SNRNP40 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SNRNP40
Entrez Gene ID	9410
Full Name	small nuclear ribonucleoprotein U5 subunit 40
Synonyms	40K,HPRP8BP,PRP8BP,PRPF8BP,SPF38,WDR57
General protein information	Preferred Names small nuclear ribonucleoprotein U5 subunit 40 Names U5 small nuclear ribonucleoprotein 40 kDa protein 38 kDa-splicing factor Prp8-binding protein U5 snRNP 40 kDa protein U5 snRNP-specific 40 kDa protein (hPrp8-binding) U5-40K U5-40kD protein WD repeat domain 57 (U5 snRNP specific) WD repeat-containing protein 57 small nuclear ribonucleoprotein 40kDa (U5) small nuclear ribonucleoprotein, U5 40kDa subunit
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p35.2
Summary	This gene encodes a component of the U5 small nuclear ribonucleoprotein (snRNP) particle. The U5 snRNP is part of the spliceosome, a multiprotein complex that catalyzes the removal of introns from pre-messenger RNAs. [provided by RefSeq, Jul 2008].
Disorder MIM:	607797

mRNA and Protein(s)

mRNA	Protein	Name
NM_004814.3	NP_004805.2	U5 small nuclear ribonucleoprotein 40 kDa protein
NM_004814.2	NP_004805.2	U5 small nuclear ribonucleoprotein 40 kDa protein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	SNRNP40	XP_003307985.1
	SNRNP40	XP_002802329.1
Bos taurus (cattle)	SNRNP40	NP_001039847.1
Danio rerio (zebrafish)	snrnp40	NP_956616.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009506	XP_310190.3
Neurospora crassa	NCU05797	XP_960057.1
Oryza sativa (rice)	Os06g0653800	NP_001058241.1
Xenopus tropicalis (tropical clawed frog)	snrnp40	NP_001025544.1
Canis lupus familiaris (dog)	SNRNP40	XP_854730.1
Caenorhabditis elegans (roundworm)	C18E3.5	NP_491325.1
Homo sapiens (human)	SNRNP40	NP_004805.2
Mus musculus (house mouse)	Snrnp40	NP_079921.2
Gallus gallus (chicken)	SNRNP40	NP_001006308.1
Drosophila melanogaster (fruit fly)	CG3436	NP_608501.1
Magnaporthe oryzae (rice blast fungus)	MGG_04693	XP_003710838.1
Arabidopsis thaliana (thale cress)	AT2G43770	NP_181905.1
Rattus norvegicus (Norway rat)	Snrnp40	NP_001128028.1
Caenorhabditis elegans (roundworm)	F08G12.2	NP_509886.1
Schizosaccharomyces pombe (fission yeast)	spf38	NP_596835.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Cryo-EM structure of a human spliceosome activated for step 2 of splicing.
Bertram K, Agafonov DE, Liu WT, Dybkov O, Will CL, Hartmuth K, Urlaub H, Kastner B, Stark H, L?hrmann R
Nature542(7641)318-323(2017 02)

Highly variable cancer subpopulations that exhibit enhanced transcriptome variability and metastatic fitness.
Nguyen A, Yoshida M, Goodarzi H, Tavazoie SF
Nature communications711246(2016 May)

NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent.
Zuo L, Wang K, Zhang XY, Krystal JH, Li CS, Zhang F, Zhang H, Luo X
Drug and alcohol dependence129(3)254-64(2013 May)

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Clinically, low SNRNP40 expression is associated with metastatic relapse.
Title: Highly variable cancer subpopulations that exhibit enhanced transcriptome variability and metastatic fitness.

The following SNRNP40 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SNRNP40 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25853	NM_004814.3 Latest version!	Homo sapiens small nuclear ribonucleoprotein U5 subunit 40 (SNRNP40), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu25853	NM_004814.2	Homo sapiens small nuclear ribonucleoprotein U5 subunit 40 (SNRNP40), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SNRNP40 ( NM_004814.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004805.2 Homo sapiens small nuclear ribonucleoprotein U5 subunit 40 (SNRNP40), mRNA.

Price & Availability↑

CloneID	OHu25853
Clone ID Related Accession (Same CDS sequence)	NM_004814.3 , NM_004814.2
Accession Version	NM_004814.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1074bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	U5 small nuclear ribonucleoprotein 40 kDa protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CR736901.1, BC001494.2, AC114495.2 and BM150898.1. On Nov 24, 2018 this sequence version replaced NM_004814.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.246669.1, SRR5189658.116334.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000263694.9/ ENSP00000263694.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGATAGAAC AGCAGAAGCG TAAGGGCCCA GAGTTGCCGC TGGTTCCAGT CAAGCGGCAG 
CGGCATGAGT TGCTGTTGGG AGCGGGGTCT GGCCCAGGAG CCGGGCAGCA GCAGGCGACG 
CCGGGAGCCT TGCTGCAAGC GGGACCTCCA AGATGTTCCT CCCTTCAAGC CCCAATCATG 
CTGCTCTCTG GACATGAAGG GGAAGTCTAC TGCTGCAAGT TCCACCCCAA CGGATCCACC 
TTAGCATCTG CAGGATTTGA CCGACTGATA TTACTGTGGA ATGTCTATGG TGACTGTGAT 
AACTATGCCA CACTGAAGGG ACACAGTGGA GCAGTGATGG AATTGCATTA CAACACAGAT 
GGCAGTATGC TTTTCTCAGC ATCCACAGAT AAAACCGTGG CTGTGTGGGA TAGTGAAACA 
GGTGAGAGGG TTAAAAGGCT AAAGGGACAT ACTTCCTTTG TGAATTCCTG TTATCCAGCC 
AGGAGAGGCC CTCAGCTTGT CTGCACTGGC AGTGACGATG GCACAGTTAA GCTTTGGGAC 
ATCCGGAAGA AAGCAGCCAT CCAGACATTT CAGAACACGT ACCAGGTGTT AGCTGTGACC 
TTCAATGACA CAAGTGATCA GATTATTTCT GGTGGAATAG ACAATGATAT CAAGGTCTGG 
GACCTGCGCC AGAACAAGCT AACCTACACC ATGAGAGGCC ATGCAGATTC AGTGACTGGC 
CTGAGTTTAA GTTCTGAAGG CTCTTATCTT TTGTCCAATG CAATGGACAA TACAGTTCGT 
GTCTGGGATG TCCGGCCATT TGCCCCCAAA GAGAGATGTG TAAAGATATT TCAAGGAAAT 
GTGCACAACT TTGAAAAGAA CCTTCTGAGA TGTTCTTGGT CACCTGATGG AAGCAAAATA 
GCAGCTGGCT CAGCCGACAG GTTTGTTTAT GTGTGGGATA CCACAAGCAG GAGAATATTG 
TATAAGCTGC CCGGCCATGC TGGCTCCATC AATGAAGTGG CTTTCCACCC TGATGAGCCC 
ATCATTATCT CAGCATCGAG TGACAAGAGA CTGTATATGG GAGAGATTCA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004805.2
CDS	38..1111
Translation	MIEQQKRKGPELPLVPVKRQRHELLLGAGSGPGAGQQQATPGALLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ

Target ORF information:

RefSeq Version	NM_004814.3
Organism	Homo sapiens(human)
Definition	Homo sapiens small nuclear ribonucleoprotein U5 subunit 40 (SNRNP40), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004814.3

ORF Insert Sequence:

ATGATAGAAC AGCAGAAGCG TAAGGGCCCA GAGTTGCCGC TGGTTCCAGT CAAGCGGCAG 
CGGCATGAGT TGCTGTTGGG AGCGGGGTCT GGCCCAGGAG CCGGGCAGCA GCAGGCGACG 
CCGGGAGCCT TGCTGCAAGC GGGACCTCCA AGATGTTCCT CCCTTCAAGC CCCAATCATG 
CTGCTCTCTG GACATGAAGG GGAAGTCTAC TGCTGCAAGT TCCACCCCAA CGGATCCACC 
TTAGCATCTG CAGGATTTGA CCGACTGATA TTACTGTGGA ATGTCTATGG TGACTGTGAT 
AACTATGCCA CACTGAAGGG ACACAGTGGA GCAGTGATGG AATTGCATTA CAACACAGAT 
GGCAGTATGC TTTTCTCAGC ATCCACAGAT AAAACCGTGG CTGTGTGGGA TAGTGAAACA 
GGTGAGAGGG TTAAAAGGCT AAAGGGACAT ACTTCCTTTG TGAATTCCTG TTATCCAGCC 
AGGAGAGGCC CTCAGCTTGT CTGCACTGGC AGTGACGATG GCACAGTTAA GCTTTGGGAC 
ATCCGGAAGA AAGCAGCCAT CCAGACATTT CAGAACACGT ACCAGGTGTT AGCTGTGACC 
TTCAATGACA CAAGTGATCA GATTATTTCT GGTGGAATAG ACAATGATAT CAAGGTCTGG 
GACCTGCGCC AGAACAAGCT AACCTACACC ATGAGAGGCC ATGCAGATTC AGTGACTGGC 
CTGAGTTTAA GTTCTGAAGG CTCTTATCTT TTGTCCAATG CAATGGACAA TACAGTTCGT 
GTCTGGGATG TCCGGCCATT TGCCCCCAAA GAGAGATGTG TAAAGATATT TCAAGGAAAT 
GTGCACAACT TTGAAAAGAA CCTTCTGAGA TGTTCTTGGT CACCTGATGG AAGCAAAATA 
GCAGCTGGCT CAGCCGACAG GTTTGTTTAT GTGTGGGATA CCACAAGCAG GAGAATATTG 
TATAAGCTGC CCGGCCATGC TGGCTCCATC AATGAAGTGG CTTTCCACCC TGATGAGCCC 
ATCATTATCT CAGCATCGAG TGACAAGAGA CTGTATATGG GAGAGATTCA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SNRNP40 ( NM_004814.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_004805.2 Homo sapiens small nuclear ribonucleoprotein U5 subunit 40 (SNRNP40), mRNA.

Price & Availability↑

CloneID	OHu25853
Clone ID Related Accession (Same CDS sequence)	NM_004814.3 , NM_004814.2
Accession Version	NM_004814.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1074bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	U5 small nuclear ribonucleoprotein 40 kDa protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CR736901.1, BC001494.2, AC114495.2 and BM150898.1. On Sep 22, 2006 this sequence version replaced NM_004814.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.110734.1, AK074516.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATAGAAC AGCAGAAGCG TAAGGGCCCA GAGTTGCCGC TGGTTCCAGT CAAGCGGCAG 
CGGCATGAGT TGCTGTTGGG AGCGGGGTCT GGCCCAGGAG CCGGGCAGCA GCAGGCGACG 
CCGGGAGCCT TGCTGCAAGC GGGACCTCCA AGATGTTCCT CCCTTCAAGC CCCAATCATG 
CTGCTCTCTG GACATGAAGG GGAAGTCTAC TGCTGCAAGT TCCACCCCAA CGGATCCACC 
TTAGCATCTG CAGGATTTGA CCGACTGATA TTACTGTGGA ATGTCTATGG TGACTGTGAT 
AACTATGCCA CACTGAAGGG ACACAGTGGA GCAGTGATGG AATTGCATTA CAACACAGAT 
GGCAGTATGC TTTTCTCAGC ATCCACAGAT AAAACCGTGG CTGTGTGGGA TAGTGAAACA 
GGTGAGAGGG TTAAAAGGCT AAAGGGACAT ACTTCCTTTG TGAATTCCTG TTATCCAGCC 
AGGAGAGGCC CTCAGCTTGT CTGCACTGGC AGTGACGATG GCACAGTTAA GCTTTGGGAC 
ATCCGGAAGA AAGCAGCCAT CCAGACATTT CAGAACACGT ACCAGGTGTT AGCTGTGACC 
TTCAATGACA CAAGTGATCA GATTATTTCT GGTGGAATAG ACAATGATAT CAAGGTCTGG 
GACCTGCGCC AGAACAAGCT AACCTACACC ATGAGAGGCC ATGCAGATTC AGTGACTGGC 
CTGAGTTTAA GTTCTGAAGG CTCTTATCTT TTGTCCAATG CAATGGACAA TACAGTTCGT 
GTCTGGGATG TCCGGCCATT TGCCCCCAAA GAGAGATGTG TAAAGATATT TCAAGGAAAT 
GTGCACAACT TTGAAAAGAA CCTTCTGAGA TGTTCTTGGT CACCTGATGG AAGCAAAATA 
GCAGCTGGCT CAGCCGACAG GTTTGTTTAT GTGTGGGATA CCACAAGCAG GAGAATATTG 
TATAAGCTGC CCGGCCATGC TGGCTCCATC AATGAAGTGG CTTTCCACCC TGATGAGCCC 
ATCATTATCT CAGCATCGAG TGACAAGAGA CTGTATATGG GAGAGATTCA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004805.2
CDS	47..1120
Translation	MIEQQKRKGPELPLVPVKRQRHELLLGAGSGPGAGQQQATPGALLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ

Target ORF information:

RefSeq Version	NM_004814.2
Organism	Homo sapiens(human)
Definition	Homo sapiens small nuclear ribonucleoprotein U5 subunit 40 (SNRNP40), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004814.2

ORF Insert Sequence:

ATGATAGAAC AGCAGAAGCG TAAGGGCCCA GAGTTGCCGC TGGTTCCAGT CAAGCGGCAG 
CGGCATGAGT TGCTGTTGGG AGCGGGGTCT GGCCCAGGAG CCGGGCAGCA GCAGGCGACG 
CCGGGAGCCT TGCTGCAAGC GGGACCTCCA AGATGTTCCT CCCTTCAAGC CCCAATCATG 
CTGCTCTCTG GACATGAAGG GGAAGTCTAC TGCTGCAAGT TCCACCCCAA CGGATCCACC 
TTAGCATCTG CAGGATTTGA CCGACTGATA TTACTGTGGA ATGTCTATGG TGACTGTGAT 
AACTATGCCA CACTGAAGGG ACACAGTGGA GCAGTGATGG AATTGCATTA CAACACAGAT 
GGCAGTATGC TTTTCTCAGC ATCCACAGAT AAAACCGTGG CTGTGTGGGA TAGTGAAACA 
GGTGAGAGGG TTAAAAGGCT AAAGGGACAT ACTTCCTTTG TGAATTCCTG TTATCCAGCC 
AGGAGAGGCC CTCAGCTTGT CTGCACTGGC AGTGACGATG GCACAGTTAA GCTTTGGGAC 
ATCCGGAAGA AAGCAGCCAT CCAGACATTT CAGAACACGT ACCAGGTGTT AGCTGTGACC 
TTCAATGACA CAAGTGATCA GATTATTTCT GGTGGAATAG ACAATGATAT CAAGGTCTGG 
GACCTGCGCC AGAACAAGCT AACCTACACC ATGAGAGGCC ATGCAGATTC AGTGACTGGC 
CTGAGTTTAA GTTCTGAAGG CTCTTATCTT TTGTCCAATG CAATGGACAA TACAGTTCGT 
GTCTGGGATG TCCGGCCATT TGCCCCCAAA GAGAGATGTG TAAAGATATT TCAAGGAAAT 
GTGCACAACT TTGAAAAGAA CCTTCTGAGA TGTTCTTGGT CACCTGATGG AAGCAAAATA 
GCAGCTGGCT CAGCCGACAG GTTTGTTTAT GTGTGGGATA CCACAAGCAG GAGAATATTG 
TATAAGCTGC CCGGCCATGC TGGCTCCATC AATGAAGTGG CTTTCCACCC TGATGAGCCC 
ATCATTATCT CAGCATCGAG TGACAAGAGA CTGTATATGG GAGAGATTCA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Cryo-EM structure of a human spliceosome activated for step 2 of splicing.
Nature542(7641)318-323(2017 02)
Bertram K,Agafonov DE,Liu WT,Dybkov O,Will CL,Hartmuth K,Urlaub H,Kastner B,Stark H,L?hrmann R

Highly variable cancer subpopulations that exhibit enhanced transcriptome variability and metastatic fitness.
Nature communications711246(2016 May)
Nguyen A,Yoshida M,Goodarzi H,Tavazoie SF

NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent.
Drug and alcohol dependence129(3)254-64(2013 May)
Zuo L,Wang K,Zhang XY,Krystal JH,Li CS,Zhang F,Zhang H,Luo X

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW

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SNRNP40 cDNA ORF clone, Homo sapiens(human)

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Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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