×

IL2RB cDNA ORF clone, Homo sapiens (human)

Gene Symbol IL2RB
Entrez Gene ID 3560
Full Name interleukin 2 receptor, beta
Synonyms CD122, IL15RB, P70-75
General protein information
Preferred Names
interleukin-2 receptor subunit beta
Names
interleukin-2 receptor subunit beta
p75
IL-2RB
CD122 antigen
IL-2R subunit beta
IL-2 receptor subunit beta
interleukin 15 receptor, beta
high affinity IL-2 receptor beta subunit
high affinity IL-2 receptor subunit beta
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

22

22q13.1

Summary The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

146710


mRNA and Protein(s)

mRNA Protein Name
NM_000878 NP_000869 interleukin-2 receptor subunit beta precursor



Homo sapiens (human) IL2RB NP_000869.1
Pan troglodytes (chimpanzee) IL2RB NP_001030599.1
Macaca mulatta (Rhesus monkey) IL2RB XP_002798417.1
Canis lupus familiaris (dog) IL2RB XP_003431552.2
Bos taurus (cattle) LOC510185 XP_002687736.2
Mus musculus (house mouse) Il2rb NP_032394.1
Rattus norvegicus (Norway rat) Il2rb NP_037327.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following IL2RB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL2RB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

Free ORF Clone
for Every Scientist
More Detail >>

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu15617
NM_000878 Homo sapiens interleukin 2 receptor, beta (IL2RB), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$189.50-$265.30
$379.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu15617
Clone ID Related Accession (Same CDS sequence) NM_000878
Accession Version NM_000878.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1656bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product interleukin-2 receptor subunit beta precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M26062.1, BC025691.1 and AA834613.1. On Jun 13, 2012 this sequence version replaced gi:23238195. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M26062.1, BC025691.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
ATGGCGGCCC CTGCTCTGTC CTGGCGTCTG CCCCTCCTCA TCCTCCTCCT GCCCCTGGCT 
ACCTCTTGGG CATCTGCAGC GGTGAATGGC ACTTCCCAGT TCACATGCTT CTACAACTCG
AGAGCCAACA TCTCCTGTGT CTGGAGCCAA GATGGGGCTC TGCAGGACAC TTCCTGCCAA
GTCCATGCCT GGCCGGACAG ACGGCGGTGG AACCAAACCT GTGAGCTGCT CCCCGTGAGT
CAAGCATCCT GGGCCTGCAA CCTGATCCTC GGAGCCCCAG ATTCTCAGAA ACTGACCACA
GTTGACATCG TCACCCTGAG GGTGCTGTGC CGTGAGGGGG TGCGATGGAG GGTGATGGCC
ATCCAGGACT TCAAGCCCTT TGAGAACCTT CGCCTGATGG CCCCCATCTC CCTCCAAGTT
GTCCACGTGG AGACCCACAG ATGCAACATA AGCTGGGAAA TCTCCCAAGC CTCCCACTAC
TTTGAAAGAC ACCTGGAGTT CGAGGCCCGG ACGCTGTCCC CAGGCCACAC CTGGGAGGAG
GCCCCCCTGC TGACTCTCAA GCAGAAGCAG GAATGGATCT GCCTGGAGAC GCTCACCCCA
GACACCCAGT ATGAGTTTCA GGTGCGGGTC AAGCCTCTGC AAGGCGAGTT CACGACCTGG
AGCCCCTGGA GCCAGCCCCT GGCCTTCAGG ACAAAGCCTG CAGCCCTTGG GAAGGACACC
ATTCCGTGGC TCGGCCACCT CCTCGTGGGC CTCAGCGGGG CTTTTGGCTT CATCATCTTA
GTGTACTTGC TGATCAACTG CAGGAACACC GGGCCATGGC TGAAGAAGGT CCTGAAGTGT
AACACCCCAG ACCCCTCGAA GTTCTTTTCC CAGCTGAGCT CAGAGCATGG AGGAGACGTC
CAGAAGTGGC TCTCTTCGCC CTTCCCCTCA TCGTCCTTCA GCCCTGGCGG CCTGGCACCT
GAGATCTCGC CACTAGAAGT GCTGGAGAGG GACAAGGTGA CGCAGCTGCT CCTGCAGCAG
GACAAGGTGC CTGAGCCCGC ATCCTTAAGC AGCAACCACT CGCTGACCAG CTGCTTCACC
AACCAGGGTT ACTTCTTCTT CCACCTCCCG GATGCCTTGG AGATAGAGGC CTGCCAGGTG
TACTTTACTT ACGACCCCTA CTCAGAGGAA GACCCTGATG AGGGTGTGGC CGGGGCACCC
ACAGGGTCTT CCCCCCAACC CCTGCAGCCT CTGTCAGGGG AGGACGACGC CTACTGCACC
TTCCCCTCCA GGGATGACCT GCTGCTCTTC TCCCCCAGTC TCCTCGGTGG CCCCAGCCCC
CCAAGCACTG CCCCTGGGGG CAGTGGGGCC GGTGAAGAGA GGATGCCCCC TTCTTTGCAA
GAAAGAGTCC CCAGAGACTG GGACCCCCAG CCCCTGGGGC CTCCCACCCC AGGAGTCCCA
GACCTGGTGG ATTTTCAGCC ACCCCCTGAG CTGGTGCTGC GAGAGGCTGG GGAGGAGGTC
CCTGACGCTG GCCCCAGGGA GGGAGTCAGT TTCCCCTGGT CCAGGCCTCC TGGGCAGGGG
GAGTTCAGGG CCCTTAATGC TCGCCTGCCC CTGAACACTG ATGCCTACTT GTCCCTCCAA
GAACTCCAGG GTCAGGACCC AACTCACTTG GTGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000869.1
CDS132..1787
Misc Feature(1)531..824(+)
Misc Feature(2)729..776(+)
Misc Feature(3)789..803(+)
Misc Feature(4)789..803(+)
Misc Feature(5)852..926(+)
Misc Feature(6)963..989(+)
Misc Feature(7)1221..1223(+)
Misc Feature(8)1272..1274(+)
Misc Feature(9)1281..1283(+)
Misc Feature(10)1290..1292(+)
Misc Feature(11)1383..1385(+)
Misc Feature(12)1737..1739(+)
Exon (1)1..98
Gene:IL2RB
Gene Synonym:
Exon (2)99..219
Gene:IL2RB
Gene Synonym:
Exon (3)220..334
Gene:IL2RB
Gene Synonym:
Exon (4)335..413
Gene:IL2RB
Gene Synonym:
Exon (5)414..519
Gene:IL2RB
Gene Synonym:
Exon (6)520..668
Gene:IL2RB
Gene Synonym:
Exon (7)669..834
Gene:IL2RB
Gene Synonym:
Exon (8)835..949
Gene:IL2RB
Gene Synonym:
Exon (9)950..1034
Gene:IL2RB
Gene Synonym:
Exon (10)1035..4045
Gene:IL2RB
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_000878
Organism Homo sapiens (human)
Definition Homo sapiens interleukin 2 receptor, beta (IL2RB), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000878

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
ATGGCGGCCC CTGCTCTGTC CTGGCGTCTG CCCCTCCTCA TCCTCCTCCT GCCCCTGGCT 
ACCTCTTGGG CATCTGCAGC GGTGAATGGC ACTTCCCAGT TCACATGCTT CTACAACTCG
AGAGCCAACA TCTCCTGTGT CTGGAGCCAA GATGGGGCTC TGCAGGACAC TTCCTGCCAA
GTCCATGCCT GGCCGGACAG ACGGCGGTGG AACCAAACCT GTGAGCTGCT CCCCGTGAGT
CAAGCATCCT GGGCCTGCAA CCTGATCCTC GGAGCCCCAG ATTCTCAGAA ACTGACCACA
GTTGACATCG TCACCCTGAG GGTGCTGTGC CGTGAGGGGG TGCGATGGAG GGTGATGGCC
ATCCAGGACT TCAAGCCCTT TGAGAACCTT CGCCTGATGG CCCCCATCTC CCTCCAAGTT
GTCCACGTGG AGACCCACAG ATGCAACATA AGCTGGGAAA TCTCCCAAGC CTCCCACTAC
TTTGAAAGAC ACCTGGAGTT CGAGGCCCGG ACGCTGTCCC CAGGCCACAC CTGGGAGGAG
GCCCCCCTGC TGACTCTCAA GCAGAAGCAG GAATGGATCT GCCTGGAGAC GCTCACCCCA
GACACCCAGT ATGAGTTTCA GGTGCGGGTC AAGCCTCTGC AAGGCGAGTT CACGACCTGG
AGCCCCTGGA GCCAGCCCCT GGCCTTCAGG ACAAAGCCTG CAGCCCTTGG GAAGGACACC
ATTCCGTGGC TCGGCCACCT CCTCGTGGGC CTCAGCGGGG CTTTTGGCTT CATCATCTTA
GTGTACTTGC TGATCAACTG CAGGAACACC GGGCCATGGC TGAAGAAGGT CCTGAAGTGT
AACACCCCAG ACCCCTCGAA GTTCTTTTCC CAGCTGAGCT CAGAGCATGG AGGAGACGTC
CAGAAGTGGC TCTCTTCGCC CTTCCCCTCA TCGTCCTTCA GCCCTGGCGG CCTGGCACCT
GAGATCTCGC CACTAGAAGT GCTGGAGAGG GACAAGGTGA CGCAGCTGCT CCTGCAGCAG
GACAAGGTGC CTGAGCCCGC ATCCTTAAGC AGCAACCACT CGCTGACCAG CTGCTTCACC
AACCAGGGTT ACTTCTTCTT CCACCTCCCG GATGCCTTGG AGATAGAGGC CTGCCAGGTG
TACTTTACTT ACGACCCCTA CTCAGAGGAA GACCCTGATG AGGGTGTGGC CGGGGCACCC
ACAGGGTCTT CCCCCCAACC CCTGCAGCCT CTGTCAGGGG AGGACGACGC CTACTGCACC
TTCCCCTCCA GGGATGACCT GCTGCTCTTC TCCCCCAGTC TCCTCGGTGG CCCCAGCCCC
CCAAGCACTG CCCCTGGGGG CAGTGGGGCC GGTGAAGAGA GGATGCCCCC TTCTTTGCAA
GAAAGAGTCC CCAGAGACTG GGACCCCCAG CCCCTGGGGC CTCCCACCCC AGGAGTCCCA
GACCTGGTGG ATTTTCAGCC ACCCCCTGAG CTGGTGCTGC GAGAGGCTGG GGAGGAGGTC
CCTGACGCTG GCCCCAGGGA GGGAGTCAGT TTCCCCTGGT CCAGGCCTCC TGGGCAGGGG
GAGTTCAGGG CCCTTAATGC TCGCCTGCCC CTGAACACTG ATGCCTACTT GTCCCTCCAA
GAACTCCAGG GTCAGGACCC AACTCACTTG GTGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Genome-wide association study of ancestry-specific TB risk in the South African Coloured population
Hum. Mol. Genet. 23 (3), 796-809 (2014)
Chimusa ER, Zaitlen N, Daya M, Moller M, van Helden PD, Mulder NJ, Price AL and Hoal EG.


book

Chimeric gammac cytokine receptors confer cytokine independent engraftment of human T lymphocytes
Mol. Immunol. 56 (1-2), 1-11 (2013)
Hunter MR, Prosser ME, Mahadev V, Wang X, Aguilar B, Brown CE, Forman SJ and Jensen MC.


book

Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors
J. Immunol. 190 (6), 2554-2566 (2013)
Pekalski ML, Ferreira RC, Coulson RM, Cutler AJ, Guo H, Smyth DJ, Downes K, Dendrou CA, Castro Dopico X, Esposito L, Coleman G, Stevens HE, Nutland S, Walker NM, Guy C, Dunger DB, Wallace C, Tree TI, Todd JA and Wicker LS.


book

Evaluation of the IL2/IL21, IL2RA and IL2RB genetic variants influence on the endogenous non-anterior uveitis genetic predisposition
BMC Med. Genet. 14, 52 (2013)
Cenit MC, Marquez A, Cordero-Coma M, Fonollosa A, Adan A, Martinez-Berriotxoa A, Llorenc V, Diaz Valle D, Blanco R, Canal J, Diaz-Llopis M, Garcia Serrano JL, de Ramon E, del Rio MJ, Begona Gorrono-Echebarria M, Martin-Villa JM, Ortego-Centeno N and Martin J.


book

Lack of association of IL-2RA and IL-2RB polymorphisms with rheumatoid arthritis in a Han Chinese population
Genet. Mol. Res. 12 (1), 581-586 (2013)
Zhu J, He F, Zhang DD, Yang JY, Cheng J, Wu R, Gong B, Liu XQ, Ma S and Zhou B.


book

Suppression of interleukin-2 and interleukin-2 receptor expression in Jurkat cells stably expressing the human immunodeficiency virus Tat protein
Cell. Immunol. 144 (1), 32-42 (1992)
Purvis SF, Georges DL, Williams TM and Lederman MM.


book

Interleukin-2 (IL-2) induces tyrosine kinase-dependent translocation of active raf-1 from the IL-2 receptor into the cytosol
J. Biol. Chem. 267 (22), 15281-15284 (1992)
Maslinski W, Remillard B, Tsudo M and Strom TB.


book

Interleukin 2 regulates the activity of the lyn protein-tyrosine kinase in a B-cell line
Proc. Natl. Acad. Sci. U.S.A. 89 (7), 2674-2678 (1992)
Torigoe T, Saragovi HU and Reed JC.


book

The integrity of the conserved 'WS motif' common to IL-2 and other cytokine receptors is essential for ligand binding and signal transduction
EMBO J. 10 (11), 3191-3197 (1991)
Miyazaki T, Maruyama M, Yamada G, Hatakeyama M and Taniguchi T.


book

The human interleukin-2 receptor beta-chain gene: genomic organization, promoter analysis and chromosomal assignment
Nucleic Acids Res. 18 (13), 3697-3703 (1990)
Shibuya H, Yoneyama M, Nakamura Y, Harada H, Hatakeyama M, Minamoto S, Kono T, Doi T, White R and Taniguchi T.


 
*
*
*
*