IL27RA cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | IL27RA |
| Entrez Gene ID | 9466 |
| Full Name | interleukin 27 receptor subunit alpha |
| Synonyms | CRL1,IL-27RA,IL27R,TCCR,WSX1,zcytor1 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_004843.3 | NP_004834.1 | interleukin-27 receptor subunit alpha precursor |
| NM_004843.4 | NP_004834.1 | interleukin-27 receptor subunit alpha precursor |
| Canis lupus familiaris (dog) | IL27RA | XP_005633266.1 |
| Homo sapiens (human) | IL27RA | NP_004834.1 |
| Bos taurus (cattle) | IL27RA | NP_001091497.1 |
| Mus musculus (house mouse) | Il27ra | NP_057880.2 |
| Pan troglodytes (chimpanzee) | IL27RA | XP_512969.2 |
| IL27RA | XP_001111176.1 | |
| Rattus norvegicus (Norway rat) | Il27ra | NP_001099413.1 |
Related articles in PubMed
IL-27 induces a pro-inflammatory response in human fetal membranes mediating preterm birth.
Yin N, Wang H, Zhang H, Ge H, Tan B, Yuan Y, Luo X, Olson DM, Baker PN, Qi H
International immunopharmacology50361-369(2017 Sep)
Identification of Interleukin-27 (IL-27)/IL-27 Receptor Subunit Alpha as a Critical Immune Axis for
Ruiz-Riol M, Berdnik D, Llano A, Mothe B, G?lvez C, P?rez-?lvarez S, Oriol-Tordera B, Olvera A, Silva-Arrieta S, Meulbroek M, Pujol F, Coll J, Martinez-Picado J, Ganoza C, Sanchez J, G?mez G, Wyss-Coray T, Brander C
Journal of virology91(16)(2017 Aug)
Production of IL-27 in multiple sclerosis lesions by astrocytes and myeloid cells: Modulation of local immune responses.
S?n?cal V, Deblois G, Beauseigle D, Schneider R, Brandenburg J, Newcombe J, Moore CS, Prat A, Antel J, Arbour N
Glia64(4)553-69(2016 Apr)
Interleukin 27R regulates CD4+ T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection.
Torrado E, Fountain JJ, Liao M, Tighe M, Reiley WW, Lai RP, Meintjes G, Pearl JE, Chen X, Zak DE, Thompson EG, Aderem A, Ghilardi N, Solache A, McKinstry KK, Strutt TM, Wilkinson RJ, Swain SL, Cooper AM
The Journal of experimental medicine212(9)1449-63(2015 Aug)
A soluble form of IL-27R? is a natural IL-27 antagonist.
Dietrich C, Candon S, Ruemmele FM, Devergne O
Journal of immunology (Baltimore, Md. : 1950)192(11)5382-9(2014 Jun)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
These results identify IL-27 and its specific receptor IL27RA as a critical immune axis for the antiviral immune response and as robust correlates of viral load and proviral reservoir size in mononuclear leukocytes in HIV infection.
Title: Identification of Interleukin-27 (IL-27)/IL-27 Receptor Subunit Alpha as a Critical Immune Axis for
Findings demonstrated that IL-27 and IL-27R were elevated in multiple sclerosis lesions and that local IL-27 can modulate immune properties of astrocytes and infiltrating immune cells
Title: Production of IL-27 in multiple sclerosis lesions by astrocytes and myeloid cells: Modulation of local immune responses.
The significant expression of IL-27 in TB and the negative influence of IL-27R on T cell function demonstrate the pathway by which this cytokine/receptor pair is detrimental in TB.
Title: Interleukin 27R regulates CD4+ T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection.
natural sIL-27Ralpha binds rIL-27, inhibits IL-27 binding to its cell surface receptor, and is a potent inhibitor of IL-27 signaling, as shown by its ability to specifically block IL-27-mediated STAT activation, at low molar excess over IL-27.
Title: A soluble form of IL-27R? is a natural IL-27 antagonist.
Aberrant hypermethylation and reduced expression of IL27RA is associated with myelodysplastic syndromes.
Title: Genome-wide profiling of methylation identifies novel targets with aberrant hypermethylation and reduced expression in low-risk myelodysplastic syndromes.
The following IL27RA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL27RA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu27514 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_004843.3 , NM_004843.4 | |
| Accession Version | NM_004843.3 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1911bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-10-02 | |
| Organism | Homo sapiens(human) | |
| Product | interleukin-27 receptor subunit alpha precursor | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF053004.1 and AF106912.1. On Jul 3, 2012 this sequence version replaced NM_004843.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF106912.1, AF053004.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGCGGGGAG GCAGGGGCGC CCCTTTCTGG CTGTGGCCGC TGCCCAAGCT GGCGCTGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_004834.1 |
| CDS | 134..2044 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_004843.3 |
ORF Insert Sequence:
1 | ATGCGGGGAG GCAGGGGCGC CCCTTTCTGG CTGTGGCCGC TGCCCAAGCT GGCGCTGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu27514 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_004843.3 , NM_004843.4 | |
| Accession Version | NM_004843.4 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1911bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-09-26 | |
| Organism | Homo sapiens(human) | |
| Product | interleukin-27 receptor subunit alpha precursor | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF053004.1, AF106912.1 and AC022098.9. On Nov 22, 2018 this sequence version replaced NM_004843.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF106912.1, AY358876.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000263379.4/ ENSP00000263379.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. | |
1 | ATGCGGGGAG GCAGGGGCGC CCCTTTCTGG CTGTGGCCGC TGCCCAAGCT GGCGCTGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_004834.1 |
| CDS | 112..2022 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_004843.4 |
ORF Insert Sequence:
1 | ATGCGGGGAG GCAGGGGCGC CCCTTTCTGG CTGTGGCCGC TGCCCAAGCT GGCGCTGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
IL-27 induces a pro-inflammatory response in human fetal membranes mediating preterm birth. |
|
Identification of Interleukin-27 (IL-27)/IL-27 Receptor Subunit Alpha as a Critical Immune Axis for |
|
Production of IL-27 in multiple sclerosis lesions by astrocytes and myeloid cells: Modulation of local immune responses. |
|
Interleukin 27R regulates CD4+ T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection. |
|
A soluble form of IL-27R? is a natural IL-27 antagonist. |