TNFSF18 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TNFSF18
Entrez Gene ID	8995
Full Name	TNF superfamily member 18
Synonyms	AITRL,GITRL,TL6,TNLG2A,hGITRL
General protein information	Preferred Names TNF superfamily member 18 Names tumor necrosis factor ligand superfamily member 18 AITR ligand GITR ligand activation-inducible TNF-related ligand glucocorticoid-induced TNF-related ligand glucocorticoid-induced TNFR-related protein ligand tumor necrosis factor (ligand) superfamily, member 18 tumor necrosis factor ligand 2A tumor necrosis factor superfamily member 18
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q25.1
Summary	The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. [provided by RefSeq, Jul 2008].
Disorder MIM:	603898

mRNA and Protein(s)

mRNA	Protein	Name
NM_005092.3	NP_005083.2	tumor necrosis factor ligand superfamily member 18

Pathways from BioSystems

Homologies

Homo sapiens (human)	TNFSF18	NP_005083.2
Bos taurus (cattle)	TNFSF18	NP_001070604.1
Mus musculus (house mouse)	Tnfsf18	NP_899247.3
	TNFSF18	NP_001035281.1
Canis lupus familiaris (dog)	TNFSF18	XP_005623023.1
Rattus norvegicus (Norway rat)	Tnfsf18	XP_344167.6
Pan troglodytes (chimpanzee)	TNFSF18	XP_001147996.2

Gene Ontology
Bibliography

Related articles in PubMed

The Proinflammatory Cytokine GITRL Contributes to TRAIL-mediated Neurotoxicity in the HCN-2 Human Neuronal Cell Line.
Benedetto GD, Saccone S, Lempereur L, Ronsisvalle N, Nocentini G, Bianchini R, Riccardi C, Bernardini R, Cantarella G
Current Alzheimer research14(10)1090-1101(2017)

GITRL is associated with increased autoantibody production in patients with rheumatoid arthritis.
Li L, Wen W, Jia R, Li Y, Liu X, Sun X, Li Z
Clinical rheumatology35(9)2195-202(2016 Sep)

GITRL modulates the activities of p38 MAPK and STAT3 to promote Th17 cell differentiation in autoimmune arthritis.
Tang X, Tian J, Ma J, Wang J, Qi C, Rui K, Wang Y, Xu H, Lu L, Wang S
Oncotarget7(8)8590-600(2016 Feb)

Comparative genomic analysis of eutherian tumor necrosis factor ligand genes.
Premzl M
Immunogenetics68(2)125-32(2016 Feb)

Th17/Treg cells imbalance and GITRL profile in patients with Hashimoto's thyroiditis.
Liu Y, Tang X, Tian J, Zhu C, Peng H, Rui K, Wang Y, Mao C, Ma J, Lu L, Xu H, Wang S
International journal of molecular sciences15(12)21674-86(2014 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

GITRL levels are significantly elevated in rheumatoid arthritis serum and synovial fluid and are positively correlated with autoantibody production in rheumatoid arthritis, suggesting a role of GITRL in the development of rheumatoid arthritis.
Title: GITRL is associated with increased autoantibody production in patients with rheumatoid arthritis.

GITRL modulates the activities of p38 MAPK and STAT3 to promote Th17 cell differentiation in autoimmune arthritis.
Title: GITRL modulates the activities of p38 MAPK and STAT3 to promote Th17 cell differentiation in autoimmune arthritis.

An increase in GITRL may impair the balance of Th17/Treg, and contribute to the pathopoiesis of Hashimoto's thyroiditis.
Title: Th17/Treg cells imbalance and GITRL profile in patients with Hashimoto's thyroiditis.

Our findings indicate the possible involvement of GITR-GITRL pathway in the pathogenesis of pSS.
Title: Correlation of increased blood levels of GITR and GITRL with disease severity in patients with primary Sj?gren's syndrome.

Serum GITRL levels were higher in SLE patients.
Title: Correlation of circulating glucocorticoid-induced TNFR-related protein ligand levels with disease activity in patients with systemic lupus erythematosus.

The following TNFSF18 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TNFSF18 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu08924	NM_005092.3 Latest version!	Homo sapiens TNF superfamily member 18 (TNFSF18), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TNFSF18 ( NM_005092.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005083.2 Homo sapiens TNF superfamily member 18 (TNFSF18), mRNA.

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CloneID	OHu08924
Clone ID Related Accession (Same CDS sequence)	NM_005092.3
Accession Version	NM_005092.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 600bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Homo sapiens(human)
Product	tumor necrosis factor ligand superfamily member 18
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC112032.1 and AY358868.1. On Sep 21, 2007 this sequence version replaced NM_005092.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC112032.1, SRR1803616.35513.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGACATTGC ATCCTTCACC CATCACTTGT GAATTTTTGT TTTCCACAGC TCTCATTTCT 
CCAAAAATGT GTTTGAGCCA CTTGGAAAAT ATGCCTTTAA GCCATTCAAG AACTCAAGGA 
GCTCAGAGAT CATCCTGGAA GCTGTGGCTC TTTTGCTCAA TAGTTATGTT GCTATTTCTT 
TGCTCCTTCA GTTGGCTAAT CTTTATTTTT CTCCAATTAG AGACTGCTAA GGAGCCCTGT 
ATGGCTAAGT TTGGACCATT ACCCTCAAAA TGGCAAATGG CATCTTCTGA ACCTCCTTGC 
GTGAATAAGG TGTCTGACTG GAAGCTGGAG ATACTTCAGA ATGGCTTATA TTTAATTTAT 
GGCCAAGTGG CTCCCAATGC AAACTACAAT GATGTAGCTC CTTTTGAGGT GCGGCTGTAT 
AAAAACAAAG ACATGATACA AACTCTAACA AACAAATCTA AAATCCAAAA TGTAGGAGGG 
ACTTATGAAT TGCATGTTGG GGACACCATA GACTTGATAT TCAACTCTGA GCATCAGGTT 
CTAAAAAATA ATACATACTG GGGTATCATT TTACTAGCAA ATCCCCAATT CATCTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005083.2
CDS	2..601
Translation	MTLHPSPITCEFLFSTALISPKMCLSHLENMPLSHSRTQGAQRSSWKLWLFCSIVMLLFLCSFSWLIFIFLQLETAKEPCMAKFGPLPSKWQMASSEPPCVNKVSDWKLEILQNGLYLIYGQVAPNANYNDVAPFEVRLYKNKDMIQTLTNKSKIQNVGGTYELHVGDTIDLIFNSEHQVLKNNTYWGIILLANPQFIS

Target ORF information:

RefSeq Version	NM_005092.3
Organism	Homo sapiens(human)
Definition	Homo sapiens TNF superfamily member 18 (TNFSF18), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005092.3

ORF Insert Sequence:

ATGACATTGC ATCCTTCACC CATCACTTGT GAATTTTTGT TTTCCACAGC TCTCATTTCT 
CCAAAAATGT GTTTGAGCCA CTTGGAAAAT ATGCCTTTAA GCCATTCAAG AACTCAAGGA 
GCTCAGAGAT CATCCTGGAA GCTGTGGCTC TTTTGCTCAA TAGTTATGTT GCTATTTCTT 
TGCTCCTTCA GTTGGCTAAT CTTTATTTTT CTCCAATTAG AGACTGCTAA GGAGCCCTGT 
ATGGCTAAGT TTGGACCATT ACCCTCAAAA TGGCAAATGG CATCTTCTGA ACCTCCTTGC 
GTGAATAAGG TGTCTGACTG GAAGCTGGAG ATACTTCAGA ATGGCTTATA TTTAATTTAT 
GGCCAAGTGG CTCCCAATGC AAACTACAAT GATGTAGCTC CTTTTGAGGT GCGGCTGTAT 
AAAAACAAAG ACATGATACA AACTCTAACA AACAAATCTA AAATCCAAAA TGTAGGAGGG 
ACTTATGAAT TGCATGTTGG GGACACCATA GACTTGATAT TCAACTCTGA GCATCAGGTT 
CTAAAAAATA ATACATACTG GGGTATCATT TTACTAGCAA ATCCCCAATT CATCTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Proinflammatory Cytokine GITRL Contributes to TRAIL-mediated Neurotoxicity in the HCN-2 Human Neuronal Cell Line.
Current Alzheimer research14(10)1090-1101(2017)
Benedetto GD,Saccone S,Lempereur L,Ronsisvalle N,Nocentini G,Bianchini R,Riccardi C,Bernardini R,Cantarella G

GITRL is associated with increased autoantibody production in patients with rheumatoid arthritis.
Clinical rheumatology35(9)2195-202(2016 Sep)
Li L,Wen W,Jia R,Li Y,Liu X,Sun X,Li Z

GITRL modulates the activities of p38 MAPK and STAT3 to promote Th17 cell differentiation in autoimmune arthritis.
Oncotarget7(8)8590-600(2016 Feb)
Tang X,Tian J,Ma J,Wang J,Qi C,Rui K,Wang Y,Xu H,Lu L,Wang S

Comparative genomic analysis of eutherian tumor necrosis factor ligand genes.
Immunogenetics68(2)125-32(2016 Feb)
Premzl M

Th17/Treg cells imbalance and GITRL profile in patients with Hashimoto's thyroiditis.
International journal of molecular sciences15(12)21674-86(2014 Nov)
Liu Y,Tang X,Tian J,Zhu C,Peng H,Rui K,Wang Y,Mao C,Ma J,Lu L,Xu H,Wang S

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TNFSF18 cDNA ORF clone, Homo sapiens(human)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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