Gene Symbol | Calr |
Entrez Gene ID | 12317 |
Full Name | calreticulin |
Synonyms | CRT,Calregulin |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Calr cDNA ORF clone
Gene Symbol | Calr |
Entrez Gene ID | 12317 |
Full Name | calreticulin |
Synonyms | CRT,Calregulin |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_007591.3 | NP_031617.1 | calreticulin precursor |
Bos taurus (cattle) | CALR | NP_776425.1 |
Danio rerio (zebrafish) | calrl2 | NP_956007.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP004212 | XP_313116.1 |
Arabidopsis thaliana (thale cress) | CRT1b | NP_172392.1 |
Mus musculus (house mouse) | Calr | NP_031617.1 |
Rattus norvegicus (Norway rat) | Calr | NP_071794.1 |
Gallus gallus (chicken) | CALR3 | XP_418262.3 |
Arabidopsis thaliana (thale cress) | CRT1a | NP_176030.1 |
Homo sapiens (human) | CALR | NP_004334.1 |
Oryza sativa (rice) | Os03g0832200 | NP_001051799.1 |
Pan troglodytes (chimpanzee) | CALR | XP_003316194.1 |
Canis lupus familiaris (dog) | CALR | XP_867310.2 |
Caenorhabditis elegans (roundworm) | crt-1 | NP_504575.1 |
Oryza sativa (rice) | Os07g0246200 | NP_001059283.1 |
Xenopus tropicalis (tropical clawed frog) | calr | NP_001001253.1 |
CALR | XP_001110217.1 | |
Drosophila melanogaster (fruit fly) | Crc | NP_001262430.1 |
Mutant calreticulin knock-in mice develop thrombocytosis and myelofibrosis without a stem cell self-renewal advantage.
Li J, Prins D, Park HJ, Grinfeld J, Gonzalez-Arias C, Loughran S, Dovey OM, Klampfl T, Bennett C, Hamilton TL, Pask DC, Sneade R, Williams M, Aungier J, Ghevaert C, Vassiliou GS, Kent DG, Green AR
Blood(2017 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
study provides a model showing that the C-terminal of mutant CALR activated JAK-STAT signaling specifically downstream of MPL and may have a central role in CALR-induced myeloproliferative neoplasms
Title: Calreticulin mutant mice develop essential thrombocythemia that is ameliorated by the JAK inhibitor ruxolitinib.
a profound impairment in calreticulin function when its lectin site was inactivated. Remarkably, inactivation of the polypeptide binding site had little impact. These findings indicate that the lectin-based mode of client interaction is the predominant contributor to the chaperone functions of calreticulin within the endoplasmic reticulum.
Title: Contributions of the Lectin and Polypeptide Binding Sites of Calreticulin to Its Chaperone Functions in Vitro and in Cells.
the results of this investigation provide the first molecular insights into the phospholipid binding site of calreticulin as a key anchor point for the cell surface expression of calreticulin on apoptotic cells
Title: The C-Terminal Acidic Region of Calreticulin Mediates Phosphatidylserine Binding and Apoptotic Cell Phagocytosis.
This essential role of calreticulin in nucleocytoplasmic communication competency ties its regulatory action with proficiency of cardiac myofibrillogenesis essential for proper cardiac development.
Title: Calreticulin secures calcium-dependent nuclear pore competency required for cardiogenesis.
Calreticulin mediates vascular smooth muscle cell responses to injury through the regulation of collagen deposition and neointima formation.
Title: Calreticulin Regulates Neointima Formation and Collagen Deposition following Carotid Artery Ligation.
The following Calr gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Calr cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu17916 | |
Clone ID Related Accession (Same CDS sequence) | NM_007591.3 | |
Accession Version | NM_007591.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1251bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-24 | |
Organism | Mus musculus(house mouse) | |
Product | calreticulin precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY291864.1, AK075605.1, AK160197.1 and BB727203.1. On Oct 31, 2006 this sequence version replaced NM_007591.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK075605.1, X14926.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGCTCCTTT CGGTGCCGCT CCTGCTTGGC CTCCTCGGCC TGGCCGCCGC AGACCCTGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_031617.1 |
CDS | 134..1384 |
Translation |
Target ORF information:
Target ORF information:
|
NM_007591.3 |
1 | ATGCTCCTTT CGGTGCCGCT CCTGCTTGGC CTCCTCGGCC TGGCCGCCGC AGACCCTGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Mutant calreticulin knock-in mice develop thrombocytosis and myelofibrosis without a stem cell self-renewal advantage. |