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FA2H cDNA ORF clone, Homo sapiens(Human)

Gene Symbol FA2H
Entrez Gene ID 79152
Full Name fatty acid 2-hydroxylase
Synonyms FAAH,FAH1,FAXDC1,SCS7,SPG35
General protein information
Preferred Names

fatty acid 2-hydroxylase

Names

fatty acid 2-hydroxylase
fatty acid alpha-hydroxylase
fatty acid hydroxylase domain containing 1
spastic paraplegia 35 (autosomal recessive)

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

16

16q23.1

Summary This gene encodes a protein that catalyzes the synthesis of 2-hydroxysphingolipids, a subset of sphingolipids that contain 2-hydroxy fatty acids. Sphingolipids play roles in many cellular processes and their structural diversity arises from modification of the hydrophobic ceramide moiety, such as by 2-hydroxylation of the N-acyl chain, and the existence of many different head groups. Mutations in this gene have been associated with leukodystrophy dysmyelinating with spastic paraparesis with or without dystonia.[provided by RefSeq, Mar 2010].
Disorder MIM:

611026

Disorder Html: Leukodystrophy, dysmyelinating, and spastic paraparesis with or

mRNA and Protein(s)

mRNA Protein Name
XM_011523319.2 XP_011521621.1 fatty acid 2-hydroxylase isoform X2
NM_024306.4 NP_077282.3 fatty acid 2-hydroxylase
XM_011523317.2 XP_011521619.1 fatty acid 2-hydroxylase isoform X1



Macaca mulatta (rhesus monkey) FA2H XP_001108607.1
Pan troglodytes (chimpanzee) FA2H XP_511106.3
Mus musculus (house mouse) Fa2h NP_835187.2
Neurospora crassa NCU03492 XP_955879.1
Saccharomyces cerevisiae (baker's yeast) SCS7 NP_013999.1
Kluyveromyces lactis KLLA0D01639g XP_453142.1
Arabidopsis thaliana (thale cress) FAH1 NP_181023.1
Xenopus tropicalis (tropical clawed frog) fa2h NP_001025677.1
Canis lupus familiaris (dog) FA2H XP_853014.1
Bos taurus (cattle) FA2H NP_001179384.1
Oryza sativa (rice) Os03g0780800 NP_001051453.1
Oryza sativa (rice) Os12g0628400 NP_001067329.1
Homo sapiens (human) FA2H NP_077282.3
Rattus norvegicus (Norway rat) Fa2h NP_001129055.1
Eremothecium gossypii AGOS_AAL183W NP_982359.1
Magnaporthe oryzae (rice blast fungus) MGG_03920 XP_003719946.1
Gallus gallus (chicken) FA2H XP_414053.4
Drosophila melanogaster (fruit fly) fa2h NP_610279.3
Caenorhabditis elegans (roundworm) CELE_C25A1.5 NP_492678.1


Related articles in PubMed

Mutations in FA2H in three Arab families with a clinical spectrum of neurodegeneration and hereditary spastic paraparesis.
Zaki MS, Selim L, Mansour L, Mahmoud IG, Fenstermaker AG, Gabriel SB, Gleeson JG
Clinical genetics88(1)95-7(2015 Jul)

Δ(9)-THC modulation of fatty acid 2-hydroxylase (FA2H) gene expression: possible involvement of induced levels of PPARα in MDA-MB-231 breast cancer cells.
Takeda S, Ikeda E, Su S, Harada M, Okazaki H, Yoshioka Y, Nishimura H, Ishii H, Kakizoe K, Taniguchi A, Tokuyasu M, Himeno T, Watanabe K, Omiecinski CJ, Aramaki H
Toxicology32618-24(2014 Dec)

Results of a "GWAS plus:" general cognitive ability is substantially heritable and massively polygenic.
Kirkpatrick RM, McGue M, Iacono WG, Miller MB, Basu S
PloS one9(11)e112390(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Novel mutations in FA2H in Arab patients with a clinical spectrum of neurodegeneration and hereditary spastic paraparesis were identified.
Title: Mutations in FA2H in three Arab families with a clinical spectrum of neurodegeneration and hereditary spastic paraparesis.

Three novel mutations in Chinese patients significantly reduce FA2H enzyme activity leading to hereditary spastic paraplegia.
Title: SPG35 contributes to the second common subtype of AR-HSP in China: frequency analysis and functional characterization of FA2H gene mutations.

Induced levels of PPARalpha may be involved in the Delta(9)-THC up-regulation of FA2H in MDA-MB-231 cells.
Title: Δ(9)-THC modulation of fatty acid 2-hydroxylase (FA2H) gene expression: possible involvement of induced levels of PPARα in MDA-MB-231 breast cancer cells.

One heterozygous deletion within 16q22.3-q23.1 including FA2H was observed in two siblings who share symptoms of autism and severe cognitive impairment, axial T2-FLAIR weighted MRI posterior periventricular white matter lesions.
Title: Heterozygous FA2H mutations in autism spectrum disorders.

Identification of a novel triple heterozygous mutations in FA2H gene (c.968C>A; c.976G>A; c.688G>A) in a Chinese family with Hereditary Spastic Paraplegia Type 35.
Title: A rare family with Hereditary Spastic Paraplegia Type 35 due to novel FA2H mutations: a case report with literature review.

The following FA2H gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FA2H cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu26599
NM_024306.4
Latest version!
Homo sapiens fatty acid 2-hydroxylase (FA2H), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$189.50-$265.30
$379.00
OHu71804 XM_011523319.2
Latest version!
Homo sapiens fatty acid 2-hydroxylase (FA2H), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $139.30
$199.00
OHu71802 XM_011523317.2
Latest version!
Homo sapiens fatty acid 2-hydroxylase (FA2H), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $223.30
$319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu26599
Clone ID Related Accession (Same CDS sequence) NM_024306.4
Accession Version NM_024306.4 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1119bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-10-06
Organism Homo sapiens(Human)
Product fatty acid 2-hydroxylase
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA890369.1, BC017049.1 and AA857184.1. This sequence is a reference standard in the RefSeqGene project. On Mar 27, 2010 this sequence version replaced NM_024306.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK058016.1, BC017049.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

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ATGGCCCCCG CTCCGCCCCC CGCCGCCTCC TTCTCGCCCT CCGAGGTCCA GCGGCGCCTG 
GCGGCCGGCG CGTGCTGGGT CCGCCGCGGG GCCCGCCTCT ACGACCTCTC CAGCTTCGTG
CGGCACCACC CGGGGGGCGA GCAGCTGCTG CGGGCCAGGG CGGGCCAGGA CATCAGCGCC
GACCTGGACG GGCCGCCGCA CAGGCACTCG GCCAACGCGC GCCGCTGGCT GGAGCAGTAC
TACGTGGGAG AGCTCCGCGG GGAGCAGCAG GGCTCCATGG AGAACGAGCC TGTAGCCCTT
GAGGAAACTC AGAAGACAGA TCCTGCTATG GAACCACGGT TCAAAGTGGT GGATTGGGAC
AAGGACCTGG TGGACTGGCG AAAGCCTCTC CTGTGGCAGG TGGGCCACTT GGGAGAGAAG
TACGATGAGT GGGTTCACCA GCCGGTGACC AGGCCCATCC GCCTCTTCCA CTCAGACCTC
ATTGAGGGCC TCTCTAAGAC TGTCTGGTAC AGTGTCCCCA TCATCTGGGT GCCCCTGGTG
CTGTATCTCA GCTGGTCCTA CTACCGAACC TTTGCCCAGG GCAACGTCCG ACTCTTCACG
TCATTTACAA CAGAGTACAC GGTGGCAGTG CCCAAGTCCA TGTTCCCCGG GCTCTTCATG
CTGGGGACAT TCCTCTGGAG CCTCATCGAG TACCTCATCC ACCGCTTCCT GTTCCACATG
AAGCCCCCCA GCGACAGCTA TTACCTCATC ATGCTGCACT TCGTCATGCA CGGCCAGCAC
CACAAGGCAC CCTTCGACGG CTCCCGCCTG GTCTTCCCCC CTGTGCCAGC CTCCCTGGTG
ATCGGCGTCT TCTACTTGTG CATGCAGCTC ATCCTGCCCG AGGCAGTAGG GGGCACTGTG
TTTGCGGGGG GCCTCCTGGG CTACGTCCTC TATGACATGA CCCATTACTA CCTGCACTTT
GGCTCGCCGC ACAAGGGCTC CTACCTGTAC AGCCTGAAGG CCCACCACGT CAAGCACCAC
TTTGCACATC AGAAGTCAGG ATTTGGTATC AGCACTAAAT TGTGGGATTA CTGTTTCCAC
ACCCTCACTC CAGAGAAACC CCACCTGAAG ACGCAGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_077282.3
CDS77..1195
Misc Feature(1)11..13
Misc Feature(2)119..331
Misc Feature(3)446..1174
Misc Feature(4)578..640
Misc Feature(5)<704..1177
Misc Feature(6)713..775
Misc Feature(7)878..940
Misc Feature(8)944..1006
Exon (1)1..346
Exon (2)347..439
Exon (3)440..582
Exon (4)583..689
Exon (5)690..862
Exon (6)863..1115
Exon (7)1116..2430
Translation

Target ORF information:

RefSeq Version NM_024306.4
Organism Homo sapiens(Human)
Definition Homo sapiens fatty acid 2-hydroxylase (FA2H), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_024306.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGGCCCCCG CTCCGCCCCC CGCCGCCTCC TTCTCGCCCT CCGAGGTCCA GCGGCGCCTG 
GCGGCCGGCG CGTGCTGGGT CCGCCGCGGG GCCCGCCTCT ACGACCTCTC CAGCTTCGTG
CGGCACCACC CGGGGGGCGA GCAGCTGCTG CGGGCCAGGG CGGGCCAGGA CATCAGCGCC
GACCTGGACG GGCCGCCGCA CAGGCACTCG GCCAACGCGC GCCGCTGGCT GGAGCAGTAC
TACGTGGGAG AGCTCCGCGG GGAGCAGCAG GGCTCCATGG AGAACGAGCC TGTAGCCCTT
GAGGAAACTC AGAAGACAGA TCCTGCTATG GAACCACGGT TCAAAGTGGT GGATTGGGAC
AAGGACCTGG TGGACTGGCG AAAGCCTCTC CTGTGGCAGG TGGGCCACTT GGGAGAGAAG
TACGATGAGT GGGTTCACCA GCCGGTGACC AGGCCCATCC GCCTCTTCCA CTCAGACCTC
ATTGAGGGCC TCTCTAAGAC TGTCTGGTAC AGTGTCCCCA TCATCTGGGT GCCCCTGGTG
CTGTATCTCA GCTGGTCCTA CTACCGAACC TTTGCCCAGG GCAACGTCCG ACTCTTCACG
TCATTTACAA CAGAGTACAC GGTGGCAGTG CCCAAGTCCA TGTTCCCCGG GCTCTTCATG
CTGGGGACAT TCCTCTGGAG CCTCATCGAG TACCTCATCC ACCGCTTCCT GTTCCACATG
AAGCCCCCCA GCGACAGCTA TTACCTCATC ATGCTGCACT TCGTCATGCA CGGCCAGCAC
CACAAGGCAC CCTTCGACGG CTCCCGCCTG GTCTTCCCCC CTGTGCCAGC CTCCCTGGTG
ATCGGCGTCT TCTACTTGTG CATGCAGCTC ATCCTGCCCG AGGCAGTAGG GGGCACTGTG
TTTGCGGGGG GCCTCCTGGG CTACGTCCTC TATGACATGA CCCATTACTA CCTGCACTTT
GGCTCGCCGC ACAAGGGCTC CTACCTGTAC AGCCTGAAGG CCCACCACGT CAAGCACCAC
TTTGCACATC AGAAGTCAGG ATTTGGTATC AGCACTAAAT TGTGGGATTA CTGTTTCCAC
ACCCTCACTC CAGAGAAACC CCACCTGAAG ACGCAGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu71804
Clone ID Related Accession (Same CDS sequence) XM_011523319.2
Accession Version XM_011523319.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 879bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product fatty acid 2-hydroxylase isoform X2
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000016.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011523319.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

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ATGGATGGTG TTCGCCTGTG GAATTCAAGG GGCTCCATGG AGAACGAGCC TGTAGCCCTT 
GAGGAAACTC AGAAGACAGA TCCTGCTATG GAACCACGGT TCAAAGTGGT GGATTGGGAC
AAGGACCTGG TGGACTGGCG AAAGCCTCTC CTGTGGCAGG TGGGCCACTT GGGAGAGAAG
TACGATGAGT GGGTTCACCA GCCGGTGACC AGGCCCATCC GCCTCTTCCA CTCAGACCTC
ATTGAGGGCC TCTCTAAGAC TGTCTGGTAC AGTGTCCCCA TCATCTGGGT GCCCCTGGTG
CTGTATCTCA GCTGGTCCTA CTACCGAACC TTTGCCCAGG GCAACGTCCG ACTCTTCACG
TCATTTACAA CAGAGTACAC GGTGGCAGTG CCCAAGTCCA TGTTCCCCGG GCTCTTCATG
CTGGGGACAT TCCTCTGGAG CCTCATCGAG TACCTCATCC ACCGCTTCCT GTTCCACATG
AAGCCCCCCA GCGACAGCTA TTACCTCATC ATGCTGCACT TCGTCATGCA CGGCCAGCAC
CACAAGGCAC CCTTCGACGG CTCCCGCCTG GTCTTCCCCC CTGTGCCAGC CTCCCTGGTG
ATCGGCGTCT TCTACTTGTG CATGCAGCTC ATCCTGCCCG AGGCAGTAGG GGGCACTGTG
TTTGCGGGGG GCCTCCTGGG CTACGTCCTC TATGACATGA CCCATTACTA CCTGCACTTT
GGCTCGCCGC ACAAGGGCTC CTACCTGTAC AGCCTGAAGG CCCACCACGT CAAGCACCAC
TTTGCACATC AGAAGTCAGG ATTTGGTATC AGCACTAAAT TGTGGGATTA CTGTTTCCAC
ACCCTCACTC CAGAGAAACC CCACCTGAAG ACGCAGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011521621.1
CDS16..894
Misc Feature(1)145..873
Misc Feature(2)<403..876
Translation

Target ORF information:

RefSeq Version XM_011523319.2
Organism Homo sapiens(Human)
Definition Homo sapiens fatty acid 2-hydroxylase (FA2H), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011523319.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGGATGGTG TTCGCCTGTG GAATTCAAGG GGCTCCATGG AGAACGAGCC TGTAGCCCTT 
GAGGAAACTC AGAAGACAGA TCCTGCTATG GAACCACGGT TCAAAGTGGT GGATTGGGAC
AAGGACCTGG TGGACTGGCG AAAGCCTCTC CTGTGGCAGG TGGGCCACTT GGGAGAGAAG
TACGATGAGT GGGTTCACCA GCCGGTGACC AGGCCCATCC GCCTCTTCCA CTCAGACCTC
ATTGAGGGCC TCTCTAAGAC TGTCTGGTAC AGTGTCCCCA TCATCTGGGT GCCCCTGGTG
CTGTATCTCA GCTGGTCCTA CTACCGAACC TTTGCCCAGG GCAACGTCCG ACTCTTCACG
TCATTTACAA CAGAGTACAC GGTGGCAGTG CCCAAGTCCA TGTTCCCCGG GCTCTTCATG
CTGGGGACAT TCCTCTGGAG CCTCATCGAG TACCTCATCC ACCGCTTCCT GTTCCACATG
AAGCCCCCCA GCGACAGCTA TTACCTCATC ATGCTGCACT TCGTCATGCA CGGCCAGCAC
CACAAGGCAC CCTTCGACGG CTCCCGCCTG GTCTTCCCCC CTGTGCCAGC CTCCCTGGTG
ATCGGCGTCT TCTACTTGTG CATGCAGCTC ATCCTGCCCG AGGCAGTAGG GGGCACTGTG
TTTGCGGGGG GCCTCCTGGG CTACGTCCTC TATGACATGA CCCATTACTA CCTGCACTTT
GGCTCGCCGC ACAAGGGCTC CTACCTGTAC AGCCTGAAGG CCCACCACGT CAAGCACCAC
TTTGCACATC AGAAGTCAGG ATTTGGTATC AGCACTAAAT TGTGGGATTA CTGTTTCCAC
ACCCTCACTC CAGAGAAACC CCACCTGAAG ACGCAGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu71802
Clone ID Related Accession (Same CDS sequence) XM_011523317.2
Accession Version XM_011523317.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1110bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product fatty acid 2-hydroxylase isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000016.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011523317.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGGCCCCCG CTCCGCCCCC CGCCGCCTCC TTCTCGCCCT CCGAGGTCCA GCGGCGCCTG 
GCGGCCGGCG CGTGCTGGGT CCGCCGCGGG GCCCGCCTCT ACGACCTCTC CAGCTTCGTG
CGGCACCACC CGGGGGGCGA GCAGCTGCTG CGGGCCAGGG CGGGCCAGGA CATCAGCGCC
GACCTGGACG GGCCGCCGCA CAGGCACTCG GCCAACGCGC GCCGCTGGCT GGAGCAGTAC
TACGTGGGAG AGCTCCGCGG GGAGCAGCAG GGCTCCATGG AGAACGAGCC TGTAGCCCTT
GAGGAAACTC AGAAGACAGA TCCTGCTATG GAACCACGGT TCAAAGTGGT GGATTGGGAC
AAGGACCTGG TGGACTGGCG AAAGCCTCTC CTGTGGCAGG TGGGCCACTT GGGAGAGAAG
TACGATGAGT GGGTTCACCA GCCGGTGACC AGGCCCATCC GCCTCTTCCA CTCAGACCTC
ATTGAGGGCC TCTCTAAGAC TGTCTGGTAC AGTGTCCCCA TCATCTGGGT GCCCCTGGTG
CTGTATCTCA GCTGGTCCTA CTACCGAACC TTTGCCCAGG GCAACGTCCG ACTCTTCACG
TCATTTACAA CAGAGTACAC GGTGGCAGTG CCCAAGTCCA TGTTCCCCGG GCTCTTCATG
CTGGGGACAT TCCTCTGGAG CCTCATCGAG TACCTCATCC ACCGCTTCCT GTTCCACATG
AAGCCCCCCA GCGACAGCTA TTACCTCATC ATGCTGCACT TCGTCATGCA CGGCCAGCAC
CACAAGAGCA GGAGACTGAG GCCTAGGAGG ACTAAGGAAC TTGCCCCAGG TCACACTTGG
CACAGCCAGG ATGTCGTACC CCATTCTGGG GATTCCAGAG TCTGCGCTCT CAATCACCCT
TCCCCTGAGG CCCTTCAAGG ACTCCACGAC AGTCCCAGAA GCTGGCCCGA GAAGATAGGT
CTGCCCAAAG GAAGCTACCT CCCCTGTACC CCCCGCTGCT TCTCTGTCCC TGCATTGTGC
TGTCCTTGGC CCATCCCAGG CTGTTCCCCA GCCCGTCTCC ACACTCTGTT CTCTGCTGGG
CATAAATCAG AGAAAATATG GCAGATATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011521619.1
CDS69..1178
Misc Feature(1)111..323
Misc Feature(2)438..>857
Translation

Target ORF information:

RefSeq Version XM_011523317.2
Organism Homo sapiens(Human)
Definition Homo sapiens fatty acid 2-hydroxylase (FA2H), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011523317.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGGCCCCCG CTCCGCCCCC CGCCGCCTCC TTCTCGCCCT CCGAGGTCCA GCGGCGCCTG 
GCGGCCGGCG CGTGCTGGGT CCGCCGCGGG GCCCGCCTCT ACGACCTCTC CAGCTTCGTG
CGGCACCACC CGGGGGGCGA GCAGCTGCTG CGGGCCAGGG CGGGCCAGGA CATCAGCGCC
GACCTGGACG GGCCGCCGCA CAGGCACTCG GCCAACGCGC GCCGCTGGCT GGAGCAGTAC
TACGTGGGAG AGCTCCGCGG GGAGCAGCAG GGCTCCATGG AGAACGAGCC TGTAGCCCTT
GAGGAAACTC AGAAGACAGA TCCTGCTATG GAACCACGGT TCAAAGTGGT GGATTGGGAC
AAGGACCTGG TGGACTGGCG AAAGCCTCTC CTGTGGCAGG TGGGCCACTT GGGAGAGAAG
TACGATGAGT GGGTTCACCA GCCGGTGACC AGGCCCATCC GCCTCTTCCA CTCAGACCTC
ATTGAGGGCC TCTCTAAGAC TGTCTGGTAC AGTGTCCCCA TCATCTGGGT GCCCCTGGTG
CTGTATCTCA GCTGGTCCTA CTACCGAACC TTTGCCCAGG GCAACGTCCG ACTCTTCACG
TCATTTACAA CAGAGTACAC GGTGGCAGTG CCCAAGTCCA TGTTCCCCGG GCTCTTCATG
CTGGGGACAT TCCTCTGGAG CCTCATCGAG TACCTCATCC ACCGCTTCCT GTTCCACATG
AAGCCCCCCA GCGACAGCTA TTACCTCATC ATGCTGCACT TCGTCATGCA CGGCCAGCAC
CACAAGAGCA GGAGACTGAG GCCTAGGAGG ACTAAGGAAC TTGCCCCAGG TCACACTTGG
CACAGCCAGG ATGTCGTACC CCATTCTGGG GATTCCAGAG TCTGCGCTCT CAATCACCCT
TCCCCTGAGG CCCTTCAAGG ACTCCACGAC AGTCCCAGAA GCTGGCCCGA GAAGATAGGT
CTGCCCAAAG GAAGCTACCT CCCCTGTACC CCCCGCTGCT TCTCTGTCCC TGCATTGTGC
TGTCCTTGGC CCATCCCAGG CTGTTCCCCA GCCCGTCTCC ACACTCTGTT CTCTGCTGGG
CATAAATCAG AGAAAATATG GCAGATATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Mutations in FA2H in three Arab families with a clinical spectrum of neurodegeneration and hereditary spastic paraparesis.
Clinical genetics88(1)95-7(2015 Jul)
Zaki MS,Selim L,Mansour L,Mahmoud IG,Fenstermaker AG,Gabriel SB,Gleeson JG


book

Δ(9)-THC modulation of fatty acid 2-hydroxylase (FA2H) gene expression: possible involvement of induced levels of PPARα in MDA-MB-231 breast cancer cells.
Toxicology32618-24(2014 Dec)
Takeda S,Ikeda E,Su S,Harada M,Okazaki H,Yoshioka Y,Nishimura H,Ishii H,Kakizoe K,Taniguchi A,Tokuyasu M,Himeno T,Watanabe K,Omiecinski CJ,Aramaki H


book

Results of a "GWAS plus:" general cognitive ability is substantially heritable and massively polygenic.
PloS one9(11)e112390(2014)
Kirkpatrick RM,McGue M,Iacono WG,Miller MB,Basu S


 
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