WDR19 cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | WDR19 |
| Entrez Gene ID | 57728 |
| Full Name | WD repeat domain 19 |
| Synonyms | ATD5,CED4,DYF-2,IFT144,NPHP13,ORF26,Oseg6,PWDMP,SRTD5 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | The protein encoded by this gene is a member of the WD (tryptophan-aspartic acid) repeat family, which is a large family of structurally-related proteins known to participate in a wide range of cellular processes. Each WD repeat typically contains about 40 amino acids that are usually bracketed by glycine-histidine and tryptophan-aspartic acid (WD) dipeptides. This protein contains six WD repeats, three transmembrane domains, and a clathrin heavy-chain repeat. Mutations in this gene have been described in individuals with a wide range of disorders affecting function of the cilium. These disorders are known as ciliopathies, and include Jeune syndrome, Sensenbrenner syndromes, Senior-Loken syndrome, combined or isolated nephronophthisis (NPHP), and retinitis pigmentosa (RP). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]. |
| Disorder MIM: | |
| Disorder Html: | Nephronophthisis 13, 614377 (3); ?Cranioectodermal dysplasia 4, 614378 (3); ?Short-rib thoracic dysplasia 5 with or without polydactyly, 614376 (3); Senior-Loken syndrome 8, 616307 (3) |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| XM_011513726.3 | XP_011512028.1 | WD repeat-containing protein 19 isoform X3 |
| XM_011513725.2 | XP_011512027.1 | WD repeat-containing protein 19 isoform X2 |
| NM_001317924.2 | NP_001304853.1 | WD repeat-containing protein 19 isoform 2 |
| NM_025132.4 | NP_079408.3 | WD repeat-containing protein 19 isoform 1 |
| XM_011513726.2 | XP_011512028.1 | WD repeat-containing protein 19 isoform X3 |
| XM_011513727.1 | XP_011512029.1 | WD repeat-containing protein 19 isoform X3 |
| XM_017008501.1 | XP_016863990.1 | WD repeat-containing protein 19 isoform X4 |
| NM_025132.3 | NP_079408.3 | WD repeat-containing protein 19 isoform 1 |
| XM_011513724.1 | XP_011512026.1 | WD repeat-containing protein 19 isoform X1 |
| NM_001317924.1 | NP_001304853.1 | WD repeat-containing protein 19 isoform 2 |
| Mus musculus (house mouse) | Wdr19 | NP_700440.2 |
| Gallus gallus (chicken) | WDR19 | XP_428380.3 |
| Drosophila melanogaster (fruit fly) | Oseg6 | NP_611426.1 |
| Caenorhabditis elegans (roundworm) | dyf-2 | NP_001076655.1 |
| Homo sapiens (human) | WDR19 | NP_079408.3 |
| WDR19 | XP_001090341.1 | |
| Canis lupus familiaris (dog) | WDR19 | XP_005618677.1 |
| Danio rerio (zebrafish) | wdr19 | XP_684320.1 |
| Anopheles gambiae (African malaria mosquito) | AgaP_AGAP010418 | XP_559033.3 |
| Pan troglodytes (chimpanzee) | WDR19 | XP_517152.2 |
| Bos taurus (cattle) | WDR19 | NP_001192956.1 |
| Rattus norvegicus (Norway rat) | Wdr19 | NP_001178608.2 |
Related articles in PubMed
Ciliopathy-associated mutations of IFT122 impair ciliary protein trafficking but not ciliogenesis.
Takahara M, Katoh Y, Nakamura K, Hirano T, Sugawa M, Tsurumi Y, Nakayama K
Human molecular genetics(2017 Dec)
Diversity of renal phenotypes in patients with WDR19 mutations: Two case reports.
Yoshikawa T, Kamei K, Nagata H, Saida K, Sato M, Ogura M, Ito S, Miyazaki O, Urushihara M, Kondo S, Sugawara N, Ishizuka K, Hamasaki Y, Shishido S, Morisada N, Iijima K, Nagata M, Yoshioka T, Ogata K, Ishikura K
Nephrology (Carlton, Vic.)22(7)566-571(2017 Jul)
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Boldt K, van Reeuwijk J, Lu Q, Koutroumpas K, Nguyen TM, Texier Y, van Beersum SE, Horn N, Willer JR, Mans DA, Dougherty G, Lamers IJ, Coene KL, Arts HH, Betts MJ, Beyer T, Bolat E, Gloeckner CJ, Haidari K, Hetterschijt L, Iaconis D, Jenkins D, Klose F, Knapp B, Latour B, Letteboer SJ, Marcelis CL, Mitic D, Morleo M, Oud MM, Riemersma M, Rix S, Terhal PA, Toedt G, van Dam TJ, de Vrieze E, Wissinger Y, Wu KM, Apic G, Beales PL, Blacque OE, Gibson TJ, Huynen MA, Katsanis N, Kremer H, Omran H, van Wijk E, Wolfrum U, Kepes F, Davis EE, Franco B, Giles RH, Ueffing M, Russell RB, Roepman R,
Nature communications711491(2016 May)
Nephronophthisis 13: implications of its association with Caroli disease and altered intracellular localization of WDR19 in the kidney.
Lee JM, Ahn YH, Kang HG, Ha II, Lee K, Moon KC, Lee JH, Park YS, Cho YM, Bae JS, Kim NK, Park WY, Cheong HI
Pediatric nephrology (Berlin, Germany)30(9)1451-8(2015 Sep)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Nephronophthisis 13 (Autosomal Recessive Polycystic Kidney Disease) is associated with mutations in the WDR19 gene.Caroli disease is a major extra-renal phenotype associated with mutations in WDR19 in the Korean population.
Title: Nephronophthisis 13: implications of its association with Caroli disease and altered intracellular localization of WDR19 in the kidney.
WDR19 mutations can cause a broad spectrum of ciliopathies that extends to Jeune and Sensenbrenner syndromes, RP and renal NPHP-like phenotypes
Title: Mutations in WDR19 encoding the intraflagellar transport component IFT144 cause a broad spectrum of ciliopathies.
WDR19: an ancient, retrograde, intraflagellar ciliary protein is mutated in autosomal recessive retinitis pigmentosa and in Senior-Loken syndrome.
Title: WDR19: an ancient, retrograde, intraflagellar ciliary protein is mutated in autosomal recessive retinitis pigmentosa and in Senior-Loken syndrome.
Mutations in WDR19 gene is associated with Caroli disease.
Title: Identification of 99 novel mutations in a worldwide cohort of 1,056 patients with a nephronophthisis-related ciliopathy.
Ciliopathies with skeletal anomalies and renal insufficiency due to mutations in the IFT-A gene WDR19
Title: Ciliopathies with skeletal anomalies and renal insufficiency due to mutations in the IFT-A gene WDR19.
The following WDR19 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the WDR19 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu70927 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001317924.2 , XM_017008501.1 , NM_001317924.1 | |
| Accession Version | NM_001317924.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 3549bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-09-27 | |
| Organism | Homo sapiens(human) | |
| Product | WD repeat-containing protein 19 isoform 2 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK294730.1 and AK225588.1. On May 31, 2019 this sequence version replaced NM_001317924.1. Transcript Variant: This variant (2) differs in its 5' UTR compared to variant 1. This variant represents translation initiation at a downstream start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream start codon to encode an isoform (2) that has a shorter N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK294730.1, SRR1660809.209143.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGATTACAG TTAGTAATCA GGAAGGTGAC ACGATAAGAC AGACACAAGT GAGATCAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001304853.1 |
| CDS | 394..3942 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001317924.2 |
ORF Insert Sequence:
1 | ATGATTACAG TTAGTAATCA GGAAGGTGAC ACGATAAGAC AGACACAAGT GAGATCAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu70927 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001317924.2 , XM_017008501.1 , NM_001317924.1 | |
| Accession Version | NM_001317924.1 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 3549bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-02-24 | |
| Organism | Homo sapiens(human) | |
| Product | WD repeat-containing protein 19 isoform 2 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY029257.1, AK294730.1 and AK225588.1. On Dec 15, 2015 this sequence version replaced XM_011513728.1. Transcript Variant: This variant (2) differs in its 5' UTR compared to variant 1. This variant represents translation initiation at a downstream start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream start codon to encode an isoform (2) that has a shorter N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.109373.1, SRR1803612.189973.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGATTACAG TTAGTAATCA GGAAGGTGAC ACGATAAGAC AGACACAAGT GAGATCAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001304853.1 |
| CDS | 519..4067 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001317924.1 |
ORF Insert Sequence:
1 | ATGATTACAG TTAGTAATCA GGAAGGTGAC ACGATAAGAC AGACACAAGT GAGATCAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu70925 | |
| Clone ID Related Accession (Same CDS sequence) | XM_011513725.2 | |
| Accession Version | XM_011513725.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 3975bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-05 | |
| Organism | Homo sapiens(human) | |
| Product | WD repeat-containing protein 19 isoform X2 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011513725.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGAAGCGTA TTTTCTCACT GCTAGAAAAG ACTTGGCTTG GCGCACCAAT ACAGTTTGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_011512027.1 |
| CDS | 86..4060 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_011513725.2 |
ORF Insert Sequence:
1 | ATGAAGCGTA TTTTCTCACT GCTAGAAAAG ACTTGGCTTG GCGCACCAAT ACAGTTTGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu70926 | |
| Clone ID Related Accession (Same CDS sequence) | XM_011513726.3 , XM_011513726.2 , XM_011513727.1 | |
| Accession Version | XM_011513726.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 3561bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-05 | |
| Organism | Homo sapiens(human) | |
| Product | WD repeat-containing protein 19 isoform X3 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011513726.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGATTACAG TTAGTAATCA GGAAGGTGAC ACGATAAGAC AGACACAAGT GAGATCAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_011512028.1 |
| CDS | 394..3954 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_011513726.3 |
ORF Insert Sequence:
1 | ATGATTACAG TTAGTAATCA GGAAGGTGAC ACGATAAGAC AGACACAAGT GAGATCAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu70926 | |
| Clone ID Related Accession (Same CDS sequence) | XM_011513726.3 , XM_011513726.2 , XM_011513727.1 | |
| Accession Version | XM_011513726.2 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 3561bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-06-05 | |
| Organism | Homo sapiens(human) | |
| Product | WD repeat-containing protein 19 isoform X3 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011513726.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGATTACAG TTAGTAATCA GGAAGGTGAC ACGATAAGAC AGACACAAGT GAGATCAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_011512028.1 |
| CDS | 408..3968 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_011513726.2 |
ORF Insert Sequence:
1 | ATGATTACAG TTAGTAATCA GGAAGGTGAC ACGATAAGAC AGACACAAGT GAGATCAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu70926 | |
| Clone ID Related Accession (Same CDS sequence) | XM_011513726.3 , XM_011513726.2 , XM_011513727.1 | |
| Accession Version | XM_011513727.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 3561bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-05 | |
| Organism | Homo sapiens(human) | |
| Product | WD repeat-containing protein 19 isoform X3 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGATTACAG TTAGTAATCA GGAAGGTGAC ACGATAAGAC AGACACAAGT GAGATCAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_011512029.1 |
| CDS | 328..3888 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_011513727.1 |
ORF Insert Sequence:
1 | ATGATTACAG TTAGTAATCA GGAAGGTGAC ACGATAAGAC AGACACAAGT GAGATCAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu70927 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001317924.2 , XM_017008501.1 , NM_001317924.1 | |
| Accession Version | XM_017008501.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 3549bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-05 | |
| Organism | Homo sapiens(human) | |
| Product | WD repeat-containing protein 19 isoform X4 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGATTACAG TTAGTAATCA GGAAGGTGAC ACGATAAGAC AGACACAAGT GAGATCAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_016863990.1 |
| CDS | 328..3876 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_017008501.1 |
ORF Insert Sequence:
1 | ATGATTACAG TTAGTAATCA GGAAGGTGAC ACGATAAGAC AGACACAAGT GAGATCAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu25824 | |
| Clone ID Related Accession (Same CDS sequence) | NM_025132.4 , NM_025132.3 | |
| Accession Version | NM_025132.4 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 4029bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-09-26 | |
| Organism | Homo sapiens(human) | |
| Product | WD repeat-containing protein 19 isoform 1 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY029257.1, BC032578.2, AK026780.1, AB046858.1 and AK122908.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_025132.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY029257.1, SRR1660803.208102.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000399820.8/ ENSP00000382717.3 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length. | |
1 | ATGAAGCGTA TTTTCTCACT GCTAGAAAAG ACTTGGCTTG GCGCACCAAT ACAGTTTGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_079408.3 |
| CDS | 30..4058 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_025132.4 |
ORF Insert Sequence:
1 | ATGAAGCGTA TTTTCTCACT GCTAGAAAAG ACTTGGCTTG GCGCACCAAT ACAGTTTGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu25824 | |
| Clone ID Related Accession (Same CDS sequence) | NM_025132.4 , NM_025132.3 | |
| Accession Version | NM_025132.3 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 4029bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-09-30 | |
| Organism | Homo sapiens(human) | |
| Product | WD repeat-containing protein 19 isoform 1 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY029257.1, BC032578.1, AK026780.1, AB046858.1 and AK122908.1. This sequence is a reference standard in the RefSeqGene project. On Nov 15, 2004 this sequence version replaced NM_025132.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY029257.1, SRR1660807.187395.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGAAGCGTA TTTTCTCACT GCTAGAAAAG ACTTGGCTTG GCGCACCAAT ACAGTTTGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_079408.3 |
| CDS | 155..4183 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_025132.3 |
ORF Insert Sequence:
1 | ATGAAGCGTA TTTTCTCACT GCTAGAAAAG ACTTGGCTTG GCGCACCAAT ACAGTTTGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu70924 | |
| Clone ID Related Accession (Same CDS sequence) | XM_011513724.1 | |
| Accession Version | XM_011513724.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 4041bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-05 | |
| Organism | Homo sapiens(human) | |
| Product | WD repeat-containing protein 19 isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGAAGCGTA TTTTCTCACT GCTAGAAAAG ACTTGGCTTG GCGCACCAAT ACAGTTTGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_011512026.1 |
| CDS | 65..4105 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_011513724.1 |
ORF Insert Sequence:
1 | ATGAAGCGTA TTTTCTCACT GCTAGAAAAG ACTTGGCTTG GCGCACCAAT ACAGTTTGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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Ciliopathy-associated mutations of IFT122 impair ciliary protein trafficking but not ciliogenesis. |
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Diversity of renal phenotypes in patients with WDR19 mutations: Two case reports. |
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An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. |
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Nephronophthisis 13: implications of its association with Caroli disease and altered intracellular localization of WDR19 in the kidney. |