MARVELD1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MARVELD1
Entrez Gene ID	83742
Full Name	MARVEL domain containing 1
Synonyms	GB14,MARVD1,MRVLDC1,bA548K23.8
General protein information	Preferred Names MARVEL domain containing 1 Names MARVEL domain-containing protein 1 MARVEL (membrane-associating) domain containing 1 putative MARVEL domain-containing protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q24.2
Disorder MIM:	616970

mRNA and Protein(s)

mRNA	Protein	Name
NM_031484.4	NP_113672.1	MARVEL domain-containing protein 1
NM_031484.3	NP_113672.1	MARVEL domain-containing protein 1

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	MARVELD1	XP_004942445.1
Xenopus tropicalis (tropical clawed frog)	marveld1	XP_002936480.1
Mus musculus (house mouse)	Marveld1	NP_899018.1
Homo sapiens (human)	MARVELD1	NP_113672.1
Danio rerio (zebrafish)	marveld1	NP_001189346.1
Pan troglodytes (chimpanzee)	MARVELD1	XP_529337.2
	MARVELD1	XP_001095041.1
Bos taurus (cattle)	MARVELD1	NP_001094732.1

Gene Ontology
Bibliography

Related articles in PubMed

MARVELD1 modulates cell surface morphology and suppresses epithelial-mesenchymal transition in non-small cell lung cancer.
Yao Y, Shi M, Liu S, Li Y, Guo K, Ci Y, Liu W, Li Y
Molecular carcinogenesis55(11)1714-1727(2016 Nov)

[Importin-?1 plays a key role in the nucleocytoplasmic transportation process of MARVELD1].
Wang ZY, Shi M, Li Y
Molekuliarnaia biologiia49(3)491-7(2015 May-Jun)

Biological and clinical significance of epigenetic silencing of MARVELD1 gene in lung cancer.
Shi M, Wang S, Yao Y, Li Y, Zhang H, Han F, Nie H, Su J, Wang Z, Yue L, Cao J, Li Y
Scientific reports47545(2014 Dec)

MARVELD1 regulates integrin ?1-mediated cell adhesion and actin organization via inhibiting its pre-mRNA processing.
Wang S, Hu J, Yao Y, Shi M, Yue L, Han F, Zhang H, He J, Liu S, Li Y
The international journal of biochemistry & cell biology45(11)2679-87(2013 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study demonstrates that MARVELD1-mediated balance of integrin beta1 and beta4 regulates cell surface ultrastructure and epithelial-mesenchymal transition phenotype of non-small cell lung cancer (NSCLC).
Title: MARVELD1 modulates cell surface morphology and suppresses epithelial-mesenchymal transition in non-small cell lung cancer.

Importin-beta1 mediates the non-classical nucleocytoplasmic transport of MARVELD1.
Title: [Importin-?1 plays a key role in the nucleocytoplasmic transportation process of MARVELD1].

MARVELD1 silencing is an appealing diagnostic biomarker for lung cancer.
Title: Biological and clinical significance of epigenetic silencing of MARVELD1 gene in lung cancer.

MARVELD1 plays a role in pre-mRNA processing of integrin beta1.
Title: MARVELD1 regulates integrin ?1-mediated cell adhesion and actin organization via inhibiting its pre-mRNA processing.

MARVELD1 substantially inhibits nonsense-mediated RNA decay by decreasing the pioneer round of translation but not steady-state translation, and is an important component of the molecular machinery containing UPF1 and Y14. MARVELD1 promotes the dissociation of SMG1 from UPF1, resulting in the repression of serine phosphorylation of UPF1, and subsequently blocks the recruitment of SMG5.
Title: MARVELD1 Inhibits Nonsense-Mediated RNA Decay by Repressing Serine Phosphorylation of UPF1.

The following MARVELD1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MARVELD1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29063	NM_031484.4 Latest version!	Homo sapiens MARVEL domain containing 1 (MARVELD1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	Quote Price
View Old Accession Versions >>
OHu29063	NM_031484.3	Homo sapiens MARVEL domain containing 1 (MARVELD1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	Quote Price
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MARVELD1 ( NM_031484.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_113672.1 Homo sapiens MARVEL domain containing 1 (MARVELD1), mRNA.

Price & Availability↑

CloneID	OHu29063
Clone ID Related Accession (Same CDS sequence)	NM_031484.4 , NM_031484.3
Accession Version	NM_031484.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 522bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-10
Organism	Homo sapiens(human)
Product	MARVEL domain-containing protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC004995.1 and AI347102.1. On Nov 23, 2018 this sequence version replaced NM_031484.3. ##Evidence-Data-START## Transcript exon combination :: BC062544.1, BC004995.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000285605.8/ ENSP00000441365.1 NMD candidate :: PMID: 19364627 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTCCCGC CGCCCCCGCG CCAGCCGCCG CCCCAGGCGC GTGCGGCCCG CGGCGCGGTG 
CGCCTGCAGC GGCCCTTCCT GCGCAGCCCG CTGGGCGTGT TGCGGCTGCT GCAGCTGCTG 
GCCGGCGCTG CCTTCTGGAT CACTATCGCC ACCAGCAAGT ACCAGGGCCC CGTGCACTTC 
GCGCTCTTCG TGTCCGTGCT CTTCTGGCTG CTCACCCTGG GCCTCTACTT CCTCACGCTG 
CTGGGCAAGC ACGAGCTGGT CCCCGTGCTG GGCTCGCGCT GGCTCATGGT CAACGTGGCG 
CACGATGTGC TGGCGGCCGC GCTCTACGGC GCCGCCACCG GCATCATGAG CGACCAGATG 
CAGCGCCACA GCTACTGCAA CCTCAAGGAT TACCCGCTCC CCTGCGCCTA CCACGCCTTC 
CTGGCGGCCG CCGTCTGCGG CGGCGTCTGC CACGGCCTCT ACCTGCTTTC GGCGCTCTAT 
GGCTGCGGGC GTCGCTGCCA GGGCAAGCAG GAGGTGGCGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113672.1
CDS	148..669
Translation	MLPPPPRQPPPQARAARGAVRLQRPFLRSPLGVLRLLQLLAGAAFWITIATSKYQGPVHFALFVSVLFWLLTLGLYFLTLLGKHELVPVLGSRWLMVNVAHDVLAAALYGAATGIMSDQMQRHSYCNLKDYPLPCAYHAFLAAAVCGGVCHGLYLLSALYGCGRRCQGKQEVA

Target ORF information:

RefSeq Version	NM_031484.4
Organism	Homo sapiens(human)
Definition	Homo sapiens MARVEL domain containing 1 (MARVELD1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031484.4

ORF Insert Sequence:

ATGCTCCCGC CGCCCCCGCG CCAGCCGCCG CCCCAGGCGC GTGCGGCCCG CGGCGCGGTG 
CGCCTGCAGC GGCCCTTCCT GCGCAGCCCG CTGGGCGTGT TGCGGCTGCT GCAGCTGCTG 
GCCGGCGCTG CCTTCTGGAT CACTATCGCC ACCAGCAAGT ACCAGGGCCC CGTGCACTTC 
GCGCTCTTCG TGTCCGTGCT CTTCTGGCTG CTCACCCTGG GCCTCTACTT CCTCACGCTG 
CTGGGCAAGC ACGAGCTGGT CCCCGTGCTG GGCTCGCGCT GGCTCATGGT CAACGTGGCG 
CACGATGTGC TGGCGGCCGC GCTCTACGGC GCCGCCACCG GCATCATGAG CGACCAGATG 
CAGCGCCACA GCTACTGCAA CCTCAAGGAT TACCCGCTCC CCTGCGCCTA CCACGCCTTC 
CTGGCGGCCG CCGTCTGCGG CGGCGTCTGC CACGGCCTCT ACCTGCTTTC GGCGCTCTAT 
GGCTGCGGGC GTCGCTGCCA GGGCAAGCAG GAGGTGGCGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MARVELD1 ( NM_031484.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_113672.1 Homo sapiens MARVEL domain containing 1 (MARVELD1), mRNA.

Price & Availability↑

CloneID	OHu29063
Clone ID Related Accession (Same CDS sequence)	NM_031484.4 , NM_031484.3
Accession Version	NM_031484.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 522bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-15
Organism	Homo sapiens(human)
Product	MARVEL domain-containing protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CF125014.1, BC004995.1 and AI347102.1. On or before Jan 5, 2010 this sequence version replaced NR_026753.1, NM_031484.2. ##Evidence-Data-START## Transcript exon combination :: BC062544.1, AK025996.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## NMD candidate :: PMID: 19364627 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTCCCGC CGCCCCCGCG CCAGCCGCCG CCCCAGGCGC GTGCGGCCCG CGGCGCGGTG 
CGCCTGCAGC GGCCCTTCCT GCGCAGCCCG CTGGGCGTGT TGCGGCTGCT GCAGCTGCTG 
GCCGGCGCTG CCTTCTGGAT CACTATCGCC ACCAGCAAGT ACCAGGGCCC CGTGCACTTC 
GCGCTCTTCG TGTCCGTGCT CTTCTGGCTG CTCACCCTGG GCCTCTACTT CCTCACGCTG 
CTGGGCAAGC ACGAGCTGGT CCCCGTGCTG GGCTCGCGCT GGCTCATGGT CAACGTGGCG 
CACGATGTGC TGGCGGCCGC GCTCTACGGC GCCGCCACCG GCATCATGAG CGACCAGATG 
CAGCGCCACA GCTACTGCAA CCTCAAGGAT TACCCGCTCC CCTGCGCCTA CCACGCCTTC 
CTGGCGGCCG CCGTCTGCGG CGGCGTCTGC CACGGCCTCT ACCTGCTTTC GGCGCTCTAT 
GGCTGCGGGC GTCGCTGCCA GGGCAAGCAG GAGGTGGCGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113672.1
CDS	170..691
Translation	MLPPPPRQPPPQARAARGAVRLQRPFLRSPLGVLRLLQLLAGAAFWITIATSKYQGPVHFALFVSVLFWLLTLGLYFLTLLGKHELVPVLGSRWLMVNVAHDVLAAALYGAATGIMSDQMQRHSYCNLKDYPLPCAYHAFLAAAVCGGVCHGLYLLSALYGCGRRCQGKQEVA

Target ORF information:

RefSeq Version	NM_031484.3
Organism	Homo sapiens(human)
Definition	Homo sapiens MARVEL domain containing 1 (MARVELD1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031484.3

ORF Insert Sequence:

ATGCTCCCGC CGCCCCCGCG CCAGCCGCCG CCCCAGGCGC GTGCGGCCCG CGGCGCGGTG 
CGCCTGCAGC GGCCCTTCCT GCGCAGCCCG CTGGGCGTGT TGCGGCTGCT GCAGCTGCTG 
GCCGGCGCTG CCTTCTGGAT CACTATCGCC ACCAGCAAGT ACCAGGGCCC CGTGCACTTC 
GCGCTCTTCG TGTCCGTGCT CTTCTGGCTG CTCACCCTGG GCCTCTACTT CCTCACGCTG 
CTGGGCAAGC ACGAGCTGGT CCCCGTGCTG GGCTCGCGCT GGCTCATGGT CAACGTGGCG 
CACGATGTGC TGGCGGCCGC GCTCTACGGC GCCGCCACCG GCATCATGAG CGACCAGATG 
CAGCGCCACA GCTACTGCAA CCTCAAGGAT TACCCGCTCC CCTGCGCCTA CCACGCCTTC 
CTGGCGGCCG CCGTCTGCGG CGGCGTCTGC CACGGCCTCT ACCTGCTTTC GGCGCTCTAT 
GGCTGCGGGC GTCGCTGCCA GGGCAAGCAG GAGGTGGCGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MARVELD1 modulates cell surface morphology and suppresses epithelial-mesenchymal transition in non-small cell lung cancer.
Molecular carcinogenesis55(11)1714-1727(2016 Nov)
Yao Y,Shi M,Liu S,Li Y,Guo K,Ci Y,Liu W,Li Y

[Importin-?1 plays a key role in the nucleocytoplasmic transportation process of MARVELD1].
Molekuliarnaia biologiia49(3)491-7(2015 May-Jun)
Wang ZY,Shi M,Li Y

Biological and clinical significance of epigenetic silencing of MARVELD1 gene in lung cancer.
Scientific reports47545(2014 Dec)
Shi M,Wang S,Yao Y,Li Y,Zhang H,Han F,Nie H,Su J,Wang Z,Yue L,Cao J,Li Y

MARVELD1 regulates integrin ?1-mediated cell adhesion and actin organization via inhibiting its pre-mRNA processing.
The international journal of biochemistry & cell biology45(11)2679-87(2013 Nov)
Wang S,Hu J,Yao Y,Shi M,Yue L,Han F,Zhang H,He J,Liu S,Li Y

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MARVELD1 cDNA ORF clone, Homo sapiens(human)

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Related articles in PubMed

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

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