ACADL cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ACADL
Entrez Gene ID	33
Full Name	acyl-CoA dehydrogenase long chain
Synonyms	ACAD4,LCAD
General protein information	Preferred Names acyl-CoA dehydrogenase long chain Names long-chain specific acyl-CoA dehydrogenase, mitochondrial acyl-Coenzyme A dehydrogenase, long chain
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q34
Summary	The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family, which is a family of mitochondrial flavoenzymes involved in fatty acid and branched chain amino-acid metabolism. This protein is one of the four enzymes that catalyze the initial step of mitochondrial beta-oxidation of straight-chain fatty acid. Defects in this gene are the cause of long-chain acyl-CoA dehydrogenase (LCAD) deficiency, leading to nonketotic hypoglycemia. [provided by RefSeq, Jul 2008].
Disorder MIM:	609576

mRNA and Protein(s)

mRNA	Protein	Name
XM_017003955.1	XP_016859444.1	long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X2
NM_001608.4	NP_001599.1	long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor
NM_001608.3	NP_001599.1	long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor
XM_005246517.4	XP_005246574.1	long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Acadl	NP_031407.2
Homo sapiens (human)	ACADL	NP_001599.1
	LOC711485	XP_001109931.2
Canis lupus familiaris (dog)	ACADL	XP_536053.3
Rattus norvegicus (Norway rat)	Acadl	NP_036951.1
Bos taurus (cattle)	ACADL	NP_001070404.1
Pan troglodytes (chimpanzee)	ACADL	XP_516063.3
Xenopus tropicalis (tropical clawed frog)	acadl	NP_001039250.1
Gallus gallus (chicken)	ACADL	NP_001006511.1
Danio rerio (zebrafish)	acadl	NP_957475.1

Gene Ontology
Bibliography

Related articles in PubMed

An atlas of genetic influences on human blood metabolites.
Shin SY, Fauman EB, Petersen AK, Krumsiek J, Santos R, Huang J, Arnold M, Erte I, Forgetta V, Yang TP, Walter K, Menni C, Chen L, Vasquez L, Valdes AM, Hyde CL, Wang V, Ziemek D, Roberts P, Xi L, Grundberg E, , Waldenberger M, Richards JB, Mohney RP, Milburn MV, John SL, Trimmer J, Theis FJ, Overington JP, Suhre K, Brosnan MJ, Gieger C, Kastenm?ller G, Spector TD, Soranzo N
Nature genetics46(6)543-550(2014 Jun)

Long-chain acyl-CoA dehydrogenase deficiency as a cause of pulmonary surfactant dysfunction.
Goetzman ES, Alcorn JF, Bharathi SS, Uppala R, McHugh KJ, Kosmider B, Chen R, Zuo YY, Beck ME, McKinney RW, Skilling H, Suhrie KR, Karunanidhi A, Yeasted R, Otsubo C, Ellis B, Tyurina YY, Kagan VE, Mallampalli RK, Vockley J
The Journal of biological chemistry289(15)10668-79(2014 Apr)

Genome-wide association study of metabolic traits reveals novel gene-metabolite-disease links.
Rueedi R, Ledda M, Nicholls AW, Salek RM, Marques-Vidal P, Morya E, Sameshima K, Montoliu I, Da Silva L, Collino S, Martin FP, Rezzi S, Steinbeck C, Waterworth DM, Waeber G, Vollenweider P, Beckmann JS, Le Coutre J, Mooser V, Bergmann S, Genick UK, Kutalik Z
PLoS genetics10(2)e1004132(2014 Feb)

Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site.
Bharathi SS, Zhang Y, Mohsen AW, Uppala R, Balasubramani M, Schreiber E, Uechi G, Beck ME, Rardin MJ, Vockley J, Verdin E, Gibson BW, Hirschey MD, Goetzman ES
The Journal of biological chemistry288(47)33837-47(2013 Nov)

A genome-wide assessment of variability in human serum metabolism.
Hong MG, Karlsson R, Magnusson PK, Lewis MR, Isaacs W, Zheng LS, Xu J, Gr?nberg H, Ingelsson E, Pawitan Y, Broeckling C, Prenni JE, Wiklund F, Prince JA
Human mutation34(3)515-24(2013 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the fatty acid oxidation pathway and LCAD are factors contributing to the pathophysiology of pulmonary disease
Title: Long-chain acyl-CoA dehydrogenase deficiency as a cause of pulmonary surfactant dysfunction.

Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site.
Title: Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

LCAD is minimally expressed in human skeletal muscle and likely does not play a significant role in long-chain fatty acid oxidation.
Title: Low expression of long-chain acyl-CoA dehydrogenase in human skeletal muscle.

The following ACADL gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ACADL cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18513	NM_001608.4 Latest version!	Homo sapiens acyl-CoA dehydrogenase long chain (ACADL), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu36181	XM_005246517.4 Latest version!	Homo sapiens acyl-CoA dehydrogenase long chain (ACADL), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu89352	XM_017003955.1 Latest version!	Homo sapiens acyl-CoA dehydrogenase long chain (ACADL), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu18513	NM_001608.3	Homo sapiens acyl-CoA dehydrogenase long chain (ACADL), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ACADL ( NM_001608.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001599.1 Homo sapiens acyl-CoA dehydrogenase long chain (ACADL), mRNA.

Price & Availability↑

CloneID	OHu18513
Clone ID Related Accession (Same CDS sequence)	NM_001608.4 , NM_001608.3
Accession Version	NM_001608.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1293bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC350098.1, BC039063.1 and AC006994.4. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_001608.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.176300.1, SRR1803616.261303.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000233710.4/ ENSP00000233710.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCGCAC GCCTTCTCCG AGGGTCCCTA CGCGTCCTGG GCGGCCACCG TGCGCCGCGC 
CAGCTGCCCG CCGCGCGATG TTCTCATTCC GGAGGGGAAG AACGTCTAGA AACTCCTTCT 
GCTAAAAAAT TAACAGATAT AGGAATTCGA AGAATCTTTT CTCCAGAGCA TGACATTTTC 
CGGAAAAGTG TAAGGAAGTT TTTCCAAGAA GAAGTGATTC CTCATCACTC AGAATGGGAG 
AAAGCTGGAG AAGTAAGTAG GGAGGTTTGG GAAAAAGCTG GAAAACAAGG ACTGCTTGGT 
GTCAATATTG CAGAGCATCT TGGTGGAATT GGAGGGGATC TGTACTCCGC AGCTATTGTC 
TGGGAGGAGC AAGCTTATTC AAATTGTTCA GGCCCAGGTT TTAGTATTCA TTCAGGTATT 
GTCATGTCCT ATATTACAAA CCATGGCTCA GAAGAACAGA TTAAGCACTT TATTCCCCAG 
ATGACTGCAG GCAAATGTAT TGGTGCAATA GCAATGACAG AGCCTGGAGC TGGAAGTGAC 
TTACAGGGAA TAAAAACAAA TGCTAAAAAG GATGGAAGTG ACTGGATTCT CAATGGAAGC 
AAGGTGTTCA TCAGTAATGG GTCATTAAGT GATGTTGTGA TTGTAGTTGC GGTCACAAAT 
CATGAAGCTC CCTCCCCTGC CCATGGTATT AGCCTTTTTC TGGTGGAAAA TGGAATGAAA 
GGATTTATCA AGGGACGAAA GCTACATAAA ATGGGATTAA AAGCCCAGGA TACCGCAGAA 
CTATTCTTTG AAGATATACG GTTGCCAGCT AGTGCCCTAC TTGGAGAAGA GAATAAAGGC 
TTCTATTACA TCATGAAAGA GCTTCCACAG GAAAGGCTGT TAATTGCTGA TGTGGCAATT 
TCAGCTAGTG AATTCATGTT TGAAGAAACC AGGAACTATG TTAAACAAAG AAAAGCTTTT 
GGCAAAACAG TTGCTCACCT ACAGACAGTG CAACATAAAT TAGCAGAATT AAAAACACAT 
ATATGTGTAA CCCGAGCATT TGTGGACAAC TGTCTCCAGC TGCATGAAGC GAAACGTTTG 
GACTCCGCCA CTGCTTGCAT GGCGAAATAT TGGGCATCTG AGTTACAAAA TAGTGTAGCT 
TACGACTGTG TACAGCTCCA TGGAGGTTGG GGATACATGT GGGAGTACCC AATTGCAAAA 
GCTTATGTGG ATGCCAGAGT TCAGCCAATC TATGGTGGTA CAAATGAAAT AATGAAGGAG 
CTGATTGCAA GAGAGATTGT CTTTGACAAG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001599.1
CDS	185..1477
Translation	MAARLLRGSLRVLGGHRAPRQLPAARCSHSGGEERLETPSAKKLTDIGIRRIFSPEHDIFRKSVRKFFQEEVIPHHSEWEKAGEVSREVWEKAGKQGLLGVNIAEHLGGIGGDLYSAAIVWEEQAYSNCSGPGFSIHSGIVMSYITNHGSEEQIKHFIPQMTAGKCIGAIAMTEPGAGSDLQGIKTNAKKDGSDWILNGSKVFISNGSLSDVVIVVAVTNHEAPSPAHGISLFLVENGMKGFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKGFYYIMKELPQERLLIADVAISASEFMFEETRNYVKQRKAFGKTVAHLQTVQHKLAELKTHICVTRAFVDNCLQLHEAKRLDSATACMAKYWASELQNSVAYDCVQLHGGWGYMWEYPIAKAYVDARVQPIYGGTNEIMKELIAREIVFDK

Target ORF information:

RefSeq Version	NM_001608.4
Organism	Homo sapiens(human)
Definition	Homo sapiens acyl-CoA dehydrogenase long chain (ACADL), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001608.4

ORF Insert Sequence:

ATGGCCGCAC GCCTTCTCCG AGGGTCCCTA CGCGTCCTGG GCGGCCACCG TGCGCCGCGC 
CAGCTGCCCG CCGCGCGATG TTCTCATTCC GGAGGGGAAG AACGTCTAGA AACTCCTTCT 
GCTAAAAAAT TAACAGATAT AGGAATTCGA AGAATCTTTT CTCCAGAGCA TGACATTTTC 
CGGAAAAGTG TAAGGAAGTT TTTCCAAGAA GAAGTGATTC CTCATCACTC AGAATGGGAG 
AAAGCTGGAG AAGTAAGTAG GGAGGTTTGG GAAAAAGCTG GAAAACAAGG ACTGCTTGGT 
GTCAATATTG CAGAGCATCT TGGTGGAATT GGAGGGGATC TGTACTCCGC AGCTATTGTC 
TGGGAGGAGC AAGCTTATTC AAATTGTTCA GGCCCAGGTT TTAGTATTCA TTCAGGTATT 
GTCATGTCCT ATATTACAAA CCATGGCTCA GAAGAACAGA TTAAGCACTT TATTCCCCAG 
ATGACTGCAG GCAAATGTAT TGGTGCAATA GCAATGACAG AGCCTGGAGC TGGAAGTGAC 
TTACAGGGAA TAAAAACAAA TGCTAAAAAG GATGGAAGTG ACTGGATTCT CAATGGAAGC 
AAGGTGTTCA TCAGTAATGG GTCATTAAGT GATGTTGTGA TTGTAGTTGC GGTCACAAAT 
CATGAAGCTC CCTCCCCTGC CCATGGTATT AGCCTTTTTC TGGTGGAAAA TGGAATGAAA 
GGATTTATCA AGGGACGAAA GCTACATAAA ATGGGATTAA AAGCCCAGGA TACCGCAGAA 
CTATTCTTTG AAGATATACG GTTGCCAGCT AGTGCCCTAC TTGGAGAAGA GAATAAAGGC 
TTCTATTACA TCATGAAAGA GCTTCCACAG GAAAGGCTGT TAATTGCTGA TGTGGCAATT 
TCAGCTAGTG AATTCATGTT TGAAGAAACC AGGAACTATG TTAAACAAAG AAAAGCTTTT 
GGCAAAACAG TTGCTCACCT ACAGACAGTG CAACATAAAT TAGCAGAATT AAAAACACAT 
ATATGTGTAA CCCGAGCATT TGTGGACAAC TGTCTCCAGC TGCATGAAGC GAAACGTTTG 
GACTCCGCCA CTGCTTGCAT GGCGAAATAT TGGGCATCTG AGTTACAAAA TAGTGTAGCT 
TACGACTGTG TACAGCTCCA TGGAGGTTGG GGATACATGT GGGAGTACCC AATTGCAAAA 
GCTTATGTGG ATGCCAGAGT TCAGCCAATC TATGGTGGTA CAAATGAAAT AATGAAGGAG 
CTGATTGCAA GAGAGATTGT CTTTGACAAG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ACADL ( NM_001608.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001599.1 Homo sapiens acyl-CoA dehydrogenase long chain (ACADL), mRNA.

Price & Availability↑

CloneID	OHu18513
Clone ID Related Accession (Same CDS sequence)	NM_001608.4 , NM_001608.3
Accession Version	NM_001608.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1293bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-26
Organism	Homo sapiens(human)
Product	long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC350098.1 and BC039063.1. This sequence is a reference standard in the RefSeqGene project. On May 16, 2008 this sequence version replaced NM_001608.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC039063.1, SRR1803616.261303.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCGCAC GCCTTCTCCG AGGGTCCCTA CGCGTCCTGG GCGGCCACCG TGCGCCGCGC 
CAGCTGCCCG CCGCGCGATG TTCTCATTCC GGAGGGGAAG AACGTCTAGA AACTCCTTCT 
GCTAAAAAAT TAACAGATAT AGGAATTCGA AGAATCTTTT CTCCAGAGCA TGACATTTTC 
CGGAAAAGTG TAAGGAAGTT TTTCCAAGAA GAAGTGATTC CTCATCACTC AGAATGGGAG 
AAAGCTGGAG AAGTAAGTAG GGAGGTTTGG GAAAAAGCTG GAAAACAAGG ACTGCTTGGT 
GTCAATATTG CAGAGCATCT TGGTGGAATT GGAGGGGATC TGTACTCCGC AGCTATTGTC 
TGGGAGGAGC AAGCTTATTC AAATTGTTCA GGCCCAGGTT TTAGTATTCA TTCAGGTATT 
GTCATGTCCT ATATTACAAA CCATGGCTCA GAAGAACAGA TTAAGCACTT TATTCCCCAG 
ATGACTGCAG GCAAATGTAT TGGTGCAATA GCAATGACAG AGCCTGGAGC TGGAAGTGAC 
TTACAGGGAA TAAAAACAAA TGCTAAAAAG GATGGAAGTG ACTGGATTCT CAATGGAAGC 
AAGGTGTTCA TCAGTAATGG GTCATTAAGT GATGTTGTGA TTGTAGTTGC GGTCACAAAT 
CATGAAGCTC CCTCCCCTGC CCATGGTATT AGCCTTTTTC TGGTGGAAAA TGGAATGAAA 
GGATTTATCA AGGGACGAAA GCTACATAAA ATGGGATTAA AAGCCCAGGA TACCGCAGAA 
CTATTCTTTG AAGATATACG GTTGCCAGCT AGTGCCCTAC TTGGAGAAGA GAATAAAGGC 
TTCTATTACA TCATGAAAGA GCTTCCACAG GAAAGGCTGT TAATTGCTGA TGTGGCAATT 
TCAGCTAGTG AATTCATGTT TGAAGAAACC AGGAACTATG TTAAACAAAG AAAAGCTTTT 
GGCAAAACAG TTGCTCACCT ACAGACAGTG CAACATAAAT TAGCAGAATT AAAAACACAT 
ATATGTGTAA CCCGAGCATT TGTGGACAAC TGTCTCCAGC TGCATGAAGC GAAACGTTTG 
GACTCCGCCA CTGCTTGCAT GGCGAAATAT TGGGCATCTG AGTTACAAAA TAGTGTAGCT 
TACGACTGTG TACAGCTCCA TGGAGGTTGG GGATACATGT GGGAGTACCC AATTGCAAAA 
GCTTATGTGG ATGCCAGAGT TCAGCCAATC TATGGTGGTA CAAATGAAAT AATGAAGGAG 
CTGATTGCAA GAGAGATTGT CTTTGACAAG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001599.1
CDS	229..1521
Translation	MAARLLRGSLRVLGGHRAPRQLPAARCSHSGGEERLETPSAKKLTDIGIRRIFSPEHDIFRKSVRKFFQEEVIPHHSEWEKAGEVSREVWEKAGKQGLLGVNIAEHLGGIGGDLYSAAIVWEEQAYSNCSGPGFSIHSGIVMSYITNHGSEEQIKHFIPQMTAGKCIGAIAMTEPGAGSDLQGIKTNAKKDGSDWILNGSKVFISNGSLSDVVIVVAVTNHEAPSPAHGISLFLVENGMKGFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKGFYYIMKELPQERLLIADVAISASEFMFEETRNYVKQRKAFGKTVAHLQTVQHKLAELKTHICVTRAFVDNCLQLHEAKRLDSATACMAKYWASELQNSVAYDCVQLHGGWGYMWEYPIAKAYVDARVQPIYGGTNEIMKELIAREIVFDK

Target ORF information:

RefSeq Version	NM_001608.3
Organism	Homo sapiens(human)
Definition	Homo sapiens acyl-CoA dehydrogenase long chain (ACADL), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001608.3

ORF Insert Sequence:

ATGGCCGCAC GCCTTCTCCG AGGGTCCCTA CGCGTCCTGG GCGGCCACCG TGCGCCGCGC 
CAGCTGCCCG CCGCGCGATG TTCTCATTCC GGAGGGGAAG AACGTCTAGA AACTCCTTCT 
GCTAAAAAAT TAACAGATAT AGGAATTCGA AGAATCTTTT CTCCAGAGCA TGACATTTTC 
CGGAAAAGTG TAAGGAAGTT TTTCCAAGAA GAAGTGATTC CTCATCACTC AGAATGGGAG 
AAAGCTGGAG AAGTAAGTAG GGAGGTTTGG GAAAAAGCTG GAAAACAAGG ACTGCTTGGT 
GTCAATATTG CAGAGCATCT TGGTGGAATT GGAGGGGATC TGTACTCCGC AGCTATTGTC 
TGGGAGGAGC AAGCTTATTC AAATTGTTCA GGCCCAGGTT TTAGTATTCA TTCAGGTATT 
GTCATGTCCT ATATTACAAA CCATGGCTCA GAAGAACAGA TTAAGCACTT TATTCCCCAG 
ATGACTGCAG GCAAATGTAT TGGTGCAATA GCAATGACAG AGCCTGGAGC TGGAAGTGAC 
TTACAGGGAA TAAAAACAAA TGCTAAAAAG GATGGAAGTG ACTGGATTCT CAATGGAAGC 
AAGGTGTTCA TCAGTAATGG GTCATTAAGT GATGTTGTGA TTGTAGTTGC GGTCACAAAT 
CATGAAGCTC CCTCCCCTGC CCATGGTATT AGCCTTTTTC TGGTGGAAAA TGGAATGAAA 
GGATTTATCA AGGGACGAAA GCTACATAAA ATGGGATTAA AAGCCCAGGA TACCGCAGAA 
CTATTCTTTG AAGATATACG GTTGCCAGCT AGTGCCCTAC TTGGAGAAGA GAATAAAGGC 
TTCTATTACA TCATGAAAGA GCTTCCACAG GAAAGGCTGT TAATTGCTGA TGTGGCAATT 
TCAGCTAGTG AATTCATGTT TGAAGAAACC AGGAACTATG TTAAACAAAG AAAAGCTTTT 
GGCAAAACAG TTGCTCACCT ACAGACAGTG CAACATAAAT TAGCAGAATT AAAAACACAT 
ATATGTGTAA CCCGAGCATT TGTGGACAAC TGTCTCCAGC TGCATGAAGC GAAACGTTTG 
GACTCCGCCA CTGCTTGCAT GGCGAAATAT TGGGCATCTG AGTTACAAAA TAGTGTAGCT 
TACGACTGTG TACAGCTCCA TGGAGGTTGG GGATACATGT GGGAGTACCC AATTGCAAAA 
GCTTATGTGG ATGCCAGAGT TCAGCCAATC TATGGTGGTA CAAATGAAAT AATGAAGGAG 
CTGATTGCAA GAGAGATTGT CTTTGACAAG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ACADL ( XM_005246517.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_005246574.1 Homo sapiens acyl-CoA dehydrogenase long chain (ACADL), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu36181
Clone ID Related Accession (Same CDS sequence)	XM_005246517.4
Accession Version	XM_005246517.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1230bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005246517.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACAGCAT TGGTATGTTC TCATTCCGGA GGGGAAGAAC GTCTAGAAAC TCCTTCTGCT 
AAAAAATTAA CAGATATAGG AATTCGAAGA ATCTTTTCTC CAGAGCATGA CATTTTCCGG 
AAAAGTGTAA GGAAGTTTTT CCAAGAAGAA GTGATTCCTC ATCACTCAGA ATGGGAGAAA 
GCTGGAGAAG TAAGTAGGGA GGTTTGGGAA AAAGCTGGAA AACAAGGACT GCTTGGTGTC 
AATATTGCAG AGCATCTTGG TGGAATTGGA GGGGATCTGT ACTCCGCAGC TATTGTCTGG 
GAGGAGCAAG CTTATTCAAA TTGTTCAGGC CCAGGTTTTA GTATTCATTC AGGTATTGTC 
ATGTCCTATA TTACAAACCA TGGCTCAGAA GAACAGATTA AGCACTTTAT TCCCCAGATG 
ACTGCAGGCA AATGTATTGG TGCAATAGCA ATGACAGAGC CTGGAGCTGG AAGTGACTTA 
CAGGGAATAA AAACAAATGC TAAAAAGGAT GGAAGTGACT GGATTCTCAA TGGAAGCAAG 
GTGTTCATCA GTAATGGGTC ATTAAGTGAT GTTGTGATTG TAGTTGCGGT CACAAATCAT 
GAAGCTCCCT CCCCTGCCCA TGGTATTAGC CTTTTTCTGG TGGAAAATGG AATGAAAGGA 
TTTATCAAGG GACGAAAGCT ACATAAAATG GGATTAAAAG CCCAGGATAC CGCAGAACTA 
TTCTTTGAAG ATATACGGTT GCCAGCTAGT GCCCTACTTG GAGAAGAGAA TAAAGGCTTC 
TATTACATCA TGAAAGAGCT TCCACAGGAA AGGCTGTTAA TTGCTGATGT GGCAATTTCA 
GCTAGTGAAT TCATGTTTGA AGAAACCAGG AACTATGTTA AACAAAGAAA AGCTTTTGGC 
AAAACAGTTG CTCACCTACA GACAGTGCAA CATAAATTAG CAGAATTAAA AACACATATA 
TGTGTAACCC GAGCATTTGT GGACAACTGT CTCCAGCTGC ATGAAGCGAA ACGTTTGGAC 
TCCGCCACTG CTTGCATGGC GAAATATTGG GCATCTGAGT TACAAAATAG TGTAGCTTAC 
GACTGTGTAC AGCTCCATGG AGGTTGGGGA TACATGTGGG AGTACCCAAT TGCAAAAGCT 
TATGTGGATG CCAGAGTTCA GCCAATCTAT GGTGGTACAA ATGAAATAAT GAAGGAGCTG 
ATTGCAAGAG AGATTGTCTT TGACAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005246574.1
CDS	744..1973
Translation	MTALVCSHSGGEERLETPSAKKLTDIGIRRIFSPEHDIFRKSVRKFFQEEVIPHHSEWEKAGEVSREVWEKAGKQGLLGVNIAEHLGGIGGDLYSAAIVWEEQAYSNCSGPGFSIHSGIVMSYITNHGSEEQIKHFIPQMTAGKCIGAIAMTEPGAGSDLQGIKTNAKKDGSDWILNGSKVFISNGSLSDVVIVVAVTNHEAPSPAHGISLFLVENGMKGFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKGFYYIMKELPQERLLIADVAISASEFMFEETRNYVKQRKAFGKTVAHLQTVQHKLAELKTHICVTRAFVDNCLQLHEAKRLDSATACMAKYWASELQNSVAYDCVQLHGGWGYMWEYPIAKAYVDARVQPIYGGTNEIMKELIAREIVFDK

Target ORF information:

RefSeq Version	XM_005246517.4
Organism	Homo sapiens(human)
Definition	Homo sapiens acyl-CoA dehydrogenase long chain (ACADL), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005246517.4

ORF Insert Sequence:

ATGACAGCAT TGGTATGTTC TCATTCCGGA GGGGAAGAAC GTCTAGAAAC TCCTTCTGCT 
AAAAAATTAA CAGATATAGG AATTCGAAGA ATCTTTTCTC CAGAGCATGA CATTTTCCGG 
AAAAGTGTAA GGAAGTTTTT CCAAGAAGAA GTGATTCCTC ATCACTCAGA ATGGGAGAAA 
GCTGGAGAAG TAAGTAGGGA GGTTTGGGAA AAAGCTGGAA AACAAGGACT GCTTGGTGTC 
AATATTGCAG AGCATCTTGG TGGAATTGGA GGGGATCTGT ACTCCGCAGC TATTGTCTGG 
GAGGAGCAAG CTTATTCAAA TTGTTCAGGC CCAGGTTTTA GTATTCATTC AGGTATTGTC 
ATGTCCTATA TTACAAACCA TGGCTCAGAA GAACAGATTA AGCACTTTAT TCCCCAGATG 
ACTGCAGGCA AATGTATTGG TGCAATAGCA ATGACAGAGC CTGGAGCTGG AAGTGACTTA 
CAGGGAATAA AAACAAATGC TAAAAAGGAT GGAAGTGACT GGATTCTCAA TGGAAGCAAG 
GTGTTCATCA GTAATGGGTC ATTAAGTGAT GTTGTGATTG TAGTTGCGGT CACAAATCAT 
GAAGCTCCCT CCCCTGCCCA TGGTATTAGC CTTTTTCTGG TGGAAAATGG AATGAAAGGA 
TTTATCAAGG GACGAAAGCT ACATAAAATG GGATTAAAAG CCCAGGATAC CGCAGAACTA 
TTCTTTGAAG ATATACGGTT GCCAGCTAGT GCCCTACTTG GAGAAGAGAA TAAAGGCTTC 
TATTACATCA TGAAAGAGCT TCCACAGGAA AGGCTGTTAA TTGCTGATGT GGCAATTTCA 
GCTAGTGAAT TCATGTTTGA AGAAACCAGG AACTATGTTA AACAAAGAAA AGCTTTTGGC 
AAAACAGTTG CTCACCTACA GACAGTGCAA CATAAATTAG CAGAATTAAA AACACATATA 
TGTGTAACCC GAGCATTTGT GGACAACTGT CTCCAGCTGC ATGAAGCGAA ACGTTTGGAC 
TCCGCCACTG CTTGCATGGC GAAATATTGG GCATCTGAGT TACAAAATAG TGTAGCTTAC 
GACTGTGTAC AGCTCCATGG AGGTTGGGGA TACATGTGGG AGTACCCAAT TGCAAAAGCT 
TATGTGGATG CCAGAGTTCA GCCAATCTAT GGTGGTACAA ATGAAATAAT GAAGGAGCTG 
ATTGCAAGAG AGATTGTCTT TGACAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ACADL ( XM_017003955.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016859444.1 Homo sapiens acyl-CoA dehydrogenase long chain (ACADL), transcript variant X2, mRNA.

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CloneID	OHu89352
Clone ID Related Accession (Same CDS sequence)	XM_017003955.1
Accession Version	XM_017003955.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 870bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCTATA TTACAAACCA TGGCTCAGAA GAACAGATTA AGCACTTTAT TCCCCAGATG 
ACTGCAGGCA AATGTATTGG TGCAATAGCA ATGACAGAGC CTGGAGCTGG AAGTGACTTA 
CAGGGAATAA AAACAAATGC TAAAAAGGAT GGAAGTGACT GGATTCTCAA TGGAAGCAAG 
GTGTTCATCA GTAATGGGTC ATTAAGTGAT GTTGTGATTG TAGTTGCGGT CACAAATCAT 
GAAGCTCCCT CCCCTGCCCA TGGTATTAGC CTTTTTCTGG TGGAAAATGG AATGAAAGGA 
TTTATCAAGG GACGAAAGCT ACATAAAATG GGATTAAAAG CCCAGGATAC CGCAGAACTA 
TTCTTTGAAG ATATACGGTT GCCAGCTAGT GCCCTACTTG GAGAAGAGAA TAAAGGCTTC 
TATTACATCA TGAAAGAGCT TCCACAGGAA AGGCTGTTAA TTGCTGATGT GGCAATTTCA 
GCTAGTGAAT TCATGTTTGA AGAAACCAGG AACTATGTTA AACAAAGAAA AGCTTTTGGC 
AAAACAGTTG CTCACCTACA GACAGTGCAA CATAAATTAG CAGAATTAAA AACACATATA 
TGTGTAACCC GAGCATTTGT GGACAACTGT CTCCAGCTGC ATGAAGCGAA ACGTTTGGAC 
TCCGCCACTG CTTGCATGGC GAAATATTGG GCATCTGAGT TACAAAATAG TGTAGCTTAC 
GACTGTGTAC AGCTCCATGG AGGTTGGGGA TACATGTGGG AGTACCCAAT TGCAAAAGCT 
TATGTGGATG CCAGAGTTCA GCCAATCTAT GGTGGTACAA ATGAAATAAT GAAGGAGCTG 
ATTGCAAGAG AGATTGTCTT TGACAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016859444.1
CDS	1080..1949
Translation	MSYITNHGSEEQIKHFIPQMTAGKCIGAIAMTEPGAGSDLQGIKTNAKKDGSDWILNGSKVFISNGSLSDVVIVVAVTNHEAPSPAHGISLFLVENGMKGFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKGFYYIMKELPQERLLIADVAISASEFMFEETRNYVKQRKAFGKTVAHLQTVQHKLAELKTHICVTRAFVDNCLQLHEAKRLDSATACMAKYWASELQNSVAYDCVQLHGGWGYMWEYPIAKAYVDARVQPIYGGTNEIMKELIAREIVFDK

Target ORF information:

RefSeq Version	XM_017003955.1
Organism	Homo sapiens(human)
Definition	Homo sapiens acyl-CoA dehydrogenase long chain (ACADL), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017003955.1

ORF Insert Sequence:

ATGTCCTATA TTACAAACCA TGGCTCAGAA GAACAGATTA AGCACTTTAT TCCCCAGATG 
ACTGCAGGCA AATGTATTGG TGCAATAGCA ATGACAGAGC CTGGAGCTGG AAGTGACTTA 
CAGGGAATAA AAACAAATGC TAAAAAGGAT GGAAGTGACT GGATTCTCAA TGGAAGCAAG 
GTGTTCATCA GTAATGGGTC ATTAAGTGAT GTTGTGATTG TAGTTGCGGT CACAAATCAT 
GAAGCTCCCT CCCCTGCCCA TGGTATTAGC CTTTTTCTGG TGGAAAATGG AATGAAAGGA 
TTTATCAAGG GACGAAAGCT ACATAAAATG GGATTAAAAG CCCAGGATAC CGCAGAACTA 
TTCTTTGAAG ATATACGGTT GCCAGCTAGT GCCCTACTTG GAGAAGAGAA TAAAGGCTTC 
TATTACATCA TGAAAGAGCT TCCACAGGAA AGGCTGTTAA TTGCTGATGT GGCAATTTCA 
GCTAGTGAAT TCATGTTTGA AGAAACCAGG AACTATGTTA AACAAAGAAA AGCTTTTGGC 
AAAACAGTTG CTCACCTACA GACAGTGCAA CATAAATTAG CAGAATTAAA AACACATATA 
TGTGTAACCC GAGCATTTGT GGACAACTGT CTCCAGCTGC ATGAAGCGAA ACGTTTGGAC 
TCCGCCACTG CTTGCATGGC GAAATATTGG GCATCTGAGT TACAAAATAG TGTAGCTTAC 
GACTGTGTAC AGCTCCATGG AGGTTGGGGA TACATGTGGG AGTACCCAAT TGCAAAAGCT 
TATGTGGATG CCAGAGTTCA GCCAATCTAT GGTGGTACAA ATGAAATAAT GAAGGAGCTG 
ATTGCAAGAG AGATTGTCTT TGACAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

An atlas of genetic influences on human blood metabolites.
Nature genetics46(6)543-550(2014 Jun)
Shin SY,Fauman EB,Petersen AK,Krumsiek J,Santos R,Huang J,Arnold M,Erte I,Forgetta V,Yang TP,Walter K,Menni C,Chen L,Vasquez L,Valdes AM,Hyde CL,Wang V,Ziemek D,Roberts P,Xi L,Grundberg E,,Waldenberger M,Richards JB,Mohney RP,Milburn MV,John SL,Trimmer J,Theis FJ,Overington JP,Suhre K,Brosnan MJ,Gieger C,Kastenm?ller G,Spector TD,Soranzo N

Long-chain acyl-CoA dehydrogenase deficiency as a cause of pulmonary surfactant dysfunction.
The Journal of biological chemistry289(15)10668-79(2014 Apr)
Goetzman ES,Alcorn JF,Bharathi SS,Uppala R,McHugh KJ,Kosmider B,Chen R,Zuo YY,Beck ME,McKinney RW,Skilling H,Suhrie KR,Karunanidhi A,Yeasted R,Otsubo C,Ellis B,Tyurina YY,Kagan VE,Mallampalli RK,Vockley J

Genome-wide association study of metabolic traits reveals novel gene-metabolite-disease links.
PLoS genetics10(2)e1004132(2014 Feb)
Rueedi R,Ledda M,Nicholls AW,Salek RM,Marques-Vidal P,Morya E,Sameshima K,Montoliu I,Da Silva L,Collino S,Martin FP,Rezzi S,Steinbeck C,Waterworth DM,Waeber G,Vollenweider P,Beckmann JS,Le Coutre J,Mooser V,Bergmann S,Genick UK,Kutalik Z

Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site.
The Journal of biological chemistry288(47)33837-47(2013 Nov)
Bharathi SS,Zhang Y,Mohsen AW,Uppala R,Balasubramani M,Schreiber E,Uechi G,Beck ME,Rardin MJ,Vockley J,Verdin E,Gibson BW,Hirschey MD,Goetzman ES

A genome-wide assessment of variability in human serum metabolism.
Human mutation34(3)515-24(2013 Mar)
Hong MG,Karlsson R,Magnusson PK,Lewis MR,Isaacs W,Zheng LS,Xu J,Gr?nberg H,Ingelsson E,Pawitan Y,Broeckling C,Prenni JE,Wiklund F,Prince JA

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ACADL cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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