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GDF6 cDNA ORF clone, Homo sapiens (human)

Gene Symbol GDF6
Entrez Gene ID 392255
Full Name growth differentiation factor 6
Synonyms BMP-13, BMP13, CDMP2, KFM, KFS, KFS1, KFSL, LCA17, MCOP4, MCOPCB6, SCDO4, SGM1
General protein information
Preferred Names
growth/differentiation factor 6
Names
growth/differentiation factor 6
GDF-6
Klippel-Feil syndrome
Klip-Feil malformation
Klippel-Feil malformation
growth/differentiation factor 16
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

8

8q22.1

Summary This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily of secreted signaling molecules. It is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. Mutations in this gene result in colobomata, which are congenital abnormalities in ocular development, and in Klippel-Feil syndrome (KFS), which is a congenital disorder of spinal segmentation. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

601147

Disorder Html: Klippel-Feil syndrome 1, autosomal dominant, 118100 (3);

mRNA and Protein(s)

mRNA Protein Name
XM_011517030 XP_011515332 growth/differentiation factor 6 isoform X1
NM_001001557 NP_001001557 growth/differentiation factor 6 precursor



Homo sapiens (human) GDF6 NP_001001557.1
Pan troglodytes (chimpanzee) GDF6 XP_003311926.1
Macaca mulatta (Rhesus monkey) GDF6 XP_001090825.1
Bos taurus (cattle) GDF6 NP_001001140.1
Mus musculus (house mouse) Gdf6 NP_038554.1
Rattus norvegicus (Norway rat) Gdf6 NP_001013056.1
Danio rerio (zebrafish) gdf6a NP_001153466.1
Xenopus (Silurana) tropicalis (western clawed frog) gdf6 NP_001016077.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following GDF6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GDF6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu80050 XM_011517030 PREDICTED: Homo sapiens growth differentiation factor 6 (GDF6), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $139.30
$199.00
OHu18538 NM_001001557 Homo sapiens growth differentiation factor 6 (GDF6), mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $223.30
$319.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu80050
Clone ID Related Accession (Same CDS sequence) XM_011517030
Accession Version XM_011517030.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 969bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product growth/differentiation factor 6 isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_008046.17) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
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481
541
601
661
721
781
841
901
961
ATGCAAGACG ATCTCTCGCA CACTCCTCTC CGGAGACAGA AGTATTTGTT TGATGTGTCC 
ATGCTCTCAG ACAAAGAAGA GCTGGTGGGC GCGGAGCTGC GGCTCTTTCG CCAGGCGCCC
TCAGCGCCCT GGGGGCCACC AGCCGGGCCG CTCCACGTGC AGCTCTTCCC TTGCCTTTCG
CCCCTACTGC TGGACGCGCG GACCCTGGAC CCGCAGGGGG CGCCGCCGGC CGGCTGGGAA
GTCTTCGACG TGTGGCAGGG CCTGCGCCAC CAGCCCTGGA AGCAGCTGTG CTTGGAGCTG
CGGGCCGCAT GGGGCGAGCT GGACGCCGGG GAGGCCGAGG CGCGCGCGCG GGGACCCCAG
CAACCGCCGC CCCCGGACCT GCGGAGTCTG GGCTTCGGCC GGAGGGTGCG GCCTCCCCAG
GAGCGGGCCC TGCTGGTGGT ATTCACCAGA TCCCAGCGCA AGAACCTGTT CGCAGAGATG
CGCGAGCAGC TGGGCTCGGC CGAGGCTGCG GGCCCGGGCG CGGGCGCCGA GGGGTCGTGG
CCGCCGCCGT CGGGCGCCCC GGATGCCAGG CCTTGGCTGC CCTCGCCCGG CCGCCGGCGG
CGGCGCACGG CCTTCGCCAG TCGCCATGGC AAGCGGCACG GCAAGAAGTC CAGGCTACGC
TGCAGCAAGA AGCCCCTGCA CGTGAACTTC AAGGAGCTGG GCTGGGACGA CTGGATTATC
GCGCCCCTGG AGTACGAGGC CTATCACTGC GAGGGTGTAT GCGACTTCCC GCTGCGCTCG
CACCTGGAGC CCACCAACCA CGCCATCATC CAGACGCTGA TGAACTCCAT GGACCCCGGC
TCCACCCCGC CCAGCTGCTG CGTGCCCACC AAATTGACTC CCATCAGCAT TCTATACATC
GACGCGGGCA ATAATGTGGT CTACAAGCAG TACGAGGACA TGGTGGTGGA GTCGTGCGGC
TGCAGGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011515332.1
CDS3015..3983
Misc Feature(1)3024..3458(+)
Misc Feature(2)3675..3980(+)
Translation

Target ORF information:

RefSeq Version XM_011517030
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens growth differentiation factor 6 (GDF6), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011517030

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGCAAGACG ATCTCTCGCA CACTCCTCTC CGGAGACAGA AGTATTTGTT TGATGTGTCC 
ATGCTCTCAG ACAAAGAAGA GCTGGTGGGC GCGGAGCTGC GGCTCTTTCG CCAGGCGCCC
TCAGCGCCCT GGGGGCCACC AGCCGGGCCG CTCCACGTGC AGCTCTTCCC TTGCCTTTCG
CCCCTACTGC TGGACGCGCG GACCCTGGAC CCGCAGGGGG CGCCGCCGGC CGGCTGGGAA
GTCTTCGACG TGTGGCAGGG CCTGCGCCAC CAGCCCTGGA AGCAGCTGTG CTTGGAGCTG
CGGGCCGCAT GGGGCGAGCT GGACGCCGGG GAGGCCGAGG CGCGCGCGCG GGGACCCCAG
CAACCGCCGC CCCCGGACCT GCGGAGTCTG GGCTTCGGCC GGAGGGTGCG GCCTCCCCAG
GAGCGGGCCC TGCTGGTGGT ATTCACCAGA TCCCAGCGCA AGAACCTGTT CGCAGAGATG
CGCGAGCAGC TGGGCTCGGC CGAGGCTGCG GGCCCGGGCG CGGGCGCCGA GGGGTCGTGG
CCGCCGCCGT CGGGCGCCCC GGATGCCAGG CCTTGGCTGC CCTCGCCCGG CCGCCGGCGG
CGGCGCACGG CCTTCGCCAG TCGCCATGGC AAGCGGCACG GCAAGAAGTC CAGGCTACGC
TGCAGCAAGA AGCCCCTGCA CGTGAACTTC AAGGAGCTGG GCTGGGACGA CTGGATTATC
GCGCCCCTGG AGTACGAGGC CTATCACTGC GAGGGTGTAT GCGACTTCCC GCTGCGCTCG
CACCTGGAGC CCACCAACCA CGCCATCATC CAGACGCTGA TGAACTCCAT GGACCCCGGC
TCCACCCCGC CCAGCTGCTG CGTGCCCACC AAATTGACTC CCATCAGCAT TCTATACATC
GACGCGGGCA ATAATGTGGT CTACAAGCAG TACGAGGACA TGGTGGTGGA GTCGTGCGGC
TGCAGGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu18538
Clone ID Related Accession (Same CDS sequence) NM_001001557
Accession Version NM_001001557.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1368bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product growth/differentiation factor 6 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ537424.1 and AP003465.2. This sequence is a reference standard in the RefSeqGene project. On May 15, 2008 this sequence version replaced gi:48475061. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ537424.1, CN282698.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGGATACTC CCAGGGTCCT GCTCTCGGCC GTCTTCCTCA TCAGTTTTCT GTGGGATTTG 
CCCGGTTTCC AGCAGGCTTC CATCTCATCC TCCTCGTCGT CCGCCGAGCT GGGTTCCACC
AAGGGCATGC GAAGCCGCAA GGAAGGCAAG ATGCAGCGGG CGCCGCGCGA CAGTGACGCG
GGCCGGGAGG GCCAGGAACC ACAGCCGCGG CCTCAGGACG AACCCCGGGC TCAGCAGCCC
CGGGCGCAGG AGCCGCCAGG CAGGGGTCCG CGCGTGGTGC CCCACGAGTA CATGCTGTCA
ATCTACAGGA CTTACTCCAT CGCTGAGAAG CTGGGCATCA ATGCCAGCTT TTTCCAGTCT
TCCAAGTCGG CTAATACGAT CACCAGCTTT GTAGACAGGG GACTAGACGA TCTCTCGCAC
ACTCCTCTCC GGAGACAGAA GTATTTGTTT GATGTGTCCA TGCTCTCAGA CAAAGAAGAG
CTGGTGGGCG CGGAGCTGCG GCTCTTTCGC CAGGCGCCCT CAGCGCCCTG GGGGCCACCA
GCCGGGCCGC TCCACGTGCA GCTCTTCCCT TGCCTTTCGC CCCTACTGCT GGACGCGCGG
ACCCTGGACC CGCAGGGGGC GCCGCCGGCC GGCTGGGAAG TCTTCGACGT GTGGCAGGGC
CTGCGCCACC AGCCCTGGAA GCAGCTGTGC TTGGAGCTGC GGGCCGCATG GGGCGAGCTG
GACGCCGGGG AGGCCGAGGC GCGCGCGCGG GGACCCCAGC AACCGCCGCC CCCGGACCTG
CGGAGTCTGG GCTTCGGCCG GAGGGTGCGG CCTCCCCAGG AGCGGGCCCT GCTGGTGGTA
TTCACCAGAT CCCAGCGCAA GAACCTGTTC GCAGAGATGC GCGAGCAGCT GGGCTCGGCC
GAGGCTGCGG GCCCGGGCGC GGGCGCCGAG GGGTCGTGGC CGCCGCCGTC GGGCGCCCCG
GATGCCAGGC CTTGGCTGCC CTCGCCCGGC CGCCGGCGGC GGCGCACGGC CTTCGCCAGT
CGCCATGGCA AGCGGCACGG CAAGAAGTCC AGGCTACGCT GCAGCAAGAA GCCCCTGCAC
GTGAACTTCA AGGAGCTGGG CTGGGACGAC TGGATTATCG CGCCCCTGGA GTACGAGGCC
TATCACTGCG AGGGTGTATG CGACTTCCCG CTGCGCTCGC ACCTGGAGCC CACCAACCAC
GCCATCATCC AGACGCTGAT GAACTCCATG GACCCCGGCT CCACCCCGCC CAGCTGCTGC
GTGCCCACCA AATTGACTCC CATCAGCATT CTATACATCG ACGCGGGCAA TAATGTGGTC
TACAAGCAGT ACGAGGACAT GGTGGTGGAG TCGTGCGGCT GCAGGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001001557.1
CDS101..1468
Misc Feature(1)302..943(+)
Misc Feature(2)1160..1465(+)
Exon (1)1..506
Gene:GDF6
Gene Synonym:
Exon (2)507..3701
Gene:GDF6
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001001557
Organism Homo sapiens (human)
Definition Homo sapiens growth differentiation factor 6 (GDF6), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001001557

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGGATACTC CCAGGGTCCT GCTCTCGGCC GTCTTCCTCA TCAGTTTTCT GTGGGATTTG 
CCCGGTTTCC AGCAGGCTTC CATCTCATCC TCCTCGTCGT CCGCCGAGCT GGGTTCCACC
AAGGGCATGC GAAGCCGCAA GGAAGGCAAG ATGCAGCGGG CGCCGCGCGA CAGTGACGCG
GGCCGGGAGG GCCAGGAACC ACAGCCGCGG CCTCAGGACG AACCCCGGGC TCAGCAGCCC
CGGGCGCAGG AGCCGCCAGG CAGGGGTCCG CGCGTGGTGC CCCACGAGTA CATGCTGTCA
ATCTACAGGA CTTACTCCAT CGCTGAGAAG CTGGGCATCA ATGCCAGCTT TTTCCAGTCT
TCCAAGTCGG CTAATACGAT CACCAGCTTT GTAGACAGGG GACTAGACGA TCTCTCGCAC
ACTCCTCTCC GGAGACAGAA GTATTTGTTT GATGTGTCCA TGCTCTCAGA CAAAGAAGAG
CTGGTGGGCG CGGAGCTGCG GCTCTTTCGC CAGGCGCCCT CAGCGCCCTG GGGGCCACCA
GCCGGGCCGC TCCACGTGCA GCTCTTCCCT TGCCTTTCGC CCCTACTGCT GGACGCGCGG
ACCCTGGACC CGCAGGGGGC GCCGCCGGCC GGCTGGGAAG TCTTCGACGT GTGGCAGGGC
CTGCGCCACC AGCCCTGGAA GCAGCTGTGC TTGGAGCTGC GGGCCGCATG GGGCGAGCTG
GACGCCGGGG AGGCCGAGGC GCGCGCGCGG GGACCCCAGC AACCGCCGCC CCCGGACCTG
CGGAGTCTGG GCTTCGGCCG GAGGGTGCGG CCTCCCCAGG AGCGGGCCCT GCTGGTGGTA
TTCACCAGAT CCCAGCGCAA GAACCTGTTC GCAGAGATGC GCGAGCAGCT GGGCTCGGCC
GAGGCTGCGG GCCCGGGCGC GGGCGCCGAG GGGTCGTGGC CGCCGCCGTC GGGCGCCCCG
GATGCCAGGC CTTGGCTGCC CTCGCCCGGC CGCCGGCGGC GGCGCACGGC CTTCGCCAGT
CGCCATGGCA AGCGGCACGG CAAGAAGTCC AGGCTACGCT GCAGCAAGAA GCCCCTGCAC
GTGAACTTCA AGGAGCTGGG CTGGGACGAC TGGATTATCG CGCCCCTGGA GTACGAGGCC
TATCACTGCG AGGGTGTATG CGACTTCCCG CTGCGCTCGC ACCTGGAGCC CACCAACCAC
GCCATCATCC AGACGCTGAT GAACTCCATG GACCCCGGCT CCACCCCGCC CAGCTGCTGC
GTGCCCACCA AATTGACTCC CATCAGCATT CTATACATCG ACGCGGGCAA TAATGTGGTC
TACAAGCAGT ACGAGGACAT GGTGGTGGAG TCGTGCGGCT GCAGGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

 
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