TSPY1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TSPY1
Entrez Gene ID	7258
Full Name	testis specific protein, Y-linked 1
Synonyms	CT78,DYS14,TSPY,pJA923
General protein information	Preferred Names testis specific protein, Y-linked 1 Names testis-specific Y-encoded protein 1 cancer/testis antigen 78
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: Y Map Location: Yp11.2
Summary	The protein encoded by this gene is found only in testicular tissue and may be involved in spermatogenesis. Many functional paralogs and pseudogenes of this gene are present in a cluster in humans, but only a single, nonfunctional orthologous gene is found in mouse. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].
Disorder MIM:	480100

mRNA and Protein(s)

mRNA	Protein	Name
NM_003308.4	NP_003299.2	testis-specific Y-encoded protein 1 isoform TSPY-S
NM_001320964.1	NP_001307893.1	testis-specific Y-encoded protein 1 isoform 3
NM_001197242.2	NP_001184171.1	testis-specific Y-encoded protein 1 isoform TSPY-L
NM_003308.3	NP_003299.2	testis-specific Y-encoded protein 1 isoform TSPY-L
XM_017030064.1	XP_016885553.1	testis-specific Y-encoded protein 1 isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LOC101059018	XP_003954179.1
Homo sapiens (human)	TSPY4	NP_001157943.1
Homo sapiens (human)	TSPY1	NP_003299.2
Homo sapiens (human)	TSPY8	NP_001230650.1
Pan troglodytes (chimpanzee)	LOC744381	XP_003954178.1
Homo sapiens (human)	TSPY3	NP_001071165.2
Homo sapiens (human)	TSPY10	NP_001269398.1
Homo sapiens (human)	TSPY2	NP_072095.2

Gene Ontology
Bibliography

Related articles in PubMed

Spermatogenic phenotype of testis-specific protein, Y-encoded, 1 (TSPY1) dosage deficiency is independent of variations in TSPY-like 1 (TSPYL1) and TSPY-like 5 (TSPYL5): a case-control study in a Han Chinese population.
Yang X, Leng X, Tu W, Liu Y, Xu J, Pei X, Ma Y, Yang D, Yang Y
Reproduction, fertility, and development(2017 Aug)

The Y-located proto-oncogene TSPY exacerbates and its X-homologue TSPX inhibits transactivation functions of androgen receptor and its constitutively active variants.
Li Y, Zhang DJ, Qiu Y, Kido T, Lau YC
Human molecular genetics26(5)901-912(2017 03)

Noninvasive Diagnosis of Fetal Gender: Utility of Combining DYS14 and SRY.
Jacob RR, Saxena R, Verma IC
Genetic testing and molecular biomarkers19(9)505-11(2015 Sep)

The potential contributions of a Y-located protooncogene and its X homologue in sexual dimorphisms in hepatocellular carcinoma.
Kido T, Lo RC, Li Y, Lee J, Tabatabai ZL, Ng IO, Lau YF
Human pathology45(9)1847-58(2014 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TSPY and TSPX exert opposing effects on the transactivation functions of AR and AR-Vs important for various physiological and disease processes sensitive to male sex hormone actions, thereby not only affecting the pathogenesis of male-specific prostate cancer but also likely contributing to sex differences in the health and diseases of man.
Title: The Y-located proto-oncogene TSPY exacerbates and its X-homologue TSPX inhibits transactivation functions of androgen receptor and its constitutively active variants.

The aim of this study was to compare two Y chromosome markers-SRY and DYS14-for their utility in the diagnosis of fetal gender.
Title: Noninvasive Diagnosis of Fetal Gender: Utility of Combining DYS14 and SRY.

Studies indicate that TSPY1 (testis-specific protein, Y-linked 1) gene has been identified to be the most important candidate gene for gonadoblastoma.
Title: [Research progress of TSPY1 gene family].

The oncogenic events leading to an ectopic activation of TSPY and/or inactivating mutation/epigenetic silencing of TSPX could collectively contribute to the sexual dimorphism(s) in HCC and related liver cancers in male-biased manners.
Title: The potential contributions of a Y-located protooncogene and its X homologue in sexual dimorphisms in hepatocellular carcinoma.

Over-expression of Testis-specific Protein Y-encoded 1 is associated with male hepatocellular carcinoma.
Title: Over-expressed Testis-specific Protein Y-encoded 1 as a novel biomarker for male hepatocellular carcinoma.

The following TSPY1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TSPY1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19138	NM_003308.4 Latest version!	Homo sapiens testis specific protein Y-linked 1 (TSPY1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu101221	NM_001320964.1 Latest version!	Homo sapiens testis specific protein Y-linked 1 (TSPY1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu20522	NM_001197242.2 Latest version!	Homo sapiens testis specific protein Y-linked 1 (TSPY1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00
OHu99581	XM_017030064.1 Latest version!	Homo sapiens testis specific protein Y-linked 1 (TSPY1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OHu19138	NM_003308.3	Homo sapiens testis specific protein, Y-linked 1 (TSPY1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TSPY1 ( NM_003308.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003299.2 Homo sapiens testis specific protein Y-linked 1 (TSPY1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19138
Clone ID Related Accession (Same CDS sequence)	NM_003308.4 , NM_003308.3
Accession Version	NM_003308.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 927bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-12
Organism	Homo sapiens(human)
Product	testis-specific Y-encoded protein 1 isoform TSPY-S
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC006156.5. This sequence is a reference standard in the RefSeqGene project. On Mar 10, 2016 this sequence version replaced NM_003308.3. Transcript Variant: This variant (1) encodes the longer isoform (TSPY-S). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000451548.6/ ENSP00000403304.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCGCCCTG AGGGCTCGCT GACCTACCGG GTGCCAGAGA GGCTGCGGCA GGGTTTCTGT 
GGCGTGGGTC GGGCAGCACA GGCCTTGGTG TGTGCGAGTG CCAAGGAGGG CACCGCCTTC 
AGGATGGAGG CTGTGCAGGA GGGGGCGGCC GGGGTGGAGA GTGAGCAGGC GGCTTTGGGG 
GAGGAGGCGG TGCTGCTGTT GGATGACATA ATGGCGGAGG TGGAGGTGGT GGCGGAGGAG 
GAGGGCCTCG TGGAGCGGCG GGAGGAGGCC CAGCGGGCAC AGCAGGCTGT GCCTGGCCCT 
GGGCCCATGA CCCCAGAGTC TGCACCGGAG GAGCTGCTGG CCGTTCAGGT GGAGCTGGAG 
CCGGTTAATG CCCAAGCCAG GAAGGCCTTT TCTCGGCAGC GGGAAAAGAT GGAGCGGAGG 
CGCAAGCCCC ACCTAGACCG CAGAGGCGCC GTCATCCAGA GCGTCCCTGG CTTCTGGGCC 
AATGTTATTG CAAACCACCC CCAGATGTCA GCCCTGATCA CTGACGAAGA TGAAGACATG 
CTGAGCTACA TGGTCAGCCT GGAGGTGGGA GAAGAGAAGC ATCCTGTTCA TCTCTGCAAG 
ATCATGTTGT TCTTTCGGAG TAACCCCTAC TTCCAGAATA AAGTGATTAC CAAGGAATAT 
CTGGTGAACA TCACAGAATA CAGGGCTTCT CATTCCACTC CAATTGAGTG GTATCCGGAT 
TATGAAGTGG AGGCCTATCG CCGCAGACAC CACAACAGCA GCCTTAACTT CTTCAACTGG 
TTCTCTGACC ACAACTTCGC AGGATCTAAC AAGATTGCTG AGATCCTATG TAAGGACCTG 
TGGCGCAATC CCCTGCAATA CTACAAGAGG ATGAAGCCAC CTGAAGAGGG AACAGAGACG 
TCAGGGGACT CCCAGTTGTT GAGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003299.2
CDS	47..973
Translation	MRPEGSLTYRVPERLRQGFCGVGRAAQALVCASAKEGTAFRMEAVQEGAAGVESEQAALGEEAVLLLDDIMAEVEVVAEEEGLVERREEAQRAQQAVPGPGPMTPESAPEELLAVQVELEPVNAQARKAFSRQREKMERRRKPHLDRRGAVIQSVPGFWANVIANHPQMSALITDEDEDMLSYMVSLEVGEEKHPVHLCKIMLFFRSNPYFQNKVITKEYLVNITEYRASHSTPIEWYPDYEVEAYRRRHHNSSLNFFNWFSDHNFAGSNKIAEILCKDLWRNPLQYYKRMKPPEEGTETSGDSQLLS

Target ORF information:

RefSeq Version	NM_003308.4
Organism	Homo sapiens(human)
Definition	Homo sapiens testis specific protein Y-linked 1 (TSPY1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003308.4

ORF Insert Sequence:

ATGCGCCCTG AGGGCTCGCT GACCTACCGG GTGCCAGAGA GGCTGCGGCA GGGTTTCTGT 
GGCGTGGGTC GGGCAGCACA GGCCTTGGTG TGTGCGAGTG CCAAGGAGGG CACCGCCTTC 
AGGATGGAGG CTGTGCAGGA GGGGGCGGCC GGGGTGGAGA GTGAGCAGGC GGCTTTGGGG 
GAGGAGGCGG TGCTGCTGTT GGATGACATA ATGGCGGAGG TGGAGGTGGT GGCGGAGGAG 
GAGGGCCTCG TGGAGCGGCG GGAGGAGGCC CAGCGGGCAC AGCAGGCTGT GCCTGGCCCT 
GGGCCCATGA CCCCAGAGTC TGCACCGGAG GAGCTGCTGG CCGTTCAGGT GGAGCTGGAG 
CCGGTTAATG CCCAAGCCAG GAAGGCCTTT TCTCGGCAGC GGGAAAAGAT GGAGCGGAGG 
CGCAAGCCCC ACCTAGACCG CAGAGGCGCC GTCATCCAGA GCGTCCCTGG CTTCTGGGCC 
AATGTTATTG CAAACCACCC CCAGATGTCA GCCCTGATCA CTGACGAAGA TGAAGACATG 
CTGAGCTACA TGGTCAGCCT GGAGGTGGGA GAAGAGAAGC ATCCTGTTCA TCTCTGCAAG 
ATCATGTTGT TCTTTCGGAG TAACCCCTAC TTCCAGAATA AAGTGATTAC CAAGGAATAT 
CTGGTGAACA TCACAGAATA CAGGGCTTCT CATTCCACTC CAATTGAGTG GTATCCGGAT 
TATGAAGTGG AGGCCTATCG CCGCAGACAC CACAACAGCA GCCTTAACTT CTTCAACTGG 
TTCTCTGACC ACAACTTCGC AGGATCTAAC AAGATTGCTG AGATCCTATG TAAGGACCTG 
TGGCGCAATC CCCTGCAATA CTACAAGAGG ATGAAGCCAC CTGAAGAGGG AACAGAGACG 
TCAGGGGACT CCCAGTTGTT GAGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TSPY1 ( NM_003308.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003299.2 Homo sapiens testis specific protein, Y-linked 1 (TSPY1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19138
Clone ID Related Accession (Same CDS sequence)	NM_003308.4 , NM_003308.3
Accession Version	NM_003308.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 927bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	testis-specific Y-encoded protein 1 isoform TSPY-L
Comment

ATGCGCCCTG AGGGCTCGCT GACCTACCGG GTGCCAGAGA GGCTGCGGCA GGGTTTCTGT 
GGCGTGGGTC GGGCAGCACA GGCCTTGGTG TGTGCGAGTG CCAAGGAGGG CACCGCCTTC 
AGGATGGAGG CTGTGCAGGA GGGGGCGGCC GGGGTGGAGA GTGAGCAGGC GGCTTTGGGG 
GAGGAGGCGG TGCTGCTGTT GGATGACATA ATGGCGGAGG TGGAGGTGGT GGCGGAGGAG 
GAGGGCCTCG TGGAGCGGCG GGAGGAGGCC CAGCGGGCAC AGCAGGCTGT GCCTGGCCCT 
GGGCCCATGA CCCCAGAGTC TGCACCGGAG GAGCTGCTGG CCGTTCAGGT GGAGCTGGAG 
CCGGTTAATG CCCAAGCCAG GAAGGCCTTT TCTCGGCAGC GGGAAAAGAT GGAGCGGAGG 
CGCAAGCCCC ACCTAGACCG CAGAGGCGCC GTCATCCAGA GCGTCCCTGG CTTCTGGGCC 
AATGTTATTG CAAACCACCC CCAGATGTCA GCCCTGATCA CTGACGAAGA TGAAGACATG 
CTGAGCTACA TGGTCAGCCT GGAGGTGGGA GAAGAGAAGC ATCCTGTTCA TCTCTGCAAG 
ATCATGTTGT TCTTTCGGAG TAACCCCTAC TTCCAGAATA AAGTGATTAC CAAGGAATAT 
CTGGTGAACA TCACAGAATA CAGGGCTTCT CATTCCACTC CAATTGAGTG GTATCCGGAT 
TATGAAGTGG AGGCCTATCG CCGCAGACAC CACAACAGCA GCCTTAACTT CTTCAACTGG 
TTCTCTGACC ACAACTTCGC AGGATCTAAC AAGATTGCTG AGATCCTATG TAAGGACCTG 
TGGCGCAATC CCCTGCAATA CTACAAGAGG ATGAAGCCAC CTGAAGAGGG AACAGAGACG 
TCAGGGGACT CCCAGTTGTT GAGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003299.2
Translation	MRPEGSLTYRVPERLRQGFCGVGRAAQALVCASAKEGTAFRMEAVQEGAAGVESEQAALGEEAVLLLDDIMAEVEVVAEEEGLVERREEAQRAQQAVPGPGPMTPESAPEELLAVQVELEPVNAQARKAFSRQREKMERRRKPHLDRRGAVIQSVPGFWANVIANHPQMSALITDEDEDMLSYMVSLEVGEEKHPVHLCKIMLFFRSNPYFQNKVITKEYLVNITEYRASHSTPIEWYPDYEVEAYRRRHHNSSLNFFNWFSDHNFAGSNKIAEILCKDLWRNPLQYYKRMKPPEEGTETSGDSQLLS

Target ORF information:

RefSeq Version	NM_003308.3
Organism	Homo sapiens(Human)
Definition	Homo sapiens testis specific protein, Y-linked 1 (TSPY1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003308.3

ORF Insert Sequence:

ATGCGCCCTG AGGGCTCGCT GACCTACCGG GTGCCAGAGA GGCTGCGGCA GGGTTTCTGT 
GGCGTGGGTC GGGCAGCACA GGCCTTGGTG TGTGCGAGTG CCAAGGAGGG CACCGCCTTC 
AGGATGGAGG CTGTGCAGGA GGGGGCGGCC GGGGTGGAGA GTGAGCAGGC GGCTTTGGGG 
GAGGAGGCGG TGCTGCTGTT GGATGACATA ATGGCGGAGG TGGAGGTGGT GGCGGAGGAG 
GAGGGCCTCG TGGAGCGGCG GGAGGAGGCC CAGCGGGCAC AGCAGGCTGT GCCTGGCCCT 
GGGCCCATGA CCCCAGAGTC TGCACCGGAG GAGCTGCTGG CCGTTCAGGT GGAGCTGGAG 
CCGGTTAATG CCCAAGCCAG GAAGGCCTTT TCTCGGCAGC GGGAAAAGAT GGAGCGGAGG 
CGCAAGCCCC ACCTAGACCG CAGAGGCGCC GTCATCCAGA GCGTCCCTGG CTTCTGGGCC 
AATGTTATTG CAAACCACCC CCAGATGTCA GCCCTGATCA CTGACGAAGA TGAAGACATG 
CTGAGCTACA TGGTCAGCCT GGAGGTGGGA GAAGAGAAGC ATCCTGTTCA TCTCTGCAAG 
ATCATGTTGT TCTTTCGGAG TAACCCCTAC TTCCAGAATA AAGTGATTAC CAAGGAATAT 
CTGGTGAACA TCACAGAATA CAGGGCTTCT CATTCCACTC CAATTGAGTG GTATCCGGAT 
TATGAAGTGG AGGCCTATCG CCGCAGACAC CACAACAGCA GCCTTAACTT CTTCAACTGG 
TTCTCTGACC ACAACTTCGC AGGATCTAAC AAGATTGCTG AGATCCTATG TAAGGACCTG 
TGGCGCAATC CCCTGCAATA CTACAAGAGG ATGAAGCCAC CTGAAGAGGG AACAGAGACG 
TCAGGGGACT CCCAGTTGTT GAGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TSPY1 ( NM_001320964.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001307893.1 Homo sapiens testis specific protein Y-linked 1 (TSPY1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu101221
Clone ID Related Accession (Same CDS sequence)	NM_001320964.1
Accession Version	NM_001320964.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 666bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-07
Organism	Homo sapiens(human)
Product	testis-specific Y-encoded protein 1 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC121113.1 and AI002165.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC121113.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGCCCTG AGGGCTCGCT GACCTACCGG GTGCCAGAGA GGCTGCGGCA GGGTTTCTGT 
GGCGTGGGTC GGGCAGCACA GGCCTTGGTG GAGCTGGAGC CGGTTAATGC CCAAGCCAGG 
AAGGCCTTTT CTCGGCAGCG GGAAAAGATG GAGCGGAGGC GCAAGCCCCA CCTAGACCGC 
AGAGGCGCCG TCATCCAGAG CGTCCCTGGC TTCTGGGCCA ATGTTATTGC AAACCACCCC 
CAGATGTCAG CCCTGATCAC TGACGAAGAT GAAGACATGC TGAGCTACAT GGTCAGCCTG 
GAGGTGGGAG AAGAGAAGCA TCCTGTTCAT CTCTGCAAGA TCATGTTGTT CTTTCGGAGT 
AACCCCTACT TCCAGAATAA AGTGATTACC AAGGAATATC TGGTGAACAT CACAGAATAC 
AGGGCTTCTC ATTCCACTCC AATTGAGTGG TATCCGGATT ATGAAGTGGA GGCCTATCGC 
CGCAGACACC ACAACAGCAG CCTTAACTTC TTCAACTGGT TCTCTGACCA CAACTTCGCA 
GGATCTAACA AGATTGCTGA GATCCTATGT AAGGACCTGT GGCGCAATCC CCTGCAATAC 
TACAAGAGGA TGAAGCCACC TGAAGAGGGA ACAGAGACGT CAGGGGACTC CCAGTTGTTG 
AGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001307893.1
CDS	47..712
Translation	MRPEGSLTYRVPERLRQGFCGVGRAAQALVELEPVNAQARKAFSRQREKMERRRKPHLDRRGAVIQSVPGFWANVIANHPQMSALITDEDEDMLSYMVSLEVGEEKHPVHLCKIMLFFRSNPYFQNKVITKEYLVNITEYRASHSTPIEWYPDYEVEAYRRRHHNSSLNFFNWFSDHNFAGSNKIAEILCKDLWRNPLQYYKRMKPPEEGTETSGDSQLLS

Target ORF information:

RefSeq Version	NM_001320964.1
Organism	Homo sapiens(human)
Definition	Homo sapiens testis specific protein Y-linked 1 (TSPY1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001320964.1

ORF Insert Sequence:

ATGCGCCCTG AGGGCTCGCT GACCTACCGG GTGCCAGAGA GGCTGCGGCA GGGTTTCTGT 
GGCGTGGGTC GGGCAGCACA GGCCTTGGTG GAGCTGGAGC CGGTTAATGC CCAAGCCAGG 
AAGGCCTTTT CTCGGCAGCG GGAAAAGATG GAGCGGAGGC GCAAGCCCCA CCTAGACCGC 
AGAGGCGCCG TCATCCAGAG CGTCCCTGGC TTCTGGGCCA ATGTTATTGC AAACCACCCC 
CAGATGTCAG CCCTGATCAC TGACGAAGAT GAAGACATGC TGAGCTACAT GGTCAGCCTG 
GAGGTGGGAG AAGAGAAGCA TCCTGTTCAT CTCTGCAAGA TCATGTTGTT CTTTCGGAGT 
AACCCCTACT TCCAGAATAA AGTGATTACC AAGGAATATC TGGTGAACAT CACAGAATAC 
AGGGCTTCTC ATTCCACTCC AATTGAGTGG TATCCGGATT ATGAAGTGGA GGCCTATCGC 
CGCAGACACC ACAACAGCAG CCTTAACTTC TTCAACTGGT TCTCTGACCA CAACTTCGCA 
GGATCTAACA AGATTGCTGA GATCCTATGT AAGGACCTGT GGCGCAATCC CCTGCAATAC 
TACAAGAGGA TGAAGCCACC TGAAGAGGGA ACAGAGACGT CAGGGGACTC CCAGTTGTTG 
AGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TSPY1 ( NM_001197242.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001184171.1 Homo sapiens testis specific protein Y-linked 1 (TSPY1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu20522
Clone ID Related Accession (Same CDS sequence)	NM_001197242.2
Accession Version	NM_001197242.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 885bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-07
Organism	Homo sapiens(human)
Product	testis-specific Y-encoded protein 1 isoform TSPY-L
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC006156.5. On Mar 10, 2016 this sequence version replaced NM_001197242.1. Transcript Variant: This variant (2) uses an alternate splice compared to variant 1, which results in a frameshift. The resulting isoform (TSPY-L) has a shorter and distinct C-terminus compared to isoform TSPY1-S. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGCCCTG AGGGCTCGCT GACCTACCGG GTGCCAGAGA GGCTGCGGCA GGGTTTCTGT 
GGCGTGGGTC GGGCAGCACA GGCCTTGGTG TGTGCGAGTG CCAAGGAGGG CACCGCCTTC 
AGGATGGAGG CTGTGCAGGA GGGGGCGGCC GGGGTGGAGA GTGAGCAGGC GGCTTTGGGG 
GAGGAGGCGG TGCTGCTGTT GGATGACATA ATGGCGGAGG TGGAGGTGGT GGCGGAGGAG 
GAGGGCCTCG TGGAGCGGCG GGAGGAGGCC CAGCGGGCAC AGCAGGCTGT GCCTGGCCCT 
GGGCCCATGA CCCCAGAGTC TGCACCGGAG GAGCTGCTGG CCGTTCAGGT GGAGCTGGAG 
CCGGTTAATG CCCAAGCCAG GAAGGCCTTT TCTCGGCAGC GGGAAAAGAT GGAGCGGAGG 
CGCAAGCCCC ACCTAGACCG CAGAGGCGCC GTCATCCAGA GCGTCCCTGG CTTCTGGGCC 
AATGTTATTG CAAACCACCC CCAGATGTCA GCCCTGATCA CTGACGAAGA TGAAGACATG 
CTGAGCTACA TGGTCAGCCT GGAGGTGGGA GAAGAGAAGC ATCCTGTTCA TCTCTGCAAG 
ATCATGTTGT TCTTTCGGAG TAACCCCTAC TTCCAGAATA AAGTGATTAC CAAGGAATAT 
CTGGTGAACA TCACAGAATA CAGGGCTTCT CATTCCACTC CAATTGAGTG GTATCCGGAT 
TATGAAGTGG AGGCCTATCG CCGCAGACAC CACAACAGCA GCCTTAACTT CTTCAACTGG 
TTCTCTGACC ACAACTTCGC AGGATCTAAC AAGATTGCTG AGTCCCCTGA CAGATCCTAT 
GTAAGGACCT GTGGCGCAAT CCCCTGCAAT ACTACAAGAG GATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001184171.1
CDS	47..931
Translation	MRPEGSLTYRVPERLRQGFCGVGRAAQALVCASAKEGTAFRMEAVQEGAAGVESEQAALGEEAVLLLDDIMAEVEVVAEEEGLVERREEAQRAQQAVPGPGPMTPESAPEELLAVQVELEPVNAQARKAFSRQREKMERRRKPHLDRRGAVIQSVPGFWANVIANHPQMSALITDEDEDMLSYMVSLEVGEEKHPVHLCKIMLFFRSNPYFQNKVITKEYLVNITEYRASHSTPIEWYPDYEVEAYRRRHHNSSLNFFNWFSDHNFAGSNKIAESPDRSYVRTCGAIPCNTTRG

Target ORF information:

RefSeq Version	NM_001197242.2
Organism	Homo sapiens(human)
Definition	Homo sapiens testis specific protein Y-linked 1 (TSPY1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001197242.2

ORF Insert Sequence:

ATGCGCCCTG AGGGCTCGCT GACCTACCGG GTGCCAGAGA GGCTGCGGCA GGGTTTCTGT 
GGCGTGGGTC GGGCAGCACA GGCCTTGGTG TGTGCGAGTG CCAAGGAGGG CACCGCCTTC 
AGGATGGAGG CTGTGCAGGA GGGGGCGGCC GGGGTGGAGA GTGAGCAGGC GGCTTTGGGG 
GAGGAGGCGG TGCTGCTGTT GGATGACATA ATGGCGGAGG TGGAGGTGGT GGCGGAGGAG 
GAGGGCCTCG TGGAGCGGCG GGAGGAGGCC CAGCGGGCAC AGCAGGCTGT GCCTGGCCCT 
GGGCCCATGA CCCCAGAGTC TGCACCGGAG GAGCTGCTGG CCGTTCAGGT GGAGCTGGAG 
CCGGTTAATG CCCAAGCCAG GAAGGCCTTT TCTCGGCAGC GGGAAAAGAT GGAGCGGAGG 
CGCAAGCCCC ACCTAGACCG CAGAGGCGCC GTCATCCAGA GCGTCCCTGG CTTCTGGGCC 
AATGTTATTG CAAACCACCC CCAGATGTCA GCCCTGATCA CTGACGAAGA TGAAGACATG 
CTGAGCTACA TGGTCAGCCT GGAGGTGGGA GAAGAGAAGC ATCCTGTTCA TCTCTGCAAG 
ATCATGTTGT TCTTTCGGAG TAACCCCTAC TTCCAGAATA AAGTGATTAC CAAGGAATAT 
CTGGTGAACA TCACAGAATA CAGGGCTTCT CATTCCACTC CAATTGAGTG GTATCCGGAT 
TATGAAGTGG AGGCCTATCG CCGCAGACAC CACAACAGCA GCCTTAACTT CTTCAACTGG 
TTCTCTGACC ACAACTTCGC AGGATCTAAC AAGATTGCTG AGTCCCCTGA CAGATCCTAT 
GTAAGGACCT GTGGCGCAAT CCCCTGCAAT ACTACAAGAG GATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TSPY1 ( XM_017030064.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016885553.1 Homo sapiens testis specific protein Y-linked 1 (TSPY1), transcript variant X1, mRNA.

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CloneID	OHu99581
Clone ID Related Accession (Same CDS sequence)	XM_017030064.1
Accession Version	XM_017030064.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 867bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	testis-specific Y-encoded protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000024.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCGCCCTG AGGGCTCGCT GACCTACCGG GTGCCAGAGA GGCTGCGGCA GGGTTTCTGT 
GGCGTGGGTC GGGCAGCACA GGCCTTGGTG TGTGCGAGTG CCAAGGAGGG CACCGCCTTC 
AGGATGGAGG CTGTGCAGGA GGGGGCGGCC GGGGTGGAGA GTGAGCAGGC GGCTTTGGGG 
GAGGAGGCGG TGCTGCTGTT GGATGACATA ATGGCGGAGG TGGAGGTGGT GGCGGAGGAG 
GAGGGCCTCG TGGAGCGGCG GGAGGAGGCC CAGCGGGCAC AGCAGGCTGT GCCTGGCCCT 
GGGCCCATGA CCCCAGAGTC TGCACCGGAG GAGCTGCTGG CCGTTCAGGT GGAGCTGGAG 
CCGGTTAATG CCCAAGCCAG GAAGGCCTTT TCTCGGCAGC GGGAAAAGAT GGAGCGGAGG 
CGCAAGCCCC ACCTAGACCG CAGAGGCGCC GTCATCCAGA GCGTCCCTGG CTTCTGGGCC 
AATGTTATTG CAAACCACCC CCAGATGTCA GCCCTGATCA CTGACGAAGA TGAAGACATG 
CTGAGCTACA TGGTCAGCCT GGAGGTGGGA GAAGAGAAGC ATCCTGTTCA TCTCTGCAAG 
ATCATGTTGT TCTTTCGGAG TAACCCCTAC TTCCAGAATA AAGTGATTAC CAAGGAATAT 
CTGGTGAACA TCACAGGGCT TCTCATTCCA CTCCAATTGA GTGGTATCCG GATTATGAAG 
TGGAGGCCTA TCGCCGCAGA CACCACAACA GCAGCCTTAA CTTCTTCAAC TGGTTCTCTG 
ACCACAACTT CGCAGGATCT AACAAGATTG CTGAGATCCT ATGTAAGGAC CTGTGGCGCA 
ATCCCCTGCA ATACTACAAG AGGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016885553.1
CDS	22..888
Translation	MRPEGSLTYRVPERLRQGFCGVGRAAQALVCASAKEGTAFRMEAVQEGAAGVESEQAALGEEAVLLLDDIMAEVEVVAEEEGLVERREEAQRAQQAVPGPGPMTPESAPEELLAVQVELEPVNAQARKAFSRQREKMERRRKPHLDRRGAVIQSVPGFWANVIANHPQMSALITDEDEDMLSYMVSLEVGEEKHPVHLCKIMLFFRSNPYFQNKVITKEYLVNITGLLIPLQLSGIRIMKWRPIAADTTTAALTSSTGSLTTTSQDLTRLLRSYVRTCGAIPCNTTRG

Target ORF information:

RefSeq Version	XM_017030064.1
Organism	Homo sapiens(human)
Definition	Homo sapiens testis specific protein Y-linked 1 (TSPY1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017030064.1

ORF Insert Sequence:

ATGCGCCCTG AGGGCTCGCT GACCTACCGG GTGCCAGAGA GGCTGCGGCA GGGTTTCTGT 
GGCGTGGGTC GGGCAGCACA GGCCTTGGTG TGTGCGAGTG CCAAGGAGGG CACCGCCTTC 
AGGATGGAGG CTGTGCAGGA GGGGGCGGCC GGGGTGGAGA GTGAGCAGGC GGCTTTGGGG 
GAGGAGGCGG TGCTGCTGTT GGATGACATA ATGGCGGAGG TGGAGGTGGT GGCGGAGGAG 
GAGGGCCTCG TGGAGCGGCG GGAGGAGGCC CAGCGGGCAC AGCAGGCTGT GCCTGGCCCT 
GGGCCCATGA CCCCAGAGTC TGCACCGGAG GAGCTGCTGG CCGTTCAGGT GGAGCTGGAG 
CCGGTTAATG CCCAAGCCAG GAAGGCCTTT TCTCGGCAGC GGGAAAAGAT GGAGCGGAGG 
CGCAAGCCCC ACCTAGACCG CAGAGGCGCC GTCATCCAGA GCGTCCCTGG CTTCTGGGCC 
AATGTTATTG CAAACCACCC CCAGATGTCA GCCCTGATCA CTGACGAAGA TGAAGACATG 
CTGAGCTACA TGGTCAGCCT GGAGGTGGGA GAAGAGAAGC ATCCTGTTCA TCTCTGCAAG 
ATCATGTTGT TCTTTCGGAG TAACCCCTAC TTCCAGAATA AAGTGATTAC CAAGGAATAT 
CTGGTGAACA TCACAGGGCT TCTCATTCCA CTCCAATTGA GTGGTATCCG GATTATGAAG 
TGGAGGCCTA TCGCCGCAGA CACCACAACA GCAGCCTTAA CTTCTTCAAC TGGTTCTCTG 
ACCACAACTT CGCAGGATCT AACAAGATTG CTGAGATCCT ATGTAAGGAC CTGTGGCGCA 
ATCCCCTGCA ATACTACAAG AGGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Spermatogenic phenotype of testis-specific protein, Y-encoded, 1 (TSPY1) dosage deficiency is independent of variations in TSPY-like 1 (TSPYL1) and TSPY-like 5 (TSPYL5): a case-control study in a Han Chinese population.
Reproduction, fertility, and development(2017 Aug)
Yang X,Leng X,Tu W,Liu Y,Xu J,Pei X,Ma Y,Yang D,Yang Y

The Y-located proto-oncogene TSPY exacerbates and its X-homologue TSPX inhibits transactivation functions of androgen receptor and its constitutively active variants.
Human molecular genetics26(5)901-912(2017 03)
Li Y,Zhang DJ,Qiu Y,Kido T,Lau YC

Noninvasive Diagnosis of Fetal Gender: Utility of Combining DYS14 and SRY.
Genetic testing and molecular biomarkers19(9)505-11(2015 Sep)
Jacob RR,Saxena R,Verma IC

The potential contributions of a Y-located protooncogene and its X homologue in sexual dimorphisms in hepatocellular carcinoma.
Human pathology45(9)1847-58(2014 Sep)
Kido T,Lo RC,Li Y,Lee J,Tabatabai ZL,Ng IO,Lau YF

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TSPY1 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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