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TGIF2 cDNA ORF clone, Homo sapiens(human)

Summary

Gene Symbol TGIF2
Entrez Gene ID 60436
Full Name TGFB induced factor homeobox 2
General protein information
Preferred Names

TGFB induced factor homeobox 2

Names

homeobox protein TGIF2
5'-TG-3' interacting factor 2
TGF(beta)-induced transcription factor 2
TGFB-induced factor 2 (TALE family homeobox)
transcription growth factor-beta-induced factor 2
Gene Type protein-coding
Organism Homo sapiens(human)
Genome

20

20q11.23
Summary The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene. [provided by RefSeq, Dec 2010].
Disorder MIM:

607294


Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_021809.7 NP_068581.1 homeobox protein TGIF2
NM_001199515.1 NP_001186444.1 homeobox protein TGIF2
NM_001199514.2 NP_001186443.1 homeobox protein TGIF2
NM_021809.6 NP_068581.1 homeobox protein TGIF2
NM_001199514.1 NP_001186443.1 homeobox protein TGIF2
NM_001199513.1 NP_001186442.1 homeobox protein TGIF2

Pathways from BioSystems


Homologies


Mus musculus (house mouse) Tgif2 NP_775572.1
Xenopus tropicalis (tropical clawed frog) tgif2 XP_002932898.1
Rattus norvegicus (Norway rat) Tgif2 NP_001128455.1
TGIF2 XP_002798197.1
Canis lupus familiaris (dog) TGIF2 XP_005635061.1
Homo sapiens (human) TGIF2 NP_001186444.1
Bos taurus (cattle) TGIF2 NP_001193014.1
Danio rerio (zebrafish) LOC100535338 XP_005168761.1

Gene Ontology


Bibliography

Related articles in PubMed

Tgif1 and Tgif2 Repress Expression of the RabGAP Evi5l.
Anderson AE, Taniguchi K, Hao Y, Melhuish TA, Shah A, Turner SD, Sutherland AE, Wotton D
Molecular and cellular biology37(5)(2017 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Tgifs regulate ciliogenesis and suggests that Evi5l mediates at least part of this effect.
Title: Tgif1 and Tgif2 Repress Expression of the RabGAP Evi5l.

Data show that TGFB-induced factor 2 protein (TGIF2) is involved in microRNA miR-541-3p-regulated cell proliferation, invasion, migration, as well as cell cycle of non-small lung cancer (NSCLC) cells.
Title: MiR-541-3p reverses cancer progression by directly targeting TGIF2 in non-small cell lung cancer.

Authors suggest that miR-148a inhibits OC cell proliferation and invasion partly through inhibition of TGFI2. Therefore, this study highlights the importance of the miR-148a/TGFI2 axis in the malignant progression of OC.
Title: Suppressive Role of MicroRNA-148a in Cell Proliferation and Invasion in Ovarian Cancer Through Targeting Transforming Growth Factor-?-Induced 2.

expression of miR-148a was regulated by DNA methylation and targeted by TGIF2. Its methylation may be a potential prognostic indicator in skin cancer
Title: Down-Regulation of miR-148a Promotes Metastasis by DNA Methylation and is Associated with Prognosis of Skin Cancer by Targeting TGIF2.

miR-34a could inhibit tumor invasion and metastasis in gastric cancer by targeting Tgif2
Title: MicroRNA-34a inhibits tumor invasion and metastasis in gastric cancer by targeting Tgif2.

The following TGIF2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TGIF2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu03741 NM_001199513.1
Latest version!		 Homo sapiens TGFB induced factor homeobox 2 (TGIF2), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
OHu03741 NM_021809.7
Latest version!		 Homo sapiens TGFB induced factor homeobox 2 (TGIF2), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
OHu03741 NM_001199515.1
Latest version!		 Homo sapiens TGFB induced factor homeobox 2 (TGIF2), transcript variant 4, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
OHu03741 NM_001199514.2
Latest version!		 Homo sapiens TGFB induced factor homeobox 2 (TGIF2), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
View Old Accession Versions >>
OHu03741 NM_021809.6 Homo sapiens TGFB induced factor homeobox 2 (TGIF2), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
OHu03741 NM_001199514.1 Homo sapiens TGFB induced factor homeobox 2 (TGIF2), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OHu03741
Clone ID Related Accession (Same CDS sequence) NM_021809.7 , NM_001199515.1 , NM_001199514.2 , NM_021809.6 , NM_001199514.1 , NM_001199513.1
Accession Version NM_021809.7 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 714bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-09
Organism Homo sapiens(human)
Product homeobox protein TGIF2
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL050318.13. On Jun 2, 2019 this sequence version replaced NM_021809.6. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All variants (1-4) encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC006549.2, SRR6380202.60869.7 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
ATGTCGGACA GTGATCTAGG TGAGGACGAA GGCCTCCTCT CCCTGGCGGG CAAAAGGAAG 
CGCAGGGGGA ACCTGCCCAA GGAGTCGGTG AAGATCCTCC GGGACTGGCT GTACTTGCAC 
CGCTACAACG CCTACCCCTC AGAGCAGGAG AAGCTGAGCC TTTCTGGACA GACCAACCTG 
TCAGTGCTGC AAATATGTAA CTGGTTCATC AATGCCCGGC GGCGGCTTCT CCCAGACATG 
CTTCGGAAGG ATGGCAAAGA CCCTAATCAG TTTACCATTT CCCGCCGCGG GGGTAAGGCC 
TCAGATGTGG CCCTCCCCCG TGGCAGCAGC CCCTCAGTGC TGGCTGTGTC TGTCCCAGCC 
CCCACCAATG TGCTCTCCCT GTCTGTGTGC TCCATGCCGC TTCACTCAGG CCAGGGGGAA 
AAGCCAGCAG CCCCTTTCCC ACGTGGGGAG CTGGAGTCTC CCAAGCCCCT GGTGACCCCT 
GGTAGCACAC TTACTCTGCT GACCAGGGCT GAGGCTGGAA GCCCCACAGG TGGACTCTTC 
AACACGCCAC CACCCACACC CCCAGAGCAG GACAAAGAGG ACTTCAGCAG CTTCCAGCTG 
CTGGTGGAGG TGGCGCTACA GAGGGCTGCT GAGATGGAGC TTCAGAAGCA GCAGGACCCA 
TCACTCCCAT TACTGCACAC TCCCATCCCT TTAGTCTCTG AAAATCCCCA GTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_068581.1
CDS184..897
Translation

Target ORF information:

RefSeq Version NM_021809.7
Organism Homo sapiens(human)
Definition Homo sapiens TGFB induced factor homeobox 2 (TGIF2), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_021809.7

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGTCGGACA GTGATCTAGG TGAGGACGAA GGCCTCCTCT CCCTGGCGGG CAAAAGGAAG 
CGCAGGGGGA ACCTGCCCAA GGAGTCGGTG AAGATCCTCC GGGACTGGCT GTACTTGCAC 
CGCTACAACG CCTACCCCTC AGAGCAGGAG AAGCTGAGCC TTTCTGGACA GACCAACCTG 
TCAGTGCTGC AAATATGTAA CTGGTTCATC AATGCCCGGC GGCGGCTTCT CCCAGACATG 
CTTCGGAAGG ATGGCAAAGA CCCTAATCAG TTTACCATTT CCCGCCGCGG GGGTAAGGCC 
TCAGATGTGG CCCTCCCCCG TGGCAGCAGC CCCTCAGTGC TGGCTGTGTC TGTCCCAGCC 
CCCACCAATG TGCTCTCCCT GTCTGTGTGC TCCATGCCGC TTCACTCAGG CCAGGGGGAA 
AAGCCAGCAG CCCCTTTCCC ACGTGGGGAG CTGGAGTCTC CCAAGCCCCT GGTGACCCCT 
GGTAGCACAC TTACTCTGCT GACCAGGGCT GAGGCTGGAA GCCCCACAGG TGGACTCTTC 
AACACGCCAC CACCCACACC CCCAGAGCAG GACAAAGAGG ACTTCAGCAG CTTCCAGCTG 
CTGGTGGAGG TGGCGCTACA GAGGGCTGCT GAGATGGAGC TTCAGAAGCA GCAGGACCCA 
TCACTCCCAT TACTGCACAC TCCCATCCCT TTAGTCTCTG AAAATCCCCA GTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu03741
Clone ID Related Accession (Same CDS sequence) NM_021809.7 , NM_001199515.1 , NM_001199514.2 , NM_021809.6 , NM_001199514.1 , NM_001199513.1
Accession Version NM_001199515.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 714bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-09
Organism Homo sapiens(human)
Product homeobox protein TGIF2
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP353213.1, AK074802.1, BQ881960.1 and BI869422.1. Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All variants (1-4) encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BP353213.1, SRR1660805.202118.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
ATGTCGGACA GTGATCTAGG TGAGGACGAA GGCCTCCTCT CCCTGGCGGG CAAAAGGAAG 
CGCAGGGGGA ACCTGCCCAA GGAGTCGGTG AAGATCCTCC GGGACTGGCT GTACTTGCAC 
CGCTACAACG CCTACCCCTC AGAGCAGGAG AAGCTGAGCC TTTCTGGACA GACCAACCTG 
TCAGTGCTGC AAATATGTAA CTGGTTCATC AATGCCCGGC GGCGGCTTCT CCCAGACATG 
CTTCGGAAGG ATGGCAAAGA CCCTAATCAG TTTACCATTT CCCGCCGCGG GGGTAAGGCC 
TCAGATGTGG CCCTCCCCCG TGGCAGCAGC CCCTCAGTGC TGGCTGTGTC TGTCCCAGCC 
CCCACCAATG TGCTCTCCCT GTCTGTGTGC TCCATGCCGC TTCACTCAGG CCAGGGGGAA 
AAGCCAGCAG CCCCTTTCCC ACGTGGGGAG CTGGAGTCTC CCAAGCCCCT GGTGACCCCT 
GGTAGCACAC TTACTCTGCT GACCAGGGCT GAGGCTGGAA GCCCCACAGG TGGACTCTTC 
AACACGCCAC CACCCACACC CCCAGAGCAG GACAAAGAGG ACTTCAGCAG CTTCCAGCTG 
CTGGTGGAGG TGGCGCTACA GAGGGCTGCT GAGATGGAGC TTCAGAAGCA GCAGGACCCA 
TCACTCCCAT TACTGCACAC TCCCATCCCT TTAGTCTCTG AAAATCCCCA GTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001186444.1
CDS117..830
Translation

Target ORF information:

RefSeq Version NM_001199515.1
Organism Homo sapiens(human)
Definition Homo sapiens TGFB induced factor homeobox 2 (TGIF2), transcript variant 4, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001199515.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGTCGGACA GTGATCTAGG TGAGGACGAA GGCCTCCTCT CCCTGGCGGG CAAAAGGAAG 
CGCAGGGGGA ACCTGCCCAA GGAGTCGGTG AAGATCCTCC GGGACTGGCT GTACTTGCAC 
CGCTACAACG CCTACCCCTC AGAGCAGGAG AAGCTGAGCC TTTCTGGACA GACCAACCTG 
TCAGTGCTGC AAATATGTAA CTGGTTCATC AATGCCCGGC GGCGGCTTCT CCCAGACATG 
CTTCGGAAGG ATGGCAAAGA CCCTAATCAG TTTACCATTT CCCGCCGCGG GGGTAAGGCC 
TCAGATGTGG CCCTCCCCCG TGGCAGCAGC CCCTCAGTGC TGGCTGTGTC TGTCCCAGCC 
CCCACCAATG TGCTCTCCCT GTCTGTGTGC TCCATGCCGC TTCACTCAGG CCAGGGGGAA 
AAGCCAGCAG CCCCTTTCCC ACGTGGGGAG CTGGAGTCTC CCAAGCCCCT GGTGACCCCT 
GGTAGCACAC TTACTCTGCT GACCAGGGCT GAGGCTGGAA GCCCCACAGG TGGACTCTTC 
AACACGCCAC CACCCACACC CCCAGAGCAG GACAAAGAGG ACTTCAGCAG CTTCCAGCTG 
CTGGTGGAGG TGGCGCTACA GAGGGCTGCT GAGATGGAGC TTCAGAAGCA GCAGGACCCA 
TCACTCCCAT TACTGCACAC TCCCATCCCT TTAGTCTCTG AAAATCCCCA GTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu03741
Clone ID Related Accession (Same CDS sequence) NM_021809.7 , NM_001199515.1 , NM_001199514.2 , NM_021809.6 , NM_001199514.1 , NM_001199513.1
Accession Version NM_001199514.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 714bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-09
Organism Homo sapiens(human)
Product homeobox protein TGIF2
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL050318.13. On Jun 2, 2019 this sequence version replaced NM_001199514.1. Transcript Variant: This variant (1) represents the longest transcript. All variants (1-4) encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279868.1673.1, DRR138524.415503.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
ATGTCGGACA GTGATCTAGG TGAGGACGAA GGCCTCCTCT CCCTGGCGGG CAAAAGGAAG 
CGCAGGGGGA ACCTGCCCAA GGAGTCGGTG AAGATCCTCC GGGACTGGCT GTACTTGCAC 
CGCTACAACG CCTACCCCTC AGAGCAGGAG AAGCTGAGCC TTTCTGGACA GACCAACCTG 
TCAGTGCTGC AAATATGTAA CTGGTTCATC AATGCCCGGC GGCGGCTTCT CCCAGACATG 
CTTCGGAAGG ATGGCAAAGA CCCTAATCAG TTTACCATTT CCCGCCGCGG GGGTAAGGCC 
TCAGATGTGG CCCTCCCCCG TGGCAGCAGC CCCTCAGTGC TGGCTGTGTC TGTCCCAGCC 
CCCACCAATG TGCTCTCCCT GTCTGTGTGC TCCATGCCGC TTCACTCAGG CCAGGGGGAA 
AAGCCAGCAG CCCCTTTCCC ACGTGGGGAG CTGGAGTCTC CCAAGCCCCT GGTGACCCCT 
GGTAGCACAC TTACTCTGCT GACCAGGGCT GAGGCTGGAA GCCCCACAGG TGGACTCTTC 
AACACGCCAC CACCCACACC CCCAGAGCAG GACAAAGAGG ACTTCAGCAG CTTCCAGCTG 
CTGGTGGAGG TGGCGCTACA GAGGGCTGCT GAGATGGAGC TTCAGAAGCA GCAGGACCCA 
TCACTCCCAT TACTGCACAC TCCCATCCCT TTAGTCTCTG AAAATCCCCA GTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001186443.1
CDS91..804
Translation

Target ORF information:

RefSeq Version NM_001199514.2
Organism Homo sapiens(human)
Definition Homo sapiens TGFB induced factor homeobox 2 (TGIF2), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001199514.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGTCGGACA GTGATCTAGG TGAGGACGAA GGCCTCCTCT CCCTGGCGGG CAAAAGGAAG 
CGCAGGGGGA ACCTGCCCAA GGAGTCGGTG AAGATCCTCC GGGACTGGCT GTACTTGCAC 
CGCTACAACG CCTACCCCTC AGAGCAGGAG AAGCTGAGCC TTTCTGGACA GACCAACCTG 
TCAGTGCTGC AAATATGTAA CTGGTTCATC AATGCCCGGC GGCGGCTTCT CCCAGACATG 
CTTCGGAAGG ATGGCAAAGA CCCTAATCAG TTTACCATTT CCCGCCGCGG GGGTAAGGCC 
TCAGATGTGG CCCTCCCCCG TGGCAGCAGC CCCTCAGTGC TGGCTGTGTC TGTCCCAGCC 
CCCACCAATG TGCTCTCCCT GTCTGTGTGC TCCATGCCGC TTCACTCAGG CCAGGGGGAA 
AAGCCAGCAG CCCCTTTCCC ACGTGGGGAG CTGGAGTCTC CCAAGCCCCT GGTGACCCCT 
GGTAGCACAC TTACTCTGCT GACCAGGGCT GAGGCTGGAA GCCCCACAGG TGGACTCTTC 
AACACGCCAC CACCCACACC CCCAGAGCAG GACAAAGAGG ACTTCAGCAG CTTCCAGCTG 
CTGGTGGAGG TGGCGCTACA GAGGGCTGCT GAGATGGAGC TTCAGAAGCA GCAGGACCCA 
TCACTCCCAT TACTGCACAC TCCCATCCCT TTAGTCTCTG AAAATCCCCA GTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu03741
Clone ID Related Accession (Same CDS sequence) NM_021809.7 , NM_001199515.1 , NM_001199514.2 , NM_021809.6 , NM_001199514.1 , NM_001199513.1
Accession Version NM_021809.6 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 714bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-03-11
Organism Homo sapiens(human)
Product homeobox protein TGIF2
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK313919.1, AK074802.1, BQ881960.1 and BI869422.1. On Dec 8, 2010 this sequence version replaced NM_021809.5. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All variants (1-4) encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK313919.1, BC006549.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
ATGTCGGACA GTGATCTAGG TGAGGACGAA GGCCTCCTCT CCCTGGCGGG CAAAAGGAAG 
CGCAGGGGGA ACCTGCCCAA GGAGTCGGTG AAGATCCTCC GGGACTGGCT GTACTTGCAC 
CGCTACAACG CCTACCCCTC AGAGCAGGAG AAGCTGAGCC TTTCTGGACA GACCAACCTG 
TCAGTGCTGC AAATATGTAA CTGGTTCATC AATGCCCGGC GGCGGCTTCT CCCAGACATG 
CTTCGGAAGG ATGGCAAAGA CCCTAATCAG TTTACCATTT CCCGCCGCGG GGGTAAGGCC 
TCAGATGTGG CCCTCCCCCG TGGCAGCAGC CCCTCAGTGC TGGCTGTGTC TGTCCCAGCC 
CCCACCAATG TGCTCTCCCT GTCTGTGTGC TCCATGCCGC TTCACTCAGG CCAGGGGGAA 
AAGCCAGCAG CCCCTTTCCC ACGTGGGGAG CTGGAGTCTC CCAAGCCCCT GGTGACCCCT 
GGTAGCACAC TTACTCTGCT GACCAGGGCT GAGGCTGGAA GCCCCACAGG TGGACTCTTC 
AACACGCCAC CACCCACACC CCCAGAGCAG GACAAAGAGG ACTTCAGCAG CTTCCAGCTG 
CTGGTGGAGG TGGCGCTACA GAGGGCTGCT GAGATGGAGC TTCAGAAGCA GCAGGACCCA 
TCACTCCCAT TACTGCACAC TCCCATCCCT TTAGTCTCTG AAAATCCCCA GTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_068581.1
CDS174..887
Translation

Target ORF information:

RefSeq Version NM_021809.6
Organism Homo sapiens(human)
Definition Homo sapiens TGFB induced factor homeobox 2 (TGIF2), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_021809.6

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGTCGGACA GTGATCTAGG TGAGGACGAA GGCCTCCTCT CCCTGGCGGG CAAAAGGAAG 
CGCAGGGGGA ACCTGCCCAA GGAGTCGGTG AAGATCCTCC GGGACTGGCT GTACTTGCAC 
CGCTACAACG CCTACCCCTC AGAGCAGGAG AAGCTGAGCC TTTCTGGACA GACCAACCTG 
TCAGTGCTGC AAATATGTAA CTGGTTCATC AATGCCCGGC GGCGGCTTCT CCCAGACATG 
CTTCGGAAGG ATGGCAAAGA CCCTAATCAG TTTACCATTT CCCGCCGCGG GGGTAAGGCC 
TCAGATGTGG CCCTCCCCCG TGGCAGCAGC CCCTCAGTGC TGGCTGTGTC TGTCCCAGCC 
CCCACCAATG TGCTCTCCCT GTCTGTGTGC TCCATGCCGC TTCACTCAGG CCAGGGGGAA 
AAGCCAGCAG CCCCTTTCCC ACGTGGGGAG CTGGAGTCTC CCAAGCCCCT GGTGACCCCT 
GGTAGCACAC TTACTCTGCT GACCAGGGCT GAGGCTGGAA GCCCCACAGG TGGACTCTTC 
AACACGCCAC CACCCACACC CCCAGAGCAG GACAAAGAGG ACTTCAGCAG CTTCCAGCTG 
CTGGTGGAGG TGGCGCTACA GAGGGCTGCT GAGATGGAGC TTCAGAAGCA GCAGGACCCA 
TCACTCCCAT TACTGCACAC TCCCATCCCT TTAGTCTCTG AAAATCCCCA GTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu03741
Clone ID Related Accession (Same CDS sequence) NM_021809.7 , NM_001199515.1 , NM_001199514.2 , NM_021809.6 , NM_001199514.1 , NM_001199513.1
Accession Version NM_001199514.1 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 714bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-03-11
Organism Homo sapiens(human)
Product homeobox protein TGIF2
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL705108.1, BG723865.1, AK074802.1, BQ881960.1 and BI869422.1. Transcript Variant: This variant (1) represents the longest transcript. All variants (1-4) encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279868.1673.1, BI907230.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
ATGTCGGACA GTGATCTAGG TGAGGACGAA GGCCTCCTCT CCCTGGCGGG CAAAAGGAAG 
CGCAGGGGGA ACCTGCCCAA GGAGTCGGTG AAGATCCTCC GGGACTGGCT GTACTTGCAC 
CGCTACAACG CCTACCCCTC AGAGCAGGAG AAGCTGAGCC TTTCTGGACA GACCAACCTG 
TCAGTGCTGC AAATATGTAA CTGGTTCATC AATGCCCGGC GGCGGCTTCT CCCAGACATG 
CTTCGGAAGG ATGGCAAAGA CCCTAATCAG TTTACCATTT CCCGCCGCGG GGGTAAGGCC 
TCAGATGTGG CCCTCCCCCG TGGCAGCAGC CCCTCAGTGC TGGCTGTGTC TGTCCCAGCC 
CCCACCAATG TGCTCTCCCT GTCTGTGTGC TCCATGCCGC TTCACTCAGG CCAGGGGGAA 
AAGCCAGCAG CCCCTTTCCC ACGTGGGGAG CTGGAGTCTC CCAAGCCCCT GGTGACCCCT 
GGTAGCACAC TTACTCTGCT GACCAGGGCT GAGGCTGGAA GCCCCACAGG TGGACTCTTC 
AACACGCCAC CACCCACACC CCCAGAGCAG GACAAAGAGG ACTTCAGCAG CTTCCAGCTG 
CTGGTGGAGG TGGCGCTACA GAGGGCTGCT GAGATGGAGC TTCAGAAGCA GCAGGACCCA 
TCACTCCCAT TACTGCACAC TCCCATCCCT TTAGTCTCTG AAAATCCCCA GTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001186443.1
CDS215..928
Translation

Target ORF information:

RefSeq Version NM_001199514.1
Organism Homo sapiens(human)
Definition Homo sapiens TGFB induced factor homeobox 2 (TGIF2), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001199514.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGTCGGACA GTGATCTAGG TGAGGACGAA GGCCTCCTCT CCCTGGCGGG CAAAAGGAAG 
CGCAGGGGGA ACCTGCCCAA GGAGTCGGTG AAGATCCTCC GGGACTGGCT GTACTTGCAC 
CGCTACAACG CCTACCCCTC AGAGCAGGAG AAGCTGAGCC TTTCTGGACA GACCAACCTG 
TCAGTGCTGC AAATATGTAA CTGGTTCATC AATGCCCGGC GGCGGCTTCT CCCAGACATG 
CTTCGGAAGG ATGGCAAAGA CCCTAATCAG TTTACCATTT CCCGCCGCGG GGGTAAGGCC 
TCAGATGTGG CCCTCCCCCG TGGCAGCAGC CCCTCAGTGC TGGCTGTGTC TGTCCCAGCC 
CCCACCAATG TGCTCTCCCT GTCTGTGTGC TCCATGCCGC TTCACTCAGG CCAGGGGGAA 
AAGCCAGCAG CCCCTTTCCC ACGTGGGGAG CTGGAGTCTC CCAAGCCCCT GGTGACCCCT 
GGTAGCACAC TTACTCTGCT GACCAGGGCT GAGGCTGGAA GCCCCACAGG TGGACTCTTC 
AACACGCCAC CACCCACACC CCCAGAGCAG GACAAAGAGG ACTTCAGCAG CTTCCAGCTG 
CTGGTGGAGG TGGCGCTACA GAGGGCTGCT GAGATGGAGC TTCAGAAGCA GCAGGACCCA 
TCACTCCCAT TACTGCACAC TCCCATCCCT TTAGTCTCTG AAAATCCCCA GTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu03741
Clone ID Related Accession (Same CDS sequence) NM_021809.7 , NM_001199515.1 , NM_001199514.2 , NM_021809.6 , NM_001199514.1 , NM_001199513.1
Accession Version NM_001199513.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 714bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-09
Organism Homo sapiens(human)
Product homeobox protein TGIF2
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL705108.1, AK074802.1, BQ881960.1 and BI869422.1. Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All variants (1-4) encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL705108.1, SRR1803616.12015.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
ATGTCGGACA GTGATCTAGG TGAGGACGAA GGCCTCCTCT CCCTGGCGGG CAAAAGGAAG 
CGCAGGGGGA ACCTGCCCAA GGAGTCGGTG AAGATCCTCC GGGACTGGCT GTACTTGCAC 
CGCTACAACG CCTACCCCTC AGAGCAGGAG AAGCTGAGCC TTTCTGGACA GACCAACCTG 
TCAGTGCTGC AAATATGTAA CTGGTTCATC AATGCCCGGC GGCGGCTTCT CCCAGACATG 
CTTCGGAAGG ATGGCAAAGA CCCTAATCAG TTTACCATTT CCCGCCGCGG GGGTAAGGCC 
TCAGATGTGG CCCTCCCCCG TGGCAGCAGC CCCTCAGTGC TGGCTGTGTC TGTCCCAGCC 
CCCACCAATG TGCTCTCCCT GTCTGTGTGC TCCATGCCGC TTCACTCAGG CCAGGGGGAA 
AAGCCAGCAG CCCCTTTCCC ACGTGGGGAG CTGGAGTCTC CCAAGCCCCT GGTGACCCCT 
GGTAGCACAC TTACTCTGCT GACCAGGGCT GAGGCTGGAA GCCCCACAGG TGGACTCTTC 
AACACGCCAC CACCCACACC CCCAGAGCAG GACAAAGAGG ACTTCAGCAG CTTCCAGCTG 
CTGGTGGAGG TGGCGCTACA GAGGGCTGCT GAGATGGAGC TTCAGAAGCA GCAGGACCCA 
TCACTCCCAT TACTGCACAC TCCCATCCCT TTAGTCTCTG AAAATCCCCA GTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001186442.1
CDS87..800
Translation

Target ORF information:

RefSeq Version NM_001199513.1
Organism Homo sapiens(human)
Definition Homo sapiens TGFB induced factor homeobox 2 (TGIF2), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001199513.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGTCGGACA GTGATCTAGG TGAGGACGAA GGCCTCCTCT CCCTGGCGGG CAAAAGGAAG 
CGCAGGGGGA ACCTGCCCAA GGAGTCGGTG AAGATCCTCC GGGACTGGCT GTACTTGCAC 
CGCTACAACG CCTACCCCTC AGAGCAGGAG AAGCTGAGCC TTTCTGGACA GACCAACCTG 
TCAGTGCTGC AAATATGTAA CTGGTTCATC AATGCCCGGC GGCGGCTTCT CCCAGACATG 
CTTCGGAAGG ATGGCAAAGA CCCTAATCAG TTTACCATTT CCCGCCGCGG GGGTAAGGCC 
TCAGATGTGG CCCTCCCCCG TGGCAGCAGC CCCTCAGTGC TGGCTGTGTC TGTCCCAGCC 
CCCACCAATG TGCTCTCCCT GTCTGTGTGC TCCATGCCGC TTCACTCAGG CCAGGGGGAA 
AAGCCAGCAG CCCCTTTCCC ACGTGGGGAG CTGGAGTCTC CCAAGCCCCT GGTGACCCCT 
GGTAGCACAC TTACTCTGCT GACCAGGGCT GAGGCTGGAA GCCCCACAGG TGGACTCTTC 
AACACGCCAC CACCCACACC CCCAGAGCAG GACAAAGAGG ACTTCAGCAG CTTCCAGCTG 
CTGGTGGAGG TGGCGCTACA GAGGGCTGCT GAGATGGAGC TTCAGAAGCA GCAGGACCCA 
TCACTCCCAT TACTGCACAC TCCCATCCCT TTAGTCTCTG AAAATCCCCA GTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Tgif1 and Tgif2 Repress Expression of the RabGAP Evi5l.
Molecular and cellular biology37(5)(2017 Mar)
Anderson AE,Taniguchi K,Hao Y,Melhuish TA,Shah A,Turner SD,Sutherland AE,Wotton D