Gene Symbol | MOB2 |
Entrez Gene ID | 81532 |
Full Name | MOB kinase activator 2 |
Synonyms | HCCA2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » MOB2 cDNA ORF clone
gRNAs
Gene Symbol | MOB2 |
Entrez Gene ID | 81532 |
Full Name | MOB kinase activator 2 |
Synonyms | HCCA2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_001172223.2 | NP_001165694.1 | MOB kinase activator 2 isoform 1 |
NM_053005.5 | NP_443731.2 | MOB kinase activator 2 isoform 2 |
NM_001172223.3 | NP_001165694.1 | MOB kinase activator 2 isoform 1 |
Mus musculus (house mouse) | Mob2 | NP_082584.1 |
Homo sapiens (human) | MOB2 | NP_001165694.1 |
Pan troglodytes (chimpanzee) | MOB2 | XP_001152532.2 |
Canis lupus familiaris (dog) | MOB2 | XP_854258.2 |
Rattus norvegicus (Norway rat) | Mob2 | NP_001102629.1 |
Danio rerio (zebrafish) | mob2b | NP_001038782.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP010841 | XP_309864.4 |
Xenopus tropicalis (tropical clawed frog) | mob2.1 | NP_989013.1 |
Gallus gallus (chicken) | MOB2 | XP_421030.1 |
Danio rerio (zebrafish) | mob2a | NP_001002364.1 |
Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)
Modulation of tumor cell migration, invasion and cell-matrix adhesion by human monopolar spindle-one-binder 2.
Wu W, Zhang X, Qin H, Peng W, Xue Q, Lv H, Zhang H, Qiu Y, Cheng H, Zhang Y, Yu Z, Shen W
Oncology reports33(5)2495-503(2015 May)
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
So J, Pasculescu A, Dai AY, Williton K, James A, Nguyen V, Creixell P, Schoof EM, Sinclair J, Barrios-Rodiles M, Gu J, Krizus A, Williams R, Olhovsky M, Dennis JW, Wrana JL, Linding R, Jorgensen C, Pawson T, Colwill K
Science signaling8(371)rs3(2015 Apr)
Regulation of DNA damage responses and cell cycle progression by hMOB2.
Gomez V, Gundogdu R, Gomez M, Hoa L, Panchal N, O'Driscoll M, Hergovich A
Cellular signalling27(2)326-39(2015 Feb)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The altered cell-matrix adhesion and cell motility induced by hMOB2 expression was caused by the assembly of focal adhesions.
Title: Modulation of tumor cell migration, invasion and cell-matrix adhesion by human monopolar spindle-one-binder 2.
hMOB2 interacts with RAD50, facilitating the recruitment of the MRE11-RAD50-NBS1 (MRN) DNA damage sensor complex and activated ATM to DNA damaged chromatin.
Title: Regulation of DNA damage responses and cell cycle progression by hMOB2.
MOB2 overexpression induces apoptosis and inhibits the growth of human hepatic cancer cells
Title: Growth-inhibitory effects of MOB2 on human hepatic carcinoma cell line SMMC-7721.
Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
Title: Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.
Data indicate that human MOB2 is a negative regulator of human NDR kinases in biochemical and biological settings.
Title: Differential NDR/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR kinases.
The following MOB2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MOB2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu16037 | |
Clone ID Related Accession (Same CDS sequence) | NM_053005.5 | |
Accession Version | NM_053005.5 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 714bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-10 | |
Organism | Homo sapiens(human) | |
Product | MOB kinase activator 2 isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY032250.1, DC413532.1, BC067785.1, BC047291.1, AW874617.1 and BP388313.1. On Apr 15, 2014 this sequence version replaced NM_053005.4. Transcript Variant: This variant (2) represents use of an alternate promoter and differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA2467148 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGACTGGC TCATGGGGAA GTCCAAAGCC AAGCCTAATG GCAAGAAGCC CGCTGCGGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_443731.2 |
CDS | 104..817 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGACTGGC TCATGGGGAA GTCCAAAGCC AAGCCTAATG GCAAGAAGCC CGCTGCGGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu16039 | |
Clone ID Related Accession (Same CDS sequence) | NM_001172223.2 , NM_001172223.3 | |
Accession Version | NM_001172223.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 807bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-02 | |
Organism | Homo sapiens(human) | |
Product | MOB kinase activator 2 isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC091196.6, DC413532.1, AK296658.1, BC047291.1, AW874617.1 and BP388313.1. On Apr 15, 2014 this sequence version replaced NM_001172223.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: ERR279857.515.1, ERR279848.7072.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467148 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCTGGGAG ACCACTGCAG TCTCCCTGAA GACCAAGCCC GGCCCGGCCA GTCCCTGCAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001165694.1 |
CDS | 224..1030 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCTGGGAG ACCACTGCAG TCTCCCTGAA GACCAAGCCC GGCCCGGCCA GTCCCTGCAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu16039 | |
Clone ID Related Accession (Same CDS sequence) | NM_001172223.2 , NM_001172223.3 | |
Accession Version | NM_001172223.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 807bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-09 | |
Organism | Homo sapiens(human) | |
Product | MOB kinase activator 2 isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC091196.6, DC413532.1, AK296658.1, BC047291.1 and AW874617.1. On Nov 23, 2018 this sequence version replaced NM_001172223.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: SRR3476690.852508.1, ERR279857.515.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467148 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000329957.7/ ENSP00000328694.6 RefSeq Select criteria :: based on conservation, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGCTGGGAG ACCACTGCAG TCTCCCTGAA GACCAAGCCC GGCCCGGCCA GTCCCTGCAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001165694.1 |
CDS | 224..1030 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCTGGGAG ACCACTGCAG TCTCCCTGAA GACCAAGCCC GGCCCGGCCA GTCCCTGCAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Architecture of the human interactome defines protein communities and disease networks. |
Modulation of tumor cell migration, invasion and cell-matrix adhesion by human monopolar spindle-one-binder 2. |
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. |
Regulation of DNA damage responses and cell cycle progression by hMOB2. |