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SERPINF1 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol SERPINF1
Entrez Gene ID 5176
Full Name serpin family F member 1
Synonyms EPC-1,OI12,OI6,PEDF,PIG35
General protein information
Preferred Names

serpin family F member 1

Names

pigment epithelium-derived factor
cell proliferation-inducing gene 35 protein
serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
testis tissue sperm-binding protein Li 70n

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

17

17p13.3

Disorder MIM:

172860


mRNA and Protein(s)

mRNA Protein Name
NM_002615.5 NP_002606.3 pigment epithelium-derived factor precursor
NM_001329903.1 NP_001316832.1 pigment epithelium-derived factor isoform 1 precursor
NM_002615.6 NP_002606.3 pigment epithelium-derived factor isoform 1 precursor
NM_001329905.1 NP_001316834.1 pigment epithelium-derived factor isoform 2
NM_001329904.1 NP_001316833.1 pigment epithelium-derived factor isoform 2



Canis lupus familiaris (dog) SERPINF1 NP_001071056.2
Gallus gallus (chicken) SERPINF1 NP_001244218.1
Homo sapiens (human) SERPINF1 NP_002606.3
Pan troglodytes (chimpanzee) SERPINF1 XP_001155004.1
Mus musculus (house mouse) Serpinf1 NP_035470.3
Bos taurus (cattle) SERPINF1 NP_776565.1
Rattus norvegicus (Norway rat) Serpinf1 NP_808788.1
Danio rerio (zebrafish) serpinf1 NP_001004539.1
Xenopus tropicalis (tropical clawed frog) serpinf1 NP_989086.1


Related articles in PubMed

Mutations and altered expression of SERPINF1 in patients with familial otosclerosis.
Ziff JL, Crompton M, Powell HR, Lavy JA, Aldren CP, Steel KP, Saeed SR, Dawson SJ
Human molecular genetics25(12)2393-2403(2016 06)

PEDF and PEDF-derived peptide 44mer inhibit oxygen-glucose deprivation-induced oxidative stress through upregulating PPARγ via PEDF-R in H9c2 cells.
Zhuang W, Zhang H, Pan J, Li Z, Wei T, Cui H, Liu Z, Guan Q, Dong H, Zhang Z
Biochemical and biophysical research communications472(3)482-8(2016 Apr)

Pigment Epithelium-Derived Factor, a Protective Factor for Photoreceptors in Vivo.
Polato F, Becerra SP
Advances in experimental medicine and biology854699-706(2016)

GnRH Agonist Triggering Modulates PEDF to VEGF Ratio Inversely to hCG in Granulosa Cells.
Miller I, Chuderland D, Ron-El R, Shalgi R, Ben-Ami I
The Journal of clinical endocrinology and metabolism100(11)E1428-36(2015 Nov)

Human testicular peritubular cells secrete pigment epithelium-derived factor (PEDF), which may be responsible for the avascularity of the seminiferous tubules.
Windschüttl S, Kampfer C, Mayer C, Flenkenthaler F, Fröhlich T, Schwarzer JU, Köhn FM, Urbanski H, Arnold GJ, Mayerhofer A
Scientific reports512820(2015 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results indicated that the reduction of VEGF and increase in PEDF are causative to the evolution of infantile hemangioma. PEDF may play a key role in the spontaneous regression of infantile hemangioma and may become an important potential therapeutic agent for infantile hemangioma.
Title: The pigment epithelium-derived factor (PEDF): an important potential therapeutic agent for infantile hemangioma.

Wnt/beta-catenin pathway may mediate ox-LDL-induced endothelial injury via oxidative stress, and PEDF ameliorates endothelial injury by suppressing Wnt/beta-catenin pathway and subsequently reducing oxidative stress.
Title: Pigment epithelium-derived factor alleviates endothelial injury by inhibiting Wnt/β-catenin pathway.

PEDF represents a marker for transient cartilage during all neonatal and postnatal developmental stages and promotes the termination of cartilage tissue by upregulation of matrix-degrading factors and downregulation of cartilage-specific genes.
Title: PEDF Is Associated with the Termination of Chondrocyte Phenotype and Catabolism of Cartilage Tissue.

The changes in the SERPINH1 and SERPINF1 genes in patients with osteogenesis imperfect were synonymous polymorphisms or missense changes located in non-coding regions.
Title: Analysis of FKBP10, SERPINH1, and SERPINF1 genes in patients with osteogenesis imperfecta.

The present data provided evidence that reducing C3 activation can decreases VEGF and increase PEDF mRNA level in retinal pigment epithelial cells.
Title: C3a Increases VEGF and Decreases PEDF mRNA Levels in Human Retinal Pigment Epithelial Cells.

The following SERPINF1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SERPINF1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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Up to 50% OFF! Starting
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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu18617 NM_001329903.1
Latest version!
Homo sapiens serpin family F member 1 (SERPINF1), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$159.50-$223.30
$319.00
OHu18617 NM_002615.6
Latest version!
Homo sapiens serpin family F member 1 (SERPINF1), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$159.50-$223.30
$319.00
OHu101269 NM_001329905.1
Latest version!
Homo sapiens serpin family F member 1 (SERPINF1), transcript variant 4, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $139.30
$199.00
OHu101269 NM_001329904.1
Latest version!
Homo sapiens serpin family F member 1 (SERPINF1), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $139.30
$199.00
View Old Accession Versions >>
OHu18617 NM_002615.5 Homo sapiens serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 (SERPINF1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$159.50-$223.30
$319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu18617
Clone ID Related Accession (Same CDS sequence) NM_002615.5 , NM_001329903.1 , NM_002615.6
Accession Version NM_002615.5 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1257bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2015-03-15
Organism Homo sapiens(Human)
Product pigment epithelium-derived factor precursor
Comment

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGCAGGCCC TGGTGCTACT CCTCTGCATT GGAGCCCTCC TCGGGCACAG CAGCTGCCAG 
AACCCTGCCA GCCCCCCGGA GGAGGGCTCC CCAGACCCCG ACAGCACAGG GGCGCTGGTG
GAGGAGGAGG ATCCTTTCTT CAAAGTCCCC GTGAACAAGC TGGCAGCGGC TGTCTCCAAC
TTCGGCTATG ACCTGTACCG GGTGCGATCC AGCACGAGCC CCACGACCAA CGTGCTCCTG
TCTCCTCTCA GTGTGGCCAC GGCCCTCTCG GCCCTCTCGC TGGGAGCGGA GCAGCGAACA
GAATCCATCA TTCACCGGGC TCTCTACTAT GACTTGATCA GCAGCCCAGA CATCCATGGT
ACCTATAAGG AGCTCCTTGA CACGGTCACT GCCCCCCAGA AGAACCTCAA GAGTGCCTCC
CGGATCGTCT TTGAGAAGAA GCTGCGCATA AAATCCAGCT TTGTGGCACC TCTGGAAAAG
TCATATGGGA CCAGGCCCAG AGTCCTGACG GGCAACCCTC GCTTGGACCT GCAAGAGATC
AACAACTGGG TGCAGGCGCA GATGAAAGGG AAGCTCGCCA GGTCCACAAA GGAAATTCCC
GATGAGATCA GCATTCTCCT TCTCGGTGTG GCGCACTTCA AGGGGCAGTG GGTAACAAAG
TTTGACTCCA GAAAGACTTC CCTCGAGGAT TTCTACTTGG ATGAAGAGAG GACCGTGAGG
GTCCCCATGA TGTCGGACCC TAAGGCTGTT TTACGCTATG GCTTGGATTC AGATCTCAGC
TGCAAGATTG CCCAGCTGCC CTTGACCGGA AGCATGAGTA TCATCTTCTT CCTGCCCCTG
AAAGTGACCC AGAATTTGAC CTTGATAGAG GAGAGCCTCA CCTCCGAGTT CATTCATGAC
ATAGACCGAG AACTGAAGAC CGTGCAGGCG GTCCTCACTG TCCCCAAGCT GAAGCTGAGT
TATGAAGGCG AAGTCACCAA GTCCCTGCAG GAGATGAAGC TGCAATCCTT GTTTGATTCA
CCAGACTTTA GCAAGATCAC AGGCAAACCC ATCAAGCTGA CTCAGGTGGA ACACCGGGCT
GGCTTTGAGT GGAACGAGGA TGGGGCGGGA ACCACCCCCA GCCCAGGGCT GCAGCCTGCC
CACCTCACCT TCCCGCTGGA CTATCACCTT AACCAGCCTT TCATCTTCGT ACTGAGGGAC
ACAGACACAG GGGCCCTTCT CTTCATTGGC AAGATTCTGG ACCCCAGGGG CCCCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_002606.3
Translation

Target ORF information:

RefSeq Version NM_002615.5
Organism Homo sapiens(Human)
Definition Homo sapiens serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 (SERPINF1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002615.5

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGCAGGCCC TGGTGCTACT CCTCTGCATT GGAGCCCTCC TCGGGCACAG CAGCTGCCAG 
AACCCTGCCA GCCCCCCGGA GGAGGGCTCC CCAGACCCCG ACAGCACAGG GGCGCTGGTG
GAGGAGGAGG ATCCTTTCTT CAAAGTCCCC GTGAACAAGC TGGCAGCGGC TGTCTCCAAC
TTCGGCTATG ACCTGTACCG GGTGCGATCC AGCACGAGCC CCACGACCAA CGTGCTCCTG
TCTCCTCTCA GTGTGGCCAC GGCCCTCTCG GCCCTCTCGC TGGGAGCGGA GCAGCGAACA
GAATCCATCA TTCACCGGGC TCTCTACTAT GACTTGATCA GCAGCCCAGA CATCCATGGT
ACCTATAAGG AGCTCCTTGA CACGGTCACT GCCCCCCAGA AGAACCTCAA GAGTGCCTCC
CGGATCGTCT TTGAGAAGAA GCTGCGCATA AAATCCAGCT TTGTGGCACC TCTGGAAAAG
TCATATGGGA CCAGGCCCAG AGTCCTGACG GGCAACCCTC GCTTGGACCT GCAAGAGATC
AACAACTGGG TGCAGGCGCA GATGAAAGGG AAGCTCGCCA GGTCCACAAA GGAAATTCCC
GATGAGATCA GCATTCTCCT TCTCGGTGTG GCGCACTTCA AGGGGCAGTG GGTAACAAAG
TTTGACTCCA GAAAGACTTC CCTCGAGGAT TTCTACTTGG ATGAAGAGAG GACCGTGAGG
GTCCCCATGA TGTCGGACCC TAAGGCTGTT TTACGCTATG GCTTGGATTC AGATCTCAGC
TGCAAGATTG CCCAGCTGCC CTTGACCGGA AGCATGAGTA TCATCTTCTT CCTGCCCCTG
AAAGTGACCC AGAATTTGAC CTTGATAGAG GAGAGCCTCA CCTCCGAGTT CATTCATGAC
ATAGACCGAG AACTGAAGAC CGTGCAGGCG GTCCTCACTG TCCCCAAGCT GAAGCTGAGT
TATGAAGGCG AAGTCACCAA GTCCCTGCAG GAGATGAAGC TGCAATCCTT GTTTGATTCA
CCAGACTTTA GCAAGATCAC AGGCAAACCC ATCAAGCTGA CTCAGGTGGA ACACCGGGCT
GGCTTTGAGT GGAACGAGGA TGGGGCGGGA ACCACCCCCA GCCCAGGGCT GCAGCCTGCC
CACCTCACCT TCCCGCTGGA CTATCACCTT AACCAGCCTT TCATCTTCGT ACTGAGGGAC
ACAGACACAG GGGCCCTTCT CTTCATTGGC AAGATTCTGG ACCCCAGGGG CCCCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu18617
Clone ID Related Accession (Same CDS sequence) NM_002615.5 , NM_001329903.1 , NM_002615.6
Accession Version NM_001329903.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1257bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-12
Organism Homo sapiens(Human)
Product pigment epithelium-derived factor isoform 1 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC130343.7 and AC130689.8. This sequence is a reference standard in the RefSeqGene project. On Aug 4, 2016 this sequence version replaced XM_017024754.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279828.2743.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGCAGGCCC TGGTGCTACT CCTCTGCATT GGAGCCCTCC TCGGGCACAG CAGCTGCCAG 
AACCCTGCCA GCCCCCCGGA GGAGGGCTCC CCAGACCCCG ACAGCACAGG GGCGCTGGTG
GAGGAGGAGG ATCCTTTCTT CAAAGTCCCC GTGAACAAGC TGGCAGCGGC TGTCTCCAAC
TTCGGCTATG ACCTGTACCG GGTGCGATCC AGCACGAGCC CCACGACCAA CGTGCTCCTG
TCTCCTCTCA GTGTGGCCAC GGCCCTCTCG GCCCTCTCGC TGGGAGCGGA GCAGCGAACA
GAATCCATCA TTCACCGGGC TCTCTACTAT GACTTGATCA GCAGCCCAGA CATCCATGGT
ACCTATAAGG AGCTCCTTGA CACGGTCACT GCCCCCCAGA AGAACCTCAA GAGTGCCTCC
CGGATCGTCT TTGAGAAGAA GCTGCGCATA AAATCCAGCT TTGTGGCACC TCTGGAAAAG
TCATATGGGA CCAGGCCCAG AGTCCTGACG GGCAACCCTC GCTTGGACCT GCAAGAGATC
AACAACTGGG TGCAGGCGCA GATGAAAGGG AAGCTCGCCA GGTCCACAAA GGAAATTCCC
GATGAGATCA GCATTCTCCT TCTCGGTGTG GCGCACTTCA AGGGGCAGTG GGTAACAAAG
TTTGACTCCA GAAAGACTTC CCTCGAGGAT TTCTACTTGG ATGAAGAGAG GACCGTGAGG
GTCCCCATGA TGTCGGACCC TAAGGCTGTT TTACGCTATG GCTTGGATTC AGATCTCAGC
TGCAAGATTG CCCAGCTGCC CTTGACCGGA AGCATGAGTA TCATCTTCTT CCTGCCCCTG
AAAGTGACCC AGAATTTGAC CTTGATAGAG GAGAGCCTCA CCTCCGAGTT CATTCATGAC
ATAGACCGAG AACTGAAGAC CGTGCAGGCG GTCCTCACTG TCCCCAAGCT GAAGCTGAGT
TATGAAGGCG AAGTCACCAA GTCCCTGCAG GAGATGAAGC TGCAATCCTT GTTTGATTCA
CCAGACTTTA GCAAGATCAC AGGCAAACCC ATCAAGCTGA CTCAGGTGGA ACACCGGGCT
GGCTTTGAGT GGAACGAGGA TGGGGCGGGA ACCACCCCCA GCCCAGGGCT GCAGCCTGCC
CACCTCACCT TCCCGCTGGA CTATCACCTT AACCAGCCTT TCATCTTCGT ACTGAGGGAC
ACAGACACAG GGGCCCTTCT CTTCATTGGC AAGATTCTGG ACCCCAGGGG CCCCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001316832.1
CDS89..1345
Misc Feature(1)44..46
Misc Feature(2)146..148
Misc Feature(3)158..160
Misc Feature(4)428..430
Misc Feature(5)767..769
Misc Feature(6)1199..1237
Exon (1)1..80
Exon (2)81..172
Exon (3)173..371
Exon (4)372..527
Exon (5)528..731
Exon (6)732..874
Exon (7)875..1085
Exon (8)1086..1473
Translation

Target ORF information:

RefSeq Version NM_001329903.1
Organism Homo sapiens(Human)
Definition Homo sapiens serpin family F member 1 (SERPINF1), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001329903.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGCAGGCCC TGGTGCTACT CCTCTGCATT GGAGCCCTCC TCGGGCACAG CAGCTGCCAG 
AACCCTGCCA GCCCCCCGGA GGAGGGCTCC CCAGACCCCG ACAGCACAGG GGCGCTGGTG
GAGGAGGAGG ATCCTTTCTT CAAAGTCCCC GTGAACAAGC TGGCAGCGGC TGTCTCCAAC
TTCGGCTATG ACCTGTACCG GGTGCGATCC AGCACGAGCC CCACGACCAA CGTGCTCCTG
TCTCCTCTCA GTGTGGCCAC GGCCCTCTCG GCCCTCTCGC TGGGAGCGGA GCAGCGAACA
GAATCCATCA TTCACCGGGC TCTCTACTAT GACTTGATCA GCAGCCCAGA CATCCATGGT
ACCTATAAGG AGCTCCTTGA CACGGTCACT GCCCCCCAGA AGAACCTCAA GAGTGCCTCC
CGGATCGTCT TTGAGAAGAA GCTGCGCATA AAATCCAGCT TTGTGGCACC TCTGGAAAAG
TCATATGGGA CCAGGCCCAG AGTCCTGACG GGCAACCCTC GCTTGGACCT GCAAGAGATC
AACAACTGGG TGCAGGCGCA GATGAAAGGG AAGCTCGCCA GGTCCACAAA GGAAATTCCC
GATGAGATCA GCATTCTCCT TCTCGGTGTG GCGCACTTCA AGGGGCAGTG GGTAACAAAG
TTTGACTCCA GAAAGACTTC CCTCGAGGAT TTCTACTTGG ATGAAGAGAG GACCGTGAGG
GTCCCCATGA TGTCGGACCC TAAGGCTGTT TTACGCTATG GCTTGGATTC AGATCTCAGC
TGCAAGATTG CCCAGCTGCC CTTGACCGGA AGCATGAGTA TCATCTTCTT CCTGCCCCTG
AAAGTGACCC AGAATTTGAC CTTGATAGAG GAGAGCCTCA CCTCCGAGTT CATTCATGAC
ATAGACCGAG AACTGAAGAC CGTGCAGGCG GTCCTCACTG TCCCCAAGCT GAAGCTGAGT
TATGAAGGCG AAGTCACCAA GTCCCTGCAG GAGATGAAGC TGCAATCCTT GTTTGATTCA
CCAGACTTTA GCAAGATCAC AGGCAAACCC ATCAAGCTGA CTCAGGTGGA ACACCGGGCT
GGCTTTGAGT GGAACGAGGA TGGGGCGGGA ACCACCCCCA GCCCAGGGCT GCAGCCTGCC
CACCTCACCT TCCCGCTGGA CTATCACCTT AACCAGCCTT TCATCTTCGT ACTGAGGGAC
ACAGACACAG GGGCCCTTCT CTTCATTGGC AAGATTCTGG ACCCCAGGGG CCCCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu18617
Clone ID Related Accession (Same CDS sequence) NM_002615.5 , NM_001329903.1 , NM_002615.6
Accession Version NM_002615.6 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1257bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-12
Organism Homo sapiens(Human)
Product pigment epithelium-derived factor isoform 1 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC130343.7, CA405781.1, AY513280.1 and BQ773314.1. This sequence is a reference standard in the RefSeqGene project. On Aug 4, 2016 this sequence version replaced NM_002615.5. Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein (isoform 1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: HM005693.1, M76979.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGCAGGCCC TGGTGCTACT CCTCTGCATT GGAGCCCTCC TCGGGCACAG CAGCTGCCAG 
AACCCTGCCA GCCCCCCGGA GGAGGGCTCC CCAGACCCCG ACAGCACAGG GGCGCTGGTG
GAGGAGGAGG ATCCTTTCTT CAAAGTCCCC GTGAACAAGC TGGCAGCGGC TGTCTCCAAC
TTCGGCTATG ACCTGTACCG GGTGCGATCC AGCACGAGCC CCACGACCAA CGTGCTCCTG
TCTCCTCTCA GTGTGGCCAC GGCCCTCTCG GCCCTCTCGC TGGGAGCGGA GCAGCGAACA
GAATCCATCA TTCACCGGGC TCTCTACTAT GACTTGATCA GCAGCCCAGA CATCCATGGT
ACCTATAAGG AGCTCCTTGA CACGGTCACT GCCCCCCAGA AGAACCTCAA GAGTGCCTCC
CGGATCGTCT TTGAGAAGAA GCTGCGCATA AAATCCAGCT TTGTGGCACC TCTGGAAAAG
TCATATGGGA CCAGGCCCAG AGTCCTGACG GGCAACCCTC GCTTGGACCT GCAAGAGATC
AACAACTGGG TGCAGGCGCA GATGAAAGGG AAGCTCGCCA GGTCCACAAA GGAAATTCCC
GATGAGATCA GCATTCTCCT TCTCGGTGTG GCGCACTTCA AGGGGCAGTG GGTAACAAAG
TTTGACTCCA GAAAGACTTC CCTCGAGGAT TTCTACTTGG ATGAAGAGAG GACCGTGAGG
GTCCCCATGA TGTCGGACCC TAAGGCTGTT TTACGCTATG GCTTGGATTC AGATCTCAGC
TGCAAGATTG CCCAGCTGCC CTTGACCGGA AGCATGAGTA TCATCTTCTT CCTGCCCCTG
AAAGTGACCC AGAATTTGAC CTTGATAGAG GAGAGCCTCA CCTCCGAGTT CATTCATGAC
ATAGACCGAG AACTGAAGAC CGTGCAGGCG GTCCTCACTG TCCCCAAGCT GAAGCTGAGT
TATGAAGGCG AAGTCACCAA GTCCCTGCAG GAGATGAAGC TGCAATCCTT GTTTGATTCA
CCAGACTTTA GCAAGATCAC AGGCAAACCC ATCAAGCTGA CTCAGGTGGA ACACCGGGCT
GGCTTTGAGT GGAACGAGGA TGGGGCGGGA ACCACCCCCA GCCCAGGGCT GCAGCCTGCC
CACCTCACCT TCCCGCTGGA CTATCACCTT AACCAGCCTT TCATCTTCGT ACTGAGGGAC
ACAGACACAG GGGCCCTTCT CTTCATTGGC AAGATTCTGG ACCCCAGGGG CCCCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_002606.3
CDS198..1454
Misc Feature(1)93..95
Misc Feature(2)255..257
Misc Feature(3)267..269
Misc Feature(4)315..1442
Misc Feature(5)order(426..437,447..521,552..566)
Misc Feature(6)537..539
Misc Feature(7)876..878
Misc Feature(8)1050..1052
Misc Feature(9)order(1299..1310,1359..1376)
Misc Feature(10)1308..1346
Exon (1)1..189
Exon (2)190..281
Exon (3)282..480
Exon (4)481..636
Exon (5)637..840
Exon (6)841..983
Exon (7)984..1194
Exon (8)1195..1582
Translation

Target ORF information:

RefSeq Version NM_002615.6
Organism Homo sapiens(Human)
Definition Homo sapiens serpin family F member 1 (SERPINF1), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002615.6

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGCAGGCCC TGGTGCTACT CCTCTGCATT GGAGCCCTCC TCGGGCACAG CAGCTGCCAG 
AACCCTGCCA GCCCCCCGGA GGAGGGCTCC CCAGACCCCG ACAGCACAGG GGCGCTGGTG
GAGGAGGAGG ATCCTTTCTT CAAAGTCCCC GTGAACAAGC TGGCAGCGGC TGTCTCCAAC
TTCGGCTATG ACCTGTACCG GGTGCGATCC AGCACGAGCC CCACGACCAA CGTGCTCCTG
TCTCCTCTCA GTGTGGCCAC GGCCCTCTCG GCCCTCTCGC TGGGAGCGGA GCAGCGAACA
GAATCCATCA TTCACCGGGC TCTCTACTAT GACTTGATCA GCAGCCCAGA CATCCATGGT
ACCTATAAGG AGCTCCTTGA CACGGTCACT GCCCCCCAGA AGAACCTCAA GAGTGCCTCC
CGGATCGTCT TTGAGAAGAA GCTGCGCATA AAATCCAGCT TTGTGGCACC TCTGGAAAAG
TCATATGGGA CCAGGCCCAG AGTCCTGACG GGCAACCCTC GCTTGGACCT GCAAGAGATC
AACAACTGGG TGCAGGCGCA GATGAAAGGG AAGCTCGCCA GGTCCACAAA GGAAATTCCC
GATGAGATCA GCATTCTCCT TCTCGGTGTG GCGCACTTCA AGGGGCAGTG GGTAACAAAG
TTTGACTCCA GAAAGACTTC CCTCGAGGAT TTCTACTTGG ATGAAGAGAG GACCGTGAGG
GTCCCCATGA TGTCGGACCC TAAGGCTGTT TTACGCTATG GCTTGGATTC AGATCTCAGC
TGCAAGATTG CCCAGCTGCC CTTGACCGGA AGCATGAGTA TCATCTTCTT CCTGCCCCTG
AAAGTGACCC AGAATTTGAC CTTGATAGAG GAGAGCCTCA CCTCCGAGTT CATTCATGAC
ATAGACCGAG AACTGAAGAC CGTGCAGGCG GTCCTCACTG TCCCCAAGCT GAAGCTGAGT
TATGAAGGCG AAGTCACCAA GTCCCTGCAG GAGATGAAGC TGCAATCCTT GTTTGATTCA
CCAGACTTTA GCAAGATCAC AGGCAAACCC ATCAAGCTGA CTCAGGTGGA ACACCGGGCT
GGCTTTGAGT GGAACGAGGA TGGGGCGGGA ACCACCCCCA GCCCAGGGCT GCAGCCTGCC
CACCTCACCT TCCCGCTGGA CTATCACCTT AACCAGCCTT TCATCTTCGT ACTGAGGGAC
ACAGACACAG GGGCCCTTCT CTTCATTGGC AAGATTCTGG ACCCCAGGGG CCCCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu101269
Clone ID Related Accession (Same CDS sequence) NM_001329905.1 , NM_001329904.1
Accession Version NM_001329905.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 696bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-12
Organism Homo sapiens(Human)
Product pigment epithelium-derived factor isoform 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC130689.8. This sequence is a reference standard in the RefSeqGene project. Transcript Variant: This variant (4, also known as 012) lacks a portion of the 5' UTR and 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.176344.1, ERR279857.1974.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
ATGAAAGGGA AGCTCGCCAG GTCCACAAAG GAAATTCCCG ATGAGATCAG CATTCTCCTT 
CTCGGTGTGG CGCACTTCAA GGGGCAGTGG GTAACAAAGT TTGACTCCAG AAAGACTTCC
CTCGAGGATT TCTACTTGGA TGAAGAGAGG ACCGTGAGGG TCCCCATGAT GTCGGACCCT
AAGGCTGTTT TACGCTATGG CTTGGATTCA GATCTCAGCT GCAAGATTGC CCAGCTGCCC
TTGACCGGAA GCATGAGTAT CATCTTCTTC CTGCCCCTGA AAGTGACCCA GAATTTGACC
TTGATAGAGG AGAGCCTCAC CTCCGAGTTC ATTCATGACA TAGACCGAGA ACTGAAGACC
GTGCAGGCGG TCCTCACTGT CCCCAAGCTG AAGCTGAGTT ATGAAGGCGA AGTCACCAAG
TCCCTGCAGG AGATGAAGCT GCAATCCTTG TTTGATTCAC CAGACTTTAG CAAGATCACA
GGCAAACCCA TCAAGCTGAC TCAGGTGGAA CACCGGGCTG GCTTTGAGTG GAACGAGGAT
GGGGCGGGAA CCACCCCCAG CCCAGGGCTG CAGCCTGCCC ACCTCACCTT CCCGCTGGAC
TATCACCTTA ACCAGCCTTT CATCTTCGTA CTGAGGGACA CAGACACAGG GGCCCTTCTC
TTCATTGGCA AGATTCTGGA CCCCAGGGGC CCCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001316834.1
CDS324..1019
Misc Feature(1)177..179
Exon (1)1..405
Exon (2)406..548
Exon (3)549..759
Exon (4)760..1147
Translation

Target ORF information:

RefSeq Version NM_001329905.1
Organism Homo sapiens(Human)
Definition Homo sapiens serpin family F member 1 (SERPINF1), transcript variant 4, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001329905.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGAAAGGGA AGCTCGCCAG GTCCACAAAG GAAATTCCCG ATGAGATCAG CATTCTCCTT 
CTCGGTGTGG CGCACTTCAA GGGGCAGTGG GTAACAAAGT TTGACTCCAG AAAGACTTCC
CTCGAGGATT TCTACTTGGA TGAAGAGAGG ACCGTGAGGG TCCCCATGAT GTCGGACCCT
AAGGCTGTTT TACGCTATGG CTTGGATTCA GATCTCAGCT GCAAGATTGC CCAGCTGCCC
TTGACCGGAA GCATGAGTAT CATCTTCTTC CTGCCCCTGA AAGTGACCCA GAATTTGACC
TTGATAGAGG AGAGCCTCAC CTCCGAGTTC ATTCATGACA TAGACCGAGA ACTGAAGACC
GTGCAGGCGG TCCTCACTGT CCCCAAGCTG AAGCTGAGTT ATGAAGGCGA AGTCACCAAG
TCCCTGCAGG AGATGAAGCT GCAATCCTTG TTTGATTCAC CAGACTTTAG CAAGATCACA
GGCAAACCCA TCAAGCTGAC TCAGGTGGAA CACCGGGCTG GCTTTGAGTG GAACGAGGAT
GGGGCGGGAA CCACCCCCAG CCCAGGGCTG CAGCCTGCCC ACCTCACCTT CCCGCTGGAC
TATCACCTTA ACCAGCCTTT CATCTTCGTA CTGAGGGACA CAGACACAGG GGCCCTTCTC
TTCATTGGCA AGATTCTGGA CCCCAGGGGC CCCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu101269
Clone ID Related Accession (Same CDS sequence) NM_001329905.1 , NM_001329904.1
Accession Version NM_001329904.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 696bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-12
Organism Homo sapiens(Human)
Product pigment epithelium-derived factor isoform 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC130343.7 and AC130689.8. This sequence is a reference standard in the RefSeqGene project. Transcript Variant: This variant (3) lacks a portion of the 5' UTR and 5' coding region, compared to variant 1, and initiates translation at a downstream start codon. The encoded isoform (2) has a shorter N-terminus than isoform 1. Variants 3 and 4 encode the same isoform (2). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.329730.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
ATGAAAGGGA AGCTCGCCAG GTCCACAAAG GAAATTCCCG ATGAGATCAG CATTCTCCTT 
CTCGGTGTGG CGCACTTCAA GGGGCAGTGG GTAACAAAGT TTGACTCCAG AAAGACTTCC
CTCGAGGATT TCTACTTGGA TGAAGAGAGG ACCGTGAGGG TCCCCATGAT GTCGGACCCT
AAGGCTGTTT TACGCTATGG CTTGGATTCA GATCTCAGCT GCAAGATTGC CCAGCTGCCC
TTGACCGGAA GCATGAGTAT CATCTTCTTC CTGCCCCTGA AAGTGACCCA GAATTTGACC
TTGATAGAGG AGAGCCTCAC CTCCGAGTTC ATTCATGACA TAGACCGAGA ACTGAAGACC
GTGCAGGCGG TCCTCACTGT CCCCAAGCTG AAGCTGAGTT ATGAAGGCGA AGTCACCAAG
TCCCTGCAGG AGATGAAGCT GCAATCCTTG TTTGATTCAC CAGACTTTAG CAAGATCACA
GGCAAACCCA TCAAGCTGAC TCAGGTGGAA CACCGGGCTG GCTTTGAGTG GAACGAGGAT
GGGGCGGGAA CCACCCCCAG CCCAGGGCTG CAGCCTGCCC ACCTCACCTT CCCGCTGGAC
TATCACCTTA ACCAGCCTTT CATCTTCGTA CTGAGGGACA CAGACACAGG GGCCCTTCTC
TTCATTGGCA AGATTCTGGA CCCCAGGGGC CCCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001316833.1
CDS667..1362
Misc Feature(1)157..159
Exon (1)1..189
Exon (2)190..388
Exon (3)389..544
Exon (4)545..748
Exon (5)749..891
Exon (6)892..1102
Exon (7)1103..1490
Translation

Target ORF information:

RefSeq Version NM_001329904.1
Organism Homo sapiens(Human)
Definition Homo sapiens serpin family F member 1 (SERPINF1), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001329904.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGAAAGGGA AGCTCGCCAG GTCCACAAAG GAAATTCCCG ATGAGATCAG CATTCTCCTT 
CTCGGTGTGG CGCACTTCAA GGGGCAGTGG GTAACAAAGT TTGACTCCAG AAAGACTTCC
CTCGAGGATT TCTACTTGGA TGAAGAGAGG ACCGTGAGGG TCCCCATGAT GTCGGACCCT
AAGGCTGTTT TACGCTATGG CTTGGATTCA GATCTCAGCT GCAAGATTGC CCAGCTGCCC
TTGACCGGAA GCATGAGTAT CATCTTCTTC CTGCCCCTGA AAGTGACCCA GAATTTGACC
TTGATAGAGG AGAGCCTCAC CTCCGAGTTC ATTCATGACA TAGACCGAGA ACTGAAGACC
GTGCAGGCGG TCCTCACTGT CCCCAAGCTG AAGCTGAGTT ATGAAGGCGA AGTCACCAAG
TCCCTGCAGG AGATGAAGCT GCAATCCTTG TTTGATTCAC CAGACTTTAG CAAGATCACA
GGCAAACCCA TCAAGCTGAC TCAGGTGGAA CACCGGGCTG GCTTTGAGTG GAACGAGGAT
GGGGCGGGAA CCACCCCCAG CCCAGGGCTG CAGCCTGCCC ACCTCACCTT CCCGCTGGAC
TATCACCTTA ACCAGCCTTT CATCTTCGTA CTGAGGGACA CAGACACAGG GGCCCTTCTC
TTCATTGGCA AGATTCTGGA CCCCAGGGGC CCCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Mutations and altered expression of SERPINF1 in patients with familial otosclerosis.
Human molecular genetics25(12)2393-2403(2016 06)
Ziff JL,Crompton M,Powell HR,Lavy JA,Aldren CP,Steel KP,Saeed SR,Dawson SJ


book

PEDF and PEDF-derived peptide 44mer inhibit oxygen-glucose deprivation-induced oxidative stress through upregulating PPARγ via PEDF-R in H9c2 cells.
Biochemical and biophysical research communications472(3)482-8(2016 Apr)
Zhuang W,Zhang H,Pan J,Li Z,Wei T,Cui H,Liu Z,Guan Q,Dong H,Zhang Z


book

Pigment Epithelium-Derived Factor, a Protective Factor for Photoreceptors in Vivo.
Advances in experimental medicine and biology854699-706(2016)
Polato F,Becerra SP


book

GnRH Agonist Triggering Modulates PEDF to VEGF Ratio Inversely to hCG in Granulosa Cells.
The Journal of clinical endocrinology and metabolism100(11)E1428-36(2015 Nov)
Miller I,Chuderland D,Ron-El R,Shalgi R,Ben-Ami I


book

Human testicular peritubular cells secrete pigment epithelium-derived factor (PEDF), which may be responsible for the avascularity of the seminiferous tubules.
Scientific reports512820(2015 Sep)
Windschüttl S,Kampfer C,Mayer C,Flenkenthaler F,Fröhlich T,Schwarzer JU,Köhn FM,Urbanski H,Arnold GJ,Mayerhofer A


 
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