HINT2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HINT2
Entrez Gene ID	84681
Full Name	histidine triad nucleotide binding protein 2
Synonyms	HIT-17
General protein information	Preferred Names histidine triad nucleotide binding protein 2 Names histidine triad nucleotide-binding protein 2, mitochondrial HINT-2 HINT-3 HIT-17kDa PKCI-1-related HIT protein protein kinase C inhibitor-2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9p13.3
Summary	Histidine triad proteins, such as HINT2, are nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides (Brenner, 2002 [PubMed 12119013]).[supplied by OMIM, Mar 2008].
Disorder MIM:	609997

mRNA and Protein(s)

mRNA	Protein	Name
XM_024447703.1	XP_024303471.1	histidine triad nucleotide-binding protein 2, mitochondrial isoform X2
XM_024447702.1	XP_024303470.1	histidine triad nucleotide-binding protein 2, mitochondrial isoform X1
NM_032593.3	NP_115982.1	histidine triad nucleotide-binding protein 2, mitochondrial precursor
NM_032593.2	NP_115982.1	histidine triad nucleotide-binding protein 2, mitochondrial precursor
XM_024447704.1	XP_024303472.1	histidine triad nucleotide-binding protein 2, mitochondrial isoform X3

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	HINT2	XP_538721.4
Bos taurus (cattle)	HINT2	NP_776765.1
Mus musculus (house mouse)	Hint2	NP_081147.1
Homo sapiens (human)	HINT2	NP_115982.1
Pan troglodytes (chimpanzee)	HINT2	XP_001158309.1
	HINT2	XP_001084633.1
Rattus norvegicus (Norway rat)	Hint2	NP_001101425.2
Gallus gallus (chicken)	LOC100859112	XP_003643021.2
Arabidopsis thaliana (thale cress)	HINT 2	NP_174401.1
Danio rerio (zebrafish)	hint2	NP_001077041.1

Gene Ontology
Bibliography

Related articles in PubMed

HINT2 triggers mitochondrial Ca
Chen L, Sun Q, Zhou D, Song W, Yang Q, Ju B, Zhang L, Xie H, Zhou L, Hu Z, Yao H, Zheng S, Wang W
Cancer letters411106-116(2017 Dec)

HINT2 downregulation promotes colorectal carcinoma migration and metastasis.
Li W, Cai S, Wang L, Yang C, Zhou B, Wang H
Oncotarget8(8)13521-13531(2017 Feb)

Progesterone enhances calcitriol antitumor activity by upregulating vitamin D receptor expression and promoting apoptosis in endometrial cancer cells.
Lee LR, Teng PN, Nguyen H, Hood BL, Kavandi L, Wang G, Turbov JM, Thaete LG, Hamilton CA, Maxwell GL, Rodriguez GC, Conrads TP, Syed V
Cancer prevention research (Philadelphia, Pa.)6(7)731-43(2013 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Authors deduced that HINT2 triggers apoptosis in pancreatic cancer cells by regulating mitochondrial Ca(2+) influx through the mitochondrial calcium uniporter (MCU). Authors found that HINT2 can sensitize BxPC-3 and L3.6pl cells to gemcitabine-induced apoptosis and that gemcitabine up-regulates HINT2 expression.
Title: HINT2 triggers mitochondrial Ca

HINT2 downregulation depended on hypoxia inducible factor (HIF)-2alpha-mediated transcriptional activation of zinc finger E-box-binding homeobox 1 (ZEB1). These results suggest that HINT2 downregulation promotes HIF-2alpha expression, which induces EMT and enhances CRC cell migration and invasion.
Title: HINT2 downregulation promotes colorectal carcinoma migration and metastasis.

Low HINT2 expression is associated with low response to therapy in endometrial cancer.
Title: Progesterone enhances calcitriol antitumor activity by upregulating vitamin D receptor expression and promoting apoptosis in endometrial cancer cells.

X-ray crystal structure of human HINT2 with and without bound AMP.
Title: Structural characterization of human histidine triad nucleotide-binding protein 2, a member of the histidine triad superfamily.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

The following HINT2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HINT2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13028	NM_032593.3 Latest version!	Homo sapiens histidine triad nucleotide binding protein 2 (HINT2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu106207	XM_024447704.1 Latest version!	Homo sapiens histidine triad nucleotide binding protein 2 (HINT2), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu42870	XM_024447702.1 Latest version!	Homo sapiens histidine triad nucleotide binding protein 2 (HINT2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu73701	XM_024447703.1 Latest version!	Homo sapiens histidine triad nucleotide binding protein 2 (HINT2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu13028	NM_032593.2	Homo sapiens histidine triad nucleotide binding protein 2 (HINT2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HINT2 ( NM_032593.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_115982.1 Homo sapiens histidine triad nucleotide binding protein 2 (HINT2), mRNA.

Price & Availability↑

CloneID	OHu13028
Clone ID Related Accession (Same CDS sequence)	NM_032593.3 , NM_032593.2
Accession Version	NM_032593.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 492bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	histidine triad nucleotide-binding protein 2, mitochondrial precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BI759951.1, BM764627.1 and BC047737.2. On Nov 22, 2018 this sequence version replaced NM_032593.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.327484.1, DN994618.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1968189 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000259667.6/ ENSP00000259667.5 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGCAG CCGTGGTGCT GGCTGCTGGG TTGCGCGCGG CGCGCAGAGC CGTGGCGGCC 
ACGGGGGTGC GCGGGGGGCA GGTCCGAGGA GCTGCAGGTG TGACTGATGG GAATGAAGTG 
GCCAAGGCCC AGCAGGCAAC TCCTGGGGGA GCAGCCCCAA CCATCTTCTC CCGGATCCTG 
GACAAGAGCC TCCCAGCTGA CATTCTCTAT GAGGACCAGC AGTGTCTTGT GTTCCGTGAT 
GTGGCCCCTC AGGCTCCTGT GCACTTCCTG GTCATTCCTA AGAAGCCCAT TCCTCGGATT 
AGCCAGGCTG AAGAAGAAGA CCAGCAGCTT CTAGGACACC TACTCCTTGT GGCCAAGCAG 
ACAGCAAAGG CTGAGGGCCT GGGAGATGGA TACCGACTTG TGATCAACGA TGGGAAGCTG 
GGTGCACAAT CTGTGTATCA TCTGCACATT CATGTACTTG GGGGCCGGCA GCTCCAGTGG 
CCTCCAGGTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115982.1
CDS	64..555
Translation	MAAAVVLAAGLRAARRAVAATGVRGGQVRGAAGVTDGNEVAKAQQATPGGAAPTIFSRILDKSLPADILYEDQQCLVFRDVAPQAPVHFLVIPKKPIPRISQAEEEDQQLLGHLLLVAKQTAKAEGLGDGYRLVINDGKLGAQSVYHLHIHVLGGRQLQWPPG

Target ORF information:

RefSeq Version	NM_032593.3
Organism	Homo sapiens(human)
Definition	Homo sapiens histidine triad nucleotide binding protein 2 (HINT2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032593.3

ORF Insert Sequence:

ATGGCGGCAG CCGTGGTGCT GGCTGCTGGG TTGCGCGCGG CGCGCAGAGC CGTGGCGGCC 
ACGGGGGTGC GCGGGGGGCA GGTCCGAGGA GCTGCAGGTG TGACTGATGG GAATGAAGTG 
GCCAAGGCCC AGCAGGCAAC TCCTGGGGGA GCAGCCCCAA CCATCTTCTC CCGGATCCTG 
GACAAGAGCC TCCCAGCTGA CATTCTCTAT GAGGACCAGC AGTGTCTTGT GTTCCGTGAT 
GTGGCCCCTC AGGCTCCTGT GCACTTCCTG GTCATTCCTA AGAAGCCCAT TCCTCGGATT 
AGCCAGGCTG AAGAAGAAGA CCAGCAGCTT CTAGGACACC TACTCCTTGT GGCCAAGCAG 
ACAGCAAAGG CTGAGGGCCT GGGAGATGGA TACCGACTTG TGATCAACGA TGGGAAGCTG 
GGTGCACAAT CTGTGTATCA TCTGCACATT CATGTACTTG GGGGCCGGCA GCTCCAGTGG 
CCTCCAGGTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HINT2 ( NM_032593.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_115982.1 Homo sapiens histidine triad nucleotide binding protein 2 (HINT2), mRNA.

Price & Availability↑

CloneID	OHu13028
Clone ID Related Accession (Same CDS sequence)	NM_032593.3 , NM_032593.2
Accession Version	NM_032593.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 492bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-10
Organism	Homo sapiens(human)
Product	histidine triad nucleotide-binding protein 2, mitochondrial precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BI759951.1, BM764627.1 and BC047737.2. On Jul 1, 2004 this sequence version replaced NM_032593.1. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.327484.1, DN994618.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1968189 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END##

ATGGCGGCAG CCGTGGTGCT GGCTGCTGGG TTGCGCGCGG CGCGCAGAGC CGTGGCGGCC 
ACGGGGGTGC GCGGGGGGCA GGTCCGAGGA GCTGCAGGTG TGACTGATGG GAATGAAGTG 
GCCAAGGCCC AGCAGGCAAC TCCTGGGGGA GCAGCCCCAA CCATCTTCTC CCGGATCCTG 
GACAAGAGCC TCCCAGCTGA CATTCTCTAT GAGGACCAGC AGTGTCTTGT GTTCCGTGAT 
GTGGCCCCTC AGGCTCCTGT GCACTTCCTG GTCATTCCTA AGAAGCCCAT TCCTCGGATT 
AGCCAGGCTG AAGAAGAAGA CCAGCAGCTT CTAGGACACC TACTCCTTGT GGCCAAGCAG 
ACAGCAAAGG CTGAGGGCCT GGGAGATGGA TACCGACTTG TGATCAACGA TGGGAAGCTG 
GGTGCACAAT CTGTGTATCA TCTGCACATT CATGTACTTG GGGGCCGGCA GCTCCAGTGG 
CCTCCAGGTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115982.1
CDS	67..558
Translation	MAAAVVLAAGLRAARRAVAATGVRGGQVRGAAGVTDGNEVAKAQQATPGGAAPTIFSRILDKSLPADILYEDQQCLVFRDVAPQAPVHFLVIPKKPIPRISQAEEEDQQLLGHLLLVAKQTAKAEGLGDGYRLVINDGKLGAQSVYHLHIHVLGGRQLQWPPG

Target ORF information:

RefSeq Version	NM_032593.2
Organism	Homo sapiens(human)
Definition	Homo sapiens histidine triad nucleotide binding protein 2 (HINT2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032593.2

ORF Insert Sequence:

ATGGCGGCAG CCGTGGTGCT GGCTGCTGGG TTGCGCGCGG CGCGCAGAGC CGTGGCGGCC 
ACGGGGGTGC GCGGGGGGCA GGTCCGAGGA GCTGCAGGTG TGACTGATGG GAATGAAGTG 
GCCAAGGCCC AGCAGGCAAC TCCTGGGGGA GCAGCCCCAA CCATCTTCTC CCGGATCCTG 
GACAAGAGCC TCCCAGCTGA CATTCTCTAT GAGGACCAGC AGTGTCTTGT GTTCCGTGAT 
GTGGCCCCTC AGGCTCCTGT GCACTTCCTG GTCATTCCTA AGAAGCCCAT TCCTCGGATT 
AGCCAGGCTG AAGAAGAAGA CCAGCAGCTT CTAGGACACC TACTCCTTGT GGCCAAGCAG 
ACAGCAAAGG CTGAGGGCCT GGGAGATGGA TACCGACTTG TGATCAACGA TGGGAAGCTG 
GGTGCACAAT CTGTGTATCA TCTGCACATT CATGTACTTG GGGGCCGGCA GCTCCAGTGG 
CCTCCAGGTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HINT2 ( XM_024447704.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024303472.1 Homo sapiens histidine triad nucleotide binding protein 2 (HINT2), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu106207
Clone ID Related Accession (Same CDS sequence)	XM_024447704.1
Accession Version	XM_024447704.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 414bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	histidine triad nucleotide-binding protein 2, mitochondrial isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGCAG CCGTGGTGCT GGCTGCTGGG TTGCGCGCGG CGCGCAGAGC CGTGGCGGCC 
ACGGGGGTGC GCGGGGGGCA GGTCCGAGGA GCTGCAGGTG TGACTGATGG GAATGAAGTG 
GCCAAGGCCC AGCAGGCAAC TCCTGGGGGA GCAGCCCCAA CCATCTTCTC CCGGATCCTG 
GACAAGAGCC TCCCAGCTGA CATTCTCTAT GAGGACCAGC AGTGTCTTGT GTTCCGTGAT 
GTGGCCCCTC AGGCTCCTGT GCACTTCCTG GTCATTCCTA AGAAGCCCAT TCCTCGGATT 
AGCCAGGCTG AAGAAGAAGA CCAGCAGCTT CTAGGACACC TACTCCTTGT GGCCAAGCAG 
ACAGCAAAGG CTGAGGGCCT GGGAGATGGA TACCGACTTG CTCAATTTCA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024303472.1
CDS	100..513
Translation	MAAAVVLAAGLRAARRAVAATGVRGGQVRGAAGVTDGNEVAKAQQATPGGAAPTIFSRILDKSLPADILYEDQQCLVFRDVAPQAPVHFLVIPKKPIPRISQAEEEDQQLLGHLLLVAKQTAKAEGLGDGYRLAQFQ

Target ORF information:

RefSeq Version	XM_024447704.1
Organism	Homo sapiens(human)
Definition	Homo sapiens histidine triad nucleotide binding protein 2 (HINT2), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024447704.1

ORF Insert Sequence:

ATGGCGGCAG CCGTGGTGCT GGCTGCTGGG TTGCGCGCGG CGCGCAGAGC CGTGGCGGCC 
ACGGGGGTGC GCGGGGGGCA GGTCCGAGGA GCTGCAGGTG TGACTGATGG GAATGAAGTG 
GCCAAGGCCC AGCAGGCAAC TCCTGGGGGA GCAGCCCCAA CCATCTTCTC CCGGATCCTG 
GACAAGAGCC TCCCAGCTGA CATTCTCTAT GAGGACCAGC AGTGTCTTGT GTTCCGTGAT 
GTGGCCCCTC AGGCTCCTGT GCACTTCCTG GTCATTCCTA AGAAGCCCAT TCCTCGGATT 
AGCCAGGCTG AAGAAGAAGA CCAGCAGCTT CTAGGACACC TACTCCTTGT GGCCAAGCAG 
ACAGCAAAGG CTGAGGGCCT GGGAGATGGA TACCGACTTG CTCAATTTCA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HINT2 ( XM_024447702.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024303470.1 Homo sapiens histidine triad nucleotide binding protein 2 (HINT2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu42870
Clone ID Related Accession (Same CDS sequence)	XM_024447702.1
Accession Version	XM_024447702.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 498bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	histidine triad nucleotide-binding protein 2, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAATGGA AAATTGTCCT CGCGTTGGTA GAAGCAGCCA ATGAGATGAA AAGAGCCCGC 
CTCCAAAGTG GCTGCAGAGG CAATGGGGTC CGAGGAGCTG CAGGTGTGAC TGATGGGAAT 
GAAGTGGCCA AGGCCCAGCA GGCAACTCCT GGGGGAGCAG CCCCAACCAT CTTCTCCCGG 
ATCCTGGACA AGAGCCTCCC AGCTGACATT CTCTATGAGG ACCAGCAGTG TCTTGTGTTC 
CGTGATGTGG CCCCTCAGGC TCCTGTGCAC TTCCTGGTCA TTCCTAAGAA GCCCATTCCT 
CGGATTAGCC AGGCTGAAGA AGAAGACCAG CAGCTTCTAG GACACCTACT CCTTGTGGCC 
AAGCAGACAG CAAAGGCTGA GGGCCTGGGA GATGGATACC GACTTGTGAT CAACGATGGG 
AAGCTGGGTG CACAATCTGT GTATCATCTG CACATTCATG TACTTGGGGG CCGGCAGCTC 
CAGTGGCCTC CAGGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024303470.1
CDS	21..518
Translation	MEWKIVLALVEAANEMKRARLQSGCRGNGVRGAAGVTDGNEVAKAQQATPGGAAPTIFSRILDKSLPADILYEDQQCLVFRDVAPQAPVHFLVIPKKPIPRISQAEEEDQQLLGHLLLVAKQTAKAEGLGDGYRLVINDGKLGAQSVYHLHIHVLGGRQLQWPPG

Target ORF information:

RefSeq Version	XM_024447702.1
Organism	Homo sapiens(human)
Definition	Homo sapiens histidine triad nucleotide binding protein 2 (HINT2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024447702.1

ORF Insert Sequence:

ATGGAATGGA AAATTGTCCT CGCGTTGGTA GAAGCAGCCA ATGAGATGAA AAGAGCCCGC 
CTCCAAAGTG GCTGCAGAGG CAATGGGGTC CGAGGAGCTG CAGGTGTGAC TGATGGGAAT 
GAAGTGGCCA AGGCCCAGCA GGCAACTCCT GGGGGAGCAG CCCCAACCAT CTTCTCCCGG 
ATCCTGGACA AGAGCCTCCC AGCTGACATT CTCTATGAGG ACCAGCAGTG TCTTGTGTTC 
CGTGATGTGG CCCCTCAGGC TCCTGTGCAC TTCCTGGTCA TTCCTAAGAA GCCCATTCCT 
CGGATTAGCC AGGCTGAAGA AGAAGACCAG CAGCTTCTAG GACACCTACT CCTTGTGGCC 
AAGCAGACAG CAAAGGCTGA GGGCCTGGGA GATGGATACC GACTTGTGAT CAACGATGGG 
AAGCTGGGTG CACAATCTGT GTATCATCTG CACATTCATG TACTTGGGGG CCGGCAGCTC 
CAGTGGCCTC CAGGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HINT2 ( XM_024447703.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024303471.1 Homo sapiens histidine triad nucleotide binding protein 2 (HINT2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu73701
Clone ID Related Accession (Same CDS sequence)	XM_024447703.1
Accession Version	XM_024447703.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 420bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	histidine triad nucleotide-binding protein 2, mitochondrial isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAATGGA AAATTGTCCT CGCGTTGGTA GAAGCAGCCA ATGAGATGAA AAGAGCCCGC 
CTCCAAAGTG GCTGCAGAGG CAATGGGGTC CGAGGAGCTG CAGGTGTGAC TGATGGGAAT 
GAAGTGGCCA AGGCCCAGCA GGCAACTCCT GGGGGAGCAG CCCCAACCAT CTTCTCCCGG 
ATCCTGGACA AGAGCCTCCC AGCTGACATT CTCTATGAGG ACCAGCAGTG TCTTGTGTTC 
CGTGATGTGG CCCCTCAGGC TCCTGTGCAC TTCCTGGTCA TTCCTAAGAA GCCCATTCCT 
CGGATTAGCC AGGCTGAAGA AGAAGACCAG CAGCTTCTAG GACACCTACT CCTTGTGGCC 
AAGCAGACAG CAAAGGCTGA GGGCCTGGGA GATGGATACC GACTTGCTCA ATTTCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024303471.1
CDS	265..684
Translation	MEWKIVLALVEAANEMKRARLQSGCRGNGVRGAAGVTDGNEVAKAQQATPGGAAPTIFSRILDKSLPADILYEDQQCLVFRDVAPQAPVHFLVIPKKPIPRISQAEEEDQQLLGHLLLVAKQTAKAEGLGDGYRLAQFQ

Target ORF information:

RefSeq Version	XM_024447703.1
Organism	Homo sapiens(human)
Definition	Homo sapiens histidine triad nucleotide binding protein 2 (HINT2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024447703.1

ORF Insert Sequence:

ATGGAATGGA AAATTGTCCT CGCGTTGGTA GAAGCAGCCA ATGAGATGAA AAGAGCCCGC 
CTCCAAAGTG GCTGCAGAGG CAATGGGGTC CGAGGAGCTG CAGGTGTGAC TGATGGGAAT 
GAAGTGGCCA AGGCCCAGCA GGCAACTCCT GGGGGAGCAG CCCCAACCAT CTTCTCCCGG 
ATCCTGGACA AGAGCCTCCC AGCTGACATT CTCTATGAGG ACCAGCAGTG TCTTGTGTTC 
CGTGATGTGG CCCCTCAGGC TCCTGTGCAC TTCCTGGTCA TTCCTAAGAA GCCCATTCCT 
CGGATTAGCC AGGCTGAAGA AGAAGACCAG CAGCTTCTAG GACACCTACT CCTTGTGGCC 
AAGCAGACAG CAAAGGCTGA GGGCCTGGGA GATGGATACC GACTTGCTCA ATTTCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

HINT2 triggers mitochondrial Ca
Cancer letters411106-116(2017 Dec)
Chen L,Sun Q,Zhou D,Song W,Yang Q,Ju B,Zhang L,Xie H,Zhou L,Hu Z,Yao H,Zheng S,Wang W

HINT2 downregulation promotes colorectal carcinoma migration and metastasis.
Oncotarget8(8)13521-13531(2017 Feb)
Li W,Cai S,Wang L,Yang C,Zhou B,Wang H

Progesterone enhances calcitriol antitumor activity by upregulating vitamin D receptor expression and promoting apoptosis in endometrial cancer cells.
Cancer prevention research (Philadelphia, Pa.)6(7)731-43(2013 Jul)
Lee LR,Teng PN,Nguyen H,Hood BL,Kavandi L,Wang G,Turbov JM,Thaete LG,Hamilton CA,Maxwell GL,Rodriguez GC,Conrads TP,Syed V

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HINT2 cDNA ORF clone, Homo sapiens(human)

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