Kpnb1 cDNA ORF clone, Mus musculus(house mouse)
| Gene Symbol | Kpnb1 |
| Entrez Gene ID | 16211 |
| Full Name | karyopherin (importin) beta 1 |
| Synonyms | AA409963,IPOB,Impnb |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_008379.3 | NP_032405.3 | importin subunit beta-1 |
| Gallus gallus (chicken) | KPNB1 | XP_004950071.1 |
| Caenorhabditis elegans (roundworm) | imb-1 | NP_491477.2 |
| Kluyveromyces lactis | KLLA0B05665g | XP_451788.1 |
| Homo sapiens (human) | KPNB1 | NP_002256.2 |
| Bos taurus (cattle) | KPNB1 | NP_001180082.1 |
| Mus musculus (house mouse) | Kpnb1 | NP_032405.3 |
| Drosophila melanogaster (fruit fly) | Fs(2)Ket | NP_001246109.1 |
| Neurospora crassa | NCU02011 | XP_964876.1 |
| Oryza sativa (rice) | Os12g0568800 | NP_001067068.1 |
| Saccharomyces cerevisiae (baker's yeast) | KAP95 | NP_013451.1 |
| Schizosaccharomyces pombe (fission yeast) | kap95 | NP_594233.1 |
| Pan troglodytes (chimpanzee) | KPNB1 | XP_003315429.1 |
| Anopheles gambiae (African malaria mosquito) | AgaP_AGAP009921 | XP_319040.3 |
| Arabidopsis thaliana (thale cress) | AT5G53480 | NP_200160.1 |
| Xenopus tropicalis (tropical clawed frog) | kpnb1 | XP_002940197.1 |
| KPNB1 | XP_001082833.2 | |
| Canis lupus familiaris (dog) | KPNB1 | XP_005624657.1 |
| Rattus norvegicus (Norway rat) | Kpnb1 | NP_058759.1 |
| Danio rerio (zebrafish) | kpnb1 | NP_001032791.2 |
| Eremothecium gossypii | AGOS_ACL187W | NP_983217.2 |
| Magnaporthe oryzae (rice blast fungus) | MGG_03668 | XP_003716218.1 |
Related articles in PubMed
AMP Kinase Activation Alters Oxidant-Induced Stress Granule Assembly by Modulating Cell Signaling and Microtubule Organization.
Mahboubi H, Koromilas AE, Stochaj U
Molecular pharmacology90(4)460-8(2016 Oct)
Nucleolin-Mediated RNA Localization Regulates Neuron Growth and Cycling Cell Size.
Perry RB, Rishal I, Doron-Mandel E, Kalinski AL, Medzihradszky KF, Terenzio M, Alber S, Koley S, Lin A, Rozenbaum M, Yudin D, Sahoo PK, Gomes C, Shinder V, Geraisy W, Huebner EA, Woolf CJ, Yaron A, Burlingame AL, Twiss JL, Fainzilber M
Cell reports16(6)1664-1676(2016 08)
The importin protein karyopherin-?1 regulates the mice fibroblast-like synoviocytes inflammation via facilitating nucleus transportation of STAT3 transcription factor.
Sun C, Yu Z, Wang Y, Tao T
Biochemical and biophysical research communications471(4)553-9(2016 Mar)
KPN?1 promotes palmitate-induced insulin resistance via NF-?B signaling in hepatocytes.
Wang S, Zhao Y, Xia N, Zhang W, Tang Z, Wang C, Zhu X, Cui S
Journal of physiology and biochemistry71(4)763-72(2015 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
KPNB1 may play a key role in the inflammation process of rheumatoid arthritis via STAT3 signal transduction pathway.
Title: The importin protein karyopherin-?1 regulates the mice fibroblast-like synoviocytes inflammation via facilitating nucleus transportation of STAT3 transcription factor.
KPNb1 acts as a positive regulator in the NF-kappaB pathway to enhance palmitate-induced inflammation response.
Title: KPN?1 promotes palmitate-induced insulin resistance via NF-?B signaling in hepatocytes.
The study revealed a regulatory role of the p97-Npl4-Ufd1 complex in regulating a partial degradation of the NF-kappaB subunit p100.
Title: The Transitional Endoplasmic Reticulum ATPase p97 Regulates the Alternative Nuclear Factor NF-?B Signaling via Partial Degradation of the NF-?B Subunit p100.
Ei24 can bind specifically to IMPbeta1 and IMPalpha2 to impede their normal role in nuclear import.
Title: The p53-induced factor Ei24 inhibits nuclear import through an importin ?-binding-like domain.
Identification of a karyopherin beta1/beta2 proline-tyrosine nuclear localization signal in huntingtin protein.
Title: Identification of a karyopherin ?1/?2 proline-tyrosine nuclear localization signal in huntingtin protein.
The following Kpnb1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kpnb1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OMu01812 | |
| Clone ID Related Accession (Same CDS sequence) | NM_008379.3 | |
| Accession Version | NM_008379.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2631bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-25 | |
| Organism | Mus musculus(house mouse) | |
| Product | importin subunit beta-1 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK147175.1, BC052438.1 and AL627445.21. On Feb 17, 2006 this sequence version replaced NM_008379.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK147175.1, AK077709.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164137, SAMN01164139 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGAGCTCA TAACCATCCT CGAGAAGACC GTGTCTCCGG ATCGGCTGGA GCTGGAAGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_032405.3 |
| CDS | 308..2938 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_008379.3 |
ORF Insert Sequence:
1 | ATGGAGCTCA TAACCATCCT CGAGAAGACC GTGTCTCCGG ATCGGCTGGA GCTGGAAGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
AMP Kinase Activation Alters Oxidant-Induced Stress Granule Assembly by Modulating Cell Signaling and Microtubule Organization. |
|
Nucleolin-Mediated RNA Localization Regulates Neuron Growth and Cycling Cell Size. |
|
The importin protein karyopherin-?1 regulates the mice fibroblast-like synoviocytes inflammation via facilitating nucleus transportation of STAT3 transcription factor. |
|
KPN?1 promotes palmitate-induced insulin resistance via NF-?B signaling in hepatocytes. |