CLEC4G cDNA ORF clone, Homo sapiens(human)
Gene Symbol | CLEC4G |
Entrez Gene ID | 339390 |
Full Name | C-type lectin domain family 4 member G |
Synonyms | DTTR431,LP2698,LSECtin,UNQ431 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the T-cell immune response. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]. |
Disorder MIM: |
mRNA and Protein(s)
mRNA | Protein | Name |
---|---|---|
NM_001244856.1 | NP_001231785.1 | C-type lectin domain family 4 member G isoform 2 |
NM_198492.3 | NP_940894.1 | C-type lectin domain family 4 member G isoform 1 |
XM_024451485.1 | XP_024307253.1 | C-type lectin domain family 4 member G isoform X1 |

Canis lupus familiaris (dog) | CLEC4G | XP_005633000.1 |
Mus musculus (house mouse) | Clec4g | NP_083741.1 |
Homo sapiens (human) | CLEC4G | NP_940894.1 |
Rattus norvegicus (Norway rat) | Clec4g | XP_006248857.1 |
Pan troglodytes (chimpanzee) | CLEC4G | XP_001154312.3 |
Bos taurus (cattle) | CLEC4G | NP_001192535.1 |

Related articles in PubMed
Distinct usage of three C-type lectins by Japanese encephalitis virus: DC-SIGN, DC-SIGNR, and LSECtin.
Shimojima M, Takenouchi A, Shimoda H, Kimura N, Maeda K
Archives of virology159(8)2023-31(2014 Aug)
Novel roles of liver sinusoidal endothelial cell lectin in colon carcinoma cell adhesion, migration and in-vivo metastasis to the liver.
Zuo Y, Ren S, Wang M, Liu B, Yang J, Kuai X, Lin C, Zhao D, Tang L, He F
Gut62(8)1169-78(2013 Aug)
Mobility study of individual residue sites in the carbohydrate recognition domain of LSECtin using SDSL-EPR technique.
Wang C, Yang J, Zhou Y, Cong J, Dong G, Hu X, Tang L, Wu K
Applied biochemistry and biotechnology167(8)2295-304(2012 Aug)
Identification of cell surface molecules involved in dystroglycan-independent Lassa virus cell entry.
Shimojima M, Str?her U, Ebihara H, Feldmann H, Kawaoka Y
Journal of virology86(4)2067-78(2012 Feb)
Mouse LSECtin as a model for a human Ebola virus receptor.
Pipirou Z, Powlesland AS, Steffen I, P?hlmann S, Taylor ME, Drickamer K
Glycobiology21(6)806-12(2011 Jun)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Japanese encephalitis virus infected cells through three virus receptors: DC-SIGN, DC-SIGNR and LSECtin.
Title: Distinct usage of three C-type lectins by Japanese encephalitis virus: DC-SIGN, DC-SIGNR, and LSECtin.
The results indicate that LSECtin plays an important role in colorectal carcinoma liver metastasis and may be a promising new target for intervention in metastasis formation.
Title: Novel roles of liver sinusoidal endothelial cell lectin in colon carcinoma cell adhesion, migration and in-vivo metastasis to the liver.
The mobility of LSECtin-carbohydrate recognition domain increased after addition of Ca(2+) and N-acetylglucosamine.
Title: Mobility study of individual residue sites in the carbohydrate recognition domain of LSECtin using SDSL-EPR technique.
Axl,Tyro3,DC-SIGN and LSECtin are identified as new virus receptors for Lassa virus cell entry.
Title: Identification of cell surface molecules involved in dystroglycan-independent Lassa virus cell entry.
The human LSECtin have been shown to bind Ebola virus glycoprotein with equivalent affinities, and the GlcNAcbeta1-2Man disaccharide has been demonstrated to be an effective inhibitor of this interaction.
Title: Mouse LSECtin as a model for a human Ebola virus receptor.
The following CLEC4G gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CLEC4G cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OHu18887![]() |
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Clone ID Related Accession (Same CDS sequence) | NM_198492.3 | |
Accession Version | NM_198492.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 882bp) Protein sequence SNP |
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Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-23 | |
Organism | Homo sapiens(human) | |
Product | C-type lectin domain family 4 member G isoform 1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY423706.1 and AY203939.1. This sequence is a reference standard in the RefSeqGene project. On Jan 22, 2009 this sequence version replaced NM_198492.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY423706.1, AY358431.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## |
1 | ATGGACACCA CCAGGTACAG CAAGTGGGGC GGCAGCTCCG AGGAGGTCCC CGGAGGGCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_940894.1 |
CDS | 70..951 |
Translation |

Target ORF information:
Target ORF information:
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ORF Insert Sequence:
1 | ATGGACACCA CCAGGTACAG CAAGTGGGGC GGCAGCTCCG AGGAGGTCCC CGGAGGGCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu02385 | |
Clone ID Related Accession (Same CDS sequence) | NM_001244856.1 | |
Accession Version | NM_001244856.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 846bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-22 | |
Organism | Homo sapiens(human) | |
Product | C-type lectin domain family 4 member G isoform 2 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY423706.1, BC143309.1 and AY203939.1. Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC143309.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGGACACCA CCAGGTACAG GCCCTGGGGA CGCTGGGTGC ACTGGAGCAG GAGACCCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001231785.1 |
CDS | 70..915 |
Translation |

Target ORF information:
Target ORF information:
|
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ORF Insert Sequence:
1 | ATGGACACCA CCAGGTACAG GCCCTGGGGA CGCTGGGTGC ACTGGAGCAG GAGACCCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu104671 | |
Clone ID Related Accession (Same CDS sequence) | XM_024451485.1 | |
Accession Version | XM_024451485.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1065bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | C-type lectin domain family 4 member G isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGACACCA CCAGGTACAG CAAGTGGGGC GGCAGCTCCG AGGAGGTCCC CGGAGGGCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_024307253.1 |
CDS | 80..1144 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGACACCA CCAGGTACAG CAAGTGGGGC GGCAGCTCCG AGGAGGTCCC CGGAGGGCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
![]() |
Distinct usage of three C-type lectins by Japanese encephalitis virus: DC-SIGN, DC-SIGNR, and LSECtin. |
![]() |
Novel roles of liver sinusoidal endothelial cell lectin in colon carcinoma cell adhesion, migration and in-vivo metastasis to the liver. |
![]() |
Mobility study of individual residue sites in the carbohydrate recognition domain of LSECtin using SDSL-EPR technique. |
![]() |
Identification of cell surface molecules involved in dystroglycan-independent Lassa virus cell entry. |
![]() |
Mouse LSECtin as a model for a human Ebola virus receptor. |