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TNFRSF17 cDNA ORF clone, Homo sapiens (human)

Gene Symbol TNFRSF17
Entrez Gene ID 608
Full Name tumor necrosis factor receptor superfamily, member 17
Synonyms BCM, BCMA, CD269, TNFRSF13A
General protein information
Preferred Names
tumor necrosis factor receptor superfamily member 17
Names
tumor necrosis factor receptor superfamily member 17
B-cell maturation factor
B cell maturation antigen
B-cell maturation protein
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

16

16p13.1

Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

109545


mRNA and Protein(s)

mRNA Protein Name
NM_001192 NP_001183 tumor necrosis factor receptor superfamily member 17



Homo sapiens (human) TNFRSF17 NP_001183.2
Pan troglodytes (chimpanzee) TNFRSF17 XP_523298.2
Macaca mulatta (Rhesus monkey) TNFRSF17 XP_001106892.1
Canis lupus familiaris (dog) TNFRSF17 XP_005621587.1
Bos taurus (cattle) TNFRSF17 XP_002698012.2
Mus musculus (house mouse) Tnfrsf17 NP_035738.1
Rattus norvegicus (Norway rat) Tnfrsf17 NP_001099231.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following TNFRSF17 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TNFRSF17 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu17157
NM_001192 Homo sapiens tumor necrosis factor receptor superfamily, member 17 (TNFRSF17), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu17157
Clone ID Related Accession (Same CDS sequence) NM_001192
Accession Version NM_001192.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 555bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product tumor necrosis factor receptor superfamily member 17
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z29575.1. On Sep 20, 2002 this sequence version replaced gi:4507572. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Z29575.1, Z14954.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
ATGTTGCAGA TGGCTGGGCA GTGCTCCCAA AATGAATATT TTGACAGTTT GTTGCATGCT 
TGCATACCTT GTCAACTTCG ATGTTCTTCT AATACTCCTC CTCTAACATG TCAGCGTTAT
TGTAATGCAA GTGTGACCAA TTCAGTGAAA GGAACGAATG CGATTCTCTG GACCTGTTTG
GGACTGAGCT TAATAATTTC TTTGGCAGTT TTCGTGCTAA TGTTTTTGCT AAGGAAGATA
AACTCTGAAC CATTAAAGGA CGAGTTTAAA AACACAGGAT CAGGTCTCCT GGGCATGGCT
AACATTGACC TGGAAAAGAG CAGGACTGGT GATGAAATTA TTCTTCCGAG AGGCCTCGAG
TACACGGTGG AAGAATGCAC CTGTGAAGAC TGCATCAAGA GCAAACCGAA GGTCGACTCT
GACCATTGCT TTCCACTCCC AGCTATGGAG GAAGGCGCAA CCATTCTTGT CACCACGAAA
ACGAATGACT ATTGCAAGAG CCTGCCAGCT GCTTTGAGTG CTACGGAGAT AGAGAAATCA
ATTTCTGCTA GGTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001183.2
CDS219..773
Misc Feature(1)192..194(+)
Misc Feature(2)225..230(+)
Misc Feature(3)228..716(+)
Misc Feature(4)228..281(+)
Misc Feature(5)237..341(+)
Misc Feature(6)288..596(+)
Misc Feature(7)381..449(+)
Exon (1)1..348
Gene:TNFRSF17
Gene Synonym:
Exon (2)349..495
Gene:TNFRSF17
Gene Synonym:
Exon (3)496..994
Gene:TNFRSF17
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001192
Organism Homo sapiens (human)
Definition Homo sapiens tumor necrosis factor receptor superfamily, member 17 (TNFRSF17), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001192

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGTTGCAGA TGGCTGGGCA GTGCTCCCAA AATGAATATT TTGACAGTTT GTTGCATGCT 
TGCATACCTT GTCAACTTCG ATGTTCTTCT AATACTCCTC CTCTAACATG TCAGCGTTAT
TGTAATGCAA GTGTGACCAA TTCAGTGAAA GGAACGAATG CGATTCTCTG GACCTGTTTG
GGACTGAGCT TAATAATTTC TTTGGCAGTT TTCGTGCTAA TGTTTTTGCT AAGGAAGATA
AACTCTGAAC CATTAAAGGA CGAGTTTAAA AACACAGGAT CAGGTCTCCT GGGCATGGCT
AACATTGACC TGGAAAAGAG CAGGACTGGT GATGAAATTA TTCTTCCGAG AGGCCTCGAG
TACACGGTGG AAGAATGCAC CTGTGAAGAC TGCATCAAGA GCAAACCGAA GGTCGACTCT
GACCATTGCT TTCCACTCCC AGCTATGGAG GAAGGCGCAA CCATTCTTGT CACCACGAAA
ACGAATGACT ATTGCAAGAG CCTGCCAGCT GCTTTGAGTG CTACGGAGAT AGAGAAATCA
ATTTCTGCTA GGTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Immunogenicity of dendritic cells pulsed with MAGE3, Survivin and B-cell maturation antigen mRNA for vaccination of multiple myeloma patients
Cancer Immunol. Immunother. 62 (8), 1381-1392 (2013)
Hobo W, Strobbe L, Maas F, Fredrix H, Greupink-Draaisma A, Esendam B, de Witte T, Preijers F, Levenga H, van Rees B, Raymakers R, Schaap N and Dolstra H.


book

B-cell maturation antigen is modified by a single N-glycan chain that modulates ligand binding and surface retention
Proc. Natl. Acad. Sci. U.S.A. 110 (27), 10928-10933 (2013)
Huang HW, Chen CH, Lin CH, Wong CH and Lin KI.


book

B-cell maturation antigen is a promising target for adoptive T-cell therapy of multiple myeloma
Clin. Cancer Res. 19 (8), 2048-2060 (2013)
Carpenter RO, Evbuomwan MO, Pittaluga S, Rose JJ, Raffeld M, Yang S, Gress RE, Hakim FT and Kochenderfer JN.


book

B-cell maturation antigen, a proliferation-inducing ligand, and B-cell activating factor are candidate mediators of spinal cord injury-induced autoimmunity
J. Neurotrauma 30 (6), 434-440 (2013)
Saltzman JW, Battaglino RA, Salles L, Jha P, Sudhakar S, Garshick E, Stott HL, Zafonte R and Morse LR.


book

APRIL binding to BCMA activates a JNK2-FOXO3-GADD45 pathway and induces a G2/M cell growth arrest in liver cells
J. Immunol. 189 (10), 4748-4758 (2012)
Notas G, Alexaki VI, Kampa M, Pelekanou V, Charalampopoulos I, Sabour-Alaoui S, Pediaditakis I, Dessirier V, Gravanis A, Stathopoulos EN, Tsapis A and Castanas E.


book

TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease
Nature 404 (6781), 995-999 (2000)
Gross JA, Johnston J, Mudri S, Enselman R, Dillon SR, Madden K, Xu W, Parrish-Novak J, Foster D, Lofton-Day C, Moore M, Littau A, Grossman A, Haugen H, Foley K, Blumberg H, Harrison K, Kindsvogel W and Clegg CH.


book

Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q
Genomics 60 (3), 295-308 (1999)
Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC and Adams MD.


book

BCMAp: an integral membrane protein in the Golgi apparatus of human mature B lymphocytes
Int. Immunol. 7 (7), 1093-1106 (1995)
Gras MP, Laabi Y, Linares-Cruz G, Blondel MO, Rigaut JP, Brouet JC, Leca G, Haguenauer-Tsapis R and Tsapis A.


book

The BCMA gene, preferentially expressed during B lymphoid maturation, is bidirectionally transcribed
Nucleic Acids Res. 22 (7), 1147-1154 (1994)
Laabi Y, Gras MP, Brouet JC, Berger R, Larsen CJ and Tsapis A.


book

A new gene, BCM, on chromosome 16 is fused to the interleukin 2 gene by a t(4;16)(q26;p13) translocation in a malignant T cell lymphoma
EMBO J. 11 (11), 3897-3904 (1992)
Laabi Y, Gras MP, Carbonnel F, Brouet JC, Berger R, Larsen CJ and Tsapis A.


 
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