVLKHWEPEIPAPMSELTETVVCALGLSVGLVGIVVGTIFIIQGLRSGGTSRHPGPL

Target ORF information:

RefSeq Version	NM_010378.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus histocompatibility 2, class II antigen A, alpha (H2-Aa), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010378.3

ORF Insert Sequence:

ATGCCGCGCA GCAGAGCTCT GATTCTGGGG GTCCTCGCCC TGACCACCAT GCTCAGCCTC 
TGTGGAGGTG AAGACGACAT TGAGGCCGAC CACGTAGGCA CCTATGGTAT AAGTGTATAT 
CAGTCTCCTG GAGACATTGG CCAGTACACA TTTGAATTTG ATGGTGATGA GTTGTTCTAT 
GTGGACTTGG ATAAGAAGGA GACTGTCTGG ATGCTTCCTG AGTTTGGCCA ATTGGCAAGC 
TTTGACCCCC AAGGTGGACT GCAAAACATA GCTGTAGTAA AACACAACTT GGGAGTCTTG 
ACTAAGAGGT CAAATTCCAC CCCAGCTACC AATGAGGCTC CTCAAGCGAC TGTGTTCCCC 
AAGTCCCCTG TGCTGCTGGG TCAGCCCAAC ACCCTCATCT GCTTTGTGGA CAACATCTTC 
CCTCCTGTGA TCAACATCAC ATGGCTCAGA AATAGCAAGT CAGTCGCAGA CGGTGTTTAT 
GAGACCAGCT TCTTCGTCAA CCGTGACTAT TCCTTCCACA AGCTGTCTTA TCTCACCTTC 
ATCCCTTCTG ACGATGACAT TTATGACTGC AAGGTGGAAC ACTGGGGCCT GGAGGAGCCG 
GTTCTGAAAC ACTGGGAACC TGAGATTCCA GCCCCCATGT CAGAGCTGAC AGAGACTGTG 
GTCTGTGCCC TGGGGTTGTC TGTGGGCCTT GTGGGCATCG TGGTGGGCAC CATCTTCATC 
ATTCAAGGCC TGCGATCAGG TGGCACCTCC AGACACCCAG GGCCTTTATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A triad of molecular regions contribute to the formation of two distinct MHC class II conformers.
Molecular immunology7459-70(2016 06)
Drake LA,Drake JR

The QTL within the H2 Complex Involved in the Control of Tuberculosis Infection in Mice Is the Classical Class II H2-Ab1 Gene.
PLoS genetics11(11)e1005672(2015 Nov)
Logunova N,Korotetskaya M,Polshakov V,Apt A

Ag-presenting CpG-activated pDCs prime Th17 cells that induce tumor regression.
Cancer research74(22)6430-40(2014 Nov)
Gu?ry L,Dubrot J,Lippens C,Brighouse D,Malinge P,Irla M,Pot C,Reith W,Waldburger JM,Hugues S

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H2-Aa cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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