Gene Symbol | Rev3l |
Entrez Gene ID | 19714 |
Full Name | REV3 like, DNA directed polymerase zeta catalytic subunit |
Synonyms | Rev,Rev3,Sez4 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Rev3l cDNA ORF clone
gRNAs
Gene Symbol | Rev3l |
Entrez Gene ID | 19714 |
Full Name | REV3 like, DNA directed polymerase zeta catalytic subunit |
Synonyms | Rev,Rev3,Sez4 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006512622.2 | XP_006512685.1 | DNA polymerase zeta catalytic subunit isoform X1 |
XM_006512622.3 | XP_006512685.1 | DNA polymerase zeta catalytic subunit isoform X1 |
XM_006512624.4 | XP_006512687.1 | DNA polymerase zeta catalytic subunit isoform X3 |
XM_006512623.3 | XP_006512686.1 | DNA polymerase zeta catalytic subunit isoform X2 |
XM_006512624.3 | XP_006512687.1 | DNA polymerase zeta catalytic subunit isoform X3 |
XM_017313854.1 | XP_017169343.1 | DNA polymerase zeta catalytic subunit isoform X4 |
XM_006512623.4 | XP_006512686.1 | DNA polymerase zeta catalytic subunit isoform X2 |
XM_017313854.2 | XP_017169343.1 | DNA polymerase zeta catalytic subunit isoform X4 |
NM_011264.3 | NP_035394.2 | DNA polymerase zeta catalytic subunit |
Pan troglodytes (chimpanzee) | REV3L | XP_003950950.1 |
Canis lupus familiaris (dog) | REV3L | XP_539084.3 |
Mus musculus (house mouse) | Rev3l | NP_035394.2 |
REV3L | XP_001086055.2 | |
Bos taurus (cattle) | REV3L | NP_001193101.1 |
Rattus norvegicus (Norway rat) | Rev3l | NP_001077435.1 |
Gallus gallus (chicken) | REV3L | XP_426179.4 |
Homo sapiens (human) | REV3L | NP_002903.3 |
Danio rerio (zebrafish) | rev3l | XP_002665692.3 |
Xenopus tropicalis (tropical clawed frog) | rev3l | XP_002936975.1 |
DNA polymerase ? limits chromosomal damage and promotes cell survival following aflatoxin exposure.
Lin YC, Owen N, Minko IG, Lange SS, Li L, Stone MP, Wood RD, McCullough AK, Lloyd RS
Proceedings of the National Academy of Sciences of the United States of America113(48)13774-13779(2016 Nov)
A single aspartate mutation in the conserved catalytic site of Rev3L generates a hypomorphic phenotype in vivo and in vitro.
Fritzen R, Delbos F, De Smet A, Palancade B, Canman CE, Aoufouchi S, Weill JC, Reynaud CA, Storck S
DNA repair4637-46(2016 10)
The Polymerase Activity of Mammalian DNA Pol ? Is Specifically Required for Cell and Embryonic Viability.
Lange SS, Tomida J, Boulware KS, Bhetawal S, Wood RD
PLoS genetics12(1)e1005759(2016 Jan)
De novo mutations in PLXND1 and REV3L cause M?bius syndrome.
Tomas-Roca L, Tsaalbi-Shtylik A, Jansen JG, Singh MK, Epstein JA, Altunoglu U, Verzijl H, Soria L, van Beusekom E, Roscioli T, Iqbal Z, Gilissen C, Hoischen A, de Brouwer AP, Erasmus C, Schubert D, Brunner H, P?rez Ayt?s A, Marin F, Aroca P, Kayserili H, Carta A, de Wind N, Padberg GW, van Bokhoven H
Nature communications67199(2015 Jun)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
A single aspartate mutation in the conserved catalytic site of Rev3L generates a hypomorphic phenotype in vivo and in vitro.
Title: A single aspartate mutation in the conserved catalytic site of Rev3L generates a hypomorphic phenotype in vivo and in vitro.
the functions of REV3L in maintaining cell viability, embryonic viability and genomic stability are directly dependent on its polymerase activity, and cannot be ameliorated by an additional deletion of pol eta
Title: The Polymerase Activity of Mammalian DNA Pol ? Is Specifically Required for Cell and Embryonic Viability.
results can be unified by a model in which slowly dividing cells accumulate replication-associated DNA breaks but otherwise survive Rev3L deletion, but functional polzeta is essential for responses requiring rapid proliferation
Title: Dual role for mammalian DNA polymerase ? in maintaining genome stability and proliferative responses.
Structural basis of Rev1-mediated assembly of a quaternary vertebrate translesion polymerase complex consisting of Rev1, heterodimeric polymerase (Pol) zeta, and Pol kappa
Title: Structural basis of Rev1-mediated assembly of a quaternary vertebrate translesion polymerase complex consisting of Rev1, heterodimeric polymerase (Pol) ?, and Pol ?.
DNA polymerase zeta generates tandem mutations in immunoglobulin variable regions
Title: DNA polymerase ? generates tandem mutations in immunoglobulin variable regions.
The following Rev3l gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rev3l cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu18149 | |
Clone ID Related Accession (Same CDS sequence) | NM_011264.3 | |
Accession Version | NM_011264.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 9369bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-25 | |
Organism | Mus musculus(house mouse) | |
Product | DNA polymerase zeta catalytic subunit | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AB031049.1, AC119943.12 and AC118733.8. On Jul 25, 2007 this sequence version replaced NM_011264.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB031049.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGTTTTCTG TGCGGATAGT GACTGCCGAC TACTACATGG CCAGCCCGCT GCCGGGGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_035394.2 |
CDS | 316..9684 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGTTTTCTG TGCGGATAGT GACTGCCGAC TACTACATGG CCAGCCCGCT GCCGGGGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu43787 | |
Clone ID Related Accession (Same CDS sequence) | XM_006512622.2 , XM_006512622.3 | |
Accession Version | XM_006512622.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 9372bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | DNA polymerase zeta catalytic subunit isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006512622.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTTTTCTG TGCGGATAGT GACTGCCGAC TACTACATGG CCAGCCCGCT GCCGGGGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006512685.1 |
CDS | 401..9772 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGTTTTCTG TGCGGATAGT GACTGCCGAC TACTACATGG CCAGCCCGCT GCCGGGGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu43787 | |
Clone ID Related Accession (Same CDS sequence) | XM_006512622.2 , XM_006512622.3 | |
Accession Version | XM_006512622.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 9372bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | DNA polymerase zeta catalytic subunit isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006512622.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTTTTCTG TGCGGATAGT GACTGCCGAC TACTACATGG CCAGCCCGCT GCCGGGGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006512685.1 |
CDS | 915..10286 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGTTTTCTG TGCGGATAGT GACTGCCGAC TACTACATGG CCAGCCCGCT GCCGGGGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu43788 | |
Clone ID Related Accession (Same CDS sequence) | XM_006512623.3 , XM_006512623.4 | |
Accession Version | XM_006512623.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 9138bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | DNA polymerase zeta catalytic subunit isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006512623.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCATTCA GTATCGACAG AGCACTTAAT GTGGCTTTAG GCAATCCATC TTCCACTGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006512686.1 |
CDS | 763..9900 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCATTCA GTATCGACAG AGCACTTAAT GTGGCTTTAG GCAATCCATC TTCCACTGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu43788 | |
Clone ID Related Accession (Same CDS sequence) | XM_006512623.3 , XM_006512623.4 | |
Accession Version | XM_006512623.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 9138bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | DNA polymerase zeta catalytic subunit isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006512623.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCATTCA GTATCGACAG AGCACTTAAT GTGGCTTTAG GCAATCCATC TTCCACTGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006512686.1 |
CDS | 756..9893 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCATTCA GTATCGACAG AGCACTTAAT GTGGCTTTAG GCAATCCATC TTCCACTGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu43789 | |
Clone ID Related Accession (Same CDS sequence) | XM_006512624.4 , XM_006512624.3 | |
Accession Version | XM_006512624.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 9135bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | DNA polymerase zeta catalytic subunit isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006512624.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCATTCA GTATCGACAG AGCACTTAAT GTGGCTTTAG GCAATCCATC TTCCACTGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006512687.1 |
CDS | 732..9866 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCATTCA GTATCGACAG AGCACTTAAT GTGGCTTTAG GCAATCCATC TTCCACTGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu43789 | |
Clone ID Related Accession (Same CDS sequence) | XM_006512624.4 , XM_006512624.3 | |
Accession Version | XM_006512624.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 9135bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | DNA polymerase zeta catalytic subunit isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006512624.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCATTCA GTATCGACAG AGCACTTAAT GTGGCTTTAG GCAATCCATC TTCCACTGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006512687.1 |
CDS | 763..9897 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCATTCA GTATCGACAG AGCACTTAAT GTGGCTTTAG GCAATCCATC TTCCACTGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu77468 | |
Clone ID Related Accession (Same CDS sequence) | XM_017313854.1 , XM_017313854.2 | |
Accession Version | XM_017313854.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 8538bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | DNA polymerase zeta catalytic subunit isoform X4 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTTTTCTG TGCGGATAGT GACTGCCGAC TACTACATGG CCAGCCCGCT GCCGGGGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017169343.1 |
CDS | 407..8944 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTTTTCTG TGCGGATAGT GACTGCCGAC TACTACATGG CCAGCCCGCT GCCGGGGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu77468 | |
Clone ID Related Accession (Same CDS sequence) | XM_017313854.1 , XM_017313854.2 | |
Accession Version | XM_017313854.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 8538bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | DNA polymerase zeta catalytic subunit isoform X4 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_017313854.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTTTTCTG TGCGGATAGT GACTGCCGAC TACTACATGG CCAGCCCGCT GCCGGGGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017169343.1 |
CDS | 915..9452 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTTTTCTG TGCGGATAGT GACTGCCGAC TACTACATGG CCAGCCCGCT GCCGGGGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
DNA polymerase ? limits chromosomal damage and promotes cell survival following aflatoxin exposure. |
A single aspartate mutation in the conserved catalytic site of Rev3L generates a hypomorphic phenotype in vivo and in vitro. |
The Polymerase Activity of Mammalian DNA Pol ? Is Specifically Required for Cell and Embryonic Viability. |
De novo mutations in PLXND1 and REV3L cause M?bius syndrome. |