Gene Symbol | Hexb |
Entrez Gene ID | 15212 |
Full Name | hexosaminidase B |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Hexb cDNA ORF clone
gRNAs
Gene Symbol | Hexb |
Entrez Gene ID | 15212 |
Full Name | hexosaminidase B |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_010422.2 | NP_034552.1 | beta-hexosaminidase subunit beta precursor |
Canis lupus familiaris (dog) | HEXB | XP_005617969.1 |
Gallus gallus (chicken) | HEXB | XP_424791.3 |
Danio rerio (zebrafish) | hexa | NP_001108317.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP010056 | XP_319210.4 |
Xenopus tropicalis (tropical clawed frog) | hexb | NP_001120459.1 |
Pan troglodytes (chimpanzee) | HEXB | XP_001150632.1 |
Rattus norvegicus (Norway rat) | Hexb | NP_001011946.1 |
Oryza sativa (rice) | Os05g0115900 | NP_001054468.1 |
Mus musculus (house mouse) | Hexb | NP_034552.1 |
HEXB | XP_001103139.1 | |
Arabidopsis thaliana (thale cress) | HEXO1 | NP_567017.2 |
Homo sapiens (human) | HEXB | NP_000512.1 |
Bos taurus (cattle) | HEXB | NP_001069978.2 |
Bos taurus (cattle) | LOC786974 | XP_002696308.3 |
Caenorhabditis elegans (roundworm) | hex-1 | NP_508409.1 |
Intravenous administration of scAAV9-Hexb normalizes lifespan and prevents pathology in Sandhoff disease mice.
Niemir N, Rouvi?re L, Besse A, Vanier MT, Dmytrus J, Marais T, Astord S, Puech JP, Panasyuk G, Cooper JD, Barkats M, Caillaud C
Human molecular genetics(2018 Jan)
Abnormal differentiation of Sandhoff disease model mouse-derived multipotent stem cells toward a neural lineage.
Ogawa Y, Kaizu K, Yanagi Y, Takada S, Sakuraba H, Oishi K
PloS one12(6)e0178978(2017)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
mast cell granule beta-hexosaminidase is crucial for defense against bacterial invasion, but is not involved in the allergic response. the bactericidal mechanism of beta-hexosaminidase involves degradation of bacterial cell wall peptidoglycan.
Title: Does ?-hexosaminidase function only as a degranulation indicator in mast cells? The primary role of ?-hexosaminidase in mast cell granules.
transgenic inducible strains of Sandhoff disease mice provide a dynamic platform with which to explore the pathophysiological sequelae immediately after loss of neuronal lysosomal beta-hexosaminidase activity.
Title: Characterization of inducible models of Tay-Sachs and related disease.
Thymic involution and corticosterone level in Sandhoff disease model mice.
Title: Thymic involution and corticosterone level in Sandhoff disease model mice: new aspects the pathogenesis of GM2 gangliosidosis.
These data suggest that the restricted ketogenic diet and N-butyldeoxynojirimycin may be a potential combinatorial therapy for Sandhoff disease.
Title: Restricted ketogenic diet enhances the therapeutic action of N-butyldeoxynojirimycin towards brain GM2 accumulation in adult Sandhoff disease mice.
Mannose receptor (-/-) liver sinusoidal endothelial cells had markedly and significantly reduced enzyme activities for four out of five lysosomal enzymes tested, i.e., cathepsin-D, alpha-mannosidase, beta-hexosaminidase and arylsulfatase.
Title: Liver sinusoidal endothelial cells depend on mannose receptor-mediated recruitment of lysosomal enzymes for normal degradation capacity.
The following Hexb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hexb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu21830 | |
Clone ID Related Accession (Same CDS sequence) | NM_010422.2 | |
Accession Version | NM_010422.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1611bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-15 | |
Organism | Mus musculus(house mouse) | |
Product | beta-hexosaminidase subunit beta precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY145642.1, AK168825.1 and CD775639.1. On Mar 26, 2009 this sequence version replaced NM_010422.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK151149.1, AK159178.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGCCGCAGT CCCCGCGTAG CGCCCCCGGG CTGCTGCTGC TGCAGGCGCT GGTGTCGCTA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_034552.1 |
CDS | 97..1707 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGCCGCAGT CCCCGCGTAG CGCCCCCGGG CTGCTGCTGC TGCAGGCGCT GGTGTCGCTA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Intravenous administration of scAAV9-Hexb normalizes lifespan and prevents pathology in Sandhoff disease mice. |
Abnormal differentiation of Sandhoff disease model mouse-derived multipotent stem cells toward a neural lineage. |