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MEFV cDNA ORF clone, Homo sapiens(Human)

Gene Symbol MEFV
Entrez Gene ID 4210
Full Name MEFV, pyrin innate immunity regulator
Synonyms FMF,MEF,TRIM20
General protein information
Preferred Names

MEFV, pyrin innate immunity regulator

Names

pyrin
Mediterranean fever
marenostrin

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

16

16p13.3

Summary This gene encodes a protein, also known as pyrin or marenostrin, that is an important modulator of innate immunity. Mutations in this gene are associated with Mediterranean fever, a hereditary periodic fever syndrome. [provided by RefSeq, Jul 2008].
Disorder MIM:

608107

Disorder Html: Familial Mediterranean fever, AR, 249100 (3); Familial

mRNA and Protein(s)

mRNA Protein Name
XM_017023236.1 XP_016878725.1 pyrin isoform X1
NM_001198536.1 NP_001185465.1 pyrin isoform 2
NM_000243.2 NP_000234.1 pyrin isoform 1



Pan troglodytes (chimpanzee) MEFV XP_523280.3
Mus musculus (house mouse) Mefv NP_001155263.1
Bos taurus (cattle) LOC529195 XP_002697924.3
Homo sapiens (human) MEFV NP_000234.1
Rattus norvegicus (Norway rat) Mefv NP_113822.1
Macaca mulatta (rhesus monkey) MEFV XP_001092338.1
Canis lupus familiaris (dog) MEFV XP_547161.4


Related articles in PubMed

The M694I/M694I genotype: A genetic risk factor of AA-amyloidosis in a group of Algerian patients with familial Mediterranean fever.
Ait-Idir D, Djerdjouri B, Bouldjennet F, Taha RZ, El-Shanti H, Sari-Hamidou R, Khellaf G, Benmansour M, Benabadji M, Haddoum F
European journal of medical genetics60(3)149-153(2017 Mar)

Familial Mediterranean fever gene mutation frequencies in a sample Turkish population.
Soylemezoglu O, Kandur Y, Gonen S, Düzova A, Özçakar ZB, Fidan K, Yalcinkaya F
Clinical and experimental rheumatology34(6 Suppl 102)97-100(2016 Sep-Oct)

MEFV and SAA1 genotype associations with clinical features of familial Mediterranean fever and amyloidosis in Armenia.
Atoyan S, Hayrapetyan H, Sarkisian T, Ben-Chetrit E
Clinical and experimental rheumatology34(6 Suppl 102)72-76(2016 Sep-Oct)

Prevalence of common MEFV mutations and carrier frequencies in a large cohort of ian populations.
Beheshtian M, Izadi N, Kriegshauser G, Kahrizi K, Mehr EP, Rostami M, Hosseini M, Azad M, Montajabiniat M, Kariminejad A, Nemeth S, Oberkanins C, Najmabadi H
Journal of genetics95(3)667-74(2016 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MEFV gene variations in exons 2, 3, 5 and 10 associate with major clinical symptoms of familial Mediterranean fever. Arthritis was high in K695R heterozygous genotype.
Title: MEFV mutations and their relation to major clinical symptoms of Familial Mediterranean Fever.

RHEB, the main activator of mTOR signaling, is a valid target of miR-4520a with the relative expression levels of the latter being significantly deregulated in FMF patients and highly dependent on the presence of pyrin mutations.
Title: Differential Expression of miR-4520a Associated With Pyrin Mutations in Familial Mediterranean Fever (FMF).

High carriage rates of MEFV gene mutations in gouty arthritis suggest that it may play an important role in the pathogenesis of the disease and predisposition to the disease.
Title: Prevalence and significance of MEFV gene mutations in patients with gouty arthritis.

We report two patients with mutations in pyrin presenting with recurrent infections and infantile colitis due to familial Mediterranean fever, thus illustrating how an autoinflammatory disorder can mimic a PID.
Title: Mutations in pyrin masquerading as a primary immunodeficiency.

this paper show that the binding of 14-3-3 and PKN proteins to familial Mediterranean fever -associated mutant pyrin is substantially decreased
Title: Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS.

The following MEFV gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MEFV cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu19174 NM_000243.2
Latest version!
Homo sapiens MEFV, pyrin innate immunity regulator (MEFV), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$189.50-$265.30
$379.00
OHu21586 NM_001198536.1
Latest version!
Homo sapiens MEFV, pyrin innate immunity regulator (MEFV), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $265.30
$379.00
OHu86035 XM_017023236.1
Latest version!
Homo sapiens Mediterranean fever (MEFV), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 14-16 $391.30
$559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu19174
Clone ID Related Accession (Same CDS sequence) NM_000243.2
Accession Version NM_000243.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2346bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-15
Organism Homo sapiens(Human)
Product pyrin isoform 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF018080.1 and AJ003147.1. This sequence is a reference standard in the RefSeqGene project. On May 15, 2008 this sequence version replaced NM_000243.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF018080.1, Y14441.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
ATGGCTAAGA CCCCTAGTGA CCATCTGCTG TCCACCCTGG AGGAGCTGGT GCCCTATGAC 
TTCGAGAAGT TCAAGTTCAA GCTGCAGAAC ACCAGTGTGC AGAAGGAGCA CTCCAGGATC
CCCCGGAGCC AGATCCAGAG AGCCAGGCCG GTGAAGATGG CCACTCTGCT GGTCACCTAC
TATGGGGAAG AGTACGCCGT GCAGCTCACC CTGCAGGTCC TGCGGGCCAT CAACCAGCGC
CTGCTGGCCG AGGAGCTCCA CAGGGCAGCC ATTCAGGAAT ATTCCACACA AGAAAACGGC
ACAGATGATT CCGCAGCGTC CAGCTCCCTG GGGGAGAACA AGCCCAGGAG CCTGAAGACT
CCAGACCACC CCGAGGGGAA CGAGGGGAAC GGCCCTCGGC CGTACGGGGG CGGAGCTGCC
AGCCTGCGGT GCAGCCAGCC CGAGGCCGGG AGGGGGCTGT CGAGGAAGCC CCTGAGCAAA
CGCAGAGAGA AGGCCTCGGA GGGCCTGGAC GCGCAGGGCA AGCCTCGGAC CCGGAGCCCG
GCCCTGCCGG GCGGGAGAAG CCCCGGCCCC TGCAGGGCGC TAGAGGGGGG CCAGGCCGAG
GTCCGGCTGC GCAGAAACGC CAGCTCCGCG GGGAGGCTGC AGGGGCTGGC GGGGGGCGCC
CCGGGGCAGA AGGAGTGCAG GCCCTTCGAA GTGTACCTGC CCTCGGGAAA GATGCGACCT
AGAAGCCTTG AGGTCACCAT TTCTACAGGG GAGAAGGCGC CCGCAAATCC AGAAATTCTC
CTGACTCTAG AGGAAAAGAC AGCTGCGAAT CTGGACTCGG CAACAGAACC CCGGGCAAGG
CCCACTCCGG ATGGAGGGGC ATCTGCGGAC CTGAAGGAAG GCCCTGGAAA TCCAGAACAT
TCGGTCACCG GAAGGCCACC AGACACGGCT GCGAGTCCCC GCTGCCACGC CCAGGAAGGA
GACCCAGTTG ACGGTACCTG TGTGCGTGAT TCCTGCAGCT TCCCCGAGGC AGTTTCTGGG
CACCCCCAGG CCTCAGGCAG CCGCTCACCT GGCTGCCCCC GGTGCCAGGA CTCCCATGAA
AGGAAGAGCC CGGGAAGCCT AAGCCCCCAG CCCCTGCCAC AGTGTAAGCG CCACCTGAAG
CAGGTCCAGC TGCTCTTCTG TGAGGATCAC GATGAGCCCA TCTGCCTCAT CTGCAGTCTG
AGTCAGGAGC ACCAAGGCCA CCGGGTGCGC CCCATTGAGG AGGTCGCCCT GGAACACAAG
AAGAAAATTC AGAAGCAGCT GGAGCATCTG AAGAAGCTGA GAAAATCAGG GGAGGAGCAG
CGATCCTATG GGGAGGAGAA GGCAGTGAGC TTTCTGAAAC AAACTGAAGC GCTGAAGCAG
CGGGTGCAGA GGAAGCTGGA GCAGGTGTAC TACTTCCTGG AGCAGCAAGA GCATTTCTTT
GTGGCCTCAC TGGAGGACGT GGGCCAGATG GTTGGGCAGA TCAGGAAGGC ATATGACACC
CGCGTATCCC AGGACATCGC CCTGCTCGAT GCGCTGATTG GGGAACTGGA GGCCAAGGAG
TGCCAGTCAG AATGGGAACT TCTGCAGGAC ATTGGAGACA TCTTGCACAG GGCTAAGACA
GTGCCTGTCC CTGAAAAGTG GACCACTCCT CAAGAGATAA AACAAAAGAT CCAACTCCTC
CACCAGAAGT CAGAGTTTGT GGAGAAGAGC ACAAAGTACT TCTCAGAAAC CCTGCGTTCA
GAAATGGAAA TGTTCAATGT TCCAGAGCTG ATTGGCGCTC AGGCACATGC TGTTAATGTG
ATTCTGGATG CAGAAACCGC TTACCCCAAC CTCATCTTCT CTGATGATCT GAAGAGTGTT
AGACTTGGAA ACAAGTGGGA GAGGCTGCCT GATGGCCCGC AAAGATTTGA CAGCTGTATC
ATTGTTCTGG GCTCTCCGAG TTTCCTCTCT GGCCGCCGTT ACTGGGAGGT GGAGGTTGGA
GACAAGACAG CATGGATCCT GGGAGCCTGC AAGACATCCA TAAGCAGGAA AGGGAACATG
ACTCTGTCGC CAGAGAATGG CTACTGGGTG GTGATAATGA TGAAGGAAAA TGAGTACCAG
GCGTCCAGCG TTCCCCCGAC CCGCCTGCTA ATAAAGGAGC CTCCCAAGCG TGTGGGCATC
TTCGTGGACT ACAGAGTTGG AAGCATCTCC TTTTACAATG TGACAGCCAG ATCCCACATC
TATACATTCG CCAGCTGCTC TTTCTCTGGG CCCCTTCAAC CTATCTTCAG CCCTGGGACA
CGTGATGGAG GGAAGAACAC AGCTCCTCTG ACTATCTGTC CAGTGGGTGG TCAGGGGCCT
GACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000234.1
CDS41..2386
Misc Feature(1)56..304
Misc Feature(2)836..880
Misc Feature(3)1028..1033
Misc Feature(4)1148..1276
Misc Feature(5)order(1163..1165,1172..1174,1232..1234,1250..1252)
Misc Feature(6)<1244..1432
Misc Feature(7)1298..1786
Misc Feature(8)1298..1351
Misc Feature(9)1808..2359
Exon (1)1..317
Exon (2)318..950
Exon (3)951..1300
Exon (4)1301..1396
Exon (5)1397..1627
Exon (6)1628..1650
Exon (7)1651..1766
Exon (8)1767..1799
Exon (9)1800..1832
Exon (10)1833..3499
Translation

Target ORF information:

RefSeq Version NM_000243.2
Organism Homo sapiens(Human)
Definition Homo sapiens MEFV, pyrin innate immunity regulator (MEFV), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000243.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
ATGGCTAAGA CCCCTAGTGA CCATCTGCTG TCCACCCTGG AGGAGCTGGT GCCCTATGAC 
TTCGAGAAGT TCAAGTTCAA GCTGCAGAAC ACCAGTGTGC AGAAGGAGCA CTCCAGGATC
CCCCGGAGCC AGATCCAGAG AGCCAGGCCG GTGAAGATGG CCACTCTGCT GGTCACCTAC
TATGGGGAAG AGTACGCCGT GCAGCTCACC CTGCAGGTCC TGCGGGCCAT CAACCAGCGC
CTGCTGGCCG AGGAGCTCCA CAGGGCAGCC ATTCAGGAAT ATTCCACACA AGAAAACGGC
ACAGATGATT CCGCAGCGTC CAGCTCCCTG GGGGAGAACA AGCCCAGGAG CCTGAAGACT
CCAGACCACC CCGAGGGGAA CGAGGGGAAC GGCCCTCGGC CGTACGGGGG CGGAGCTGCC
AGCCTGCGGT GCAGCCAGCC CGAGGCCGGG AGGGGGCTGT CGAGGAAGCC CCTGAGCAAA
CGCAGAGAGA AGGCCTCGGA GGGCCTGGAC GCGCAGGGCA AGCCTCGGAC CCGGAGCCCG
GCCCTGCCGG GCGGGAGAAG CCCCGGCCCC TGCAGGGCGC TAGAGGGGGG CCAGGCCGAG
GTCCGGCTGC GCAGAAACGC CAGCTCCGCG GGGAGGCTGC AGGGGCTGGC GGGGGGCGCC
CCGGGGCAGA AGGAGTGCAG GCCCTTCGAA GTGTACCTGC CCTCGGGAAA GATGCGACCT
AGAAGCCTTG AGGTCACCAT TTCTACAGGG GAGAAGGCGC CCGCAAATCC AGAAATTCTC
CTGACTCTAG AGGAAAAGAC AGCTGCGAAT CTGGACTCGG CAACAGAACC CCGGGCAAGG
CCCACTCCGG ATGGAGGGGC ATCTGCGGAC CTGAAGGAAG GCCCTGGAAA TCCAGAACAT
TCGGTCACCG GAAGGCCACC AGACACGGCT GCGAGTCCCC GCTGCCACGC CCAGGAAGGA
GACCCAGTTG ACGGTACCTG TGTGCGTGAT TCCTGCAGCT TCCCCGAGGC AGTTTCTGGG
CACCCCCAGG CCTCAGGCAG CCGCTCACCT GGCTGCCCCC GGTGCCAGGA CTCCCATGAA
AGGAAGAGCC CGGGAAGCCT AAGCCCCCAG CCCCTGCCAC AGTGTAAGCG CCACCTGAAG
CAGGTCCAGC TGCTCTTCTG TGAGGATCAC GATGAGCCCA TCTGCCTCAT CTGCAGTCTG
AGTCAGGAGC ACCAAGGCCA CCGGGTGCGC CCCATTGAGG AGGTCGCCCT GGAACACAAG
AAGAAAATTC AGAAGCAGCT GGAGCATCTG AAGAAGCTGA GAAAATCAGG GGAGGAGCAG
CGATCCTATG GGGAGGAGAA GGCAGTGAGC TTTCTGAAAC AAACTGAAGC GCTGAAGCAG
CGGGTGCAGA GGAAGCTGGA GCAGGTGTAC TACTTCCTGG AGCAGCAAGA GCATTTCTTT
GTGGCCTCAC TGGAGGACGT GGGCCAGATG GTTGGGCAGA TCAGGAAGGC ATATGACACC
CGCGTATCCC AGGACATCGC CCTGCTCGAT GCGCTGATTG GGGAACTGGA GGCCAAGGAG
TGCCAGTCAG AATGGGAACT TCTGCAGGAC ATTGGAGACA TCTTGCACAG GGCTAAGACA
GTGCCTGTCC CTGAAAAGTG GACCACTCCT CAAGAGATAA AACAAAAGAT CCAACTCCTC
CACCAGAAGT CAGAGTTTGT GGAGAAGAGC ACAAAGTACT TCTCAGAAAC CCTGCGTTCA
GAAATGGAAA TGTTCAATGT TCCAGAGCTG ATTGGCGCTC AGGCACATGC TGTTAATGTG
ATTCTGGATG CAGAAACCGC TTACCCCAAC CTCATCTTCT CTGATGATCT GAAGAGTGTT
AGACTTGGAA ACAAGTGGGA GAGGCTGCCT GATGGCCCGC AAAGATTTGA CAGCTGTATC
ATTGTTCTGG GCTCTCCGAG TTTCCTCTCT GGCCGCCGTT ACTGGGAGGT GGAGGTTGGA
GACAAGACAG CATGGATCCT GGGAGCCTGC AAGACATCCA TAAGCAGGAA AGGGAACATG
ACTCTGTCGC CAGAGAATGG CTACTGGGTG GTGATAATGA TGAAGGAAAA TGAGTACCAG
GCGTCCAGCG TTCCCCCGAC CCGCCTGCTA ATAAAGGAGC CTCCCAAGCG TGTGGGCATC
TTCGTGGACT ACAGAGTTGG AAGCATCTCC TTTTACAATG TGACAGCCAG ATCCCACATC
TATACATTCG CCAGCTGCTC TTTCTCTGGG CCCCTTCAAC CTATCTTCAG CCCTGGGACA
CGTGATGGAG GGAAGAACAC AGCTCCTCTG ACTATCTGTC CAGTGGGTGG TCAGGGGCCT
GACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu21586
Clone ID Related Accession (Same CDS sequence) NM_001198536.1
Accession Version NM_001198536.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1338bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-15
Organism Homo sapiens(Human)
Product pyrin isoform 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF018080.1, FJ785722.1, Y14441.1 and AJ003147.1. Transcript Variant: This variant lacks an alternate in-frame exon and uses an alternate splice junction at the 5' end of an exon, that causes a frameshift. The resulting isoform (2) is shorter and has a distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: FJ785722.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGGCTAAGA CCCCTAGTGA CCATCTGCTG TCCACCCTGG AGGAGCTGGT GCCCTATGAC 
TTCGAGAAGT TCAAGTTCAA GCTGCAGAAC ACCAGTGTGC AGAAGGAGCA CTCCAGGATC
CCCCGGAGCC AGATCCAGAG AGCCAGGCCG GTGAAGATGG CCACTCTGCT GGTCACCTAC
TATGGGGAAG AGTACGCCGT GCAGCTCACC CTGCAGGTCC TGCGGGCCAT CAACCAGCGC
CTGCTGGCCG AGGAGCTCCA CAGGGCAGCC ATTCAGGGAA GGCCACCAGA CACGGCTGCG
AGTCCCCGCT GCCACGCCCA GGAAGGAGAC CCAGTTGACG GTACCTGTGT GCGTGATTCC
TGCAGCTTCC CCGAGGCAGT TTCTGGGCAC CCCCAGGCCT CAGGCAGCCG CTCACCTGGC
TGCCCCCGGT GCCAGGACTC CCATGAAAGG AAGAGCCCGG GAAGCCTAAG CCCCCAGCCC
CTGCCACAGT GTAAGCGCCA CCTGAAGCAG GTCCAGCTGC TCTTCTGTGA GGATCACGAT
GAGCCCATCT GCCTCATCTG CAGTCTGAGT CAGGAGCACC AAGGCCACCG GGTGCGCCCC
ATTGAGGAGG TCGCCCTGGA ACACAAGAAG AAAATTCAGA AGCAGCTGGA GCATCTGAAG
AAGCTGAGAA AATCAGGGGA GGAGCAGCGA TCCTATGGGG AGGAGAAGGC AGTGAGCTTT
CTGAAACAAA CTGAAGCGCT GAAGCAGCGG GTGCAGAGGA AGCTGGAGCA GGTGTACTAC
TTCCTGGAGC AGCAAGAGCA TTTCTTTGTG GCCTCACTGG AGGACGTGGG CCAGATGGTT
GGGCAGATCA GGAAGGCATA TGACACCCGC GTATCCCAGG ACATCGCCCT GCTCGATGCG
CTGATTGGGG AACTGGAGGC CAAGGAGTGC CAGTCAGAAT GGGAACTTCT GCAGGACATT
GGAGACATCT TGCACAGGGC TAAGACAGTG CCTGTCCCTG AAAAGTGGAC CACTCCTCAA
GAGATAAAAC AAAAGATCCA ACTCCTCCAC CAGAAGTCAG AGTTTGTGGA GAAGAGCACA
AAGTACTTCT CAGAAACCCT GCGTTCAGAA ATGGAAATGT TCAATGACCA CAGTCCCCAA
CATGGCCTGG GTTCCTGGGA GGAACGGGAT TATACCCAAC ATAGCATGCA GGGCCCTAAG
CAGGGGGTTC CTTGTCTTTC CTTGTTGTCA GGACAGTGTA ATTTAGCCCC TCTTAATGCT
AATGCTCAGG ATTTTTTTCC CTATCTGATT TTTCTCCGTA GTTCCAGAGC TGATTGGCGC
TCAGGCACAT GCTGTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001185465.1
CDS41..1378
Misc Feature(1)56..304
Misc Feature(2)515..643
Misc Feature(3)order(530..532,539..541,599..601,617..619)
Misc Feature(4)<611..799
Exon (1)1..317
Exon (2)318..667
Exon (3)668..763
Exon (4)764..994
Exon (5)995..1017
Exon (6)1018..1133
Exon (7)1134..1166
Exon (8)1167..1374
Exon (9)1375..3041
Translation

Target ORF information:

RefSeq Version NM_001198536.1
Organism Homo sapiens(Human)
Definition Homo sapiens MEFV, pyrin innate immunity regulator (MEFV), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001198536.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGGCTAAGA CCCCTAGTGA CCATCTGCTG TCCACCCTGG AGGAGCTGGT GCCCTATGAC 
TTCGAGAAGT TCAAGTTCAA GCTGCAGAAC ACCAGTGTGC AGAAGGAGCA CTCCAGGATC
CCCCGGAGCC AGATCCAGAG AGCCAGGCCG GTGAAGATGG CCACTCTGCT GGTCACCTAC
TATGGGGAAG AGTACGCCGT GCAGCTCACC CTGCAGGTCC TGCGGGCCAT CAACCAGCGC
CTGCTGGCCG AGGAGCTCCA CAGGGCAGCC ATTCAGGGAA GGCCACCAGA CACGGCTGCG
AGTCCCCGCT GCCACGCCCA GGAAGGAGAC CCAGTTGACG GTACCTGTGT GCGTGATTCC
TGCAGCTTCC CCGAGGCAGT TTCTGGGCAC CCCCAGGCCT CAGGCAGCCG CTCACCTGGC
TGCCCCCGGT GCCAGGACTC CCATGAAAGG AAGAGCCCGG GAAGCCTAAG CCCCCAGCCC
CTGCCACAGT GTAAGCGCCA CCTGAAGCAG GTCCAGCTGC TCTTCTGTGA GGATCACGAT
GAGCCCATCT GCCTCATCTG CAGTCTGAGT CAGGAGCACC AAGGCCACCG GGTGCGCCCC
ATTGAGGAGG TCGCCCTGGA ACACAAGAAG AAAATTCAGA AGCAGCTGGA GCATCTGAAG
AAGCTGAGAA AATCAGGGGA GGAGCAGCGA TCCTATGGGG AGGAGAAGGC AGTGAGCTTT
CTGAAACAAA CTGAAGCGCT GAAGCAGCGG GTGCAGAGGA AGCTGGAGCA GGTGTACTAC
TTCCTGGAGC AGCAAGAGCA TTTCTTTGTG GCCTCACTGG AGGACGTGGG CCAGATGGTT
GGGCAGATCA GGAAGGCATA TGACACCCGC GTATCCCAGG ACATCGCCCT GCTCGATGCG
CTGATTGGGG AACTGGAGGC CAAGGAGTGC CAGTCAGAAT GGGAACTTCT GCAGGACATT
GGAGACATCT TGCACAGGGC TAAGACAGTG CCTGTCCCTG AAAAGTGGAC CACTCCTCAA
GAGATAAAAC AAAAGATCCA ACTCCTCCAC CAGAAGTCAG AGTTTGTGGA GAAGAGCACA
AAGTACTTCT CAGAAACCCT GCGTTCAGAA ATGGAAATGT TCAATGACCA CAGTCCCCAA
CATGGCCTGG GTTCCTGGGA GGAACGGGAT TATACCCAAC ATAGCATGCA GGGCCCTAAG
CAGGGGGTTC CTTGTCTTTC CTTGTTGTCA GGACAGTGTA ATTTAGCCCC TCTTAATGCT
AATGCTCAGG ATTTTTTTCC CTATCTGATT TTTCTCCGTA GTTCCAGAGC TGATTGGCGC
TCAGGCACAT GCTGTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu86035
Clone ID Related Accession (Same CDS sequence) XM_017023236.1
Accession Version XM_017023236.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2343bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product pyrin isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000016.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
ATGGCTAAGA CCCCTAGTGA CCATCTGCTG TCCACCCTGG AGGAGCTGGT GCCCTATGAC 
TTCGAGAAGT TCAAGTTCAA GCTGCAGAAC ACCAGTGTGC AGAAGGAGCA CTCCAGGATC
CCCCGGAGCC AGATCCAGAG AGCCAGGCCG GTGAAGATGG CCACTCTGCT GGTCACCTAC
TATGGGGAAG AGTACGCCGT GCAGCTCACC CTGCAGGTCC TGCGGGCCAT CAACCAGCGC
CTGCTGGCCG AGGAGCTCCA CAGGGCAGCC ATTCAGGAAT ATTCCACACA AGAAAACGGC
ACAGATGATT CCGCAGCGTC CAGCTCCCTG GGGGAGAACA AGCCCAGGAG CCTGAAGACT
CCAGACCACC CCGAGGGGAA CGAGGGGAAC GGCCCTCGGC CGTACGGGGG CGGAGCTGCC
AGCCTGCGGT GCAGCCAGCC CGAGGCCGGG AGGGGGCTGT CGAGGAAGCC CCTGAGCAAA
CGCAGAGAGA AGGCCTCGGA GGGCCTGGAC GCGCAGGGCA AGCCTCGGAC CCGGAGCCCG
GCCCTGCCGG GCGGGAGAAG CCCCGGCCCC TGCAGGGCGC TAGAGGGGGG CCAGGCCGAG
GTCCGGCTGC GCAGAAACGC CAGCTCCGCG GGGAGGCTGC AGGGGCTGGC GGGGGGCGCC
CCGGGGCAGA AGGAGTGCAG GCCCTTCGAA GTGTACCTGC CCTCGGGAAA GATGCGACCT
AGAAGCCTTG AGGTCACCAT TTCTACAGGG GAGAAGGCGC CCGCAAATCC AGAAATTCTC
CTGACTCTAG AGGAAAAGAC AGCTGCGAAT CTGGACTCGG CAACAGAACC CCGGGCAAGG
CCCACTCCGG ATGGAGGGGC ATCTGCGGAC CTGAAGGAAG GCCCTGGAAA TCCAGAACAT
TCGGTCACCG GAAGGCCACC AGACACGGCT GCGAGTCCCC GCTGCCACGC CCAGGAAGGA
GACCCAGTTG ACGGTACCTG TGTGCGTGAT TCCTGCAGCT TCCCCGAGGC AGTTTCTGGG
CACCCCCAGG CCTCAGGCAG CCGCTCACCT GGCTGCCCCC GGTGCCAGGA CTCCCATGAA
AGGAAGAGCC CGGGAAGCCT AAGCCCCCAG CCCCTGCCAC AGTGTAAGCG CCACCTGAAG
CAGGTCCAGC TGCTCTTCTG TGAGGATCAC GATGAGCCCA TCTGCCTCAT CTGCAGTCTG
AGTCAGGAGC ACCAAGGCCA CCGGGTGCGC CCCATTGAGG AGGTCGCCCT GGAACACAAG
AAAATTCAGA AGCAGCTGGA GCATCTGAAG AAGCTGAGAA AATCAGGGGA GGAGCAGCGA
TCCTATGGGG AGGAGAAGGC AGTGAGCTTT CTGAAACAAA CTGAAGCGCT GAAGCAGCGG
GTGCAGAGGA AGCTGGAGCA GGTGTACTAC TTCCTGGAGC AGCAAGAGCA TTTCTTTGTG
GCCTCACTGG AGGACGTGGG CCAGATGGTT GGGCAGATCA GGAAGGCATA TGACACCCGC
GTATCCCAGG ACATCGCCCT GCTCGATGCG CTGATTGGGG AACTGGAGGC CAAGGAGTGC
CAGTCAGAAT GGGAACTTCT GCAGGACATT GGAGACATCT TGCACAGGGC TAAGACAGTG
CCTGTCCCTG AAAAGTGGAC CACTCCTCAA GAGATAAAAC AAAAGATCCA ACTCCTCCAC
CAGAAGTCAG AGTTTGTGGA GAAGAGCACA AAGTACTTCT CAGAAACCCT GCGTTCAGAA
ATGGAAATGT TCAATGTTCC GGAGCTGATT GGCGCTCAGG CACATGCTGT TAATGTGATT
CTGGATGCAG AAACCGCTTA CCCCAACCTC ATCTTCTCTG ATGATCTGAA GAGTGTTAGA
CTTGGAAACA AGTGGGAGAG GCTGCCTGAT GGCCCGCAAA GATTTGACAG CTGTATCATT
GTTCTGGGCT CTCCGAGTTT CCTCTCTGGC CGCCGTTACT GGGAGGTGGA GGTTGGAGAC
AAGACAGCAT GGATCCTGGG AGCCTGCAAG ACATCCATAA GCAGGAAAGG GAACATGACT
CTGTCGCCAG AGAATGGCTA CTGGGTGGTG ATAATGATGA AGGAAAATGA GTACCAGGCG
TCCAGCGTTC CCCCGACCCG CCTGCTAATA AAGGAGCCTC CCAAGCGTGT GGGCATCTTC
GTGGACTACA GAGTTGGAAG CATCTCCTTT TACAATGTGA CAGCCAGATC CCACATCTAT
ACATTCGCCA GCTGCTCTTT CTCTGGGCCC CTTCAACCTA TCTTCAGCCC TGGGACACGT
GATGGAGGGA AGAACACAGC TCCTCTGACT ATCTGTCCAG TGGGTGGTCA GGGGCCTGAC
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_016878725.1
CDS182..2524
Translation

Target ORF information:

RefSeq Version XM_017023236.1
Organism Homo sapiens(Human)
Definition Homo sapiens Mediterranean fever (MEFV), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_017023236.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
ATGGCTAAGA CCCCTAGTGA CCATCTGCTG TCCACCCTGG AGGAGCTGGT GCCCTATGAC 
TTCGAGAAGT TCAAGTTCAA GCTGCAGAAC ACCAGTGTGC AGAAGGAGCA CTCCAGGATC
CCCCGGAGCC AGATCCAGAG AGCCAGGCCG GTGAAGATGG CCACTCTGCT GGTCACCTAC
TATGGGGAAG AGTACGCCGT GCAGCTCACC CTGCAGGTCC TGCGGGCCAT CAACCAGCGC
CTGCTGGCCG AGGAGCTCCA CAGGGCAGCC ATTCAGGAAT ATTCCACACA AGAAAACGGC
ACAGATGATT CCGCAGCGTC CAGCTCCCTG GGGGAGAACA AGCCCAGGAG CCTGAAGACT
CCAGACCACC CCGAGGGGAA CGAGGGGAAC GGCCCTCGGC CGTACGGGGG CGGAGCTGCC
AGCCTGCGGT GCAGCCAGCC CGAGGCCGGG AGGGGGCTGT CGAGGAAGCC CCTGAGCAAA
CGCAGAGAGA AGGCCTCGGA GGGCCTGGAC GCGCAGGGCA AGCCTCGGAC CCGGAGCCCG
GCCCTGCCGG GCGGGAGAAG CCCCGGCCCC TGCAGGGCGC TAGAGGGGGG CCAGGCCGAG
GTCCGGCTGC GCAGAAACGC CAGCTCCGCG GGGAGGCTGC AGGGGCTGGC GGGGGGCGCC
CCGGGGCAGA AGGAGTGCAG GCCCTTCGAA GTGTACCTGC CCTCGGGAAA GATGCGACCT
AGAAGCCTTG AGGTCACCAT TTCTACAGGG GAGAAGGCGC CCGCAAATCC AGAAATTCTC
CTGACTCTAG AGGAAAAGAC AGCTGCGAAT CTGGACTCGG CAACAGAACC CCGGGCAAGG
CCCACTCCGG ATGGAGGGGC ATCTGCGGAC CTGAAGGAAG GCCCTGGAAA TCCAGAACAT
TCGGTCACCG GAAGGCCACC AGACACGGCT GCGAGTCCCC GCTGCCACGC CCAGGAAGGA
GACCCAGTTG ACGGTACCTG TGTGCGTGAT TCCTGCAGCT TCCCCGAGGC AGTTTCTGGG
CACCCCCAGG CCTCAGGCAG CCGCTCACCT GGCTGCCCCC GGTGCCAGGA CTCCCATGAA
AGGAAGAGCC CGGGAAGCCT AAGCCCCCAG CCCCTGCCAC AGTGTAAGCG CCACCTGAAG
CAGGTCCAGC TGCTCTTCTG TGAGGATCAC GATGAGCCCA TCTGCCTCAT CTGCAGTCTG
AGTCAGGAGC ACCAAGGCCA CCGGGTGCGC CCCATTGAGG AGGTCGCCCT GGAACACAAG
AAAATTCAGA AGCAGCTGGA GCATCTGAAG AAGCTGAGAA AATCAGGGGA GGAGCAGCGA
TCCTATGGGG AGGAGAAGGC AGTGAGCTTT CTGAAACAAA CTGAAGCGCT GAAGCAGCGG
GTGCAGAGGA AGCTGGAGCA GGTGTACTAC TTCCTGGAGC AGCAAGAGCA TTTCTTTGTG
GCCTCACTGG AGGACGTGGG CCAGATGGTT GGGCAGATCA GGAAGGCATA TGACACCCGC
GTATCCCAGG ACATCGCCCT GCTCGATGCG CTGATTGGGG AACTGGAGGC CAAGGAGTGC
CAGTCAGAAT GGGAACTTCT GCAGGACATT GGAGACATCT TGCACAGGGC TAAGACAGTG
CCTGTCCCTG AAAAGTGGAC CACTCCTCAA GAGATAAAAC AAAAGATCCA ACTCCTCCAC
CAGAAGTCAG AGTTTGTGGA GAAGAGCACA AAGTACTTCT CAGAAACCCT GCGTTCAGAA
ATGGAAATGT TCAATGTTCC GGAGCTGATT GGCGCTCAGG CACATGCTGT TAATGTGATT
CTGGATGCAG AAACCGCTTA CCCCAACCTC ATCTTCTCTG ATGATCTGAA GAGTGTTAGA
CTTGGAAACA AGTGGGAGAG GCTGCCTGAT GGCCCGCAAA GATTTGACAG CTGTATCATT
GTTCTGGGCT CTCCGAGTTT CCTCTCTGGC CGCCGTTACT GGGAGGTGGA GGTTGGAGAC
AAGACAGCAT GGATCCTGGG AGCCTGCAAG ACATCCATAA GCAGGAAAGG GAACATGACT
CTGTCGCCAG AGAATGGCTA CTGGGTGGTG ATAATGATGA AGGAAAATGA GTACCAGGCG
TCCAGCGTTC CCCCGACCCG CCTGCTAATA AAGGAGCCTC CCAAGCGTGT GGGCATCTTC
GTGGACTACA GAGTTGGAAG CATCTCCTTT TACAATGTGA CAGCCAGATC CCACATCTAT
ACATTCGCCA GCTGCTCTTT CTCTGGGCCC CTTCAACCTA TCTTCAGCCC TGGGACACGT
GATGGAGGGA AGAACACAGC TCCTCTGACT ATCTGTCCAG TGGGTGGTCA GGGGCCTGAC
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

The M694I/M694I genotype: A genetic risk factor of AA-amyloidosis in a group of Algerian patients with familial Mediterranean fever.
European journal of medical genetics60(3)149-153(2017 Mar)
Ait-Idir D,Djerdjouri B,Bouldjennet F,Taha RZ,El-Shanti H,Sari-Hamidou R,Khellaf G,Benmansour M,Benabadji M,Haddoum F


book

Familial Mediterranean fever gene mutation frequencies in a sample Turkish population.
Clinical and experimental rheumatology34(6 Suppl 102)97-100(2016 Sep-Oct)
Soylemezoglu O,Kandur Y,Gonen S,Düzova A,Özçakar ZB,Fidan K,Yalcinkaya F


book

MEFV and SAA1 genotype associations with clinical features of familial Mediterranean fever and amyloidosis in Armenia.
Clinical and experimental rheumatology34(6 Suppl 102)72-76(2016 Sep-Oct)
Atoyan S,Hayrapetyan H,Sarkisian T,Ben-Chetrit E


book

Prevalence of common MEFV mutations and carrier frequencies in a large cohort of Iranian populations.
Journal of genetics95(3)667-74(2016 Sep)
Beheshtian M,Izadi N,Kriegshauser G,Kahrizi K,Mehr EP,Rostami M,Hosseini M,Azad M,Montajabiniat M,Kariminejad A,Nemeth S,Oberkanins C,Najmabadi H


 
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