Gene Symbol | Traf5 |
Entrez Gene ID | 22033 |
Full Name | TNF receptor-associated factor 5 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Traf5 cDNA ORF clone
Gene Symbol | Traf5 |
Entrez Gene ID | 22033 |
Full Name | TNF receptor-associated factor 5 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_011633.2 | NP_035763.2 | TNF receptor-associated factor 5 |
Rattus norvegicus (Norway rat) | LOC684173 | XP_006250562.1 |
Homo sapiens (human) | TRAF5 | NP_001029082.1 |
Mus musculus (house mouse) | Traf5 | NP_035763.2 |
Gallus gallus (chicken) | TRAF5 | NP_989550.1 |
Danio rerio (zebrafish) | traf5 | XP_692341.6 |
Caenorhabditis elegans (roundworm) | trf-1 | NP_499773.2 |
Pan troglodytes (chimpanzee) | TRAF5 | XP_001169985.1 |
Canis lupus familiaris (dog) | TRAF5 | NP_001184047.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100491604 | XP_002934728.2 |
TRAF5 | XP_001108970.1 | |
Bos taurus (cattle) | TRAF5 | NP_001098810.1 |
Berberine prevents the apoptosis of mouse podocytes induced by TRAF5 overexpression by suppressing NF-?B activation.
Wu F, Yao DS, Lan TY, Wang C, Gao JD, He LQ, Huang D
International journal of molecular medicine41(1)555-563(2018 Jan)
Disruption of Tumor Necrosis Factor Receptor-Associated Factor 5 Exacerbates Murine Experimental Colitis via Regulating T Helper Cell-Mediated Inflammation.
Shang J, Li L, Wang X, Pan H, Liu S, He R, Li J, Zhao Q
Mediators of inflammation20169453745(2016)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
this study shows that TRAF2 and TRAF5 work as important regulators of the IL-6R signaling needed for Th17 development
Title: TNFR-Associated Factors 2 and 5 Differentially Regulate the Instructive IL-6 Receptor Signaling Required for Th17 Development.
The results indicated that TRAF5 deficiency significantly aggravated DSS-induced colitis, most likely by regulating Th cell-mediated inflammation.
Title: Disruption of Tumor Necrosis Factor Receptor-Associated Factor 5 Exacerbates Murine Experimental Colitis via Regulating T Helper Cell-Mediated Inflammation.
knock-out mice develop exaggerated experimental autoimmune encephalomyelitis due to enhanced Th17 cell differentiation
Title: The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6.
In conclusion, our results suggest that as an intrinsic cardioprotective factor, TRAF5 plays a crucial role in the development of cardiac hypertrophy through the negative regulation of the MEK-ERK1/2 pathway
Title: Disruption of tumor necrosis factor receptor associated factor 5 exacerbates pressure overload cardiac hypertrophy and fibrosis.
TRAF5 negatively regulates TLR signaling in B lymphocytes.
Title: TRAF5 negatively regulates TLR signaling in B lymphocytes.
The following Traf5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Traf5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu20087 | |
Clone ID Related Accession (Same CDS sequence) | NM_011633.2 | |
Accession Version | NM_011633.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1677bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-14 | |
Organism | Mus musculus(house mouse) | |
Product | TNF receptor-associated factor 5 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY290436.1, AK144694.1 and BE691772.1. On May 2, 2013 this sequence version replaced NM_011633.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMN00849380, SAMN01164142 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCTCATT CGGAGGAGCA AGCGGCTGTC CCCTGCGCCT TCATCCGCCA GAACTCTGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_035763.2 |
CDS | 346..2022 |
Translation |
Target ORF information:
Target ORF information:
|
NM_011633.2 |
1 | ATGGCTCATT CGGAGGAGCA AGCGGCTGTC CCCTGCGCCT TCATCCGCCA GAACTCTGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Berberine prevents the apoptosis of mouse podocytes induced by TRAF5 overexpression by suppressing NF-?B activation. |
Disruption of Tumor Necrosis Factor Receptor-Associated Factor 5 Exacerbates Murine Experimental Colitis via Regulating T Helper Cell-Mediated Inflammation. |