Gene Symbol | Mdh2 |
Entrez Gene ID | 17448 |
Full Name | malate dehydrogenase 2, NAD (mitochondrial) |
Synonyms | MDH,Mdh-2,Mor-1,Mor1 |
General protein information |
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Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Mdh2 cDNA ORF clone
gRNAs
Gene Symbol | Mdh2 |
Entrez Gene ID | 17448 |
Full Name | malate dehydrogenase 2, NAD (mitochondrial) |
Synonyms | MDH,Mdh-2,Mor-1,Mor1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_008617.2 | NP_032643.2 | malate dehydrogenase, mitochondrial precursor |
Homo sapiens (human) | MDH2 | NP_005909.2 |
Pan troglodytes (chimpanzee) | MDH2 | XP_001156205.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP001903 | XP_321163.4 |
Caenorhabditis elegans (roundworm) | mdh-2 | NP_498457.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_09367 | XP_003720254.1 |
Arabidopsis thaliana (thale cress) | mMDH1 | NP_564625.1 |
Oryza sativa (rice) | Os01g0649100 | NP_001043717.1 |
Oryza sativa (rice) | Os05g0574400 | NP_001056389.1 |
LOC719983 | XP_001114888.1 | |
Canis lupus familiaris (dog) | LOC102152275 | XP_005634130.1 |
Mus musculus (house mouse) | Mdh2 | NP_032643.2 |
Gallus gallus (chicken) | MDH2 | XP_415765.1 |
Drosophila melanogaster (fruit fly) | Mdh2 | NP_650696.1 |
Kluyveromyces lactis | KLLA0F25960g | XP_456236.1 |
Arabidopsis thaliana (thale cress) | mMDH2 | NP_188120.1 |
Xenopus tropicalis (tropical clawed frog) | mdh2 | NP_001011412.1 |
Danio rerio (zebrafish) | mdh2 | NP_998296.1 |
Schizosaccharomyces pombe (fission yeast) | SPCC306.08c | NP_587816.1 |
Canis lupus familiaris (dog) | MDH2 | XP_849944.1 |
Rattus norvegicus (Norway rat) | Mdh2 | NP_112413.2 |
Saccharomyces cerevisiae (baker's yeast) | MDH1 | NP_012838.1 |
Eremothecium gossypii | AGOS_ADR152C | NP_984248.1 |
Neurospora crassa | NCU04899 | XP_958408.1 |
MDH2 is an RNA binding protein involved in downregulation of sodium channel Scn1a expression under seizure condition.
Chen YH, Liu SJ, Gao MM, Zeng T, Lin GW, Tan NN, Tang HL, Lu P, Su T, Sun WW, Xie LC, Yi YH, Long YS
Biochimica et biophysica acta1863(6)1492-1499(2017 Jun)
Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development.
Bulusu V, Prior N, Snaebjornsson MT, Kuehne A, Sonnen KF, Kress J, Stein F, Schultz C, Sauer U, Aulehla A
Developmental cell40(4)331-341.e4(2017 02)
Targeting CAG repeat RNAs reduces Huntington's disease phenotype independently of huntingtin levels.
Ru? L, Ba?ez-Coronel M, Creus-Muncunill J, Giralt A, Alcal?-Vida R, Mentxaka G, Kagerbauer B, Zome?o-Abell?n MT, Aranda Z, Venturi V, P?rez-Navarro E, Estivill X, Mart? E
The Journal of clinical investigation126(11)4319-4330(2016 Nov)
VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease.
Guo X, Sun X, Hu D, Wang YJ, Fujioka H, Vyas R, Chakrapani S, Joshi AU, Luo Y, Mochly-Rosen D, Qi X
Nature communications712646(2016 Aug)
Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series.
Bowman CE, Zhao L, Hartung T, Wolfgang MJ
Molecular and cellular biology36(15)2089-104(2016 Aug)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The acetylation of MDH2 was affected by the cellular energy state and subsequently regulated adipogenic differentiation.
Title: Acceleration of adipogenic differentiation via acetylation of malate dehydrogenase 2.
The following Mdh2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mdh2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu14503 | |
Clone ID Related Accession (Same CDS sequence) | NM_008617.2 | |
Accession Version | NM_008617.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1017bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-14 | |
Organism | Mus musculus(house mouse) | |
Product | malate dehydrogenase, mitochondrial precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC023482.1. On Jun 19, 2003 this sequence version replaced NM_008617.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC023482.1, AK135162.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## |
1 | ATGCTGTCCG CTCTCGCCCG TCCTGCCGGC GCCGCTCTCC GCCGCAGCTT CAGCACTTCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_032643.2 |
CDS | 88..1104 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGCTGTCCG CTCTCGCCCG TCCTGCCGGC GCCGCTCTCC GCCGCAGCTT CAGCACTTCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
MDH2 is an RNA binding protein involved in downregulation of sodium channel Scn1a expression under seizure condition. |
Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. |
Targeting CAG repeat RNAs reduces Huntington's disease phenotype independently of huntingtin levels. |
VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease. |
Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series. |