Gene Symbol | MARVELD1 |
Entrez Gene ID | 83742 |
Full Name | MARVEL domain containing 1 |
Synonyms | GB14,MARVD1,MRVLDC1,bA548K23.8 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » MARVELD1 cDNA ORF clone
Gene Symbol | MARVELD1 |
Entrez Gene ID | 83742 |
Full Name | MARVEL domain containing 1 |
Synonyms | GB14,MARVD1,MRVLDC1,bA548K23.8 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_031484.4 | NP_113672.1 | MARVEL domain-containing protein 1 |
NM_031484.3 | NP_113672.1 | MARVEL domain-containing protein 1 |
Gallus gallus (chicken) | MARVELD1 | XP_004942445.1 |
Xenopus tropicalis (tropical clawed frog) | marveld1 | XP_002936480.1 |
Mus musculus (house mouse) | Marveld1 | NP_899018.1 |
Homo sapiens (human) | MARVELD1 | NP_113672.1 |
Danio rerio (zebrafish) | marveld1 | NP_001189346.1 |
Pan troglodytes (chimpanzee) | MARVELD1 | XP_529337.2 |
MARVELD1 | XP_001095041.1 | |
Bos taurus (cattle) | MARVELD1 | NP_001094732.1 |
MARVELD1 modulates cell surface morphology and suppresses epithelial-mesenchymal transition in non-small cell lung cancer.
Yao Y, Shi M, Liu S, Li Y, Guo K, Ci Y, Liu W, Li Y
Molecular carcinogenesis55(11)1714-1727(2016 Nov)
[Importin-?1 plays a key role in the nucleocytoplasmic transportation process of MARVELD1].
Wang ZY, Shi M, Li Y
Molekuliarnaia biologiia49(3)491-7(2015 May-Jun)
Biological and clinical significance of epigenetic silencing of MARVELD1 gene in lung cancer.
Shi M, Wang S, Yao Y, Li Y, Zhang H, Han F, Nie H, Su J, Wang Z, Yue L, Cao J, Li Y
Scientific reports47545(2014 Dec)
MARVELD1 regulates integrin ?1-mediated cell adhesion and actin organization via inhibiting its pre-mRNA processing.
Wang S, Hu J, Yao Y, Shi M, Yue L, Han F, Zhang H, He J, Liu S, Li Y
The international journal of biochemistry & cell biology45(11)2679-87(2013 Nov)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Study demonstrates that MARVELD1-mediated balance of integrin beta1 and beta4 regulates cell surface ultrastructure and epithelial-mesenchymal transition phenotype of non-small cell lung cancer (NSCLC).
Title: MARVELD1 modulates cell surface morphology and suppresses epithelial-mesenchymal transition in non-small cell lung cancer.
Importin-beta1 mediates the non-classical nucleocytoplasmic transport of MARVELD1.
Title: [Importin-?1 plays a key role in the nucleocytoplasmic transportation process of MARVELD1].
MARVELD1 silencing is an appealing diagnostic biomarker for lung cancer.
Title: Biological and clinical significance of epigenetic silencing of MARVELD1 gene in lung cancer.
MARVELD1 plays a role in pre-mRNA processing of integrin beta1.
Title: MARVELD1 regulates integrin ?1-mediated cell adhesion and actin organization via inhibiting its pre-mRNA processing.
MARVELD1 substantially inhibits nonsense-mediated RNA decay by decreasing the pioneer round of translation but not steady-state translation, and is an important component of the molecular machinery containing UPF1 and Y14. MARVELD1 promotes the dissociation of SMG1 from UPF1, resulting in the repression of serine phosphorylation of UPF1, and subsequently blocks the recruitment of SMG5.
Title: MARVELD1 Inhibits Nonsense-Mediated RNA Decay by Repressing Serine Phosphorylation of UPF1.
The following MARVELD1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MARVELD1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu29063 | |
Clone ID Related Accession (Same CDS sequence) | NM_031484.4 , NM_031484.3 | |
Accession Version | NM_031484.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 522bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-10 | |
Organism | Homo sapiens(human) | |
Product | MARVEL domain-containing protein 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC004995.1 and AI347102.1. On Nov 23, 2018 this sequence version replaced NM_031484.3. ##Evidence-Data-START## Transcript exon combination :: BC062544.1, BC004995.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000285605.8/ ENSP00000441365.1 NMD candidate :: PMID: 19364627 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGCTCCCGC CGCCCCCGCG CCAGCCGCCG CCCCAGGCGC GTGCGGCCCG CGGCGCGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_113672.1 |
CDS | 148..669 |
Translation |
Target ORF information:
Target ORF information:
|
NM_031484.4 |
1 | ATGCTCCCGC CGCCCCCGCG CCAGCCGCCG CCCCAGGCGC GTGCGGCCCG CGGCGCGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu29063 | |
Clone ID Related Accession (Same CDS sequence) | NM_031484.4 , NM_031484.3 | |
Accession Version | NM_031484.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 522bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-15 | |
Organism | Homo sapiens(human) | |
Product | MARVEL domain-containing protein 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CF125014.1, BC004995.1 and AI347102.1. On or before Jan 5, 2010 this sequence version replaced NR_026753.1, NM_031484.2. ##Evidence-Data-START## Transcript exon combination :: BC062544.1, AK025996.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## NMD candidate :: PMID: 19364627 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCTCCCGC CGCCCCCGCG CCAGCCGCCG CCCCAGGCGC GTGCGGCCCG CGGCGCGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_113672.1 |
CDS | 170..691 |
Translation |
Target ORF information:
Target ORF information:
|
NM_031484.3 |
1 | ATGCTCCCGC CGCCCCCGCG CCAGCCGCCG CCCCAGGCGC GTGCGGCCCG CGGCGCGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
MARVELD1 modulates cell surface morphology and suppresses epithelial-mesenchymal transition in non-small cell lung cancer. |
[Importin-?1 plays a key role in the nucleocytoplasmic transportation process of MARVELD1]. |
Biological and clinical significance of epigenetic silencing of MARVELD1 gene in lung cancer. |
MARVELD1 regulates integrin ?1-mediated cell adhesion and actin organization via inhibiting its pre-mRNA processing. |