Mdh2 cDNA ORF clone, Rattus norvegicus(Norway rat)
| Gene Symbol | Mdh2 |
| Entrez Gene ID | 81829 |
| Full Name | malate dehydrogenase 2 |
| Synonyms | Mor1 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome | |
| Summary | catalyzes the conversion of pyruvate or oxaloacetate to malate [RGD, Feb 2006]. |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_031151.2 | NP_112413.2 | malate dehydrogenase, mitochondrial precursor |
| Homo sapiens (human) | MDH2 | NP_005909.2 |
| Pan troglodytes (chimpanzee) | MDH2 | XP_001156205.1 |
| Anopheles gambiae (African malaria mosquito) | AgaP_AGAP001903 | XP_321163.4 |
| Caenorhabditis elegans (roundworm) | mdh-2 | NP_498457.1 |
| Magnaporthe oryzae (rice blast fungus) | MGG_09367 | XP_003720254.1 |
| Arabidopsis thaliana (thale cress) | mMDH1 | NP_564625.1 |
| Oryza sativa (rice) | Os01g0649100 | NP_001043717.1 |
| Oryza sativa (rice) | Os05g0574400 | NP_001056389.1 |
| LOC719983 | XP_001114888.1 | |
| Canis lupus familiaris (dog) | LOC102152275 | XP_005634130.1 |
| Mus musculus (house mouse) | Mdh2 | NP_032643.2 |
| Gallus gallus (chicken) | MDH2 | XP_415765.1 |
| Drosophila melanogaster (fruit fly) | Mdh2 | NP_650696.1 |
| Kluyveromyces lactis | KLLA0F25960g | XP_456236.1 |
| Arabidopsis thaliana (thale cress) | mMDH2 | NP_188120.1 |
| Xenopus tropicalis (tropical clawed frog) | mdh2 | NP_001011412.1 |
| Danio rerio (zebrafish) | mdh2 | NP_998296.1 |
| Schizosaccharomyces pombe (fission yeast) | SPCC306.08c | NP_587816.1 |
| Canis lupus familiaris (dog) | MDH2 | XP_849944.1 |
| Rattus norvegicus (Norway rat) | Mdh2 | NP_112413.2 |
| Saccharomyces cerevisiae (baker's yeast) | MDH1 | NP_012838.1 |
| Eremothecium gossypii | AGOS_ADR152C | NP_984248.1 |
| Neurospora crassa | NCU04899 | XP_958408.1 |
Related articles in PubMed
Mutations in MDH2, Encoding a Krebs Cycle Enzyme, Cause Early-Onset Severe Encephalopathy.
Ait-El-Mkadem S, Dayem-Quere M, Gusic M, Chaussenot A, Bannwarth S, Fran?ois B, Genin EC, Fragaki K, Volker-Touw CLM, Vasnier C, Serre V, van Gassen KLI, Lespinasse F, Richter S, Eisenhofer G, Rouzier C, Mochel F, De Saint-Martin A, Abi Warde MT, de Sain-van der Velde MGM, Jans JJM, Amiel J, Avsec Z, Mertes C, Haack TB, Strom T, Meitinger T, Bonnen PE, Taylor RW, Gagneur J, van Hasselt PM, R?tig A, Delahodde A, Prokisch H, Fuchs SA, Paquis-Flucklinger V
American journal of human genetics100(1)151-159(2017 Jan)
Acute administration of l-tyrosine alters energetic metabolism of hippocampus and striatum of infant rats.
Ramos AC, Ferreira GK, Carvalho-Silva M, Furlanetto CB, Gon?alves CL, Ferreira GC, Schuck PF, Streck EL
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience31(5)303-7(2013 Aug)
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)
Proteomic characterization of the human sperm nucleus.
de Mateo S, Castillo J, Estanyol JM, Ballesc? JL, Oliva R
Proteomics11(13)2714-26(2011 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Our results indicate an alteration in the energy metabolism in hippocampus and striatum of infant rats after acute administration of l-tyrosine.
Title: Acute administration of l-tyrosine alters energetic metabolism of hippocampus and striatum of infant rats.
L-2-hydroxyglutarate accumulates as a result of a deficiency in FAD-linked L-2-hydroxyglutarate dehydrogenase. mitochondrial L-malate dehydrogenase is responsible for the excretion of L-2-hydroxyglutarate in this condition.
Title: L-2-hydroxyglutaric aciduria, a defect of metabolite repair.
The following Mdh2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mdh2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | ORa12428 | |
| Clone ID Related Accession (Same CDS sequence) | NM_031151.2 | |
| Accession Version | NM_031151.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1017bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-09-23 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | malate dehydrogenase, mitochondrial precursor | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC063165.1. On Feb 9, 2004 this sequence version replaced NM_031151.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC063165.1, FQ213887.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906348, SAMN01906349 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## | |
1 | ATGCTGTCCG CTCTCGCCCG TCCTGTCGGT GCCGCTCTCC GCCGCAGCTT CAGCACTTCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_112413.2 |
| CDS | 104..1120 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_031151.2 |
ORF Insert Sequence:
1 | ATGCTGTCCG CTCTCGCCCG TCCTGTCGGT GCCGCTCTCC GCCGCAGCTT CAGCACTTCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Mutations in MDH2, Encoding a Krebs Cycle Enzyme, Cause Early-Onset Severe Encephalopathy. |
|
Acute administration of l-tyrosine alters energetic metabolism of hippocampus and striatum of infant rats. |
|
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. |
|
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. |
|
Proteomic characterization of the human sperm nucleus. |